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The map label for this gene is purK [H]

Identifier: 50086599

GI number: 50086599

Start: 3575624

End: 3576775

Strand: Reverse

Name: purK [H]

Synonym: ACIAD3658

Alternate gene names: 50086599

Gene position: 3576775-3575624 (Counterclockwise)

Preceding gene: 50086600

Following gene: 50086598

Centisome position: 99.39

GC content: 43.84

Gene sequence:

>1152_bases
GTGCTGAGTGAAAATATGATGATGAAACAAATCAATAAGATTGGAATTTTTGGTGGCGGTCAGCTTGGACGCATGATGGC
ACAAGCTGCGTTGCCACTGAATATTCAATGTACTTTTTTTGAAGCAAATACAGACTGTCCTGCGGCTATTTTAGGTCAGG
TATTTTCAGGCCAGAATGATGCAGAAGCGCTTCAGGCATTTATTCAAAGTGCTGAGGTTTTTAGTCTTGAATTTGAAAAT
ACGCCATTGGCAGATGTTGATGTCCTTGCACAGCAAAAAGCGATCTTTCCGCCGCGTCAAGCTTTGGCAACTGCGCAAAA
TCGTTTGCTGGAAAAAGAACTTTTTCGGCATCTTGATATTCCAGTTGCGCCGTTTCAGGCAGTTGATAGCCTGGAATCCT
TGAAAGAGGCTGTACACATACTCGGTCTTCCAATTGTTCTGAAAACTGCAACAGGCGGTTATGATGGAAAAGGTCAGTTT
GTACTGCGTGAAGCGGAGCAAATTGATCAGGCTTGGCAAGAGCTTGGCCCTGCCAAATCGCTGATTGCAGAGAGCTTTGT
GAAATTCTCAAGAGAGGTTTCGATTATTGCAGTGCGTGGTCAAGATGGCGAAGTTAAAACTTGGCCGTTGGCAGAAAATC
ATCATCATCATGGGATTTTATCGCATTCGATTGTACCTGCGCCGCATAGCGAAGATTTGCAACCTGTTGCACAAGATTAT
ATTACCCGCCTGCTCAATCATTTGAATTATGTGGGTGTATTGACCTTAGAGCTTTTTGTAACAGAACAAGGCTTGTTTGC
CAATGAAATGGCGCCAAGAGTACATAACTCAGGACATTGGTCAATTGAGGGTGCGGTATGTTCGCAGTTTGAAAACCATG
TTCGTGCCGTGGCCGGTTTACCTTTGGGTTCTACTGAGGTTATACGCCCAACCGTCATGATTAACATTATAGGCAAGCAT
CCAAAATCAGAAGATGTTTTAGCGCTCAATGGTGCACATTTGCATTTGTACAATAAGACTGAGCGTGACGGTCGTAAGCT
TGGTCATATCACATTGATGCCTTTGAACCGTAGTGAACTGACTTCACTATGTCGTCAGTTGGCTGACATTTTGCCAGAGC
CTCTAGCATTGACTCAAGACATGAACATCTAA

Upstream 100 bases:

>100_bases
TGCTAGCAATAATATTCCAGGCCAAGCGTGAGAATAAGCAGACTTAAAGCGTCGCTTTAAGCTTTTGCCTGACGCGCAAG
ACTCTAGGCGATAGCCAAAG

Downstream 100 bases:

>100_bases
TTTTAGAAAGGTCTATAAATCAGGCGATCAGCAAGCTGGTCGCTTTTTTATTGTCTTTTTTTCGCTAATATATCCGCCCT
TCTTTTCCAAGAGTTTTTTC

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MLSENMMMKQINKIGIFGGGQLGRMMAQAALPLNIQCTFFEANTDCPAAILGQVFSGQNDAEALQAFIQSAEVFSLEFEN
TPLADVDVLAQQKAIFPPRQALATAQNRLLEKELFRHLDIPVAPFQAVDSLESLKEAVHILGLPIVLKTATGGYDGKGQF
VLREAEQIDQAWQELGPAKSLIAESFVKFSREVSIIAVRGQDGEVKTWPLAENHHHHGILSHSIVPAPHSEDLQPVAQDY
ITRLLNHLNYVGVLTLELFVTEQGLFANEMAPRVHNSGHWSIEGAVCSQFENHVRAVAGLPLGSTEVIRPTVMINIIGKH
PKSEDVLALNGAHLHLYNKTERDGRKLGHITLMPLNRSELTSLCRQLADILPEPLALTQDMNI

Sequences:

>Translated_383_residues
MLSENMMMKQINKIGIFGGGQLGRMMAQAALPLNIQCTFFEANTDCPAAILGQVFSGQNDAEALQAFIQSAEVFSLEFEN
TPLADVDVLAQQKAIFPPRQALATAQNRLLEKELFRHLDIPVAPFQAVDSLESLKEAVHILGLPIVLKTATGGYDGKGQF
VLREAEQIDQAWQELGPAKSLIAESFVKFSREVSIIAVRGQDGEVKTWPLAENHHHHGILSHSIVPAPHSEDLQPVAQDY
ITRLLNHLNYVGVLTLELFVTEQGLFANEMAPRVHNSGHWSIEGAVCSQFENHVRAVAGLPLGSTEVIRPTVMINIIGKH
PKSEDVLALNGAHLHLYNKTERDGRKLGHITLMPLNRSELTSLCRQLADILPEPLALTQDMNI
>Mature_383_residues
MLSENMMMKQINKIGIFGGGQLGRMMAQAALPLNIQCTFFEANTDCPAAILGQVFSGQNDAEALQAFIQSAEVFSLEFEN
TPLADVDVLAQQKAIFPPRQALATAQNRLLEKELFRHLDIPVAPFQAVDSLESLKEAVHILGLPIVLKTATGGYDGKGQF
VLREAEQIDQAWQELGPAKSLIAESFVKFSREVSIIAVRGQDGEVKTWPLAENHHHHGILSHSIVPAPHSEDLQPVAQDY
ITRLLNHLNYVGVLTLELFVTEQGLFANEMAPRVHNSGHWSIEGAVCSQFENHVRAVAGLPLGSTEVIRPTVMINIIGKH
PKSEDVLALNGAHLHLYNKTERDGRKLGHITLMPLNRSELTSLCRQLADILPEPLALTQDMNI

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=367, Percent_Identity=37.6021798365123, Blast_Score=211, Evalue=7e-56,
Organism=Escherichia coli, GI1788155, Length=356, Percent_Identity=27.247191011236, Blast_Score=97, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324702, Length=378, Percent_Identity=32.010582010582, Blast_Score=173, Evalue=5e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 42152; Mature: 42152

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSENMMMKQINKIGIFGGGQLGRMMAQAALPLNIQCTFFEANTDCPAAILGQVFSGQND
CCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHCCCCH
AEALQAFIQSAEVFSLEFENTPLADVDVLAQQKAIFPPRQALATAQNRLLEKELFRHLDI
HHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
PVAPFQAVDSLESLKEAVHILGLPIVLKTATGGYDGKGQFVLREAEQIDQAWQELGPAKS
CCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEHHHHHHHHHHHHHCHHHH
LIAESFVKFSREVSIIAVRGQDGEVKTWPLAENHHHHGILSHSIVPAPHSEDLQPVAQDY
HHHHHHHHHCCCEEEEEEECCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
ITRLLNHLNYVGVLTLELFVTEQGLFANEMAPRVHNSGHWSIEGAVCSQFENHVRAVAGL
HHHHHHHCCHHHEEEEEEEEECCCCHHHHCCCCCCCCCCEEECHHHHHHHHHHHHHHHCC
PLGSTEVIRPTVMINIIGKHPKSEDVLALNGAHLHLYNKTERDGRKLGHITLMPLNRSEL
CCCCCHHCCCEEEEEEECCCCCCCCEEEECCCEEEEECCCCCCCCEECCEEEEECCHHHH
TSLCRQLADILPEPLALTQDMNI
HHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MLSENMMMKQINKIGIFGGGQLGRMMAQAALPLNIQCTFFEANTDCPAAILGQVFSGQND
CCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHCCCCH
AEALQAFIQSAEVFSLEFENTPLADVDVLAQQKAIFPPRQALATAQNRLLEKELFRHLDI
HHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
PVAPFQAVDSLESLKEAVHILGLPIVLKTATGGYDGKGQFVLREAEQIDQAWQELGPAKS
CCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEHHHHHHHHHHHHHCHHHH
LIAESFVKFSREVSIIAVRGQDGEVKTWPLAENHHHHGILSHSIVPAPHSEDLQPVAQDY
HHHHHHHHHCCCEEEEEEECCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
ITRLLNHLNYVGVLTLELFVTEQGLFANEMAPRVHNSGHWSIEGAVCSQFENHVRAVAGL
HHHHHHHCCHHHEEEEEEEEECCCCHHHHCCCCCCCCCCEEECHHHHHHHHHHHHHHHCC
PLGSTEVIRPTVMINIIGKHPKSEDVLALNGAHLHLYNKTERDGRKLGHITLMPLNRSEL
CCCCCHHCCCEEEEEEECCCCCCCCEEEECCCEEEEECCCCCCCCEECCEEEEECCHHHH
TSLCRQLADILPEPLALTQDMNI
HHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8816818; 10984043 [H]