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The map label for this gene is mtlA [H]

Identifier: 50842403

GI number: 50842403

Start: 1000152

End: 1002059

Strand: Reverse

Name: mtlA [H]

Synonym: PPA0919

Alternate gene names: 50842403

Gene position: 1002059-1000152 (Counterclockwise)

Preceding gene: 50842404

Following gene: 50842402

Centisome position: 39.14

GC content: 59.7

Gene sequence:

>1908_bases
ATGTCACTACCTGACACGACGATCCACAAGAACCTGCAGGGACACGGCGCACGTGCCTCCGTCCAACGGCTCGGAGGATT
CCTGGCCGGCATGATCATGCCGAATATCGGAGCCTTCACCGCTTGGGGCCTGTTAACGGCTCTTTTCATCGAAACGGGAT
GGGCACCCAATGCAACCCTCGCCAAGCTCGTTAACCCGATCCTGACCTATCTGCTTCCCGTCCTCATCGGCTACACCGGT
GGAAAGATCGTCAACGGGACACGTGGTGGCGTCATCGGCGCGATCGCCACGATGGGCGTCATCGTCGGCGCCGACATCAC
AATGTTCCTTGGCGCGATGGTAATAGGCCCCTTCGCAGCGTGGCTCCTCAAACAGGTCGACAAGCTCCTCGACGGCCGGA
TCCATTCCGGGTTCGAGATGCTCGTAGACAATTTCGAGATCGGCATTCTCGGCATGGCCCTGGCCATCATCGGGCACCTG
GGCGTCGAACCAATCGTCTCGACTCTCATGGGCTGGCTGGCGGCCGGGGTGGGATTTCTCATGCATCACGGTCTGCTGCC
ACTCGCGTCTCTCCTCGTCGAACCGGCGAAGGTCTTATTCCTTAACAACGCCGTTAACCATGGCATCTTCACTACGCTGG
GCATCCAAGAGGCCCATATCACCGGACGATCAATTCTCTTCATGGTTGAGTCGAATCCCGGCCCCGGCCTTGGCCTACTA
CTTGCCTACCAGTTCTTCGGTTCCCGTCAGATACGTCAGTCGACTCCGGGCGCCATCATCATCCACCTCTTTGGCGGCAT
CCACGAAATCTTCTTCCCATACGTACTTATGAAGCCCAAGGCCATTCTCGCCACCATTGCCGGGGGCATGAGCGGTCTGG
CGATCGGGGTCGCATTTCATGCCGGCCTCGTTGCCCCTGCCTCCCCAGGCTCGATCATCGCATGGTTCCTCATGTGCCAG
CCCGAGCACTACCTGGCCATGATTGCCGACTTCCTCGTCGCAACTGCCGTTTCCTTTGTGGTGGCAATGCTGCTCATCCG
CAAGGATAGTACCCAGGATGACATAGCGGGTGAGGGCCAGAACCCCACTGTCCCCACCACAATCGGGGCTCAAGCCCCAC
TTACCAACATCTCCAAAGTCGTCATCGCTTGCGACGCAGGTATGGGTTCCTCAGTGATGGTCGCCTCCACCATGAAGAAC
AGACTGTCCCGGTATGGGGTCGAGGTTGCCCACACGGCCGTCGACCAGATTCCCTCGGATACGTCCCTCATCCTCATTCA
AGAAGGCCTCGTCGACCGTGTCCGCAAGCGTGCCCCGAGCGTCCGTATCGTTCCCTTTACGAATTATATGAACGATCCTG
CTTTCGACCGCGTCGAGACCGAGGTTCGCGCAGCACGTGGTGACGCCGCCACCGCGCCTACTGATAACGGAGGACTCTCC
CGGGCGTCCGATGCGAACAGCCATACCCACGTCGCCACCAGCGTGCTGCCCCACGACGCCATTCGTCTGGGACAGCGCGC
CACGAGCAAGGAGGAGGCCATCACCATGGCTGGCCAGGTGCTCATTGATGAGGGCGCCGCAGACGATGTCTACGTCAAAG
GCATGCTCGCCCGGGAAAAGCAGATCTCAACCTATATGGGCGAGGGGGTCGCGATCCCCCACGGTGTCGATGAGGTCCGC
GACCACATCGACAAGGTTACCCTAGGCTTCCTCCAGTTCCCCGAGGGCGTTGAATGGGACGGGAACATCTGCACTGTCGT
CATTCCTATCGCGTCGTCCAGCGACGAGCACCTCGAGATTATGGCAGCCCTCGCAAGAATCTTGTCTAATCCCGAAACCG
CCCGGCAACTTCGTGAGGCGACATGCACCGACGAGGTCCTCAACCTCCTCGGTTCCCAGCAGGCATAA

Upstream 100 bases:

>100_bases
CAACACAACTCCTTGACAACATAAACAGACAGATCCAGACTTGTTCACAGATCGATGGGGATCCTGCCAATGATCGGCAG
CTGAACACACTGGAGTTCCG

Downstream 100 bases:

>100_bases
TCAGCGGATCTATAGAAAGGCACACATCATGAAGGCATTGAGGTTCCACGCACCCGAGGACGTTCGTCTCGAAGACGTCC
CCGAACCGGAATGCAAGTCC

Product: PTS system, mannitol-specific IIABC component

Products: NA

Alternate protein names: EIICBA-Mtl; EII-Mtl; Mannitol permease IIC component; PTS system mannitol-specific EIIC component; Mannitol-specific phosphotransferase enzyme IIB component; PTS system mannitol-specific EIIB component; Mannitol-specific phosphotransferase enzyme IIA component; PTS system mannitol-specific EIIA component [H]

Number of amino acids: Translated: 635; Mature: 634

Protein sequence:

>635_residues
MSLPDTTIHKNLQGHGARASVQRLGGFLAGMIMPNIGAFTAWGLLTALFIETGWAPNATLAKLVNPILTYLLPVLIGYTG
GKIVNGTRGGVIGAIATMGVIVGADITMFLGAMVIGPFAAWLLKQVDKLLDGRIHSGFEMLVDNFEIGILGMALAIIGHL
GVEPIVSTLMGWLAAGVGFLMHHGLLPLASLLVEPAKVLFLNNAVNHGIFTTLGIQEAHITGRSILFMVESNPGPGLGLL
LAYQFFGSRQIRQSTPGAIIIHLFGGIHEIFFPYVLMKPKAILATIAGGMSGLAIGVAFHAGLVAPASPGSIIAWFLMCQ
PEHYLAMIADFLVATAVSFVVAMLLIRKDSTQDDIAGEGQNPTVPTTIGAQAPLTNISKVVIACDAGMGSSVMVASTMKN
RLSRYGVEVAHTAVDQIPSDTSLILIQEGLVDRVRKRAPSVRIVPFTNYMNDPAFDRVETEVRAARGDAATAPTDNGGLS
RASDANSHTHVATSVLPHDAIRLGQRATSKEEAITMAGQVLIDEGAADDVYVKGMLAREKQISTYMGEGVAIPHGVDEVR
DHIDKVTLGFLQFPEGVEWDGNICTVVIPIASSSDEHLEIMAALARILSNPETARQLREATCTDEVLNLLGSQQA

Sequences:

>Translated_635_residues
MSLPDTTIHKNLQGHGARASVQRLGGFLAGMIMPNIGAFTAWGLLTALFIETGWAPNATLAKLVNPILTYLLPVLIGYTG
GKIVNGTRGGVIGAIATMGVIVGADITMFLGAMVIGPFAAWLLKQVDKLLDGRIHSGFEMLVDNFEIGILGMALAIIGHL
GVEPIVSTLMGWLAAGVGFLMHHGLLPLASLLVEPAKVLFLNNAVNHGIFTTLGIQEAHITGRSILFMVESNPGPGLGLL
LAYQFFGSRQIRQSTPGAIIIHLFGGIHEIFFPYVLMKPKAILATIAGGMSGLAIGVAFHAGLVAPASPGSIIAWFLMCQ
PEHYLAMIADFLVATAVSFVVAMLLIRKDSTQDDIAGEGQNPTVPTTIGAQAPLTNISKVVIACDAGMGSSVMVASTMKN
RLSRYGVEVAHTAVDQIPSDTSLILIQEGLVDRVRKRAPSVRIVPFTNYMNDPAFDRVETEVRAARGDAATAPTDNGGLS
RASDANSHTHVATSVLPHDAIRLGQRATSKEEAITMAGQVLIDEGAADDVYVKGMLAREKQISTYMGEGVAIPHGVDEVR
DHIDKVTLGFLQFPEGVEWDGNICTVVIPIASSSDEHLEIMAALARILSNPETARQLREATCTDEVLNLLGSQQA
>Mature_634_residues
SLPDTTIHKNLQGHGARASVQRLGGFLAGMIMPNIGAFTAWGLLTALFIETGWAPNATLAKLVNPILTYLLPVLIGYTGG
KIVNGTRGGVIGAIATMGVIVGADITMFLGAMVIGPFAAWLLKQVDKLLDGRIHSGFEMLVDNFEIGILGMALAIIGHLG
VEPIVSTLMGWLAAGVGFLMHHGLLPLASLLVEPAKVLFLNNAVNHGIFTTLGIQEAHITGRSILFMVESNPGPGLGLLL
AYQFFGSRQIRQSTPGAIIIHLFGGIHEIFFPYVLMKPKAILATIAGGMSGLAIGVAFHAGLVAPASPGSIIAWFLMCQP
EHYLAMIADFLVATAVSFVVAMLLIRKDSTQDDIAGEGQNPTVPTTIGAQAPLTNISKVVIACDAGMGSSVMVASTMKNR
LSRYGVEVAHTAVDQIPSDTSLILIQEGLVDRVRKRAPSVRIVPFTNYMNDPAFDRVETEVRAARGDAATAPTDNGGLSR
ASDANSHTHVATSVLPHDAIRLGQRATSKEEAITMAGQVLIDEGAADDVYVKGMLAREKQISTYMGEGVAIPHGVDEVRD
HIDKVTLGFLQFPEGVEWDGNICTVVIPIASSSDEHLEIMAALARILSNPETARQLREATCTDEVLNLLGSQQA

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG2213

COG function: function code G; Phosphotransferase system, mannitol-specific IIBC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1790027, Length=635, Percent_Identity=45.6692913385827, Blast_Score=549, Evalue=1e-157,
Organism=Escherichia coli, GI1789301, Length=460, Percent_Identity=46.9565217391304, Blast_Score=416, Evalue=1e-117,
Organism=Escherichia coli, GI1788494, Length=134, Percent_Identity=46.2686567164179, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004718 [H]

Pfam domain/function: PF00359 PTS_EIIA_2; PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 67275; Mature: 67144

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00372 PTS_EIIA_TYPE_2_HIS ; PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPDTTIHKNLQGHGARASVQRLGGFLAGMIMPNIGAFTAWGLLTALFIETGWAPNATL
CCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHH
AKLVNPILTYLLPVLIGYTGGKIVNGTRGGVIGAIATMGVIVGADITMFLGAMVIGPFAA
HHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
WLLKQVDKLLDGRIHSGFEMLVDNFEIGILGMALAIIGHLGVEPIVSTLMGWLAAGVGFL
HHHHHHHHHHCCHHCCCHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
MHHGLLPLASLLVEPAKVLFLNNAVNHGIFTTLGIQEAHITGRSILFMVESNPGPGLGLL
HHCCHHHHHHHHHCHHHHEEECCCCCCCCEEEECCCHHEECCCEEEEEEECCCCCCHHHH
LAYQFFGSRQIRQSTPGAIIIHLFGGIHEIFFPYVLMKPKAILATIAGGMSGLAIGVAFH
HHHHHHCCCHHHCCCCCEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHH
AGLVAPASPGSIIAWFLMCQPEHYLAMIADFLVATAVSFVVAMLLIRKDSTQDDIAGEGQ
CCCCCCCCCCHHEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
NPTVPTTIGAQAPLTNISKVVIACDAGMGSSVMVASTMKNRLSRYGVEVAHTAVDQIPSD
CCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCCC
TSLILIQEGLVDRVRKRAPSVRIVPFTNYMNDPAFDRVETEVRAARGDAATAPTDNGGLS
CEEEEEHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
RASDANSHTHVATSVLPHDAIRLGQRATSKEEAITMAGQVLIDEGAADDVYVKGMLAREK
CCCCCCCCCHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHEEECCCCCCHHHHHHHHHHH
QISTYMGEGVAIPHGVDEVRDHIDKVTLGFLQFPEGVEWDGNICTVVIPIASSSDEHLEI
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCHHHHH
MAALARILSNPETARQLREATCTDEVLNLLGSQQA
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SLPDTTIHKNLQGHGARASVQRLGGFLAGMIMPNIGAFTAWGLLTALFIETGWAPNATL
CCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHH
AKLVNPILTYLLPVLIGYTGGKIVNGTRGGVIGAIATMGVIVGADITMFLGAMVIGPFAA
HHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
WLLKQVDKLLDGRIHSGFEMLVDNFEIGILGMALAIIGHLGVEPIVSTLMGWLAAGVGFL
HHHHHHHHHHCCHHCCCHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
MHHGLLPLASLLVEPAKVLFLNNAVNHGIFTTLGIQEAHITGRSILFMVESNPGPGLGLL
HHCCHHHHHHHHHCHHHHEEECCCCCCCCEEEECCCHHEECCCEEEEEEECCCCCCHHHH
LAYQFFGSRQIRQSTPGAIIIHLFGGIHEIFFPYVLMKPKAILATIAGGMSGLAIGVAFH
HHHHHHCCCHHHCCCCCEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHH
AGLVAPASPGSIIAWFLMCQPEHYLAMIADFLVATAVSFVVAMLLIRKDSTQDDIAGEGQ
CCCCCCCCCCHHEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
NPTVPTTIGAQAPLTNISKVVIACDAGMGSSVMVASTMKNRLSRYGVEVAHTAVDQIPSD
CCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCCC
TSLILIQEGLVDRVRKRAPSVRIVPFTNYMNDPAFDRVETEVRAARGDAATAPTDNGGLS
CEEEEEHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
RASDANSHTHVATSVLPHDAIRLGQRATSKEEAITMAGQVLIDEGAADDVYVKGMLAREK
CCCCCCCCCHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHEEECCCCCCHHHHHHHHHHH
QISTYMGEGVAIPHGVDEVRDHIDKVTLGFLQFPEGVEWDGNICTVVIPIASSSDEHLEI
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCHHHHH
MAALARILSNPETARQLREATCTDEVLNLLGSQQA
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]