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The map label for this gene is iolS [H]

Identifier: 50842075

GI number: 50842075

Start: 649990

End: 650958

Strand: Direct

Name: iolS [H]

Synonym: PPA0589

Alternate gene names: 50842075

Gene position: 649990-650958 (Clockwise)

Preceding gene: 50842074

Following gene: 50842076

Centisome position: 25.39

GC content: 59.55

Gene sequence:

>969_bases
ATGACTCGTATCCCTGGCACAGATCTGGACATCAGACCATTGGTTTTGGGGGCTAATACCTTCGGCTGGACGGCTGATGA
GCACGACTCCCATACCATCCTCGACGCTTTTCTTGGTGCCGGGGGATCGCTGGTCGATACCGCTGACGGCTATTCCCATT
GGGCCGACGGCAATAACGGGGGCGAGTCTGAGCGAATCATTGGTTCTTGGGTGGAAAAAGGCGGGCGACGTGACGACATC
GTCATCGCCACGAAAGTTGCTACCCATCCAGAGTTCAAGGGCTTGGCGCCGGAGAACATCTCTGCCGCAGTTGACGCCTC
CCTGGCCCGGCTCCATACCGACCACATTGATCTCTACTACGCCCACTTCGACGACGACACCCAGCAGATCGAGGACATGG
CAGCGGCTTTTGACAAGCTTGTCAAGGCTGGCAAGGTGCGCTGGGTTGGCCTGTCGAATTTCTCGGTGGCCCGCGAGCAG
AAGTGGCTTGAGGTGGCCGAGCATGAAGGACTAGCCAGCCCGGTGGCATTGCAGCCCCAGTACAACTTGTTGCATCGCGC
AGACGTTGAGGATCCGCAGGGCTATGGTCAGCTCGCCAGTGAGTACAGTCTGGCCCTCTTCCCGTACTTTTCTCTGGCGT
CTGGGTTCCTCACAGGCAAGTACGCCACGCGGGACGACCTGCACGGTGTCGCCCGAGAATCCATGATGGCGGCGTACTTG
CCTGACGCCGAGCACGAGAAGGCGGCCTTCGCTGTCCTCGATCAATTGCGTCAGATTGCTGGGGACCATCGCGTTGAGGT
GTCCTCGGTCTCGTTGGCGTGGCTACTGGCTAAAGGGGTTACCGCACCTATTGCTTCGGCGCGCACTATCGACCAGCTTG
ATGCTTTGCTAGCCGCTCCCGACCTCGTCTTGTCCAGCGACGAAGTTTGCGCCCTGGACGAGGTGTCGGCTGTGTTCGCC
CATGAGTGA

Upstream 100 bases:

>100_bases
GACGATCTACGCTCGGAACTAGAAGCCATTGCCACCGAGATCATGGTTGACATCGATCTGGTTGACCGGTCCTGATCCCG
GGCATCGTCTAGGAGGTCTC

Downstream 100 bases:

>100_bases
ATCATCTGCCGAATGCTCGTCGTCGATGGTCTGGCCTGCATAGGGTATCGACATGGCTACTACCGCTTTCATGGGAAAAC
CCCTTAACACCGTCGGGGAC

Product: oxidoreductase, putative aldo/keto reductase

Products: NA

Alternate protein names: AKR11A; Vegetative protein 147; VEG147 [H]

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MTRIPGTDLDIRPLVLGANTFGWTADEHDSHTILDAFLGAGGSLVDTADGYSHWADGNNGGESERIIGSWVEKGGRRDDI
VIATKVATHPEFKGLAPENISAAVDASLARLHTDHIDLYYAHFDDDTQQIEDMAAAFDKLVKAGKVRWVGLSNFSVAREQ
KWLEVAEHEGLASPVALQPQYNLLHRADVEDPQGYGQLASEYSLALFPYFSLASGFLTGKYATRDDLHGVARESMMAAYL
PDAEHEKAAFAVLDQLRQIAGDHRVEVSSVSLAWLLAKGVTAPIASARTIDQLDALLAAPDLVLSSDEVCALDEVSAVFA
HE

Sequences:

>Translated_322_residues
MTRIPGTDLDIRPLVLGANTFGWTADEHDSHTILDAFLGAGGSLVDTADGYSHWADGNNGGESERIIGSWVEKGGRRDDI
VIATKVATHPEFKGLAPENISAAVDASLARLHTDHIDLYYAHFDDDTQQIEDMAAAFDKLVKAGKVRWVGLSNFSVAREQ
KWLEVAEHEGLASPVALQPQYNLLHRADVEDPQGYGQLASEYSLALFPYFSLASGFLTGKYATRDDLHGVARESMMAAYL
PDAEHEKAAFAVLDQLRQIAGDHRVEVSSVSLAWLLAKGVTAPIASARTIDQLDALLAAPDLVLSSDEVCALDEVSAVFA
HE
>Mature_321_residues
TRIPGTDLDIRPLVLGANTFGWTADEHDSHTILDAFLGAGGSLVDTADGYSHWADGNNGGESERIIGSWVEKGGRRDDIV
IATKVATHPEFKGLAPENISAAVDASLARLHTDHIDLYYAHFDDDTQQIEDMAAAFDKLVKAGKVRWVGLSNFSVAREQK
WLEVAEHEGLASPVALQPQYNLLHRADVEDPQGYGQLASEYSLALFPYFSLASGFLTGKYATRDDLHGVARESMMAAYLP
DAEHEKAAFAVLDQLRQIAGDHRVEVSSVSLAWLLAKGVTAPIASARTIDQLDALLAAPDLVLSSDEVCALDEVSAVFAH
E

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436969, Length=307, Percent_Identity=25.0814332247557, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI4504825, Length=307, Percent_Identity=25.0814332247557, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI27436964, Length=309, Percent_Identity=24.9190938511327, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI27436966, Length=309, Percent_Identity=24.9190938511327, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI27436962, Length=309, Percent_Identity=24.9190938511327, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI223718702, Length=330, Percent_Identity=27.8787878787879, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI27436971, Length=305, Percent_Identity=25.9016393442623, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI41152114, Length=218, Percent_Identity=31.1926605504587, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI41327764, Length=325, Percent_Identity=29.8461538461538, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI87081735, Length=320, Percent_Identity=32.8125, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1789199, Length=348, Percent_Identity=28.735632183908, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1789375, Length=287, Percent_Identity=28.2229965156794, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788070, Length=346, Percent_Identity=26.878612716763, Blast_Score=90, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6325169, Length=342, Percent_Identity=27.1929824561404, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6323998, Length=327, Percent_Identity=25.3822629969419, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6319958, Length=305, Percent_Identity=24.9180327868852, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319951, Length=335, Percent_Identity=25.0746268656716, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6321052, Length=162, Percent_Identity=30.8641975308642, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6322615, Length=252, Percent_Identity=24.2063492063492, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 34853; Mature: 34722

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: PS00062 ALDOKETO_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRIPGTDLDIRPLVLGANTFGWTADEHDSHTILDAFLGAGGSLVDTADGYSHWADGNNG
CCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCEEECCCCCHHCCCCCCC
GESERIIGSWVEKGGRRDDIVIATKVATHPEFKGLAPENISAAVDASLARLHTDHIDLYY
CCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEE
AHFDDDTQQIEDMAAAFDKLVKAGKVRWVGLSNFSVAREQKWLEVAEHEGLASPVALQPQ
EECCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEECCC
YNLLHRADVEDPQGYGQLASEYSLALFPYFSLASGFLTGKYATRDDLHGVARESMMAAYL
CCHHHHCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHC
PDAEHEKAAFAVLDQLRQIAGDHRVEVSSVSLAWLLAKGVTAPIASARTIDQLDALLAAP
CCCCHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC
DLVLSSDEVCALDEVSAVFAHE
CCEECCCCEECHHHHHHHHCCC
>Mature Secondary Structure 
TRIPGTDLDIRPLVLGANTFGWTADEHDSHTILDAFLGAGGSLVDTADGYSHWADGNNG
CCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCEEECCCCCHHCCCCCCC
GESERIIGSWVEKGGRRDDIVIATKVATHPEFKGLAPENISAAVDASLARLHTDHIDLYY
CCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEE
AHFDDDTQQIEDMAAAFDKLVKAGKVRWVGLSNFSVAREQKWLEVAEHEGLASPVALQPQ
EECCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEECCC
YNLLHRADVEDPQGYGQLASEYSLALFPYFSLASGFLTGKYATRDDLHGVARESMMAAYL
CCHHHHCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHC
PDAEHEKAAFAVLDQLRQIAGDHRVEVSSVSLAWLLAKGVTAPIASARTIDQLDALLAAP
CCCCHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC
DLVLSSDEVCALDEVSAVFAHE
CCEECCCCEECHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584049; 9384377; 9298659 [H]