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The map label for this gene is moeA1 [H]

Identifier: 50841978

GI number: 50841978

Start: 544192

End: 545499

Strand: Direct

Name: moeA1 [H]

Synonym: PPA0494

Alternate gene names: 50841978

Gene position: 544192-545499 (Clockwise)

Preceding gene: 50841973

Following gene: 50841979

Centisome position: 21.26

GC content: 62.39

Gene sequence:

>1308_bases
ATGGCGTTGTTCCACAGGAAGAAGCAGGTCGAGGCCCCCGAACCCGAAGCGGAGCCCCTCGGCCTGCCAGGAGCGCCGGA
GACAGATATGTCAGATCGTCGGTCTGTCGACGATCATCGTGACTACCTATGCAGCTTGGTGCAGGCCGTCCCACCAGTAG
CCGTGGAGGTGCCGAGAGCTGTCGGTCTGGCTGTTTGTGAGGACGTTCATGCGCCCCATGACGTTCCAGTCGTGACGACG
GCGGTCATTGATGGCTACGCCCTCGACTCGGCGTCGACTCGAATGGCCGGACGTCCCGATGCCGTTGAGATCCAGGTGGA
TCGACGCCCACCTAGCCCGGTAATCCCTGGTACTGCTGTGCGGGTCGTGGCTGGATCGCCGCTTCCTGAGGGGACCGACT
GCGTCTTACCACCGGATCTGCTCAATGCCGACGGCGACATTGTGTTGTTTTCTCCGGTGAAGAGATGGGCCGGTGCCCGA
CTCGCGGGCTCGGATTACGGCCGCGGCGAGGTTCTGGTACGTAACGGGACGATCCTGCACCCAGGTATCATCTCGGTGCT
CGCTTCGGCCGGAATCGACGAGGTGTTCGTCCGTCCGCGCCCCAAGGTCGTCATTGTTGCGGTGCGCGCTGATGAGGACC
AACGTGCGGAGATTGAGCGGAAGGCGCGGGCCAATGGCGCCGAGGACATTGCCTCTCTTGATGCCACTGCTGCAGCCATC
GAGTCTGCTACCCGAGCACTCGATGTGAATGTCACTGTCGTCTCCACCAACACCTCCAGTGACAGTGAGTTGACGCGATT
GCTGGCGAATGCTGGACGTGGGGCTGACCTCGTGATCGCCACGAGCGACCGGATAGTTGTGGGTCAGCAGGACCCCGTGC
CATCGGTGTTGCCACCGATGGGAGGTACTGACTTCGCCAGGGTGGCGATGGAGCCGGGCGCAAATCAAGTGTTCGCCCTG
ATAGATCCCGGTTTGGTCCCTCTCATCGTCTTGCCGGTCGGGCCTGGGCCAGCTCTGGTCTCCTTCATGGCCTTTGTGCA
GCCTCTGCTGCGCAAATTGTCCGGGCTTCCGCCGGTCGAGAAGCTCAAGGCTGAGACAGATCGACCGATTGCGCGGCATC
CGGAATCCACCACGTTCGTTCCAGTACGTCTAGCACGGGTGGGTGGCCGCCCGGTGCTATCGCGAGCAGGAATGGGCGAC
GTCACCCACGTTGTCGATTTGTCGATGGCCGATGCTATCGCTGTTGTCGGGGCGGGGGATGAGCCAGTTCCTACCGGCAT
GCCGCTGACCTGTTGGCGATTGGGGTGA

Upstream 100 bases:

>100_bases
TCTCCTATCTGACGGAACATGGTCTGTCGTCACTGACTCATGCTACGCCCTAGCCGAGTCGCTGCCAGGCAGACGGCAGA
ACGCCCTCTAGGGTGATGCT

Downstream 100 bases:

>100_bases
TGTCGTGGCCTCGCCTCGTTTGCCGTGGGGAGTGTCGATGCCGCGGCATCGACACTGGCCAGTGACTATGCAGGCTGGCG
GGGTGGTGCTGCGCCCGATG

Product: putative molybdopterin biosynthesis enzyme

Products: NA

Alternate protein names: MPT Mo-transferase 1 [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MALFHRKKQVEAPEPEAEPLGLPGAPETDMSDRRSVDDHRDYLCSLVQAVPPVAVEVPRAVGLAVCEDVHAPHDVPVVTT
AVIDGYALDSASTRMAGRPDAVEIQVDRRPPSPVIPGTAVRVVAGSPLPEGTDCVLPPDLLNADGDIVLFSPVKRWAGAR
LAGSDYGRGEVLVRNGTILHPGIISVLASAGIDEVFVRPRPKVVIVAVRADEDQRAEIERKARANGAEDIASLDATAAAI
ESATRALDVNVTVVSTNTSSDSELTRLLANAGRGADLVIATSDRIVVGQQDPVPSVLPPMGGTDFARVAMEPGANQVFAL
IDPGLVPLIVLPVGPGPALVSFMAFVQPLLRKLSGLPPVEKLKAETDRPIARHPESTTFVPVRLARVGGRPVLSRAGMGD
VTHVVDLSMADAIAVVGAGDEPVPTGMPLTCWRLG

Sequences:

>Translated_435_residues
MALFHRKKQVEAPEPEAEPLGLPGAPETDMSDRRSVDDHRDYLCSLVQAVPPVAVEVPRAVGLAVCEDVHAPHDVPVVTT
AVIDGYALDSASTRMAGRPDAVEIQVDRRPPSPVIPGTAVRVVAGSPLPEGTDCVLPPDLLNADGDIVLFSPVKRWAGAR
LAGSDYGRGEVLVRNGTILHPGIISVLASAGIDEVFVRPRPKVVIVAVRADEDQRAEIERKARANGAEDIASLDATAAAI
ESATRALDVNVTVVSTNTSSDSELTRLLANAGRGADLVIATSDRIVVGQQDPVPSVLPPMGGTDFARVAMEPGANQVFAL
IDPGLVPLIVLPVGPGPALVSFMAFVQPLLRKLSGLPPVEKLKAETDRPIARHPESTTFVPVRLARVGGRPVLSRAGMGD
VTHVVDLSMADAIAVVGAGDEPVPTGMPLTCWRLG
>Mature_434_residues
ALFHRKKQVEAPEPEAEPLGLPGAPETDMSDRRSVDDHRDYLCSLVQAVPPVAVEVPRAVGLAVCEDVHAPHDVPVVTTA
VIDGYALDSASTRMAGRPDAVEIQVDRRPPSPVIPGTAVRVVAGSPLPEGTDCVLPPDLLNADGDIVLFSPVKRWAGARL
AGSDYGRGEVLVRNGTILHPGIISVLASAGIDEVFVRPRPKVVIVAVRADEDQRAEIERKARANGAEDIASLDATAAAIE
SATRALDVNVTVVSTNTSSDSELTRLLANAGRGADLVIATSDRIVVGQQDPVPSVLPPMGGTDFARVAMEPGANQVFALI
DPGLVPLIVLPVGPGPALVSFMAFVQPLLRKLSGLPPVEKLKAETDRPIARHPESTTFVPVRLARVGGRPVLSRAGMGDV
THVVDLSMADAIAVVGAGDEPVPTGMPLTCWRLG

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=333, Percent_Identity=29.7297297297297, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI66932975, Length=333, Percent_Identity=29.7297297297297, Blast_Score=82, Evalue=8e-16,
Organism=Escherichia coli, GI1787049, Length=304, Percent_Identity=28.6184210526316, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562606, Length=398, Percent_Identity=23.3668341708543, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25147659, Length=372, Percent_Identity=24.4623655913978, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 45592; Mature: 45461

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALFHRKKQVEAPEPEAEPLGLPGAPETDMSDRRSVDDHRDYLCSLVQAVPPVAVEVPRA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHCCCCEEECCHH
VGLAVCEDVHAPHDVPVVTTAVIDGYALDSASTRMAGRPDAVEIQVDRRPPSPVIPGTAV
HHHHHHHHCCCCCCCCEEEEEEECCEEECCCCCCCCCCCCEEEEEECCCCCCCCCCCCEE
RVVAGSPLPEGTDCVLPPDLLNADGDIVLFSPVKRWAGARLAGSDYGRGEVLVRNGTILH
EEEECCCCCCCCCCCCCHHHHCCCCCEEEECCHHHHCCCEECCCCCCCCEEEEECCCEEC
PGIISVLASAGIDEVFVRPRPKVVIVAVRADEDQRAEIERKARANGAEDIASLDATAAAI
HHHHHHHHHCCCCEEEECCCCCEEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
ESATRALDVNVTVVSTNTSSDSELTRLLANAGRGADLVIATSDRIVVGQQDPVPSVLPPM
HHHHHEEEEEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCEEEECCCCCCCCCCCCC
GGTDFARVAMEPGANQVFALIDPGLVPLIVLPVGPGPALVSFMAFVQPLLRKLSGLPPVE
CCCCHHHEEECCCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCHH
KLKAETDRPIARHPESTTFVPVRLARVGGRPVLSRAGMGDVTHVVDLSMADAIAVVGAGD
HHHCCCCCCHHCCCCCCEEEEEEEECCCCCHHHHHCCCCCHHHHHHHHHHCEEEEEECCC
EPVPTGMPLTCWRLG
CCCCCCCCEEEEECC
>Mature Secondary Structure 
ALFHRKKQVEAPEPEAEPLGLPGAPETDMSDRRSVDDHRDYLCSLVQAVPPVAVEVPRA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHCCCCEEECCHH
VGLAVCEDVHAPHDVPVVTTAVIDGYALDSASTRMAGRPDAVEIQVDRRPPSPVIPGTAV
HHHHHHHHCCCCCCCCEEEEEEECCEEECCCCCCCCCCCCEEEEEECCCCCCCCCCCCEE
RVVAGSPLPEGTDCVLPPDLLNADGDIVLFSPVKRWAGARLAGSDYGRGEVLVRNGTILH
EEEECCCCCCCCCCCCCHHHHCCCCCEEEECCHHHHCCCEECCCCCCCCEEEEECCCEEC
PGIISVLASAGIDEVFVRPRPKVVIVAVRADEDQRAEIERKARANGAEDIASLDATAAAI
HHHHHHHHHCCCCEEEECCCCCEEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
ESATRALDVNVTVVSTNTSSDSELTRLLANAGRGADLVIATSDRIVVGQQDPVPSVLPPM
HHHHHEEEEEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCEEEECCCCCCCCCCCCC
GGTDFARVAMEPGANQVFALIDPGLVPLIVLPVGPGPALVSFMAFVQPLLRKLSGLPPVE
CCCCHHHEEECCCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCHH
KLKAETDRPIARHPESTTFVPVRLARVGGRPVLSRAGMGDVTHVVDLSMADAIAVVGAGD
HHHCCCCCCHHCCCCCCEEEEEEEECCCCCHHHHHCCCCCHHHHHHHHHHCEEEEEECCC
EPVPTGMPLTCWRLG
CCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]