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The map label for this gene is glmS

Identifier: 50086529

GI number: 50086529

Start: 3498186

End: 3500024

Strand: Direct

Name: glmS

Synonym: ACIAD3576

Alternate gene names: 50086529

Gene position: 3498186-3500024 (Clockwise)

Preceding gene: 50086528

Following gene: 50086530

Centisome position: 97.21

GC content: 44.81

Gene sequence:

>1839_bases
ATGTGTGGTATCGTCGGAGGCGTTGCAGAACGTAATATTGCCGAGATTTTGATCGAGGGATTAAAACGCCTTGAATACCG
TGGATACGACTCTGCGGGCGTTGCTTTAATCAATCAGCAGCAGATCTTGCGTGAGCGCCGTGTAGGTAAAGTTGCTAATT
TGGCAGAAGCGGTTGCACAAAGTAAAATTTCAGGTTCACTGGGTATTGCACATACTCGCTGGGCGACACACGGTAAACCT
ACAGAGAATAATGCACATCCGCATACTTCGGGATCGGTTGCTGTAGTACATAACGGCATTATTGAAAACTATCAAGAACT
TAAAGATGATCTTGAAGCACTGGGTTATGTGTTTACTTCTCAAACCGATACCGAAGTGGTTGCTCATCTTATTAACCATG
CCATGACTGAGCAGCATAACCTGCTGGATGCCGTACGGGAAGTTGTGCCTGAACTCAAAGGGGCTTATGCACTCGGCATT
ATCCATACCGACTATCCAGACGAACTTATTACTGTACGTGAAGGTTCGCCTTTGGTGATTGGCGTCGGGATTGGCGAAAA
CTTTATCAGCTCCGACCAACTTGCACTATTGCCTGTCACCAACCGCTTTGTGTACCTCGAAGAAGGTGATATTGCACGTC
TAACCCGTGACAGCATTGAAATTTATGCGCATGGTGTCAAAATCGAACGTCCAGTTAAAGAGCTGGATGCATCGGTAAGT
AATGCTTCAAAAGGCGAATATAAGCACTACATGCTCAAAGAGATTTATGAGCAGCCAGAAGCCATTCAGCAAACGATTTC
TCAGGCTTTAAATGGCAATGCTTTACGCGAAGATTTCCTGCAATTTGCTGAAGCAGACTTTAATCAAATTCAAAATGTAC
AGATTATTGCCTGTGGTACCAGTTACCATGCGGGGATGATTGCCAAGTACTGGTTTGAACAATTGATTGGTGTTCCCTGC
CAAGTCGAAATTGCCAGTGAGTTCCGTTATCGCTCACCTGTTATTGTGGCGAATACTCTGTACATCTGCATTTCACAATC
GGGTGAAACGGCTGATACCTTGGCTGCCCTGCGTGATACTCAAAAACGTGCCAAAGCTAAAGATATTCAGATCTCAACAT
TAACCATCTGTAATGTCGCAACATCTTCAATGGTTCGTGAAACAGACCATCATTTGCTCACCTTGGCTGGTCCAGAAATT
GGCGTGGCTTCAACCAAGGCCTTTACCACACAGCTTGCAGCATTAATGTTATTAATTCTGAAGATTGGTCAGGTGAAAGA
GCAAATTGCTGCTGAGCAAATTGCTGAGATTGCATCACAACTTTGGCACTGTCCAAAAGTGATGCTAGATACATTACAGC
ACAATGCAGAAATTTTACGCTTATCTGAGCTGTTTGTGGAAAAGCAACATTGCTTGTTCTTAGGCCGTGGCACGCATTAT
CCAATCGCACTTGAAGGTGCATTGAAGCTGAAAGAAATTTCGTACATTCATGCAGAAGGTTATGCAGCGGGTGAGCTCAA
ACATGGTCCATTGGCATTGGTCGATAATGAAATGCCTGTGGTGATTTTGGCACCTCATGACGACATGCTGGACAAGCTAA
AATCGAATATGGAAGAAGTGCAAGCACGTGGTGGTGAGCTGTTTGTCTTTGCTGATGAAAACAGTGGCGTTCGTGAGAAA
GACCGTCAACATGTGGTCTTGATTCCGGAGGTCAATGCTTGGCTGGCACCGATTGTTTACAGTATTCCAGTTCAATTACT
GTCTTACCATGTTGCGGTACTACGTGGTACAGATGTCGATCAACCACGTAACCTTGCCAAGTCGGTCACGGTGGAATAA

Upstream 100 bases:

>100_bases
TAATGTGCCAGAAAATACGTTGGCATTTGAGCGTGCGCAACAGATTGAAAAAGCGAATTATCAACGTCCACAAAAGTTGA
AAAAATAAGAGGAACTCAGT

Downstream 100 bases:

>100_bases
CTTAAGATATTGATATATATCATTTTTTAAAATATTATCTATCAACTATAAAAAACCCTGTTTCAATGAAACAGGGTTTT
TTATCTATAAATTAAATTTA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 612; Mature: 612

Protein sequence:

>612_residues
MCGIVGGVAERNIAEILIEGLKRLEYRGYDSAGVALINQQQILRERRVGKVANLAEAVAQSKISGSLGIAHTRWATHGKP
TENNAHPHTSGSVAVVHNGIIENYQELKDDLEALGYVFTSQTDTEVVAHLINHAMTEQHNLLDAVREVVPELKGAYALGI
IHTDYPDELITVREGSPLVIGVGIGENFISSDQLALLPVTNRFVYLEEGDIARLTRDSIEIYAHGVKIERPVKELDASVS
NASKGEYKHYMLKEIYEQPEAIQQTISQALNGNALREDFLQFAEADFNQIQNVQIIACGTSYHAGMIAKYWFEQLIGVPC
QVEIASEFRYRSPVIVANTLYICISQSGETADTLAALRDTQKRAKAKDIQISTLTICNVATSSMVRETDHHLLTLAGPEI
GVASTKAFTTQLAALMLLILKIGQVKEQIAAEQIAEIASQLWHCPKVMLDTLQHNAEILRLSELFVEKQHCLFLGRGTHY
PIALEGALKLKEISYIHAEGYAAGELKHGPLALVDNEMPVVILAPHDDMLDKLKSNMEEVQARGGELFVFADENSGVREK
DRQHVVLIPEVNAWLAPIVYSIPVQLLSYHVAVLRGTDVDQPRNLAKSVTVE

Sequences:

>Translated_612_residues
MCGIVGGVAERNIAEILIEGLKRLEYRGYDSAGVALINQQQILRERRVGKVANLAEAVAQSKISGSLGIAHTRWATHGKP
TENNAHPHTSGSVAVVHNGIIENYQELKDDLEALGYVFTSQTDTEVVAHLINHAMTEQHNLLDAVREVVPELKGAYALGI
IHTDYPDELITVREGSPLVIGVGIGENFISSDQLALLPVTNRFVYLEEGDIARLTRDSIEIYAHGVKIERPVKELDASVS
NASKGEYKHYMLKEIYEQPEAIQQTISQALNGNALREDFLQFAEADFNQIQNVQIIACGTSYHAGMIAKYWFEQLIGVPC
QVEIASEFRYRSPVIVANTLYICISQSGETADTLAALRDTQKRAKAKDIQISTLTICNVATSSMVRETDHHLLTLAGPEI
GVASTKAFTTQLAALMLLILKIGQVKEQIAAEQIAEIASQLWHCPKVMLDTLQHNAEILRLSELFVEKQHCLFLGRGTHY
PIALEGALKLKEISYIHAEGYAAGELKHGPLALVDNEMPVVILAPHDDMLDKLKSNMEEVQARGGELFVFADENSGVREK
DRQHVVLIPEVNAWLAPIVYSIPVQLLSYHVAVLRGTDVDQPRNLAKSVTVE
>Mature_612_residues
MCGIVGGVAERNIAEILIEGLKRLEYRGYDSAGVALINQQQILRERRVGKVANLAEAVAQSKISGSLGIAHTRWATHGKP
TENNAHPHTSGSVAVVHNGIIENYQELKDDLEALGYVFTSQTDTEVVAHLINHAMTEQHNLLDAVREVVPELKGAYALGI
IHTDYPDELITVREGSPLVIGVGIGENFISSDQLALLPVTNRFVYLEEGDIARLTRDSIEIYAHGVKIERPVKELDASVS
NASKGEYKHYMLKEIYEQPEAIQQTISQALNGNALREDFLQFAEADFNQIQNVQIIACGTSYHAGMIAKYWFEQLIGVPC
QVEIASEFRYRSPVIVANTLYICISQSGETADTLAALRDTQKRAKAKDIQISTLTICNVATSSMVRETDHHLLTLAGPEI
GVASTKAFTTQLAALMLLILKIGQVKEQIAAEQIAEIASQLWHCPKVMLDTLQHNAEILRLSELFVEKQHCLFLGRGTHY
PIALEGALKLKEISYIHAEGYAAGELKHGPLALVDNEMPVVILAPHDDMLDKLKSNMEEVQARGGELFVFADENSGVREK
DRQHVVLIPEVNAWLAPIVYSIPVQLLSYHVAVLRGTDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI205277386, Length=690, Percent_Identity=37.1014492753623, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI4826742, Length=691, Percent_Identity=36.7583212735166, Blast_Score=399, Evalue=1e-111,
Organism=Escherichia coli, GI1790167, Length=615, Percent_Identity=54.6341463414634, Blast_Score=690, Evalue=0.0,
Organism=Escherichia coli, GI1788651, Length=170, Percent_Identity=28.8235294117647, Blast_Score=73, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17539970, Length=438, Percent_Identity=38.3561643835616, Blast_Score=274, Evalue=9e-74,
Organism=Caenorhabditis elegans, GI17532897, Length=437, Percent_Identity=36.6132723112128, Blast_Score=266, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI17532899, Length=437, Percent_Identity=36.6132723112128, Blast_Score=265, Evalue=4e-71,
Organism=Saccharomyces cerevisiae, GI6322745, Length=450, Percent_Identity=36.8888888888889, Blast_Score=259, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6323731, Length=453, Percent_Identity=32.0088300220751, Blast_Score=199, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=40.4878048780488, Blast_Score=127, Evalue=4e-30,
Organism=Drosophila melanogaster, GI21357745, Length=691, Percent_Identity=36.1794500723589, Blast_Score=404, Evalue=1e-112,
Organism=Drosophila melanogaster, GI28573187, Length=267, Percent_Identity=28.0898876404494, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24659598, Length=266, Percent_Identity=25.9398496240602, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_ACIAD (Q6F6U8)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_048039.1
- ProteinModelPortal:   Q6F6U8
- SMR:   Q6F6U8
- STRING:   Q6F6U8
- GeneID:   2881138
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD3576
- NMPDR:   fig|62977.3.peg.3232
- eggNOG:   COG0449
- HOGENOM:   HBG645312
- OMA:   LGIGENF
- PhylomeDB:   Q6F6U8
- ProtClustDB:   PRK00331
- BioCyc:   ASP62977:ACIAD3576-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 67503; Mature: 67503

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS; PS00443 GATASE_TYPE_II

Important sites: ACT_SITE 2-2 ACT_SITE 607-607

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGGVAERNIAEILIEGLKRLEYRGYDSAGVALINQQQILRERRVGKVANLAEAVAQ
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHH
SKISGSLGIAHTRWATHGKPTENNAHPHTSGSVAVVHNGIIENYQELKDDLEALGYVFTS
HHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCC
QTDTEVVAHLINHAMTEQHNLLDAVREVVPELKGAYALGIIHTDYPDELITVREGSPLVI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEECCCCEEE
GVGIGENFISSDQLALLPVTNRFVYLEEGDIARLTRDSIEIYAHGVKIERPVKELDASVS
EEECCCCCCCCCCEEEEEECCEEEEEECCCCHHHHHHCEEEEEECEEECCCHHHHCCHHC
NASKGEYKHYMLKEIYEQPEAIQQTISQALNGNALREDFLQFAEADFNQIQNVQIIACGT
CCCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEECC
SYHAGMIAKYWFEQLIGVPCQVEIASEFRYRSPVIVANTLYICISQSGETADTLAALRDT
CCCHHHHHHHHHHHHHCCCCEEEHHHHCCCCCCEEEEEEEEEEEECCCCHHHHHHHHHHH
QKRAKAKDIQISTLTICNVATSSMVRETDHHLLTLAGPEIGVASTKAFTTQLAALMLLIL
HHHHHHCCEEEEEEEEEHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHH
KIGQVKEQIAAEQIAEIASQLWHCPKVMLDTLQHNAEILRLSELFVEKQHCLFLGRGTHY
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHCCEEEEECCCCC
PIALEGALKLKEISYIHAEGYAAGELKHGPLALVDNEMPVVILAPHDDMLDKLKSNMEEV
CEEECCCEEEHHEEEEEECCCCCCCCCCCCEEEECCCCCEEEECCCHHHHHHHHHHHHHH
QARGGELFVFADENSGVREKDRQHVVLIPEVNAWLAPIVYSIPVQLLSYHVAVLRGTDVD
HHCCCEEEEEECCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHEECCCCC
QPRNLAKSVTVE
CHHHHHHHCCCC
>Mature Secondary Structure
MCGIVGGVAERNIAEILIEGLKRLEYRGYDSAGVALINQQQILRERRVGKVANLAEAVAQ
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHH
SKISGSLGIAHTRWATHGKPTENNAHPHTSGSVAVVHNGIIENYQELKDDLEALGYVFTS
HHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCC
QTDTEVVAHLINHAMTEQHNLLDAVREVVPELKGAYALGIIHTDYPDELITVREGSPLVI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEECCCCEEE
GVGIGENFISSDQLALLPVTNRFVYLEEGDIARLTRDSIEIYAHGVKIERPVKELDASVS
EEECCCCCCCCCCEEEEEECCEEEEEECCCCHHHHHHCEEEEEECEEECCCHHHHCCHHC
NASKGEYKHYMLKEIYEQPEAIQQTISQALNGNALREDFLQFAEADFNQIQNVQIIACGT
CCCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEECC
SYHAGMIAKYWFEQLIGVPCQVEIASEFRYRSPVIVANTLYICISQSGETADTLAALRDT
CCCHHHHHHHHHHHHHCCCCEEEHHHHCCCCCCEEEEEEEEEEEECCCCHHHHHHHHHHH
QKRAKAKDIQISTLTICNVATSSMVRETDHHLLTLAGPEIGVASTKAFTTQLAALMLLIL
HHHHHHCCEEEEEEEEEHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHH
KIGQVKEQIAAEQIAEIASQLWHCPKVMLDTLQHNAEILRLSELFVEKQHCLFLGRGTHY
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHCCEEEEECCCCC
PIALEGALKLKEISYIHAEGYAAGELKHGPLALVDNEMPVVILAPHDDMLDKLKSNMEEV
CEEECCCEEEHHEEEEEECCCCCCCCCCCCEEEECCCCCEEEECCCHHHHHHHHHHHHHH
QARGGELFVFADENSGVREKDRQHVVLIPEVNAWLAPIVYSIPVQLLSYHVAVLRGTDVD
HHCCCEEEEEECCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHEECCCCC
QPRNLAKSVTVE
CHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA