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The map label for this gene is pyrH

Identifier: 50812227

GI number: 50812227

Start: 1719802

End: 1720524

Strand: Direct

Name: pyrH

Synonym: BSU16510

Alternate gene names: 50812227

Gene position: 1719802-1720524 (Clockwise)

Preceding gene: 16078713

Following gene: 16078715

Centisome position: 40.8

GC content: 44.12

Gene sequence:

>723_bases
ATGGAAAAACCAAAATACAAACGTATCGTATTAAAGCTTAGCGGGGAAGCATTGGCAGGAGAACAGGGAAATGGAATTAA
CCCGACTGTCATTCAATCCATTGCAAAGCAAGTGAAGGAAATCGCTGAGCTTGAAGTCGAAGTGGCTGTTGTTGTAGGCG
GCGGCAACTTATGGCGCGGAAAAACAGGAAGTGACCTGGGCATGGACCGCGCGACTGCTGACTATATGGGAATGCTGGCG
ACAGTAATGAATTCGCTTGCTCTTCAAGACAGCTTGGAAACACTCGGAATCCAGTCCAGAGTGCAAACATCCATTGAAAT
GAGACAAGTTGCTGAACCGTACATAAGAAGAAAAGCGATACGCCACTTAGAGAAAAAACGTGTCGTTATTTTCGCTGCGG
GCACAGGAAACCCATATTTCTCAACTGATACGACAGCTGCACTGCGGGCTGCTGAAATTGAGGCAGACGTTATTTTAATG
GCTAAAAATAACGTTGACGGTGTGTATAATGCTGATCCTAGAAAAGATGAATCAGCTGTTAAGTATGAATCACTTTCTTA
TCTTGACGTTCTTAAAGACGGCCTGGAAGTCATGGATTCAACAGCTTCCTCTTTATGCATGGACAATGACATTCCGCTTA
TCGTCTTTTCTATTATGGAAGAAGGAAATATCAAACGTGCCGTTATCGGTGAATCAATCGGAACGATCGTGAGGGGGAAA
TAA

Upstream 100 bases:

>100_bases
AGGGGACACATTTTGTGTTCCCTATTTTTAAAACTATATTTACAAACCTTTTTTTCTCTTGCATAATAGAAAACGGCAAT
GTTTACACTTGGAGGTTATC

Downstream 100 bases:

>100_bases
CGTGTCAAAAGAAGTATTAACTCAAACAAAAGAAAAAATGGAAAAAGCAATTGCTGCTTATCAGCGCGAATTGGCTACTG
TACGCGCAGGCCGTGCAAAT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MEKPKYKRIVLKLSGEALAGEQGNGINPTVIQSIAKQVKEIAELEVEVAVVVGGGNLWRGKTGSDLGMDRATADYMGMLA
TVMNSLALQDSLETLGIQSRVQTSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILM
AKNNVDGVYNADPRKDESAVKYESLSYLDVLKDGLEVMDSTASSLCMDNDIPLIVFSIMEEGNIKRAVIGESIGTIVRGK

Sequences:

>Translated_240_residues
MEKPKYKRIVLKLSGEALAGEQGNGINPTVIQSIAKQVKEIAELEVEVAVVVGGGNLWRGKTGSDLGMDRATADYMGMLA
TVMNSLALQDSLETLGIQSRVQTSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILM
AKNNVDGVYNADPRKDESAVKYESLSYLDVLKDGLEVMDSTASSLCMDNDIPLIVFSIMEEGNIKRAVIGESIGTIVRGK
>Mature_240_residues
MEKPKYKRIVLKLSGEALAGEQGNGINPTVIQSIAKQVKEIAELEVEVAVVVGGGNLWRGKTGSDLGMDRATADYMGMLA
TVMNSLALQDSLETLGIQSRVQTSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILM
AKNNVDGVYNADPRKDESAVKYESLSYLDVLKDGLEVMDSTASSLCMDNDIPLIVFSIMEEGNIKRAVIGESIGTIVRGK

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=235, Percent_Identity=48.5106382978723, Blast_Score=232, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 26083; Mature: 26083

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKPKYKRIVLKLSGEALAGEQGNGINPTVIQSIAKQVKEIAELEVEVAVVVGGGNLWRG
CCCCCCEEEEEEECCCEECCCCCCCCCHHHHHHHHHHHHHHHHCEEEEEEEECCCCEECC
KTGSDLGMDRATADYMGMLATVMNSLALQDSLETLGIQSRVQTSIEMRQVAEPYIRRKAI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILMAKNNVDGVYNADPRKDESAV
HHHHHCEEEEEEECCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCHH
KYESLSYLDVLKDGLEVMDSTASSLCMDNDIPLIVFSIMEEGNIKRAVIGESIGTIVRGK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEKPKYKRIVLKLSGEALAGEQGNGINPTVIQSIAKQVKEIAELEVEVAVVVGGGNLWRG
CCCCCCEEEEEEECCCEECCCCCCCCCHHHHHHHHHHHHHHHHCEEEEEEEECCCCEECC
KTGSDLGMDRATADYMGMLATVMNSLALQDSLETLGIQSRVQTSIEMRQVAEPYIRRKAI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILMAKNNVDGVYNADPRKDESAV
HHHHHCEEEEEEECCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCHH
KYESLSYLDVLKDGLEVMDSTASSLCMDNDIPLIVFSIMEEGNIKRAVIGESIGTIVRGK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA