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The map label for this gene is dapA

Identifier: 50842129

GI number: 50842129

Start: 706725

End: 707606

Strand: Direct

Name: dapA

Synonym: PPA0642

Alternate gene names: 50842129

Gene position: 706725-707606 (Clockwise)

Preceding gene: 50842127

Following gene: 50842130

Centisome position: 27.6

GC content: 59.52

Gene sequence:

>882_bases
ATGTCCGCTCCCGTTTTTGGCCGTCTGCTTACGGCCATGGTGACTCCGATGACGTTCGACGGGGCGGTGGACCTGCGTCG
GACTGGCGAGTTGGCGCACAAGCTCGTTGAGGAACAAAACAATGACGGCATTGTCGTCAACGGCACGACGGGGGAATCGC
CGACCACGACTGATTCTGAGAAGGCTGAGATCGTTAAGGCTGTCGTCGAGGCTGTCGGATCGGATGCTGCGGTTGTAGCC
GGAGTCGGAACCAATGACACCGCTCACACCATCGAACTGGCTCACCAGGCTGCCGAGGCTGGAGCTGACGGTCTACTTGT
CGTCACCCCCTACTACTCCAAGCCCTCACAGGCTGGGATCATTGAGCACTTCACCGCTGTTGCCGATGCCACCGACCTGC
CGATCATGCTTTATGACATTCCGGGACGCACCGGTACTCCGATTGAGACGAAGACCCTCATTGAACTGGCCGACCATGCA
CGGATTGTGGCCGTCAAGGACGCCAAGGGGCTTGTGGTTGAGTCAGCGACGGTGATGGCCAGCACCACTCTGGCCTACTA
CTCCGGTGACGATGCCATCACTCCGGCATTGCTGTCAGTGGGTGGAGTTGGCCTCGTCGGCACGTCAACCCATTTCACCG
GTCGACGCATGCACGAGGTCATCGACGCATATGTTGACGGCCGAATTGACGAGGCATTGTCGACCTACCGGGAGATCCTG
CCAGTGCTTACCGGTGTCTTTGCAGCTCAGGGGGCCACCATGGTTAAGGCGGGACTGGCTCACCAGGGGTTTACCGTCGG
TAGGGTGCGTCCCCCTCAGACGATGCCGACTCCTGAGCAGGCTGAGACTTTCTTCGGTGTGTTGGATCGCACTCAGCTGT
GA

Upstream 100 bases:

>100_bases
GGACTTGATGTCTGGGCTGTGCTGGACTCACACTAACAGCCTATCCCGCTGAGGCCATCTCGTGGCTACCATGGGCACCA
GCTATACAAGGAGGTTTTGC

Downstream 100 bases:

>100_bases
CAACCTCGCCATGACATTGGGAGCTCGAAGCCAGGGGTAAGGTAAAGGCCATGTCCACAGCAGGTCCAGCGGAAATCGCG
GTACTCATCGTCATTGCTGT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MSAPVFGRLLTAMVTPMTFDGAVDLRRTGELAHKLVEEQNNDGIVVNGTTGESPTTTDSEKAEIVKAVVEAVGSDAAVVA
GVGTNDTAHTIELAHQAAEAGADGLLVVTPYYSKPSQAGIIEHFTAVADATDLPIMLYDIPGRTGTPIETKTLIELADHA
RIVAVKDAKGLVVESATVMASTTLAYYSGDDAITPALLSVGGVGLVGTSTHFTGRRMHEVIDAYVDGRIDEALSTYREIL
PVLTGVFAAQGATMVKAGLAHQGFTVGRVRPPQTMPTPEQAETFFGVLDRTQL

Sequences:

>Translated_293_residues
MSAPVFGRLLTAMVTPMTFDGAVDLRRTGELAHKLVEEQNNDGIVVNGTTGESPTTTDSEKAEIVKAVVEAVGSDAAVVA
GVGTNDTAHTIELAHQAAEAGADGLLVVTPYYSKPSQAGIIEHFTAVADATDLPIMLYDIPGRTGTPIETKTLIELADHA
RIVAVKDAKGLVVESATVMASTTLAYYSGDDAITPALLSVGGVGLVGTSTHFTGRRMHEVIDAYVDGRIDEALSTYREIL
PVLTGVFAAQGATMVKAGLAHQGFTVGRVRPPQTMPTPEQAETFFGVLDRTQL
>Mature_292_residues
SAPVFGRLLTAMVTPMTFDGAVDLRRTGELAHKLVEEQNNDGIVVNGTTGESPTTTDSEKAEIVKAVVEAVGSDAAVVAG
VGTNDTAHTIELAHQAAEAGADGLLVVTPYYSKPSQAGIIEHFTAVADATDLPIMLYDIPGRTGTPIETKTLIELADHAR
IVAVKDAKGLVVESATVMASTTLAYYSGDDAITPALLSVGGVGLVGTSTHFTGRRMHEVIDAYVDGRIDEALSTYREILP
VLTGVFAAQGATMVKAGLAHQGFTVGRVRPPQTMPTPEQAETFFGVLDRTQL

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=275, Percent_Identity=28.7272727272727, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI13540533, Length=239, Percent_Identity=28.8702928870293, Blast_Score=96, Evalue=3e-20,
Organism=Escherichia coli, GI1788823, Length=295, Percent_Identity=31.864406779661, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1786463, Length=249, Percent_Identity=30.9236947791165, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI1789620, Length=249, Percent_Identity=28.1124497991968, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI87082415, Length=278, Percent_Identity=25.1798561151079, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_PROAC (Q6AA18)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_055356.1
- HSSP:   P63945
- ProteinModelPortal:   Q6AA18
- SMR:   Q6AA18
- GeneID:   2931663
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA0642
- NMPDR:   fig|267747.1.peg.633
- HOGENOM:   HBG358848
- OMA:   LFITTNP
- ProtClustDB:   CLSK2763425
- BioCyc:   PACN267747:PPA0642-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 30690; Mature: 30559

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 166-166 BINDING 111-111

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPVFGRLLTAMVTPMTFDGAVDLRRTGELAHKLVEEQNNDGIVVNGTTGESPTTTDSE
CCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHH
KAEIVKAVVEAVGSDAAVVAGVGTNDTAHTIELAHQAAEAGADGLLVVTPYYSKPSQAGI
HHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHH
IEHFTAVADATDLPIMLYDIPGRTGTPIETKTLIELADHARIVAVKDAKGLVVESATVMA
HHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCEEEEEECCCCEEEECHHHHE
STTLAYYSGDDAITPALLSVGGVGLVGTSTHFTGRRMHEVIDAYVDGRIDEALSTYREIL
EEEEEEECCCCHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHH
PVLTGVFAAQGATMVKAGLAHQGFTVGRVRPPQTMPTPEQAETFFGVLDRTQL
HHHHHHHHHCCHHHHHHHHHHCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SAPVFGRLLTAMVTPMTFDGAVDLRRTGELAHKLVEEQNNDGIVVNGTTGESPTTTDSE
CCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHH
KAEIVKAVVEAVGSDAAVVAGVGTNDTAHTIELAHQAAEAGADGLLVVTPYYSKPSQAGI
HHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHH
IEHFTAVADATDLPIMLYDIPGRTGTPIETKTLIELADHARIVAVKDAKGLVVESATVMA
HHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCEEEEEECCCCEEEECHHHHE
STTLAYYSGDDAITPALLSVGGVGLVGTSTHFTGRRMHEVIDAYVDGRIDEALSTYREIL
EEEEEEECCCCHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHH
PVLTGVFAAQGATMVKAGLAHQGFTVGRVRPPQTMPTPEQAETFFGVLDRTQL
HHHHHHHHHCCHHHHHHHHHHCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA