Click here to switch to the map view.

The map label for this gene is pth

Identifier: 50842020

GI number: 50842020

Start: 589205

End: 589807

Strand: Direct

Name: pth

Synonym: PPA0536

Alternate gene names: 50842020

Gene position: 589205-589807 (Clockwise)

Preceding gene: 50842019

Following gene: 50842025

Centisome position: 23.01

GC content: 61.19

Gene sequence:

>603_bases
GTGAGCCCATCGTGGCTCGTGATTGGGCTCGGCAATCCGGGCCCACGTTATGACGGCACCCGACACAATGTCGGGGCAGA
CGTCATAGCCGAGTTATGCCGTCGGGCTGGCGAGAAGCTCTCGCCGGCCCGCGGCCAACGGGCGGAACTCGTTCGCACCC
GCTTGAGTTCGGCCGGTCTGGGCGTACCGGCTGTGGATGCCCAGACCGTTATCCTGATGCGCAGCCGCACGTATATGAAC
GAGTCGGGGATCGCCGTCAGCAAGGTCGCGAGCTTTGCCGGAATCACCCCTGATCATCTCATCGTCGTTCATGACGAAAT
TGATCTTGATCCGGGTCGGCTACGCCTCAAAAAGGGAGGCGGAGATAATGGCCATAATGGACTGAAATCCATTCGAGCCC
ACTTACGCACCGGTGATTTCATTCGGGTGAGATTAGGCGTTGGGCGTCCCCCAGGTCATCAAGATCCGGCTGACTGGGTG
CTGGCCCGGGTGCCTGCCAGGCAGCGCGCTGAGATGGGTGTTCAGGTGGCCTTGGCCGCCGACGCCGTCGAGTCGATCAT
TATCCAAGGGCTGGCTGCGGCCCAGAACCGTTTCAATTCCTGA

Upstream 100 bases:

>100_bases
TTGCTGCCACTGTCGCCTTCCCGGAGACTGAGCCCGTTGAAGATGAAGAGTCCGCGGGGGAGGACGCTCAGGGCGAGTCC
GAGGAGAAGGCTGCGAAAGA

Downstream 100 bases:

>100_bases
CTGTTTTCCCGGCTGCGTGCAACGGGTGGTAGGCAAGGATCAGTCAGGATGTACTTCCATTAGGGGCTCACCGGTCTGTG
AAAAATCACGCAGGTATTCC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 200; Mature: 199

Protein sequence:

>200_residues
MSPSWLVIGLGNPGPRYDGTRHNVGADVIAELCRRAGEKLSPARGQRAELVRTRLSSAGLGVPAVDAQTVILMRSRTYMN
ESGIAVSKVASFAGITPDHLIVVHDEIDLDPGRLRLKKGGGDNGHNGLKSIRAHLRTGDFIRVRLGVGRPPGHQDPADWV
LARVPARQRAEMGVQVALAADAVESIIIQGLAAAQNRFNS

Sequences:

>Translated_200_residues
MSPSWLVIGLGNPGPRYDGTRHNVGADVIAELCRRAGEKLSPARGQRAELVRTRLSSAGLGVPAVDAQTVILMRSRTYMN
ESGIAVSKVASFAGITPDHLIVVHDEIDLDPGRLRLKKGGGDNGHNGLKSIRAHLRTGDFIRVRLGVGRPPGHQDPADWV
LARVPARQRAEMGVQVALAADAVESIIIQGLAAAQNRFNS
>Mature_199_residues
SPSWLVIGLGNPGPRYDGTRHNVGADVIAELCRRAGEKLSPARGQRAELVRTRLSSAGLGVPAVDAQTVILMRSRTYMNE
SGIAVSKVASFAGITPDHLIVVHDEIDLDPGRLRLKKGGGDNGHNGLKSIRAHLRTGDFIRVRLGVGRPPGHQDPADWVL
ARVPARQRAEMGVQVALAADAVESIIIQGLAAAQNRFNS

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=146, Percent_Identity=39.7260273972603, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1787455, Length=199, Percent_Identity=36.6834170854271, Blast_Score=95, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321983, Length=197, Percent_Identity=32.48730964467, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_PROAC (Q6AAC7)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_055247.1
- ProteinModelPortal:   Q6AAC7
- SMR:   Q6AAC7
- GeneID:   2931621
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA0536
- NMPDR:   fig|267747.1.peg.524
- HOGENOM:   HBG610927
- OMA:   IGIQNDE
- ProtClustDB:   PRK05426
- BioCyc:   PACN267747:PPA0536-MONOMER
- BRENDA:   3.1.1.29
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 21357; Mature: 21226

Theoretical pI: Translated: 10.89; Mature: 10.89

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPSWLVIGLGNPGPRYDGTRHNVGADVIAELCRRAGEKLSPARGQRAELVRTRLSSAGL
CCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCC
GVPAVDAQTVILMRSRTYMNESGIAVSKVASFAGITPDHLIVVHDEIDLDPGRLRLKKGG
CCCCCCCCEEEEEECCHHCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEECCC
GDNGHNGLKSIRAHLRTGDFIRVRLGVGRPPGHQDPADWVLARVPARQRAEMGVQVALAA
CCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCHHHHHCCEEEEHHH
DAVESIIIQGLAAAQNRFNS
HHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SPSWLVIGLGNPGPRYDGTRHNVGADVIAELCRRAGEKLSPARGQRAELVRTRLSSAGL
CCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCC
GVPAVDAQTVILMRSRTYMNESGIAVSKVASFAGITPDHLIVVHDEIDLDPGRLRLKKGG
CCCCCCCCEEEEEECCHHCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEECCC
GDNGHNGLKSIRAHLRTGDFIRVRLGVGRPPGHQDPADWVLARVPARQRAEMGVQVALAA
CCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCHHHHHCCEEEEHHH
DAVESIIIQGLAAAQNRFNS
HHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA