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The map label for this gene is upp [H]

Identifier: 50364922

GI number: 50364922

Start: 132935

End: 133558

Strand: Direct

Name: upp [H]

Synonym: Mfl107

Alternate gene names: 50364922

Gene position: 132935-133558 (Clockwise)

Preceding gene: 50364921

Following gene: 50364923

Centisome position: 16.76

GC content: 30.61

Gene sequence:

>624_bases
ATGGCATTTACAGAATTGAAACATCCATTGATAATTGATAAATTATCAAGAATGCGTAAAAAAGAAACATCATCAAAAGA
TTTTAGAGAAAACCTTAATGAAATAGCACAATTAATGGTTTATGAAATTTTTAGAGATTTAGAACTTGAGGCAATTGAAA
TAGAAACACCAATGACAAAAACAGTTGGGTATACAATTGATAAGCCAATTGTGTTAGTTCCTATTTTAAGAGCAGGTATA
GGAATGTTAGATGGAATACAAAAATTAATTCCAACAGCAAGAATAGCTCATATTGGACTTTATCGTGATGAAGAAACTTT
AGAAATTCATCAATACTTTGCAAAGAAAACTGAATCAATTGATGAAAGTTATGTAATAATAGTAGATCCTATGTTAGCAA
CAGGTGGTAGTGCTAACAAAGCAATTGATATAGTTAAAGGTTGAGGAGTTAAAAACATTAAATTTGTATGTTTAGTAGCT
GTTGAACCAGGAATAAGCAATGTTCTTGAAAAACACCCTGATGTTGAGATATATGCTGCATCAAAAGATGAAAAGCTTTC
TGATAAAGGATATATCATACCAGGTCTAGGAGACGCTGGAGACAGAATATTCGGTACAAAATAA

Upstream 100 bases:

>100_bases
AGAAGTTGCTAAATTATGTAAGCAATTCCCAATATATGAACATTTATCATATTAATACTTTATAATATTAATAATTTGGA
CAAATAGAGGGAAATAAGTT

Downstream 100 bases:

>100_bases
AATAGAAATTTTCTTTTTTAAAAACTCCAATAATTGGAGTTTTTTTACTTTTACCACTTTTGTTATATTTTTTGTTTATA
AGAGTAGAATATTAAAGAAC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MAFTELKHPLIIDKLSRMRKKETSSKDFRENLNEIAQLMVYEIFRDLELEAIEIETPMTKTVGYTIDKPIVLVPILRAGI
GMLDGIQKLIPTARIAHIGLYRDEETLEIHQYFAKKTESIDESYVIIVDPMLATGGSANKAIDIVKGWGVKNIKFVCLVA
VEPGISNVLEKHPDVEIYAASKDEKLSDKGYIIPGLGDAGDRIFGTK

Sequences:

>Translated_207_residues
MAFTELKHPLIIDKLSRMRKKETSSKDFRENLNEIAQLMVYEIFRDLELEAIEIETPMTKTVGYTIDKPIVLVPILRAGI
GMLDGIQKLIPTARIAHIGLYRDEETLEIHQYFAKKTESIDESYVIIVDPMLATGGSANKAIDIVKG*GVKNIKFVCLVA
VEPGISNVLEKHPDVEIYAASKDEKLSDKGYIIPGLGDAGDRIFGTK
>Mature_206_residues
AFTELKHPLIIDKLSRMRKKETSSKDFRENLNEIAQLMVYEIFRDLELEAIEIETPMTKTVGYTIDKPIVLVPILRAGIG
MLDGIQKLIPTARIAHIGLYRDEETLEIHQYFAKKTESIDESYVIIVDPMLATGGSANKAIDIVKG*GVKNIKFVCLVAV
EPGISNVLEKHPDVEIYAASKDEKLSDKGYIIPGLGDAGDRIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=193, Percent_Identity=27.4611398963731, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI57863312, Length=193, Percent_Identity=27.4611398963731, Blast_Score=71, Evalue=8e-13,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=50.4807692307692, Blast_Score=199, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=25.8706467661692, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=25.8706467661692, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321920, Length=190, Percent_Identity=36.3157894736842, Blast_Score=103, Evalue=1e-23,
Organism=Drosophila melanogaster, GI45550449, Length=196, Percent_Identity=28.0612244897959, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28573516, Length=196, Percent_Identity=28.0612244897959, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28573514, Length=196, Percent_Identity=28.0612244897959, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28573512, Length=196, Percent_Identity=28.0612244897959, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 22928; Mature: 22797

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFTELKHPLIIDKLSRMRKKETSSKDFRENLNEIAQLMVYEIFRDLELEAIEIETPMTK
CCCHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHH
TVGYTIDKPIVLVPILRAGIGMLDGIQKLIPTARIAHIGLYRDEETLEIHQYFAKKTESI
HCCEECCCCHHHHHHHHHCCHHHHHHHHHHCHHHHHHEEEECCCHHHHHHHHHHHHHCCC
DESYVIIVDPMLATGGSANKAIDIVKGGVKNIKFVCLVAVEPGISNVLEKHPDVEIYAAS
CCCEEEEECCHHHCCCCCCHHHHHHHCCCCCEEEEEEEEECCCHHHHHHCCCCEEEEECC
KDEKLSDKGYIIPGLGDAGDRIFGTK
CCCCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
AFTELKHPLIIDKLSRMRKKETSSKDFRENLNEIAQLMVYEIFRDLELEAIEIETPMTK
CCHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHH
TVGYTIDKPIVLVPILRAGIGMLDGIQKLIPTARIAHIGLYRDEETLEIHQYFAKKTESI
HCCEECCCCHHHHHHHHHCCHHHHHHHHHHCHHHHHHEEEECCCHHHHHHHHHHHHHCCC
DESYVIIVDPMLATGGSANKAIDIVKGGVKNIKFVCLVAVEPGISNVLEKHPDVEIYAAS
CCCEEEEECCHHHCCCCCCHHHHHHHCCCCCEEEEEEEEECCCHHHHHHCCCCEEEEECC
KDEKLSDKGYIIPGLGDAGDRIFGTK
CCCCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA