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The map label for this gene is ctpA [H]

Identifier: 50842178

GI number: 50842178

Start: 759859

End: 762102

Strand: Reverse

Name: ctpA [H]

Synonym: PPA0690

Alternate gene names: 50842178

Gene position: 762102-759859 (Counterclockwise)

Preceding gene: 50842179

Following gene: 50842177

Centisome position: 29.77

GC content: 60.96

Gene sequence:

>2244_bases
ATGAGCACGGCCACGATGAGTCCCCCAGACGAGGAGCAAACCGTCCTACATCCGCCGGTGCAGTTGCAGATCAGCGGGAT
GACCTGCGCTGCGTGCGCCACAACGATCGAGAAAAGGCTGTCCCGCATTGACGGGGTGCACGCGAGTGTCAATTTCGCCT
CTGAGCGGGCGACGGTAACTGGCATGGGCGTCAAGGATGCGATAGCCGCTGTCAAGGATGCCGGCTACACCGCAGCCCTG
CTCTCCGACATCGATCTAGCAGCCGAGGCAGAACGCCGCATCACCATGTTGAGGCGCCGCCTCATTGTGGCCGTGCTCCT
GACCTTGCCCCTCATGGACATCGGCCTGGTCTTAGCTTTGGAACCACAATTACGTTTCCCCACGTGGGACTGGCTACTCG
TCTCCCTCTCCCTACCGGTGGTTTTCTGGTCAGCGTGGCCATTCCACAAGGCAACATGGACAAATTTGCGCCACGGCATA
ACCTCCATGGATACCCTAGTTTCACTAGGGGTTTTAACCTCTTTCGGATGGTCGTTCATCTCCATCCTCATCGGCGCTCA
GGACCAAGAGGGGTATTGGCTGGGCTACGGCATCACCCCGGCGGGGGCTGACACCCTGTACCTTGACGTCGCCGCCGGGG
TGACCTGTTTTCTGCTAGCCGGACGCTACTTTGAAGCCCGCGCCAAGAGGTCGGCACGGTCTGTGCTAACAGCTTTGAGG
CAGCTGGCTGCCAAGAATGCGCGGGTGTTGCGTAATGGAATCGAGACCGTCGTTCCCGTCGAGCAGCTACACCAGAGTGA
CCTCTTCGTTACCTTAGCCGGAGAGACTCTGGCCGCCGATGGGGAGGTTGTCGAGGGGTCTTCCAGTATCGATACGTCGA
TGATGACCGGCGAACCGATGCCCGCCGACGTCACTGTAGGGTCAGCGGTGCTCGGCGGAACGATGAACCTTACCGGGCGG
ATCGTGGCCAGAGCTACCAGAGTTGGTGACCACAGTCAGCTCGCCCACATGGCGGTGTTAGCCGAGGAGGCCCAAGCTCG
CAAAGCCAACGTCCAGCGTCTGGTGGACAAGGTCGTCGAGATCTTTGTGCCAGCGGTTCTTGCCATCGTCGTCTTGACCT
TCTTCGGTTGGTGGATCGCCGGGGCAGGAACCCGGCATGCCCTCTCGGCAGGCCTCTCGGTGCTTGTTATAGCCTGCCCG
TGCGCCCTAGGTTTAGCGACGCCGACTGCCCTCATGGTTGGGGTTGGCCGAGGTGGTCAGCTGGGCATCCTCATTAAGGG
GCCAGAAGCTCTGGAGGCGTCCGGTCGCATTGATACTGTGGTCCTTGATAAAACCGGTACTGTCACCAGCGGGGAGATGA
CTCTCGTCGCGACGCTCCCTGCCAAAGGACAGGACGTCGATCGCGCCCATCGTTACGCCGCCGCCCTGGACCAACACTCC
ACCCACCCGGTAGCCAAAGCTGTGGTAGCAGCTGTCAAAGGCACCATTCCAGCGTGCCCCAGCCCGTGCACCCTCGCTGG
ACGAGGCGTCAGTGGCGAGGTTGAGGGGCATCGTGTCATGGTTGGCAATCCTGCGTTTCTCACGGAGGCAGAGATCAAGA
TTCCCGCCGAGCTGAGCCACACCGTTGAGAAGGCAGCCGAAACAGGCCGTTCCGCCGTCCTGGTAGCGATCGACGGTCAG
GCCGCAGCTGCCCTTGTCGTCGCCGACACCGTCAAACCCGAGGCCCCGGAAGTCATCGCCCAGCTCAAAAATATGGGGCT
ACGAACTGTTCTCCTCACTGGTGATTCGAAAGCCGCCGCAAAAGTCGTCGGAACACAACTTGGCACCGACGAGGTCCTGG
CCGAGGTCCTACCCACCGACAAAGCCGAGGTCGTTGAGAGACTTCGCTCTGAAGGCCGCGTGGTAGCCATGGTAGGTGAC
GGCGTCAACGACGCCGCTGCCTTGGCAAGCTCCGATCTCGGCATGGCACTGGTCACCGGCACTGATATCGCGATGCGCAG
CGCCGACATCATCTGCGTACGCCACCATCTCGGGGTCGTCCCAGACGCCATTGGGTTGTCGAGACGCACTCTGAGGACCA
TCCGCGGCAACCTCGCATGGGCTTTCATCTACAACATCGCAGCGATCCCGATCGCGGCCGCCGGTTTCCTGAACCCGCTG
ATATCCGGGCTTGCCATGAGCCTTTCGAGCCTCTTCGTCGTCACCCATTCCCTGAGACTTCGTAACTTCGGCACACGCAG
TTAA

Upstream 100 bases:

>100_bases
CTGAGGACGCCGACCTTGATGAGTCCCTGGCCGCCTACAACGACATGCTCGCCCGAATGGCTGGTCAGGAGATCAAGCCG
CACGATCCAGGGACCAAGTC

Downstream 100 bases:

>100_bases
ACTGGCCGGCGTGAGTGTCGAAGCAGACGGTAGAAAGCTCCTCCGAGTCGAGGTCAAGAATTCTCAGACGCCCATCGAGA
ACAAACCCCACTGGATCAAG

Product: cation-transporting P-type ATPase A

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 747; Mature: 746

Protein sequence:

>747_residues
MSTATMSPPDEEQTVLHPPVQLQISGMTCAACATTIEKRLSRIDGVHASVNFASERATVTGMGVKDAIAAVKDAGYTAAL
LSDIDLAAEAERRITMLRRRLIVAVLLTLPLMDIGLVLALEPQLRFPTWDWLLVSLSLPVVFWSAWPFHKATWTNLRHGI
TSMDTLVSLGVLTSFGWSFISILIGAQDQEGYWLGYGITPAGADTLYLDVAAGVTCFLLAGRYFEARAKRSARSVLTALR
QLAAKNARVLRNGIETVVPVEQLHQSDLFVTLAGETLAADGEVVEGSSSIDTSMMTGEPMPADVTVGSAVLGGTMNLTGR
IVARATRVGDHSQLAHMAVLAEEAQARKANVQRLVDKVVEIFVPAVLAIVVLTFFGWWIAGAGTRHALSAGLSVLVIACP
CALGLATPTALMVGVGRGGQLGILIKGPEALEASGRIDTVVLDKTGTVTSGEMTLVATLPAKGQDVDRAHRYAAALDQHS
THPVAKAVVAAVKGTIPACPSPCTLAGRGVSGEVEGHRVMVGNPAFLTEAEIKIPAELSHTVEKAAETGRSAVLVAIDGQ
AAAALVVADTVKPEAPEVIAQLKNMGLRTVLLTGDSKAAAKVVGTQLGTDEVLAEVLPTDKAEVVERLRSEGRVVAMVGD
GVNDAAALASSDLGMALVTGTDIAMRSADIICVRHHLGVVPDAIGLSRRTLRTIRGNLAWAFIYNIAAIPIAAAGFLNPL
ISGLAMSLSSLFVVTHSLRLRNFGTRS

Sequences:

>Translated_747_residues
MSTATMSPPDEEQTVLHPPVQLQISGMTCAACATTIEKRLSRIDGVHASVNFASERATVTGMGVKDAIAAVKDAGYTAAL
LSDIDLAAEAERRITMLRRRLIVAVLLTLPLMDIGLVLALEPQLRFPTWDWLLVSLSLPVVFWSAWPFHKATWTNLRHGI
TSMDTLVSLGVLTSFGWSFISILIGAQDQEGYWLGYGITPAGADTLYLDVAAGVTCFLLAGRYFEARAKRSARSVLTALR
QLAAKNARVLRNGIETVVPVEQLHQSDLFVTLAGETLAADGEVVEGSSSIDTSMMTGEPMPADVTVGSAVLGGTMNLTGR
IVARATRVGDHSQLAHMAVLAEEAQARKANVQRLVDKVVEIFVPAVLAIVVLTFFGWWIAGAGTRHALSAGLSVLVIACP
CALGLATPTALMVGVGRGGQLGILIKGPEALEASGRIDTVVLDKTGTVTSGEMTLVATLPAKGQDVDRAHRYAAALDQHS
THPVAKAVVAAVKGTIPACPSPCTLAGRGVSGEVEGHRVMVGNPAFLTEAEIKIPAELSHTVEKAAETGRSAVLVAIDGQ
AAAALVVADTVKPEAPEVIAQLKNMGLRTVLLTGDSKAAAKVVGTQLGTDEVLAEVLPTDKAEVVERLRSEGRVVAMVGD
GVNDAAALASSDLGMALVTGTDIAMRSADIICVRHHLGVVPDAIGLSRRTLRTIRGNLAWAFIYNIAAIPIAAAGFLNPL
ISGLAMSLSSLFVVTHSLRLRNFGTRS
>Mature_746_residues
STATMSPPDEEQTVLHPPVQLQISGMTCAACATTIEKRLSRIDGVHASVNFASERATVTGMGVKDAIAAVKDAGYTAALL
SDIDLAAEAERRITMLRRRLIVAVLLTLPLMDIGLVLALEPQLRFPTWDWLLVSLSLPVVFWSAWPFHKATWTNLRHGIT
SMDTLVSLGVLTSFGWSFISILIGAQDQEGYWLGYGITPAGADTLYLDVAAGVTCFLLAGRYFEARAKRSARSVLTALRQ
LAAKNARVLRNGIETVVPVEQLHQSDLFVTLAGETLAADGEVVEGSSSIDTSMMTGEPMPADVTVGSAVLGGTMNLTGRI
VARATRVGDHSQLAHMAVLAEEAQARKANVQRLVDKVVEIFVPAVLAIVVLTFFGWWIAGAGTRHALSAGLSVLVIACPC
ALGLATPTALMVGVGRGGQLGILIKGPEALEASGRIDTVVLDKTGTVTSGEMTLVATLPAKGQDVDRAHRYAAALDQHST
HPVAKAVVAAVKGTIPACPSPCTLAGRGVSGEVEGHRVMVGNPAFLTEAEIKIPAELSHTVEKAAETGRSAVLVAIDGQA
AAALVVADTVKPEAPEVIAQLKNMGLRTVLLTGDSKAAAKVVGTQLGTDEVLAEVLPTDKAEVVERLRSEGRVVAMVGDG
VNDAAALASSDLGMALVTGTDIAMRSADIICVRHHLGVVPDAIGLSRRTLRTIRGNLAWAFIYNIAAIPIAAAGFLNPLI
SGLAMSLSSLFVVTHSLRLRNFGTRS

Specific function: Involved In Copper Efflux. [C]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=794, Percent_Identity=31.6120906801008, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI115529486, Length=824, Percent_Identity=30.8252427184466, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI55743073, Length=511, Percent_Identity=36.0078277886497, Blast_Score=284, Evalue=2e-76,
Organism=Homo sapiens, GI83700225, Length=284, Percent_Identity=23.943661971831, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI48762685, Length=176, Percent_Identity=28.4090909090909, Blast_Score=67, Evalue=6e-11,
Organism=Homo sapiens, GI48762691, Length=176, Percent_Identity=28.4090909090909, Blast_Score=67, Evalue=6e-11,
Organism=Homo sapiens, GI48762687, Length=176, Percent_Identity=28.4090909090909, Blast_Score=67, Evalue=6e-11,
Organism=Homo sapiens, GI48762689, Length=176, Percent_Identity=28.4090909090909, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1786691, Length=754, Percent_Identity=37.0026525198939, Blast_Score=410, Evalue=1e-115,
Organism=Escherichia coli, GI1789879, Length=714, Percent_Identity=29.5518207282913, Blast_Score=238, Evalue=7e-64,
Organism=Escherichia coli, GI1786914, Length=500, Percent_Identity=27.6, Blast_Score=160, Evalue=3e-40,
Organism=Escherichia coli, GI2367363, Length=135, Percent_Identity=31.8518518518519, Blast_Score=66, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17556548, Length=800, Percent_Identity=30.875, Blast_Score=325, Evalue=4e-89,
Organism=Caenorhabditis elegans, GI71997262, Length=222, Percent_Identity=28.8288288288288, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71997275, Length=222, Percent_Identity=28.8288288288288, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17531459, Length=119, Percent_Identity=31.0924369747899, Blast_Score=70, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320475, Length=746, Percent_Identity=30.6970509383378, Blast_Score=318, Evalue=2e-87,
Organism=Saccharomyces cerevisiae, GI6319772, Length=674, Percent_Identity=26.2611275964392, Blast_Score=234, Evalue=5e-62,
Organism=Saccharomyces cerevisiae, GI6325221, Length=579, Percent_Identity=25.3886010362694, Blast_Score=128, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6321430, Length=581, Percent_Identity=24.7848537005164, Blast_Score=124, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6321271, Length=175, Percent_Identity=29.1428571428571, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321432, Length=99, Percent_Identity=37.3737373737374, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI221329854, Length=535, Percent_Identity=32.1495327102804, Blast_Score=226, Evalue=4e-59,
Organism=Drosophila melanogaster, GI24668708, Length=189, Percent_Identity=28.042328042328, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281366617, Length=189, Percent_Identity=28.042328042328, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24668704, Length=189, Percent_Identity=28.042328042328, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161085803, Length=189, Percent_Identity=28.042328042328, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24668696, Length=189, Percent_Identity=28.042328042328, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR000579
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 78401; Mature: 78270

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTATMSPPDEEQTVLHPPVQLQISGMTCAACATTIEKRLSRIDGVHASVNFASERATVT
CCCCCCCCCCCCCEEECCCEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEE
GMGVKDAIAAVKDAGYTAALLSDIDLAAEAERRITMLRRRLIVAVLLTLPLMDIGLVLAL
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
EPQLRFPTWDWLLVSLSLPVVFWSAWPFHKATWTNLRHGITSMDTLVSLGVLTSFGWSFI
CCCCCCCCHHHHHHHHHCCEEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
SILIGAQDQEGYWLGYGITPAGADTLYLDVAAGVTCFLLAGRYFEARAKRSARSVLTALR
HHHHCCCCCCCEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLAAKNARVLRNGIETVVPVEQLHQSDLFVTLAGETLAADGEVVEGSSSIDTSMMTGEPM
HHHHHHHHHHHHCHHHHCCHHHHCCCCEEEEECCCEEECCCCEECCCCCCCCHHCCCCCC
PADVTVGSAVLGGTMNLTGRIVARATRVGDHSQLAHMAVLAEEAQARKANVQRLVDKVVE
CCCEEECHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFVPAVLAIVVLTFFGWWIAGAGTRHALSAGLSVLVIACPCALGLATPTALMVGVGRGGQ
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCHHHHHHHHHHHHHCCCCCEEEEECCCCCE
LGILIKGPEALEASGRIDTVVLDKTGTVTSGEMTLVATLPAKGQDVDRAHRYAAALDQHS
EEEEEECCHHHCCCCCEEEEEEECCCCEECCCEEEEEECCCCCCCHHHHHHHHHHHHCCC
THPVAKAVVAAVKGTIPACPSPCTLAGRGVSGEVEGHRVMVGNPAFLTEAEIKIPAELSH
CCHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCEEEECCCCEEEECCEECCHHHHH
TVEKAAETGRSAVLVAIDGQAAAALVVADTVKPEAPEVIAQLKNMGLRTVLLTGDSKAAA
HHHHHHHCCCCEEEEEECCCCEEEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCHHHH
KVVGTQLGTDEVLAEVLPTDKAEVVERLRSEGRVVAMVGDGVNDAAALASSDLGMALVTG
HHHHCCCCHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCCEEEEEC
TDIAMRSADIICVRHHLGVVPDAIGLSRRTLRTIRGNLAWAFIYNIAAIPIAAAGFLNPL
CCHHHCCCCEEEEECCCCCCCCHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
ISGLAMSLSSLFVVTHSLRLRNFGTRS
HHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
STATMSPPDEEQTVLHPPVQLQISGMTCAACATTIEKRLSRIDGVHASVNFASERATVT
CCCCCCCCCCCCEEECCCEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEE
GMGVKDAIAAVKDAGYTAALLSDIDLAAEAERRITMLRRRLIVAVLLTLPLMDIGLVLAL
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
EPQLRFPTWDWLLVSLSLPVVFWSAWPFHKATWTNLRHGITSMDTLVSLGVLTSFGWSFI
CCCCCCCCHHHHHHHHHCCEEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
SILIGAQDQEGYWLGYGITPAGADTLYLDVAAGVTCFLLAGRYFEARAKRSARSVLTALR
HHHHCCCCCCCEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLAAKNARVLRNGIETVVPVEQLHQSDLFVTLAGETLAADGEVVEGSSSIDTSMMTGEPM
HHHHHHHHHHHHCHHHHCCHHHHCCCCEEEEECCCEEECCCCEECCCCCCCCHHCCCCCC
PADVTVGSAVLGGTMNLTGRIVARATRVGDHSQLAHMAVLAEEAQARKANVQRLVDKVVE
CCCEEECHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFVPAVLAIVVLTFFGWWIAGAGTRHALSAGLSVLVIACPCALGLATPTALMVGVGRGGQ
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCHHHHHHHHHHHHHCCCCCEEEEECCCCCE
LGILIKGPEALEASGRIDTVVLDKTGTVTSGEMTLVATLPAKGQDVDRAHRYAAALDQHS
EEEEEECCHHHCCCCCEEEEEEECCCCEECCCEEEEEECCCCCCCHHHHHHHHHHHHCCC
THPVAKAVVAAVKGTIPACPSPCTLAGRGVSGEVEGHRVMVGNPAFLTEAEIKIPAELSH
CCHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCEEEECCCCEEEECCEECCHHHHH
TVEKAAETGRSAVLVAIDGQAAAALVVADTVKPEAPEVIAQLKNMGLRTVLLTGDSKAAA
HHHHHHHCCCCEEEEEECCCCEEEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCHHHH
KVVGTQLGTDEVLAEVLPTDKAEVVERLRSEGRVVAMVGDGVNDAAALASSDLGMALVTG
HHHHCCCCHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCCEEEEEC
TDIAMRSADIICVRHHLGVVPDAIGLSRRTLRTIRGNLAWAFIYNIAAIPIAAAGFLNPL
CCHHHCCCCEEEEECCCCCCCCHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
ISGLAMSLSSLFVVTHSLRLRNFGTRS
HHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]