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The map label for this gene is pepA [H]

Identifier: 50842182

GI number: 50842182

Start: 766618

End: 768192

Strand: Reverse

Name: pepA [H]

Synonym: PPA0694

Alternate gene names: 50842182

Gene position: 768192-766618 (Counterclockwise)

Preceding gene: 50842184

Following gene: 50842181

Centisome position: 30.0

GC content: 62.86

Gene sequence:

>1575_bases
ATGACCGGGCCCATCCCGAATTATCTACCGAATGGAACCTTCCACCGAATGAGAGGAATCCTCGTGGCCAACAGCACCCA
GCTGCCCATCCGCCCGCGTCCCGACCTCAAGGTGTCGCGAAATGCCAACGGCGCCGACGTCGTGATTGCCGGTCTGGTCG
AGGGTTCCCAAGGCCCCACCGTCCAGGGGCTGGCACCGCGCGCTGTCAAAGAAGCTGAAGAGACCTTCGGCGCCCCGCTC
GTCGAAGTGGCCATTCGGGCCGGCGGATCTACCAAAATTGGTTCCACCGTGGTGCTGCCATGGTTTGGAAACAGCCTCGT
TCTGGTTGGCTGCGGAGCTGAGGGATTCGATGGTGAGTCCCTGCGCAAGGCTGCCGGTTCGGGCGCTCGTGCCGCCGCTG
ACTTATCACACGGCAGCAGCCTCAAAGTAGCCGTTGACATGGGGACAGTCTCGGCCGAGCAGGTTCGAATCGCCGCCGAG
GGGGCCTTACTCGGCTGCTACAAGGTGCCGACCATTACCGCAACCTCGAATGAGCCCGAGATCTCGACCGTCACGATAGT
GTCCAATGCCCGTGGCGCTAAGCCCGAGCTCAACAAAGCCCGTATCCTTGCTGATGCCGTCTACACCGCCCGCGACTGGG
TGGACGCTCCAGCCAACTTGCTCTACCCGAAGACTTTCGCCGCCTCGGTGCAATCCTGGTGCAACAACCTCTCGGACGTC
ACCGTCGACGTGCTCGACGAGAAAGCCCTGGGGCGTGGTGGCTTCGGCGGCATCCTCGCGGTAGGTGGAGGCTCAGCCCA
CTCCCCACGTCTGGTCCGCGTGGAATACGCCCCGGAAGGATCCACCACCACGCTGGCTCTAGTGGGCAAGGGCATTACCT
TCGACTCTGGCGGCCTCAATATCAAGACTGCTGCCAATATGTACACCATGAAGTGCGATATGGGCGGTGCTGCTGCGGTA
CTCGCCGCTATCGGCGCGATTGCCCGCCTCGGGCTCAACGTTCGCGTGGTTGCTTACGGGTGTTTGGCAGAGAATATGCC
GTCTGGATCAGGGTGGCGCCCCTCTGACGTCGTCACTATGTACGACGGGACAACAGTCGAGAATGGCAACTCCGACGCCG
AGGGACGCATCGTGATGGCCGACGGCCTGGCCCGCGCGTGTGAGGACAACCCTGACTTCATCGTCGACATTTCCACCCTG
ACCGGCGCCTGCATGGTCGCTCTCGGTAACCACACCGCAGGTGTCATGACCTCGGGGGCCCAGGCAGCAGACACCTTGCT
GGACGCTTCCGAGGCTGCCGGCGAGGACTTCTGGGAGCTTCCGATTACCGACGAGGTTCGCGAAGGCCTGCATTCTGACA
TTGCCGACGTCAAGTCCTCCGGCGCTCGCGAAGGCGGCGCGATGCTCGCTGCAGCTTTTCTGCAACGTTTCGTGACCCCA
GGCATCGACTGGGCCCATCTCGACATCGCCGGCCCGGCGTACAACGAGGCCTCGGCCCATGACTACACCCCGATTCAAGG
AACCGGGTTCGGAGTGCGCACTCTGGTCCAGCTCGCCGCACATATGGCTGGCTGA

Upstream 100 bases:

>100_bases
AGAGCCCACAAACTCACCATACTGGCGACTCATTACGACCGCGCCGCCACGCACTTGACATCCCTCGACTAGGCTGATCG
ACGAGGTGTCGCCCCGGGGA

Downstream 100 bases:

>100_bases
TCATAAATATCACCACTGGGGGCAGGGGTTATAGACCCTTGCCCCTTGCCGTATTCGGATGACATTTTCTGAATCCAAAA
ATGGGACCAACTGCACATTT

Product: putative aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 524; Mature: 523

Protein sequence:

>524_residues
MTGPIPNYLPNGTFHRMRGILVANSTQLPIRPRPDLKVSRNANGADVVIAGLVEGSQGPTVQGLAPRAVKEAEETFGAPL
VEVAIRAGGSTKIGSTVVLPWFGNSLVLVGCGAEGFDGESLRKAAGSGARAAADLSHGSSLKVAVDMGTVSAEQVRIAAE
GALLGCYKVPTITATSNEPEISTVTIVSNARGAKPELNKARILADAVYTARDWVDAPANLLYPKTFAASVQSWCNNLSDV
TVDVLDEKALGRGGFGGILAVGGGSAHSPRLVRVEYAPEGSTTTLALVGKGITFDSGGLNIKTAANMYTMKCDMGGAAAV
LAAIGAIARLGLNVRVVAYGCLAENMPSGSGWRPSDVVTMYDGTTVENGNSDAEGRIVMADGLARACEDNPDFIVDISTL
TGACMVALGNHTAGVMTSGAQAADTLLDASEAAGEDFWELPITDEVREGLHSDIADVKSSGAREGGAMLAAAFLQRFVTP
GIDWAHLDIAGPAYNEASAHDYTPIQGTGFGVRTLVQLAAHMAG

Sequences:

>Translated_524_residues
MTGPIPNYLPNGTFHRMRGILVANSTQLPIRPRPDLKVSRNANGADVVIAGLVEGSQGPTVQGLAPRAVKEAEETFGAPL
VEVAIRAGGSTKIGSTVVLPWFGNSLVLVGCGAEGFDGESLRKAAGSGARAAADLSHGSSLKVAVDMGTVSAEQVRIAAE
GALLGCYKVPTITATSNEPEISTVTIVSNARGAKPELNKARILADAVYTARDWVDAPANLLYPKTFAASVQSWCNNLSDV
TVDVLDEKALGRGGFGGILAVGGGSAHSPRLVRVEYAPEGSTTTLALVGKGITFDSGGLNIKTAANMYTMKCDMGGAAAV
LAAIGAIARLGLNVRVVAYGCLAENMPSGSGWRPSDVVTMYDGTTVENGNSDAEGRIVMADGLARACEDNPDFIVDISTL
TGACMVALGNHTAGVMTSGAQAADTLLDASEAAGEDFWELPITDEVREGLHSDIADVKSSGAREGGAMLAAAFLQRFVTP
GIDWAHLDIAGPAYNEASAHDYTPIQGTGFGVRTLVQLAAHMAG
>Mature_523_residues
TGPIPNYLPNGTFHRMRGILVANSTQLPIRPRPDLKVSRNANGADVVIAGLVEGSQGPTVQGLAPRAVKEAEETFGAPLV
EVAIRAGGSTKIGSTVVLPWFGNSLVLVGCGAEGFDGESLRKAAGSGARAAADLSHGSSLKVAVDMGTVSAEQVRIAAEG
ALLGCYKVPTITATSNEPEISTVTIVSNARGAKPELNKARILADAVYTARDWVDAPANLLYPKTFAASVQSWCNNLSDVT
VDVLDEKALGRGGFGGILAVGGGSAHSPRLVRVEYAPEGSTTTLALVGKGITFDSGGLNIKTAANMYTMKCDMGGAAAVL
AAIGAIARLGLNVRVVAYGCLAENMPSGSGWRPSDVVTMYDGTTVENGNSDAEGRIVMADGLARACEDNPDFIVDISTLT
GACMVALGNHTAGVMTSGAQAADTLLDASEAAGEDFWELPITDEVREGLHSDIADVKSSGAREGGAMLAAAFLQRFVTPG
IDWAHLDIAGPAYNEASAHDYTPIQGTGFGVRTLVQLAAHMAG

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=429, Percent_Identity=36.1305361305361, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI47155554, Length=346, Percent_Identity=37.2832369942197, Blast_Score=180, Evalue=3e-45,
Organism=Escherichia coli, GI1790710, Length=450, Percent_Identity=33.7777777777778, Blast_Score=217, Evalue=2e-57,
Organism=Escherichia coli, GI87082123, Length=381, Percent_Identity=35.6955380577428, Blast_Score=191, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17556903, Length=298, Percent_Identity=35.5704697986577, Blast_Score=151, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI17565172, Length=422, Percent_Identity=27.0142180094787, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI221379063, Length=331, Percent_Identity=36.8580060422961, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI221379062, Length=331, Percent_Identity=36.8580060422961, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI21357381, Length=331, Percent_Identity=36.8580060422961, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI20129969, Length=418, Percent_Identity=32.0574162679426, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24662227, Length=442, Percent_Identity=30.316742081448, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24661038, Length=494, Percent_Identity=28.3400809716599, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI21355645, Length=446, Percent_Identity=31.1659192825112, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24662223, Length=446, Percent_Identity=31.1659192825112, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI21355725, Length=475, Percent_Identity=28.4210526315789, Blast_Score=137, Evalue=3e-32,
Organism=Drosophila melanogaster, GI161077148, Length=413, Percent_Identity=29.7820823244552, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI20130057, Length=413, Percent_Identity=29.7820823244552, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI20129963, Length=418, Percent_Identity=30.1435406698565, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI19922386, Length=439, Percent_Identity=28.9293849658314, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24646701, Length=280, Percent_Identity=29.6428571428571, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24646703, Length=280, Percent_Identity=29.6428571428571, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21358201, Length=280, Percent_Identity=29.6428571428571, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 53882; Mature: 53751

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGPIPNYLPNGTFHRMRGILVANSTQLPIRPRPDLKVSRNANGADVVIAGLVEGSQGPT
CCCCCCCCCCCCHHHHHCEEEEECCCCCCCCCCCCCEEECCCCCCEEEEEEEEECCCCCE
VQGLAPRAVKEAEETFGAPLVEVAIRAGGSTKIGSTVVLPWFGNSLVLVGCGAEGFDGES
ECCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCCEEEEEECCCEEEEEECCCCCCCHHH
LRKAAGSGARAAADLSHGSSLKVAVDMGTVSAEQVRIAAEGALLGCYKVPTITATSNEPE
HHHHCCCCCCEEHHCCCCCEEEEEEEECCCCHHHEEEEECCCEEEEEECCEEEECCCCCC
ISTVTIVSNARGAKPELNKARILADAVYTARDWVDAPANLLYPKTFAASVQSWCNNLSDV
EEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHCCCCCC
TVDVLDEKALGRGGFGGILAVGGGSAHSPRLVRVEYAPEGSTTTLALVGKGITFDSGGLN
EEEECCCHHCCCCCCCCEEEECCCCCCCCEEEEEEECCCCCCEEEEEEECCEEECCCCEE
IKTAANMYTMKCDMGGAAAVLAAIGAIARLGLNVRVVAYGCLAENMPSGSGWRPSDVVTM
EEEECCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEEEHHCCCCCCCCCCCCCEEEE
YDGTTVENGNSDAEGRIVMADGLARACEDNPDFIVDISTLTGACMVALGNHTAGVMTSGA
ECCEEECCCCCCCCCEEEEECCHHHHHCCCCCEEEEEHHHCCEEEEEECCCCCCEEECCC
QAADTLLDASEAAGEDFWELPITDEVREGLHSDIADVKSSGAREGGAMLAAAFLQRFVTP
HHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
GIDWAHLDIAGPAYNEASAHDYTPIQGTGFGVRTLVQLAAHMAG
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TGPIPNYLPNGTFHRMRGILVANSTQLPIRPRPDLKVSRNANGADVVIAGLVEGSQGPT
CCCCCCCCCCCHHHHHCEEEEECCCCCCCCCCCCCEEECCCCCCEEEEEEEEECCCCCE
VQGLAPRAVKEAEETFGAPLVEVAIRAGGSTKIGSTVVLPWFGNSLVLVGCGAEGFDGES
ECCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCCEEEEEECCCEEEEEECCCCCCCHHH
LRKAAGSGARAAADLSHGSSLKVAVDMGTVSAEQVRIAAEGALLGCYKVPTITATSNEPE
HHHHCCCCCCEEHHCCCCCEEEEEEEECCCCHHHEEEEECCCEEEEEECCEEEECCCCCC
ISTVTIVSNARGAKPELNKARILADAVYTARDWVDAPANLLYPKTFAASVQSWCNNLSDV
EEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHCCCCCC
TVDVLDEKALGRGGFGGILAVGGGSAHSPRLVRVEYAPEGSTTTLALVGKGITFDSGGLN
EEEECCCHHCCCCCCCCEEEECCCCCCCCEEEEEEECCCCCCEEEEEEECCEEECCCCEE
IKTAANMYTMKCDMGGAAAVLAAIGAIARLGLNVRVVAYGCLAENMPSGSGWRPSDVVTM
EEEECCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEEEHHCCCCCCCCCCCCCEEEE
YDGTTVENGNSDAEGRIVMADGLARACEDNPDFIVDISTLTGACMVALGNHTAGVMTSGA
ECCEEECCCCCCCCCEEEEECCHHHHHCCCCCEEEEEHHHCCEEEEEECCCCCCEEECCC
QAADTLLDASEAAGEDFWELPITDEVREGLHSDIADVKSSGAREGGAMLAAAFLQRFVTP
HHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
GIDWAHLDIAGPAYNEASAHDYTPIQGTGFGVRTLVQLAAHMAG
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA