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The map label for this gene is cdd [H]

Identifier: 50364958

GI number: 50364958

Start: 157796

End: 158203

Strand: Direct

Name: cdd [H]

Synonym: Mfl143

Alternate gene names: 50364958

Gene position: 157796-158203 (Clockwise)

Preceding gene: 50364957

Following gene: 50364959

Centisome position: 19.89

GC content: 28.68

Gene sequence:

>408_bases
ATGACTGAAAAGCAAAATGTATTTAAAGAATTATTAAAACTTAAAGATAATTCTTATAGCCCTTATTCAAATTTTAAAGT
GGCTTGTTTAATCTATTTAAACAACAATGAAATCATTAAAGGTGTAAATGTTGAAAATGCAGCATATCCTGCAACTATAT
GTGCAGAAAGAACCGCATTGTCTCAAGTTTATTCTTTGGGTTATAAAAAAGAAGATATAAAATCTTTAGAGTTATATACT
GATTCTGAAAGTTTGGGATCACCTTGTGGAGTTTGCCGTCAAGTTATTTCTGAATTAGTAAATTGAACTACACCAATTTC
AATTTACAACAAAAATGGGTTTCAATTAGAAACAAATATAAATGAGTTATTGCCGCATGCCTTTGAGCCTGCACAACTTA
TTAAATAA

Upstream 100 bases:

>100_bases
ATTCTTCAAGTCATATTTGATAAAAGACTATCAGTAGTCTTTTTTCTTTTGGTTTAAACCTATTTTTAGATATAATATAA
TTGTTATGAAAGAGGTAAAG

Downstream 100 bases:

>100_bases
AAGGAGAGAAAATATGAATATTATGTTATTAGGAGCACCTGGTTCAGGTAAAGGAACTTTGGCAGAAAAATTAATCAAGA
ATCAAGGATTTAATCAAATG

Product: cytidine deaminase

Products: NA

Alternate protein names: CDA; Cytidine aminohydrolase [H]

Number of amino acids: Translated: 135; Mature: 134

Protein sequence:

>135_residues
MTEKQNVFKELLKLKDNSYSPYSNFKVACLIYLNNNEIIKGVNVENAAYPATICAERTALSQVYSLGYKKEDIKSLELYT
DSESLGSPCGVCRQVISELVNWTTPISIYNKNGFQLETNINELLPHAFEPAQLIK

Sequences:

>Translated_135_residues
MTEKQNVFKELLKLKDNSYSPYSNFKVACLIYLNNNEIIKGVNVENAAYPATICAERTALSQVYSLGYKKEDIKSLELYT
DSESLGSPCGVCRQVISELVN*TTPISIYNKNGFQLETNINELLPHAFEPAQLIK
>Mature_134_residues
TEKQNVFKELLKLKDNSYSPYSNFKVACLIYLNNNEIIKGVNVENAAYPATICAERTALSQVYSLGYKKEDIKSLELYTD
SESLGSPCGVCRQVISELVN*TTPISIYNKNGFQLETNINELLPHAFEPAQLIK

Specific function: This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis [H]

COG id: COG0295

COG function: function code F; Cytidine deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI11386157, Length=121, Percent_Identity=39.6694214876033, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17551074, Length=129, Percent_Identity=40.3100775193798, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17540514, Length=116, Percent_Identity=37.9310344827586, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323274, Length=127, Percent_Identity=45.6692913385827, Blast_Score=101, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24582741, Length=128, Percent_Identity=34.375, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI19920920, Length=105, Percent_Identity=37.1428571428571, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24582744, Length=138, Percent_Identity=32.6086956521739, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR006262
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.5 [H]

Molecular weight: Translated: 15040; Mature: 14909

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKQNVFKELLKLKDNSYSPYSNFKVACLIYLNNNEIIKGVNVENAAYPATICAERTAL
CCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCEEECCCCCCCCCCHHHHHHHHHH
SQVYSLGYKKEDIKSLELYTDSESLGSPCGVCRQVISELVNTTPISIYNKNGFQLETNIN
HHHHHCCCCCCCCCEEEEEECCHHCCCHHHHHHHHHHHHHCCCCEEEECCCCEEEECCHH
ELLPHAFEPAQLIK
HHCCCCCCHHHHCC
>Mature Secondary Structure 
TEKQNVFKELLKLKDNSYSPYSNFKVACLIYLNNNEIIKGVNVENAAYPATICAERTAL
CCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCEEECCCCCCCCCCHHHHHHHHHH
SQVYSLGYKKEDIKSLELYTDSESLGSPCGVCRQVISELVNTTPISIYNKNGFQLETNIN
HHHHHCCCCCCCCCEEEEEECCHHCCCHHHHHHHHHHHHHCCCCEEEECCCCEEEECCHH
ELLPHAFEPAQLIK
HHCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8349569 [H]