Click here to switch to the map view.

The map label for this gene is pdp

Identifier: 50812307

GI number: 50812307

Start: 4049009

End: 4050310

Strand: Reverse

Name: pdp

Synonym: BSU39400

Alternate gene names: 50812307

Gene position: 4050310-4049009 (Counterclockwise)

Preceding gene: 255767837

Following gene: 255767835

Centisome position: 96.08

GC content: 50.46

Gene sequence:

>1302_bases
ATGAGAATGGTAGATATCATCATCAAAAAACAAAACGGAAAAGAACTCACCACTGAAGAAATTCAATTTTTTGTGAACGG
CTATACAGATGGAAGCATTCCTGATTATCAGGCAAGCGCGCTTGCTATGGCGATTTTCTTCCAGGATATGAGTGACCGTG
AACGCGCGGACTTGACGATGGCTATGGTGAACTCCGGTGAAACGATTGATCTTTCTGCCATTGAAGGAATTAAAGTGGAT
AAACACTCTACCGGCGGCGTCGGCGACACGACAACGCTCGTTCTCGCTCCGCTTGTTGCGGCTCTTGATGTGCCGGTTGC
TAAGATGTCCGGCCGCGGCCTCGGCCATACGGGCGGCACGATTGATAAGTTAGAGGCAATCATGGGCTTCCACGTGGAAC
TGACGAAGGATGAATTTATTAAACTTGTGAACCGCGACAAGGTTGCGGTCATCGGCCAAAGCGGCAATTTAACGCCGGCT
GATAAAAAACTGTACGCGCTTCGTGATGTAACGGGAACGGTCAATTCCATTCCGCTCATTGCAAGCTCGATTATGAGCAA
AAAAATCGCTGCCGGGGCGGACGCCATCGTGCTTGACGTAAAAACGGGAGCGGGCGCCTTCATGAAAACAGAAGAAGACG
CAGCTGAACTTGCCAAAGCGATGGTACGCATCGGAAATAACGTCGGCCGTCAAACAATGGCTGTCATTTCAGACATGTCC
CAGCCACTCGGCTTTGCGATCGGAAATGCGCTTGAAGTCAAAGAAGCGATCGACACGCTCAAAGGCGAGGGGCCTGAGGA
TCTTCATGAGCTTGTCTTAACGCTCGGCAGCCAGATGGTTGTGCTTGCGAAAAAAGCCGATACATTGGACGAAGCGAGAG
CGAAGCTGGAAGAAGTCATGAAAAACGGCAAAGCACTTGAGAAATTCAAGGATTTCCTGAAAAACCAAGGCGGCGACAGC
TCAATTGTTGACGATCCGTCTAAGCTTCCGCAAGCCGCATATCAAATTGATGTGCCTGCCAAAGAAGCGGGTGTCGTCTC
TGAAATCGTCGCGGACGAAATCGGCGTCGCGGCGATGCTGTTAGGTGCCGGCCGCGCCACAAAAGAAGACGAAATCGATT
TAGCCGTCGGCATCATGCTCCGCAAAAAGGTCGGCGACAAAGTAGAAAAAGGGGAACCGCTCGTAACGCTTTACGCTAAC
CGAGAAAACGTCGATGAAGTCATCGCAAAAGTCTATGACAACATCCGCATCGCCGCGGAAGCGAAGGCGCCGAAGCTGAT
TCATACGTTAATTACAGAATAA

Upstream 100 bases:

>100_bases
GCTTGAAATTATTATACGGTGCTACGCTTGTCAGCTTTTTATCAGCAGCAATTGTGGGCTTGATTTACTGAACTTAATCG
AAAAGGATCGGTGACCAAAC

Downstream 100 bases:

>100_bases
AAAATAAAGCACATCCCATGCTGAGCGGGGTGTGCTTTTTTAATTATAGGATGTGATCGGCTGGATATTCCTCTTGGCTG
ATTTTTTTCGCTTTTGTAAC

Product: pyrimidine-nucleoside phosphorylase

Products: NA

Alternate protein names: PYNP

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MRMVDIIIKKQNGKELTTEEIQFFVNGYTDGSIPDYQASALAMAIFFQDMSDRERADLTMAMVNSGETIDLSAIEGIKVD
KHSTGGVGDTTTLVLAPLVAALDVPVAKMSGRGLGHTGGTIDKLEAIMGFHVELTKDEFIKLVNRDKVAVIGQSGNLTPA
DKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAAELAKAMVRIGNNVGRQTMAVISDMS
QPLGFAIGNALEVKEAIDTLKGEGPEDLHELVLTLGSQMVVLAKKADTLDEARAKLEEVMKNGKALEKFKDFLKNQGGDS
SIVDDPSKLPQAAYQIDVPAKEAGVVSEIVADEIGVAAMLLGAGRATKEDEIDLAVGIMLRKKVGDKVEKGEPLVTLYAN
RENVDEVIAKVYDNIRIAAEAKAPKLIHTLITE

Sequences:

>Translated_433_residues
MRMVDIIIKKQNGKELTTEEIQFFVNGYTDGSIPDYQASALAMAIFFQDMSDRERADLTMAMVNSGETIDLSAIEGIKVD
KHSTGGVGDTTTLVLAPLVAALDVPVAKMSGRGLGHTGGTIDKLEAIMGFHVELTKDEFIKLVNRDKVAVIGQSGNLTPA
DKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAAELAKAMVRIGNNVGRQTMAVISDMS
QPLGFAIGNALEVKEAIDTLKGEGPEDLHELVLTLGSQMVVLAKKADTLDEARAKLEEVMKNGKALEKFKDFLKNQGGDS
SIVDDPSKLPQAAYQIDVPAKEAGVVSEIVADEIGVAAMLLGAGRATKEDEIDLAVGIMLRKKVGDKVEKGEPLVTLYAN
RENVDEVIAKVYDNIRIAAEAKAPKLIHTLITE
>Mature_433_residues
MRMVDIIIKKQNGKELTTEEIQFFVNGYTDGSIPDYQASALAMAIFFQDMSDRERADLTMAMVNSGETIDLSAIEGIKVD
KHSTGGVGDTTTLVLAPLVAALDVPVAKMSGRGLGHTGGTIDKLEAIMGFHVELTKDEFIKLVNRDKVAVIGQSGNLTPA
DKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAAELAKAMVRIGNNVGRQTMAVISDMS
QPLGFAIGNALEVKEAIDTLKGEGPEDLHELVLTLGSQMVVLAKKADTLDEARAKLEEVMKNGKALEKFKDFLKNQGGDS
SIVDDPSKLPQAAYQIDVPAKEAGVVSEIVADEIGVAAMLLGAGRATKEDEIDLAVGIMLRKKVGDKVEKGEPLVTLYAN
RENVDEVIAKVYDNIRIAAEAKAPKLIHTLITE

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family

Homologues:

Organism=Homo sapiens, GI166158925, Length=407, Percent_Identity=39.0663390663391, Blast_Score=265, Evalue=4e-71,
Organism=Homo sapiens, GI4503445, Length=407, Percent_Identity=39.0663390663391, Blast_Score=265, Evalue=4e-71,
Organism=Homo sapiens, GI166158922, Length=407, Percent_Identity=39.0663390663391, Blast_Score=265, Evalue=4e-71,
Organism=Escherichia coli, GI1790842, Length=404, Percent_Identity=46.039603960396, Blast_Score=332, Evalue=2e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDP_BACSU (P39142)

Other databases:

- EMBL:   X82174
- EMBL:   D45912
- EMBL:   AL009126
- PIR:   S78770
- RefSeq:   NP_391819.2
- ProteinModelPortal:   P39142
- SMR:   P39142
- EnsemblBacteria:   EBBACT00000000924
- GeneID:   937540
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU39400
- GenoList:   BSU39400
- GeneTree:   EBGT00050000000919
- HOGENOM:   HBG288505
- OMA:   AEIFGRM
- PhylomeDB:   P39142
- ProtClustDB:   PRK06078
- BioCyc:   BSUB:BSU39400-MONOMER
- BRENDA:   2.4.2.2
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- PANTHER:   PTHR10515
- PIRSF:   PIRSF000478
- SMART:   SM00941
- TIGRFAMs:   TIGR02644

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3; SSF54680 PYNP_C

EC number: =2.4.2.2

Molecular weight: Translated: 46208; Mature: 46208

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMVDIIIKKQNGKELTTEEIQFFVNGYTDGSIPDYQASALAMAIFFQDMSDRERADLTM
CCEEEEEEECCCCCCCCHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHCCCCCHHHCEEE
AMVNSGETIDLSAIEGIKVDKHSTGGVGDTTTLVLAPLVAALDVPVAKMSGRGLGHTGGT
EEECCCCEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCH
IDKLEAIMGFHVELTKDEFIKLVNRDKVAVIGQSGNLTPADKKLYALRDVTGTVNSIPLI
HHHHHHHHCCEEEECHHHHHHHHCCCCEEEEECCCCCCCCHHHHEEHHHCCCCCHHHHHH
ASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAAELAKAMVRIGNNVGRQTMAVISDMS
HHHHHHHHHHCCCCEEEEEECCCCCCCEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
QPLGFAIGNALEVKEAIDTLKGEGPEDLHELVLTLGSQMVVLAKKADTLDEARAKLEEVM
CCHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHH
KNGKALEKFKDFLKNQGGDSSIVDDPSKLPQAAYQIDVPAKEAGVVSEIVADEIGVAAML
HCCHHHHHHHHHHHCCCCCCCCCCCHHHCCCHHEEECCCCHHHHHHHHHHHHHHHHHHHH
LGAGRATKEDEIDLAVGIMLRKKVGDKVEKGEPLVTLYANRENVDEVIAKVYDNIRIAAE
HHCCCCCCCCCHHHHHHHHHHHHHCCHHHCCCCEEEEEECCCCHHHHHHHHHHCEEEEEC
AKAPKLIHTLITE
CCCHHHHHHHHCC
>Mature Secondary Structure
MRMVDIIIKKQNGKELTTEEIQFFVNGYTDGSIPDYQASALAMAIFFQDMSDRERADLTM
CCEEEEEEECCCCCCCCHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHCCCCCHHHCEEE
AMVNSGETIDLSAIEGIKVDKHSTGGVGDTTTLVLAPLVAALDVPVAKMSGRGLGHTGGT
EEECCCCEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCH
IDKLEAIMGFHVELTKDEFIKLVNRDKVAVIGQSGNLTPADKKLYALRDVTGTVNSIPLI
HHHHHHHHCCEEEECHHHHHHHHCCCCEEEEECCCCCCCCHHHHEEHHHCCCCCHHHHHH
ASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAAELAKAMVRIGNNVGRQTMAVISDMS
HHHHHHHHHHCCCCEEEEEECCCCCCCEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
QPLGFAIGNALEVKEAIDTLKGEGPEDLHELVLTLGSQMVVLAKKADTLDEARAKLEEVM
CCHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHH
KNGKALEKFKDFLKNQGGDSSIVDDPSKLPQAAYQIDVPAKEAGVVSEIVADEIGVAAML
HCCHHHHHHHHHHHCCCCCCCCCCCHHHCCCHHEEECCCCHHHHHHHHHHHHHHHHHHHH
LGAGRATKEDEIDLAVGIMLRKKVGDKVEKGEPLVTLYANRENVDEVIAKVYDNIRIAAE
HHCCCCCCCCCHHHHHHHHHHHHHCCHHHCCCCEEEEEECCCCHHHHHHHHHHCEEEEEC
AKAPKLIHTLITE
CCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550462; 8867804; 9384377; 10568751