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The map label for this gene is pdhB [H]

Identifier: 50364855

GI number: 50364855

Start: 54788

End: 55777

Strand: Direct

Name: pdhB [H]

Synonym: Mfl040

Alternate gene names: 50364855

Gene position: 54788-55777 (Clockwise)

Preceding gene: 50364854

Following gene: 50364856

Centisome position: 6.91

GC content: 34.34

Gene sequence:

>990_bases
ATGGCAGTTATTAATAATATTAAAGCAGTTACTGAAGCACTTGATGTTGCAATGGACCGTGATAAAAACGTTATTGTTTT
TGGTGAGGACGTTGGTTTAGAAGGTGGAGTTTTTAGAGCTACTCAAGGATTACAACAAAAATATGGAATTGAAAGAAGTT
TTAATGCCCCTATTTCAGAAGCAATGTTTGCTGGTGTTGGATTAGGAATGGCAATGAATGGTATGAAACCTGTTGTTGAA
TTACAATTCCAAGGTTTAGGATTACCAGCATTACAAAACGTTATTGCTAATATTTCACGTATGAGAAATAGAAGCCGTGG
TAAATGAACAGCACCTATGGTTATTAGAATGCCAATGGGTGGAGGAATTAGAGCCTTAGAACATCACTCAGAAGCTTTAG
AAGCTATCTTTGCACATATTCCAGGTATTAAAACAGTTATGCCTTCTACACCTTATGATACAAAAGGTTTATTATTAGCA
GCAATTGAATCACCAGATCCAGTTATTGTTTTAGAACCAACTAAGTTATACCGTGCATTTAAACAAGAAGTACCAGATGG
ATACTATACAGTTCCAATTGGTGAAGGTTACAAAATTCAAGAAGGAAATGATTTAACAATTGTTACATATGGAGCACAAA
CAGTGGACTGTATGAAAGCTGTTGAAATGATTAAATCAACTCACCCAACAGCATCAATTGAATTAATTGATTTACGTTCA
ATTCAACCATGAGATAAAAAAATGGTAATTGAATCAGTTAAAAAAACAGGAAGATTATTAGTTGTTAGTGAAGCGGTTAG
ATCATTTGGTGTACCTGCAGAAATTATTGCAACAGTTAATGAAAATTGTTTTGACTCGTTAAAAGCACCTTTAGCAAGAT
GTACTGGATATGATGTTGTTATTCCTTATGACAGAGGGGAAGGATTCCACCAAGTGAACCCACAGAAAGTTGTAGAAGCA
ATTAAAAAAGTGCTTGACTACAAATTTTAG

Upstream 100 bases:

>100_bases
ATCAATATGCTGAATTAACAAATGATTTAAAAGATCAACTAGCAGAAGCTAAAGAGTTTTTTGCTAAATACCCAGAAACT
AAAGACGGAGGACACCACTA

Downstream 100 bases:

>100_bases
TAGAGAGGAATTAGAATAATATGTTTAAAGTAAAATTTGCCGACATTGGAGAAGGGCTTACTGAAGGAAAAGTAGCAGAA
GTTCTTGTTAAATTAGGGCA

Product: pyruvate dehydrogenase E1 beta subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MAVINNIKAVTEALDVAMDRDKNVIVFGEDVGLEGGVFRATQGLQQKYGIERSFNAPISEAMFAGVGLGMAMNGMKPVVE
LQFQGLGLPALQNVIANISRMRNRSRGKWTAPMVIRMPMGGGIRALEHHSEALEAIFAHIPGIKTVMPSTPYDTKGLLLA
AIESPDPVIVLEPTKLYRAFKQEVPDGYYTVPIGEGYKIQEGNDLTIVTYGAQTVDCMKAVEMIKSTHPTASIELIDLRS
IQPWDKKMVIESVKKTGRLLVVSEAVRSFGVPAEIIATVNENCFDSLKAPLARCTGYDVVIPYDRGEGFHQVNPQKVVEA
IKKVLDYKF

Sequences:

>Translated_329_residues
MAVINNIKAVTEALDVAMDRDKNVIVFGEDVGLEGGVFRATQGLQQKYGIERSFNAPISEAMFAGVGLGMAMNGMKPVVE
LQFQGLGLPALQNVIANISRMRNRSRGK*TAPMVIRMPMGGGIRALEHHSEALEAIFAHIPGIKTVMPSTPYDTKGLLLA
AIESPDPVIVLEPTKLYRAFKQEVPDGYYTVPIGEGYKIQEGNDLTIVTYGAQTVDCMKAVEMIKSTHPTASIELIDLRS
IQP*DKKMVIESVKKTGRLLVVSEAVRSFGVPAEIIATVNENCFDSLKAPLARCTGYDVVIPYDRGEGFHQVNPQKVVEA
IKKVLDYKF
>Mature_328_residues
AVINNIKAVTEALDVAMDRDKNVIVFGEDVGLEGGVFRATQGLQQKYGIERSFNAPISEAMFAGVGLGMAMNGMKPVVEL
QFQGLGLPALQNVIANISRMRNRSRGK*TAPMVIRMPMGGGIRALEHHSEALEAIFAHIPGIKTVMPSTPYDTKGLLLAA
IESPDPVIVLEPTKLYRAFKQEVPDGYYTVPIGEGYKIQEGNDLTIVTYGAQTVDCMKAVEMIKSTHPTASIELIDLRSI
QP*DKKMVIESVKKTGRLLVVSEAVRSFGVPAEIIATVNENCFDSLKAPLARCTGYDVVIPYDRGEGFHQVNPQKVVEAI
KKVLDYKF

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=325, Percent_Identity=40.3076923076923, Blast_Score=242, Evalue=3e-64,
Organism=Homo sapiens, GI34101272, Length=325, Percent_Identity=40.3076923076923, Blast_Score=242, Evalue=3e-64,
Organism=Homo sapiens, GI156564403, Length=325, Percent_Identity=32.9230769230769, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI291084858, Length=324, Percent_Identity=32.7160493827161, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17506935, Length=325, Percent_Identity=39.3846153846154, Blast_Score=221, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI17538422, Length=323, Percent_Identity=34.6749226006192, Blast_Score=174, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6319698, Length=328, Percent_Identity=36.5853658536585, Blast_Score=188, Evalue=1e-48,
Organism=Drosophila melanogaster, GI160714828, Length=325, Percent_Identity=36.6153846153846, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI160714832, Length=325, Percent_Identity=36.6153846153846, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI21358145, Length=323, Percent_Identity=36.2229102167183, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24650940, Length=323, Percent_Identity=36.2229102167183, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24650943, Length=85, Percent_Identity=36.4705882352941, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24650945, Length=85, Percent_Identity=36.4705882352941, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 35659; Mature: 35528

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVINNIKAVTEALDVAMDRDKNVIVFGEDVGLEGGVFRATQGLQQKYGIERSFNAPISE
CCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHH
AMFAGVGLGMAMNGMKPVVELQFQGLGLPALQNVIANISRMRNRSRGKTAPMVIRMPMGG
HHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCC
GIRALEHHSEALEAIFAHIPGIKTVMPSTPYDTKGLLLAAIESPDPVIVLEPTKLYRAFK
CHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCEEEEEECCCCCEEEECCHHHHHHHH
QEVPDGYYTVPIGEGYKIQEGNDLTIVTYGAQTVDCMKAVEMIKSTHPTASIELIDLRSI
HHCCCCEEEEECCCCEEECCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCEEEEEEECCC
QPDKKMVIESVKKTGRLLVVSEAVRSFGVPAEIIATVNENCFDSLKAPLARCTGYDVVIP
CCHHHHHHHHHHHCCCEEEEEHHHHHHCCCHHHHHHHCHHHHHHHHHHHHHHCCCEEEEE
YDRGEGFHQVNPQKVVEAIKKVLDYKF
CCCCCCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AVINNIKAVTEALDVAMDRDKNVIVFGEDVGLEGGVFRATQGLQQKYGIERSFNAPISE
CCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHH
AMFAGVGLGMAMNGMKPVVELQFQGLGLPALQNVIANISRMRNRSRGKTAPMVIRMPMGG
HHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCC
GIRALEHHSEALEAIFAHIPGIKTVMPSTPYDTKGLLLAAIESPDPVIVLEPTKLYRAFK
CHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCEEEEEECCCCCEEEECCHHHHHHHH
QEVPDGYYTVPIGEGYKIQEGNDLTIVTYGAQTVDCMKAVEMIKSTHPTASIELIDLRSI
HHCCCCEEEEECCCCEEECCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCEEEEEEECCC
QPDKKMVIESVKKTGRLLVVSEAVRSFGVPAEIIATVNENCFDSLKAPLARCTGYDVVIP
CCHHHHHHHHHHHCCCEEEEEHHHHHHCCCHHHHHHHCHHHHHHHHHHHHHHCCCEEEEE
YDRGEGFHQVNPQKVVEAIKKVLDYKF
CCCCCCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7569993 [H]