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The map label for this gene is map [H]

Identifier: 50842148

GI number: 50842148

Start: 726769

End: 727623

Strand: Reverse

Name: map [H]

Synonym: PPA0661

Alternate gene names: 50842148

Gene position: 727623-726769 (Counterclockwise)

Preceding gene: 50842149

Following gene: 50842147

Centisome position: 28.42

GC content: 60.47

Gene sequence:

>855_bases
GTGAGTGCCATCAAGCCGTATCCCCAGAGTCCTCGTCGTCATGTCCCCGGAAACATTGCCCGTCCCCCCTACGTCGGCCT
GGGCGACGTCCCGGAAACCTATGATGGCTCCCACGTACAGTCAGCCGAGACGATCGCTGCCATGGAAGAGGCTGGACGGA
TCGCCTGTGGTGCCATGTACGAGGCCGGAAAAGCCGTCGAGCCCGGAGTCACCACCGACGAACTCGACCGCATCGCTCAC
GAATACATGTGCGACCACGGCGCCTACCCATCGACCCTCGATTACCGTAACTACCCCAAATCGTGTTGCACCAGCGTCAA
CGAAGTTATCTGTCACGGCATCCCTGACTCGCGCCCGCTCGAGGACGGCGACATCGTCAAGATCGACGTCACCGCTTACA
AAAACGGCGTGCACGGCGACAACTGCTACACCTTCGGTTGCGGCAACGTTGACCAAGCATCTCTGGACCTCATCGACCAT
ACTCAGCAGGCAATGAACCGCGCCATCAAGGCCGTTAAACCCGGCCGCTCGATTTCCATCATCGGCCGGATCATCGAGAA
CTACGCCAAGCGTTTCGGCCATGGCGTGGTGCGTGACTACACCGGCCACGGTGTTCACAGCGCCTTCCACTCCGGTCTCG
TCGTCTTCCACTACGACGAACCGCGCTATGACGTCACCCTCGAGGAGGGCATGACGCTAACCATCGAGCCGATGCTCACC
CTGGGAGACCAATCCAACCATCAGTGGGACGACGGCTGGACAGTCCTCACCAATGACGGTTCGCGGTGCGCTCAGTTCGA
GCAGACCCTCGTCGTCGAGAAGGATGGAGCGCGAATCCTCACCACCCTGGAGTGA

Upstream 100 bases:

>100_bases
CCTCATTGCCCTGCACCGCTCCTGATACATACTTGGGATTTATAGACGAAGAAGAGAGACACGAACCACGGCACGCTCAC
ACGACCTAGACTGGACCGAC

Downstream 100 bases:

>100_bases
CGATCTTCAAGGTTTGACGGCTGCCTGGGTCCGGCGAGCTCGCTGTATCGCCAGGTCTGGAATGGTAACGGCACCCGCCA
CGGCGCGGGTACATTCCCCA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MSAIKPYPQSPRRHVPGNIARPPYVGLGDVPETYDGSHVQSAETIAAMEEAGRIACGAMYEAGKAVEPGVTTDELDRIAH
EYMCDHGAYPSTLDYRNYPKSCCTSVNEVICHGIPDSRPLEDGDIVKIDVTAYKNGVHGDNCYTFGCGNVDQASLDLIDH
TQQAMNRAIKAVKPGRSISIIGRIIENYAKRFGHGVVRDYTGHGVHSAFHSGLVVFHYDEPRYDVTLEEGMTLTIEPMLT
LGDQSNHQWDDGWTVLTNDGSRCAQFEQTLVVEKDGARILTTLE

Sequences:

>Translated_284_residues
MSAIKPYPQSPRRHVPGNIARPPYVGLGDVPETYDGSHVQSAETIAAMEEAGRIACGAMYEAGKAVEPGVTTDELDRIAH
EYMCDHGAYPSTLDYRNYPKSCCTSVNEVICHGIPDSRPLEDGDIVKIDVTAYKNGVHGDNCYTFGCGNVDQASLDLIDH
TQQAMNRAIKAVKPGRSISIIGRIIENYAKRFGHGVVRDYTGHGVHSAFHSGLVVFHYDEPRYDVTLEEGMTLTIEPMLT
LGDQSNHQWDDGWTVLTNDGSRCAQFEQTLVVEKDGARILTTLE
>Mature_283_residues
SAIKPYPQSPRRHVPGNIARPPYVGLGDVPETYDGSHVQSAETIAAMEEAGRIACGAMYEAGKAVEPGVTTDELDRIAHE
YMCDHGAYPSTLDYRNYPKSCCTSVNEVICHGIPDSRPLEDGDIVKIDVTAYKNGVHGDNCYTFGCGNVDQASLDLIDHT
QQAMNRAIKAVKPGRSISIIGRIIENYAKRFGHGVVRDYTGHGVHSAFHSGLVVFHYDEPRYDVTLEEGMTLTIEPMLTL
GDQSNHQWDDGWTVLTNDGSRCAQFEQTLVVEKDGARILTTLE

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=282, Percent_Identity=44.3262411347518, Blast_Score=238, Evalue=3e-63,
Organism=Homo sapiens, GI40385867, Length=282, Percent_Identity=41.4893617021277, Blast_Score=225, Evalue=4e-59,
Organism=Escherichia coli, GI1786364, Length=245, Percent_Identity=43.6734693877551, Blast_Score=199, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71996291, Length=288, Percent_Identity=42.7083333333333, Blast_Score=222, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6323273, Length=282, Percent_Identity=40.0709219858156, Blast_Score=207, Evalue=2e-54,
Organism=Drosophila melanogaster, GI21355531, Length=284, Percent_Identity=46.4788732394366, Blast_Score=256, Evalue=1e-68,
Organism=Drosophila melanogaster, GI24583427, Length=273, Percent_Identity=41.025641025641, Blast_Score=211, Evalue=5e-55,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 31216; Mature: 31085

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIKPYPQSPRRHVPGNIARPPYVGLGDVPETYDGSHVQSAETIAAMEEAGRIACGAMY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEHHHH
EAGKAVEPGVTTDELDRIAHEYMCDHGAYPSTLDYRNYPKSCCTSVNEVICHGIPDSRPL
HCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
EDGDIVKIDVTAYKNGVHGDNCYTFGCGNVDQASLDLIDHTQQAMNRAIKAVKPGRSISI
CCCCEEEEEEEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
IGRIIENYAKRFGHGVVRDYTGHGVHSAFHSGLVVFHYDEPRYDVTLEEGMTLTIEPMLT
HHHHHHHHHHHHCCCCEECCCCCCHHHHHHCCEEEEEECCCCEEEECCCCCEEEEEEEEE
LGDQSNHQWDDGWTVLTNDGSRCAQFEQTLVVEKDGARILTTLE
ECCCCCCCCCCCCEEEECCCHHHHHHHHEEEEECCCCEEEEECC
>Mature Secondary Structure 
SAIKPYPQSPRRHVPGNIARPPYVGLGDVPETYDGSHVQSAETIAAMEEAGRIACGAMY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEHHHH
EAGKAVEPGVTTDELDRIAHEYMCDHGAYPSTLDYRNYPKSCCTSVNEVICHGIPDSRPL
HCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
EDGDIVKIDVTAYKNGVHGDNCYTFGCGNVDQASLDLIDHTQQAMNRAIKAVKPGRSISI
CCCCEEEEEEEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
IGRIIENYAKRFGHGVVRDYTGHGVHSAFHSGLVVFHYDEPRYDVTLEEGMTLTIEPMLT
HHHHHHHHHHHHCCCCEECCCCCCHHHHHHCCEEEEEECCCCEEEECCCCCEEEEEEEEE
LGDQSNHQWDDGWTVLTNDGSRCAQFEQTLVVEKDGARILTTLE
ECCCCCCCCCCCCEEEECCCHHHHHHHHEEEEECCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]