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The map label for this gene is parE [H]

Identifier: 50086499

GI number: 50086499

Start: 3468943

End: 3470823

Strand: Reverse

Name: parE [H]

Synonym: ACIAD3544

Alternate gene names: 50086499

Gene position: 3470823-3468943 (Counterclockwise)

Preceding gene: 50086500

Following gene: 50086495

Centisome position: 96.45

GC content: 45.93

Gene sequence:

>1881_bases
GTGTCACAATATACGGCTCAATCGCTTGAAGTCCTGTCAGGTTTAGATCCAGTTCGCCGTCGTCCTGGAATGTATACCGA
TACCACTCGTCCGAACCACTTGGCGCAGGAAGTGATTGATAATGCTGTCGATGAAGCACTGGCGGGACATGCCAATAAAA
TTCGGGTCACGGTTTATCAGGATGGTTCGCTTGCGGTAGAAGACAATGGCCGTGGGATGCCTGTGGATATTCATCCAGAA
TATGGTCAAAGTGGTATCGAGATTATCCTGACTAAATTACATGCAGGCGGTAAATTTAGTACCGACAATTACCAGTTTTC
TGGTGGTCTGCATGGGGTCGGAATTTCAGTTGTAAACGCATTGTCTTCTCGTGTTGAAGTCGAGGTACAACGTCAGGGCA
ATCTTTACAAGATGGCGTTTGAACACGGTGAACCTGTTGCACCACTTGAAGTCTTAGCGGGTAAAGCACCCAAGCGCGCC
AGTGGCACGACAGTACATTTCTGGCCAGAAGCCAAATATTTTGATAGTCCTAAATTTGCACTCAAAGCACTCAAACATAA
CTTAAAAGCCAAAGCAGTATTGGCTGCAGGCTTACAAATTATCTATGTCGATGAAATTAATAACGAAACCATTGAATGGC
AGTTTGAAAATGGTCTTGTCGATTATTTAATGGATGAGTTGGAAGATCGTGACATTCTGCCAAATCCTGCATTTTTAAGC
AGTGGGCAGGTCGAACGTGCCAGTTGTGAATTTGCTATTTGCTGGAATGTCGAAGGTGGCGAGCAGATTCAAGAAAGTTA
CGTCAATCTGATCCCCACTGCGCAAGGCGGTACGCATGTCAATGGTTTACGCTCTGGGGTCACAGAGGCGTTGCGTGAGT
TTTGTGAATTACGCAATTTATTACCCCGTAATCTTAAACTTTCTGCAGAAGATGTTTGGGATGGTGTCAATTTTATTTTG
TCGCTTAAATTTCAGGAACCCCAGTTTTCAGGGCAGACCAAAGAGCGCTTGTCGAGTCGTGAAGCCTCTGGCGTTGTGTT
GAATATTGCCAAAGATGCTTTTGCATTGTGGCTCAACCAAAACTCAGAAATAGCAATGCAATTGGCTGAAATGGCCATTT
CTAAAGCAGGGCGCCGCCTTAAAGCAGCAAAAAAAGTTGAACGTAAAAAGATTGTGTCTGGGCCAGCCTTACCTGGAAAG
CTTGCCGATTGTGTCGGGCAAACCCGTGAAGAATCGGAGCTGTTTATTGTCGAAGGAGATTCGGCAGGTGGTAGCGCCAA
ACAGGCACGCGATAAAAACTTTCAGGCGATCATGCCGATTCGCGGCAAAATTCTAAATACTTGGGAAGTGTCTTCAGATG
AAGTGCTGGCATCACAGGAAGTCCATGATATTGCGATTGCAATTGGGGTCGACCCAGGTAGTGATGATTTATCTGAATTA
CGCTATGGCAAGATCTGTATTTTGGCCGATGCGGACTCGGACGGTTTGCATATTGCCACTTTGCTGTGCGCTTTGTTTGT
GAAGCATTTTCCTGCTTTGGTCGAAGAAGGGCATTTGTATGTGGCCATGCCGCCTTTGTTTCGAATCGATGCTGGCAAGG
ATGTGTTTTATGCCTTGGATGATGAAGAACTCGATGCAATCCTGAGCAAGCTAAAAACTAAAAATCCGCAAATTACCCGA
TTTAAAGGTCTGGGTGAAATGAACGCCAGCCAGCTGCGTGAAACCACTATGGACCCAGATACTCGCAGACTGGTTCAGCT
CGATCTGGATGATGCACATATGACCGCAGGGTTACTTGACAAGCTACTGGCCAAGAAACGCTCTGCCGACCGTAAGCATT
GGCTAGAACAAAAAGGCAATTTGGCCGATATCAGCGTTTAA

Upstream 100 bases:

>100_bases
AGATGCACATGGTAACCATGCCATGGAAGATTTCGAAAACAAGCTGCCGCTCATACTGGCATTTTTAACTTATTCGCTAA
AATAAAGGAAGTCCCACAAC

Downstream 100 bases:

>100_bases
ATGCATTATCGTGATATGAGGTTAGTGTACCTTTTGAGTATCCGTATTGCTTGGATTTGTCTCTACCTTTTGGTAAATTC
CATCGGCAAACACATTATGA

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 626; Mature: 625

Protein sequence:

>626_residues
MSQYTAQSLEVLSGLDPVRRRPGMYTDTTRPNHLAQEVIDNAVDEALAGHANKIRVTVYQDGSLAVEDNGRGMPVDIHPE
YGQSGIEIILTKLHAGGKFSTDNYQFSGGLHGVGISVVNALSSRVEVEVQRQGNLYKMAFEHGEPVAPLEVLAGKAPKRA
SGTTVHFWPEAKYFDSPKFALKALKHNLKAKAVLAAGLQIIYVDEINNETIEWQFENGLVDYLMDELEDRDILPNPAFLS
SGQVERASCEFAICWNVEGGEQIQESYVNLIPTAQGGTHVNGLRSGVTEALREFCELRNLLPRNLKLSAEDVWDGVNFIL
SLKFQEPQFSGQTKERLSSREASGVVLNIAKDAFALWLNQNSEIAMQLAEMAISKAGRRLKAAKKVERKKIVSGPALPGK
LADCVGQTREESELFIVEGDSAGGSAKQARDKNFQAIMPIRGKILNTWEVSSDEVLASQEVHDIAIAIGVDPGSDDLSEL
RYGKICILADADSDGLHIATLLCALFVKHFPALVEEGHLYVAMPPLFRIDAGKDVFYALDDEELDAILSKLKTKNPQITR
FKGLGEMNASQLRETTMDPDTRRLVQLDLDDAHMTAGLLDKLLAKKRSADRKHWLEQKGNLADISV

Sequences:

>Translated_626_residues
MSQYTAQSLEVLSGLDPVRRRPGMYTDTTRPNHLAQEVIDNAVDEALAGHANKIRVTVYQDGSLAVEDNGRGMPVDIHPE
YGQSGIEIILTKLHAGGKFSTDNYQFSGGLHGVGISVVNALSSRVEVEVQRQGNLYKMAFEHGEPVAPLEVLAGKAPKRA
SGTTVHFWPEAKYFDSPKFALKALKHNLKAKAVLAAGLQIIYVDEINNETIEWQFENGLVDYLMDELEDRDILPNPAFLS
SGQVERASCEFAICWNVEGGEQIQESYVNLIPTAQGGTHVNGLRSGVTEALREFCELRNLLPRNLKLSAEDVWDGVNFIL
SLKFQEPQFSGQTKERLSSREASGVVLNIAKDAFALWLNQNSEIAMQLAEMAISKAGRRLKAAKKVERKKIVSGPALPGK
LADCVGQTREESELFIVEGDSAGGSAKQARDKNFQAIMPIRGKILNTWEVSSDEVLASQEVHDIAIAIGVDPGSDDLSEL
RYGKICILADADSDGLHIATLLCALFVKHFPALVEEGHLYVAMPPLFRIDAGKDVFYALDDEELDAILSKLKTKNPQITR
FKGLGEMNASQLRETTMDPDTRRLVQLDLDDAHMTAGLLDKLLAKKRSADRKHWLEQKGNLADISV
>Mature_625_residues
SQYTAQSLEVLSGLDPVRRRPGMYTDTTRPNHLAQEVIDNAVDEALAGHANKIRVTVYQDGSLAVEDNGRGMPVDIHPEY
GQSGIEIILTKLHAGGKFSTDNYQFSGGLHGVGISVVNALSSRVEVEVQRQGNLYKMAFEHGEPVAPLEVLAGKAPKRAS
GTTVHFWPEAKYFDSPKFALKALKHNLKAKAVLAAGLQIIYVDEINNETIEWQFENGLVDYLMDELEDRDILPNPAFLSS
GQVERASCEFAICWNVEGGEQIQESYVNLIPTAQGGTHVNGLRSGVTEALREFCELRNLLPRNLKLSAEDVWDGVNFILS
LKFQEPQFSGQTKERLSSREASGVVLNIAKDAFALWLNQNSEIAMQLAEMAISKAGRRLKAAKKVERKKIVSGPALPGKL
ADCVGQTREESELFIVEGDSAGGSAKQARDKNFQAIMPIRGKILNTWEVSSDEVLASQEVHDIAIAIGVDPGSDDLSELR
YGKICILADADSDGLHIATLLCALFVKHFPALVEEGHLYVAMPPLFRIDAGKDVFYALDDEELDAILSKLKTKNPQITRF
KGLGEMNASQLRETTMDPDTRRLVQLDLDDAHMTAGLLDKLLAKKRSADRKHWLEQKGNLADISV

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=631, Percent_Identity=25.1980982567353, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI19913406, Length=626, Percent_Identity=25.3993610223642, Blast_Score=131, Evalue=2e-30,
Organism=Escherichia coli, GI1789408, Length=631, Percent_Identity=64.9762282091918, Blast_Score=855, Evalue=0.0,
Organism=Escherichia coli, GI48994957, Length=559, Percent_Identity=40.7871198568873, Blast_Score=392, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17535065, Length=623, Percent_Identity=23.7560192616372, Blast_Score=122, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI212645845, Length=595, Percent_Identity=22.6890756302521, Blast_Score=102, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI212645657, Length=194, Percent_Identity=27.8350515463918, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=642, Percent_Identity=24.7663551401869, Blast_Score=137, Evalue=4e-33,
Organism=Drosophila melanogaster, GI17136538, Length=622, Percent_Identity=25.4019292604502, Blast_Score=127, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 68884; Mature: 68753

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQYTAQSLEVLSGLDPVRRRPGMYTDTTRPNHLAQEVIDNAVDEALAGHANKIRVTVYQ
CCCCHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
DGSLAVEDNGRGMPVDIHPEYGQSGIEIILTKLHAGGKFSTDNYQFSGGLHGVGISVVNA
CCCEEEECCCCCCCEEECCCCCCCCCEEEEEECCCCCCCCCCCEEECCCCCHHHHHHHHH
LSSRVEVEVQRQGNLYKMAFEHGEPVAPLEVLAGKAPKRASGTTVHFWPEAKYFDSPKFA
HHHHEEEEEECCCCEEEEEECCCCCCCHHHHHCCCCCCCCCCCEEEECCCCCCCCCHHHH
LKALKHNLKAKAVLAAGLQIIYVDEINNETIEWQFENGLVDYLMDELEDRDILPNPAFLS
HHHHHHCHHHHHHHHCCEEEEEEEECCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCC
SGQVERASCEFAICWNVEGGEQIQESYVNLIPTAQGGTHVNGLRSGVTEALREFCELRNL
CCCCCCCCCCEEEEEECCCHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHC
LPRNLKLSAEDVWDGVNFILSLKFQEPQFSGQTKERLSSREASGVVLNIAKDAFALWLNQ
CCCCCEECHHHHHCCCEEEEEEEECCCCCCCHHHHHHHCCCCCCEEEEECCCEEEEEECC
NSEIAMQLAEMAISKAGRRLKAAKKVERKKIVSGPALPGKLADCVGQTREESELFIVEGD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEEEECC
SAGGSAKQARDKNFQAIMPIRGKILNTWEVSSDEVLASQEVHDIAIAIGVDPGSDDLSEL
CCCCCHHHHCCCCCEEEECCCCEEEEEEECCCCCHHHHCCCEEEEEEEECCCCCCHHHHC
RYGKICILADADSDGLHIATLLCALFVKHFPALVEEGHLYVAMPPLFRIDAGKDVFYALD
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEECCCCEEEEEC
DEELDAILSKLKTKNPQITRFKGLGEMNASQLRETTMDPDTRRLVQLDLDDAHMTAGLLD
HHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHH
KLLAKKRSADRKHWLEQKGNLADISV
HHHHHHHCCHHHHHHHHCCCEECCCC
>Mature Secondary Structure 
SQYTAQSLEVLSGLDPVRRRPGMYTDTTRPNHLAQEVIDNAVDEALAGHANKIRVTVYQ
CCCHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
DGSLAVEDNGRGMPVDIHPEYGQSGIEIILTKLHAGGKFSTDNYQFSGGLHGVGISVVNA
CCCEEEECCCCCCCEEECCCCCCCCCEEEEEECCCCCCCCCCCEEECCCCCHHHHHHHHH
LSSRVEVEVQRQGNLYKMAFEHGEPVAPLEVLAGKAPKRASGTTVHFWPEAKYFDSPKFA
HHHHEEEEEECCCCEEEEEECCCCCCCHHHHHCCCCCCCCCCCEEEECCCCCCCCCHHHH
LKALKHNLKAKAVLAAGLQIIYVDEINNETIEWQFENGLVDYLMDELEDRDILPNPAFLS
HHHHHHCHHHHHHHHCCEEEEEEEECCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCC
SGQVERASCEFAICWNVEGGEQIQESYVNLIPTAQGGTHVNGLRSGVTEALREFCELRNL
CCCCCCCCCCEEEEEECCCHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHC
LPRNLKLSAEDVWDGVNFILSLKFQEPQFSGQTKERLSSREASGVVLNIAKDAFALWLNQ
CCCCCEECHHHHHCCCEEEEEEEECCCCCCCHHHHHHHCCCCCCEEEEECCCEEEEEECC
NSEIAMQLAEMAISKAGRRLKAAKKVERKKIVSGPALPGKLADCVGQTREESELFIVEGD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEEEECC
SAGGSAKQARDKNFQAIMPIRGKILNTWEVSSDEVLASQEVHDIAIAIGVDPGSDDLSEL
CCCCCHHHHCCCCCEEEECCCCEEEEEEECCCCCHHHHCCCEEEEEEEECCCCCCHHHHC
RYGKICILADADSDGLHIATLLCALFVKHFPALVEEGHLYVAMPPLFRIDAGKDVFYALD
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEECCCCEEEEEC
DEELDAILSKLKTKNPQITRFKGLGEMNASQLRETTMDPDTRRLVQLDLDDAHMTAGLLD
HHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHH
KLLAKKRSADRKHWLEQKGNLADISV
HHHHHHHCCHHHHHHHHCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]