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The map label for this gene is ldh2 [H]

Identifier: 50841506

GI number: 50841506

Start: 15246

End: 16214

Strand: Reverse

Name: ldh2 [H]

Synonym: PPA0012

Alternate gene names: 50841506

Gene position: 16214-15246 (Counterclockwise)

Preceding gene: 50841515

Following gene: NA

Centisome position: 0.63

GC content: 61.82

Gene sequence:

>969_bases
ATGTCAATTGCACCGCACCTCGTCGTTATCGGGATCGGCCACGTCGGCTCGGACGTCGTCACCAATGCCGCAGCCTTGGG
ACTCTTCTCGCGTATATCGCTCATTGATGTCGACAAAAAGGTCCGTGACGGCCAAGCTCTCGACAACCACCAGGCCACCG
CCGTCGCCCCCGCCATGACGACCACCATCACGGCAGCCAACTATGACGCATGTCGCAGCGCCGACGTCATCATCGTCTCC
GCTGGTCCCTCCGTCCTGCCTGACAGCTACGGCGGCGGCCATGACTCACGTAACTCGCTGGCCCAAGTCAACTCGAAGGT
CATCCGCGAGGTGATGGGCAACATCTGCCAATACACCCACAGCGCACCCATCATCCTCATTACTAACCCACTAGACGTTA
ACGTCCATATCGCGGCAACCGAGTTCGACTATCCGACGAACCTCGTCGTTGGCACCGGAACCGCCCTCGACTCAGCCCGA
CTGCGCCGTCACCTAGCCGACTGGGCCGGCGTCAGTCCCGACTCGGTGCAAGCCTTCATGTTGGGAGAGCACGGGGCGAC
AGCATTTCCCTACCTCTCGCATGCCTCTATCGGTGGTCTGACCCTCGCCGAGGCGACGACCGCCCTGGGGCTGCAACCGT
TGTCCCCCGACCAGGTGGGCAACAGCGTCGTACAGTCGGCCTTCGATATCCTTGAGGGCAAGGGCTGGACGTCCTCGGGT
ATCTCGAAGGCGGCGGTGAGCTTGGCACGGGCCATGCTGCTCGACCAACGGTCCATCCATCCGGTATGCACGCTAGCCGA
CGGGGTGCTGGGATTCCACAGTGAGGTATCCCTGTCGCTGCCAACGGTGGTCAGTGGCCACGGGGTCGAACATCACCTCA
ACATCGTCTTGGACGAGTGGGAGCAAGAGAAACTGTTGGTCTCGGCCAAGGCGGTACGAGAGGTCTATGAGTCGGTGCGT
CCAGCCTGA

Upstream 100 bases:

>100_bases
ACGTGCTAAGCAGGAGCAGACAAGCTCGCCACCACGTCTCACTGTCAGAGACGGTGGTGTACCACGTGAGACGATGAACG
TCAACGGAAGGATCACACCC

Downstream 100 bases:

>100_bases
GCGCCGCGACTCCTGGCATTTCCCGTTACATCCCACCCATACAGCAGGGTGACGTCGGCCTCGATGACGAGTTCGGTGCG
CAGTTCCGGGCACCGAACTC

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: L-LDH 2 [H]

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MSIAPHLVVIGIGHVGSDVVTNAAALGLFSRISLIDVDKKVRDGQALDNHQATAVAPAMTTTITAANYDACRSADVIIVS
AGPSVLPDSYGGGHDSRNSLAQVNSKVIREVMGNICQYTHSAPIILITNPLDVNVHIAATEFDYPTNLVVGTGTALDSAR
LRRHLADWAGVSPDSVQAFMLGEHGATAFPYLSHASIGGLTLAEATTALGLQPLSPDQVGNSVVQSAFDILEGKGWTSSG
ISKAAVSLARAMLLDQRSIHPVCTLADGVLGFHSEVSLSLPTVVSGHGVEHHLNIVLDEWEQEKLLVSAKAVREVYESVR
PA

Sequences:

>Translated_322_residues
MSIAPHLVVIGIGHVGSDVVTNAAALGLFSRISLIDVDKKVRDGQALDNHQATAVAPAMTTTITAANYDACRSADVIIVS
AGPSVLPDSYGGGHDSRNSLAQVNSKVIREVMGNICQYTHSAPIILITNPLDVNVHIAATEFDYPTNLVVGTGTALDSAR
LRRHLADWAGVSPDSVQAFMLGEHGATAFPYLSHASIGGLTLAEATTALGLQPLSPDQVGNSVVQSAFDILEGKGWTSSG
ISKAAVSLARAMLLDQRSIHPVCTLADGVLGFHSEVSLSLPTVVSGHGVEHHLNIVLDEWEQEKLLVSAKAVREVYESVR
PA
>Mature_321_residues
SIAPHLVVIGIGHVGSDVVTNAAALGLFSRISLIDVDKKVRDGQALDNHQATAVAPAMTTTITAANYDACRSADVIIVSA
GPSVLPDSYGGGHDSRNSLAQVNSKVIREVMGNICQYTHSAPIILITNPLDVNVHIAATEFDYPTNLVVGTGTALDSARL
RRHLADWAGVSPDSVQAFMLGEHGATAFPYLSHASIGGLTLAEATTALGLQPLSPDQVGNSVVQSAFDILEGKGWTSSGI
SKAAVSLARAMLLDQRSIHPVCTLADGVLGFHSEVSLSLPTVVSGHGVEHHLNIVLDEWEQEKLLVSAKAVREVYESVRP
A

Specific function: Catalyzes The Reversible Oxidation Of Malate To Oxaloacetate. [C]

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. LDH family [H]

Homologues:

Organism=Homo sapiens, GI47059044, Length=314, Percent_Identity=27.0700636942675, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI221136809, Length=314, Percent_Identity=27.0700636942675, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI15082234, Length=315, Percent_Identity=27.3015873015873, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI5031857, Length=306, Percent_Identity=26.797385620915, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI260099723, Length=306, Percent_Identity=26.797385620915, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI291575128, Length=318, Percent_Identity=27.9874213836478, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI4557032, Length=318, Percent_Identity=27.9874213836478, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI9257228, Length=316, Percent_Identity=25.9493670886076, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI4504973, Length=316, Percent_Identity=25.9493670886076, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI207028494, Length=186, Percent_Identity=30.6451612903226, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI260099727, Length=204, Percent_Identity=25.9803921568627, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI260099725, Length=205, Percent_Identity=25.8536585365854, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17535107, Length=295, Percent_Identity=27.4576271186441, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI17136226, Length=318, Percent_Identity=29.559748427673, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI45550422, Length=315, Percent_Identity=26.984126984127, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: 2640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2380 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). 260 Molecules/Cell In: Stationary Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR011304
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.27 [H]

Molecular weight: Translated: 33774; Mature: 33642

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIAPHLVVIGIGHVGSDVVTNAAALGLFSRISLIDVDKKVRDGQALDNHQATAVAPAMT
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHEEECCHHHCCCCCCCCCCCCEECCHHH
TTITAANYDACRSADVIIVSAGPSVLPDSYGGGHDSRNSLAQVNSKVIREVMGNICQYTH
EEEEECCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
SAPIILITNPLDVNVHIAATEFDYPTNLVVGTGTALDSARLRRHLADWAGVSPDSVQAFM
CCCEEEEECCCEEEEEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCEEEEE
LGEHGATAFPYLSHASIGGLTLAEATTALGLQPLSPDQVGNSVVQSAFDILEGKGWTSSG
ECCCCCCCCCCHHCCCCCCEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
ISKAAVSLARAMLLDQRSIHPVCTLADGVLGFHSEVSLSLPTVVSGHGVEHHLNIVLDEW
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEECCCEECCCCCCEEEEEEECCC
EQEKLLVSAKAVREVYESVRPA
CHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SIAPHLVVIGIGHVGSDVVTNAAALGLFSRISLIDVDKKVRDGQALDNHQATAVAPAMT
CCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHEEECCHHHCCCCCCCCCCCCEECCHHH
TTITAANYDACRSADVIIVSAGPSVLPDSYGGGHDSRNSLAQVNSKVIREVMGNICQYTH
EEEEECCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
SAPIILITNPLDVNVHIAATEFDYPTNLVVGTGTALDSARLRRHLADWAGVSPDSVQAFM
CCCEEEEECCCEEEEEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCEEEEE
LGEHGATAFPYLSHASIGGLTLAEATTALGLQPLSPDQVGNSVVQSAFDILEGKGWTSSG
ECCCCCCCCCCHHCCCCCCEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
ISKAAVSLARAMLLDQRSIHPVCTLADGVLGFHSEVSLSLPTVVSGHGVEHHLNIVLDEW
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEECCCEECCCCCCEEEEEEECCC
EQEKLLVSAKAVREVYESVRPA
CHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]