BacMap

Definition	Propionibacterium acnes KPA171202, complete genome.
Accession	NC_006085
Length	2,560,265

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The map label for this gene is cypB [H]

Identifier: 50842206

GI number: 50842206

Start: 789789

End: 790301

Strand: Direct

Name: cypB [H]

Synonym: PPA0718

Alternate gene names: 50842206

Gene position: 789789-790301 (Clockwise)

Preceding gene: 50842202

Following gene: 50842207

Centisome position: 30.85

GC content: 61.4

Gene sequence:

>513_bases
GTGGCCTCTACCGCGACTCTGCGCACCAATCACGGCGACATCGTCGTTAACCTCTTTGCCGATCAGGCTCCCAAGACTGT
CGACAATTTCGTCGGTCTGGCCGGCGGCACGAAGGAGTACGTCGATCCGCACACCGGTCAGCCGACCACTGGTAAGTTCT
ACGACGGCTTGACCTTCCACCGCGTCATTGACGGGTTCATGATTCAGGGCGGCTGCCCGCTCGGCACCGGTACGGGCGGT
CCCGGGTACCGATTCGCCGACGAGTTTCACCCAGAGCTTACTTTCTCGAAGCCCTACTTGCTGGCTATGGCCAATGCCGG
TCCGGGTACCAATGGGTCCCAGTTCTTCATCACTGTGGCCCCGACGCCGCACCTCAACCGTCGTCATACCATCTTTGGTG
AAGTCGCTGACGAAGAGTCCCGAAGGGTCGTCGACGAGATCGCCCAGGTCCGCACTGGCCGCATGGACCGTCCGGTCGAG
CCGGTCGTTATTGAAAGCGTCGAGCTGGCCTGA

Upstream 100 bases:

>100_bases
CGGGGCTCAAACGGCGGCTGGCGGAATAATTCTGATCGGTTTGACGCAACAGTCAGTACTCTAGAGGGGACCACATCGTT
TCTCACAGGAAGGCAGGCAG

Downstream 100 bases:

>100_bases
GTAGCTAGCCTGGTAGGAATGGATACTGCCTCGAGGCGACCGCACCTCGAGGCCCTTCTAAGTATTCTGAATATTCTGAT
TTCCCTGTGATTGACGGTCA

Product: peptidyl-prolyl cis-trans isomerase A

Products: NA

Alternate protein names: PPIase B; Cyclophilin ScCypB; Rotamase B; S-cyclophilin [H]

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MASTATLRTNHGDIVVNLFADQAPKTVDNFVGLAGGTKEYVDPHTGQPTTGKFYDGLTFHRVIDGFMIQGGCPLGTGTGG
PGYRFADEFHPELTFSKPYLLAMANAGPGTNGSQFFITVAPTPHLNRRHTIFGEVADEESRRVVDEIAQVRTGRMDRPVE
PVVIESVELA

Sequences:

>Translated_170_residues
MASTATLRTNHGDIVVNLFADQAPKTVDNFVGLAGGTKEYVDPHTGQPTTGKFYDGLTFHRVIDGFMIQGGCPLGTGTGG
PGYRFADEFHPELTFSKPYLLAMANAGPGTNGSQFFITVAPTPHLNRRHTIFGEVADEESRRVVDEIAQVRTGRMDRPVE
PVVIESVELA
>Mature_169_residues
ASTATLRTNHGDIVVNLFADQAPKTVDNFVGLAGGTKEYVDPHTGQPTTGKFYDGLTFHRVIDGFMIQGGCPLGTGTGGP
GYRFADEFHPELTFSKPYLLAMANAGPGTNGSQFFITVAPTPHLNRRHTIFGEVADEESRRVVDEIAQVRTGRMDRPVEP
VVIESVELA

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=168, Percent_Identity=45.8333333333333, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI7706339, Length=161, Percent_Identity=46.583850931677, Blast_Score=131, Evalue=3e-31,
Organism=Homo sapiens, GI64276486, Length=166, Percent_Identity=39.7590361445783, Blast_Score=116, Evalue=8e-27,
Organism=Homo sapiens, GI19557636, Length=170, Percent_Identity=37.0588235294118, Blast_Score=112, Evalue=1e-25,
Organism=Homo sapiens, GI4758950, Length=157, Percent_Identity=43.312101910828, Blast_Score=103, Evalue=6e-23,
Organism=Homo sapiens, GI4826932, Length=129, Percent_Identity=49.6124031007752, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI42560244, Length=160, Percent_Identity=42.5, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI6631100, Length=159, Percent_Identity=42.7672955974843, Blast_Score=100, Evalue=6e-22,
Organism=Homo sapiens, GI5454154, Length=160, Percent_Identity=43.75, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI4505991, Length=152, Percent_Identity=42.7631578947368, Blast_Score=95, Evalue=3e-20,
Organism=Homo sapiens, GI10863927, Length=154, Percent_Identity=39.6103896103896, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI22547212, Length=164, Percent_Identity=40.2439024390244, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI7657473, Length=164, Percent_Identity=40.2439024390244, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI256017253, Length=130, Percent_Identity=43.0769230769231, Blast_Score=87, Evalue=6e-18,
Organism=Homo sapiens, GI221139811, Length=130, Percent_Identity=43.0769230769231, Blast_Score=87, Evalue=6e-18,
Organism=Homo sapiens, GI256017251, Length=130, Percent_Identity=43.0769230769231, Blast_Score=87, Evalue=6e-18,
Organism=Homo sapiens, GI5031987, Length=154, Percent_Identity=41.5584415584416, Blast_Score=87, Evalue=7e-18,
Organism=Homo sapiens, GI310129267, Length=154, Percent_Identity=37.6623376623377, Blast_Score=87, Evalue=8e-18,
Organism=Homo sapiens, GI310120620, Length=154, Percent_Identity=37.6623376623377, Blast_Score=87, Evalue=8e-18,
Organism=Homo sapiens, GI22547215, Length=164, Percent_Identity=40.2439024390244, Blast_Score=87, Evalue=9e-18,
Organism=Homo sapiens, GI310127646, Length=153, Percent_Identity=35.9477124183007, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI310114371, Length=153, Percent_Identity=35.9477124183007, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI310119221, Length=153, Percent_Identity=35.9477124183007, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI178057341, Length=130, Percent_Identity=42.3076923076923, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI310110104, Length=154, Percent_Identity=37.012987012987, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI169163387, Length=154, Percent_Identity=38.3116883116883, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI169164185, Length=130, Percent_Identity=42.3076923076923, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI169163623, Length=130, Percent_Identity=42.3076923076923, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI209417936, Length=129, Percent_Identity=39.5348837209302, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI30102944, Length=129, Percent_Identity=39.5348837209302, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI219842199, Length=129, Percent_Identity=39.5348837209302, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI5174637, Length=157, Percent_Identity=37.5796178343949, Blast_Score=77, Evalue=6e-15,
Organism=Homo sapiens, GI303305009, Length=130, Percent_Identity=40.7692307692308, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI45439316, Length=130, Percent_Identity=40.7692307692308, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI150418007, Length=130, Percent_Identity=38.4615384615385, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI169214050, Length=161, Percent_Identity=32.9192546583851, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI239751853, Length=161, Percent_Identity=32.9192546583851, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI113428306, Length=161, Percent_Identity=32.9192546583851, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI310132444, Length=152, Percent_Identity=35.5263157894737, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI310113152, Length=152, Percent_Identity=35.5263157894737, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI27735045, Length=156, Percent_Identity=33.974358974359, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI14277126, Length=175, Percent_Identity=32, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI310114540, Length=122, Percent_Identity=36.8852459016393, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI310127745, Length=123, Percent_Identity=40.650406504065, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI310119290, Length=123, Percent_Identity=40.650406504065, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1786736, Length=179, Percent_Identity=35.195530726257, Blast_Score=80, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17506311, Length=170, Percent_Identity=48.2352941176471, Blast_Score=134, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17539496, Length=155, Percent_Identity=44.5161290322581, Blast_Score=120, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17551282, Length=157, Percent_Identity=45.859872611465, Blast_Score=112, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17551284, Length=157, Percent_Identity=45.859872611465, Blast_Score=112, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17552780, Length=157, Percent_Identity=47.7707006369427, Blast_Score=110, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17552784, Length=163, Percent_Identity=38.6503067484663, Blast_Score=106, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI71980594, Length=168, Percent_Identity=35.1190476190476, Blast_Score=103, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71980590, Length=163, Percent_Identity=36.1963190184049, Blast_Score=102, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI71997782, Length=135, Percent_Identity=40, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17532641, Length=166, Percent_Identity=36.7469879518072, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17506307, Length=159, Percent_Identity=43.3962264150943, Blast_Score=99, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17532643, Length=158, Percent_Identity=44.9367088607595, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17565860, Length=157, Percent_Identity=41.4012738853503, Blast_Score=93, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17566266, Length=130, Percent_Identity=43.8461538461538, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17559074, Length=157, Percent_Identity=40.1273885350318, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17539498, Length=142, Percent_Identity=39.4366197183099, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17552782, Length=157, Percent_Identity=38.2165605095541, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323246, Length=162, Percent_Identity=40.1234567901235, Blast_Score=102, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6320510, Length=170, Percent_Identity=42.9411764705882, Blast_Score=96, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6320359, Length=162, Percent_Identity=41.358024691358, Blast_Score=96, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6323562, Length=165, Percent_Identity=41.2121212121212, Blast_Score=94, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6321848, Length=158, Percent_Identity=39.2405063291139, Blast_Score=83, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322492, Length=169, Percent_Identity=37.8698224852071, Blast_Score=82, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17986117, Length=162, Percent_Identity=45.0617283950617, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI19922376, Length=166, Percent_Identity=37.9518072289157, Blast_Score=122, Evalue=8e-29,
Organism=Drosophila melanogaster, GI19922912, Length=168, Percent_Identity=45.2380952380952, Blast_Score=110, Evalue=3e-25,
Organism=Drosophila melanogaster, GI21357249, Length=132, Percent_Identity=41.6666666666667, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24650807, Length=158, Percent_Identity=42.4050632911392, Blast_Score=103, Evalue=6e-23,
Organism=Drosophila melanogaster, GI20130249, Length=157, Percent_Identity=43.9490445859873, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24652460, Length=176, Percent_Identity=32.9545454545455, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24586038, Length=163, Percent_Identity=41.1042944785276, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45549139, Length=130, Percent_Identity=43.8461538461538, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17136360, Length=164, Percent_Identity=38.4146341463415, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24664125, Length=161, Percent_Identity=39.1304347826087, Blast_Score=83, Evalue=7e-17,
Organism=Drosophila melanogaster, GI21357783, Length=161, Percent_Identity=39.1304347826087, Blast_Score=83, Evalue=7e-17,
Organism=Drosophila melanogaster, GI17647301, Length=128, Percent_Identity=41.40625, Blast_Score=76, Evalue=8e-15,
Organism=Drosophila melanogaster, GI21355677, Length=157, Percent_Identity=31.2101910828025, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18378; Mature: 18247

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASTATLRTNHGDIVVNLFADQAPKTVDNFVGLAGGTKEYVDPHTGQPTTGKFYDGLTFH
CCCCEEEEECCCCEEEEEECCCCCHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCCCHHH
RVIDGFMIQGGCPLGTGTGGPGYRFADEFHPELTFSKPYLLAMANAGPGTNGSQFFITVA
HHHCCEEEECCCCCCCCCCCCCCCCCHHCCCCEECCCCEEEEEECCCCCCCCCEEEEEEC
PTPHLNRRHTIFGEVADEESRRVVDEIAQVRTGRMDRPVEPVVIESVELA
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure 
ASTATLRTNHGDIVVNLFADQAPKTVDNFVGLAGGTKEYVDPHTGQPTTGKFYDGLTFH
CCCEEEEECCCCEEEEEECCCCCHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCCCHHH
RVIDGFMIQGGCPLGTGTGGPGYRFADEFHPELTFSKPYLLAMANAGPGTNGSQFFITVA
HHHCCEEEECCCCCCCCCCCCCCCCCHHCCCCEECCCCEEEEEECCCCCCCCCEEEEEEC
PTPHLNRRHTIFGEVADEESRRVVDEIAQVRTGRMDRPVEPVVIESVELA
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9025285 [H]