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The map label for this gene is dsbD [H]

Identifier: 50086487

GI number: 50086487

Start: 3458276

End: 3460096

Strand: Reverse

Name: dsbD [H]

Synonym: ACIAD3532

Alternate gene names: 50086487

Gene position: 3460096-3458276 (Counterclockwise)

Preceding gene: 50086488

Following gene: 50086484

Centisome position: 96.15

GC content: 42.28

Gene sequence:

>1821_bases
ATGTTGAAATCTGTTCAGGTGCAAAAAATAGTTGCGTGGTTTTTCGGCACAATAGTGCTCATGCTGAGTCTGTTGGTGTT
GCCTACATATGCAGCAGAAAGTTTATTGTCACCTGAACAGGCATTTTCTTTTTCGGTAGAGTCCACCGATTCAAATCAGG
CGGTTTTATCCTGGAAGATCCAACCCAATTATTATTTGTATCAGCATAAATTTGAGGTTCGGCAGAGTGATCAGTCTATT
CGCTTAAACCTGCCACCTGCAACCGATCAGTATGATGAAAACTTTGGACACAGCAAAGTTTATTATTCTCATGTACAGCT
TTCTATAAAAACGGCTCCTGCTCAGCACTATCAGGTGACCTGGCAGGGCTGTGCCAAAGATCGAATCTGTTATCCCCCGC
AGACTATCTCATTCCAAACAGATCAGGAGGGTTTGGTCAGTCAACAGAACACATCATTTACAGGAAAAAAACGCCTGACT
GATCTTGCTAGTCTGTCGGCTCAGGCGACATCTGAACAAGCCGATACGCCTGATCATCGGTCTGTATCAATGTCATCCTC
AGCAGTTGCTCAAGATCAAGTATGGTCATCAAAGCTCGAACAACATTCTCTCGGTTATGGAATTTTACTTTTTCTGGGAT
TAGGGATTTTATTGGCATTTACGCCATGTTCGCTGCCCATGTTGCCGATTCTAACTTCCCTGATTGTTCGTGAACACCGT
GGCCTCAAGGCTTGGGCGGTTGCATTAACGTTTGTGGTGAGTATGGCGACGGTTTATGCTGTACTTGGTTTGATTGCATC
TTCAGCAGGATTAAATTTCCAGCGCTGGTTACAACAGCCAGCAACCCTGATTGGTTTTAGTTTATTGTTTATTGTGTTTG
CCTTGAATTTGTTCGGGCTTTTTGAGCTTAAACTGCCTCAAAAACTGATCAATCAACTGGATCAAATTCAATCTGTACAG
CAGGGTGGCACTTTGATTGGTGCTGCCGTGATGGGCGTGATTTCTGCTTTGCTGGTCGGCCCATGTATGACAGCACCTTT
AGCAGGAACATTGTTATTCATCGCACAGACTCAGGATCAGTGGCGTGGCGCCTTATTGTTATTTTGTCTTGGTTTCGGGA
TGGGAATTCCATTATTAATTGCCACTTTCCTTGGAACCAAAATTTTACCTAAAGCAGGACAATGGATGCATCAGATTAAG
GTGATCTTCGCCTTTATTATGCTTGCACTGGCAATTTACTTTATTCGCCCGCTTTTATCAGATGGCTGGATACAGATTGT
AAGTTTGATACTTGGTATCGCCTTTATTGTTTATGCGCTATATCGCTTGATAAAGTATCCTGATCAGTTGAAGTGGTTGT
ATCTATTGCTATTATTAGTGGTAACACCATTGGTAGCATTTGATCAGTACCAGCATAGTCAACGCTGGTTTGTACAGGAC
ACTCAAAAAACAGTTCAGTGGCATACCGCAAGGACAGCAGTAGAATTTAAGCAATTGCTTGAACGGGTTCCTGCACAGCA
ACCTGTGATCATTGATGTATATGCCGACTGGTGTGTCGCATGCCAACCGATTGAACATCGTGTTTTAAAAGATCATGATG
TTCAGCAGGCGTTAAAATCCTATTATTTAATTAAATTAGATCTGAGCCATTATGATGTTTCTCATCAACACCTGTTAAAT
GAATGGGAAATTTTAGGCCCGCCGACATATCTGTTTCTAGACCAGCACCATCAGGAAATTCGCAACTTACGCCTCACAGG
TGCGTTTAGTAAAAATGAATTACTTCAACAGCTAGCTGCATTTAAAAATATACAGCGTTAA

Upstream 100 bases:

>100_bases
TTGATGCCAGCGTTGGTGTTCAGCTCAATGGAAATGACCGAAACTATACAGGCGGTTTTGGCATATCGTATCTATTTTAA
ATCAATTTAGTACTTAATTT

Downstream 100 bases:

>100_bases
TTGATTGTATGGCTTAGAAATTCTGCTGGATATATTCTGGAAAAGTCCTCACCTGGTTTCGACCACAGGCTTTGGCAAAA
TAAAGTGCTTGATCGGCTTG

Product: thiol:disulfide interchange protein precursor

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 606; Mature: 606

Protein sequence:

>606_residues
MLKSVQVQKIVAWFFGTIVLMLSLLVLPTYAAESLLSPEQAFSFSVESTDSNQAVLSWKIQPNYYLYQHKFEVRQSDQSI
RLNLPPATDQYDENFGHSKVYYSHVQLSIKTAPAQHYQVTWQGCAKDRICYPPQTISFQTDQEGLVSQQNTSFTGKKRLT
DLASLSAQATSEQADTPDHRSVSMSSSAVAQDQVWSSKLEQHSLGYGILLFLGLGILLAFTPCSLPMLPILTSLIVREHR
GLKAWAVALTFVVSMATVYAVLGLIASSAGLNFQRWLQQPATLIGFSLLFIVFALNLFGLFELKLPQKLINQLDQIQSVQ
QGGTLIGAAVMGVISALLVGPCMTAPLAGTLLFIAQTQDQWRGALLLFCLGFGMGIPLLIATFLGTKILPKAGQWMHQIK
VIFAFIMLALAIYFIRPLLSDGWIQIVSLILGIAFIVYALYRLIKYPDQLKWLYLLLLLVVTPLVAFDQYQHSQRWFVQD
TQKTVQWHTARTAVEFKQLLERVPAQQPVIIDVYADWCVACQPIEHRVLKDHDVQQALKSYYLIKLDLSHYDVSHQHLLN
EWEILGPPTYLFLDQHHQEIRNLRLTGAFSKNELLQQLAAFKNIQR

Sequences:

>Translated_606_residues
MLKSVQVQKIVAWFFGTIVLMLSLLVLPTYAAESLLSPEQAFSFSVESTDSNQAVLSWKIQPNYYLYQHKFEVRQSDQSI
RLNLPPATDQYDENFGHSKVYYSHVQLSIKTAPAQHYQVTWQGCAKDRICYPPQTISFQTDQEGLVSQQNTSFTGKKRLT
DLASLSAQATSEQADTPDHRSVSMSSSAVAQDQVWSSKLEQHSLGYGILLFLGLGILLAFTPCSLPMLPILTSLIVREHR
GLKAWAVALTFVVSMATVYAVLGLIASSAGLNFQRWLQQPATLIGFSLLFIVFALNLFGLFELKLPQKLINQLDQIQSVQ
QGGTLIGAAVMGVISALLVGPCMTAPLAGTLLFIAQTQDQWRGALLLFCLGFGMGIPLLIATFLGTKILPKAGQWMHQIK
VIFAFIMLALAIYFIRPLLSDGWIQIVSLILGIAFIVYALYRLIKYPDQLKWLYLLLLLVVTPLVAFDQYQHSQRWFVQD
TQKTVQWHTARTAVEFKQLLERVPAQQPVIIDVYADWCVACQPIEHRVLKDHDVQQALKSYYLIKLDLSHYDVSHQHLLN
EWEILGPPTYLFLDQHHQEIRNLRLTGAFSKNELLQQLAAFKNIQR
>Mature_606_residues
MLKSVQVQKIVAWFFGTIVLMLSLLVLPTYAAESLLSPEQAFSFSVESTDSNQAVLSWKIQPNYYLYQHKFEVRQSDQSI
RLNLPPATDQYDENFGHSKVYYSHVQLSIKTAPAQHYQVTWQGCAKDRICYPPQTISFQTDQEGLVSQQNTSFTGKKRLT
DLASLSAQATSEQADTPDHRSVSMSSSAVAQDQVWSSKLEQHSLGYGILLFLGLGILLAFTPCSLPMLPILTSLIVREHR
GLKAWAVALTFVVSMATVYAVLGLIASSAGLNFQRWLQQPATLIGFSLLFIVFALNLFGLFELKLPQKLINQLDQIQSVQ
QGGTLIGAAVMGVISALLVGPCMTAPLAGTLLFIAQTQDQWRGALLLFCLGFGMGIPLLIATFLGTKILPKAGQWMHQIK
VIFAFIMLALAIYFIRPLLSDGWIQIVSLILGIAFIVYALYRLIKYPDQLKWLYLLLLLVVTPLVAFDQYQHSQRWFVQD
TQKTVQWHTARTAVEFKQLLERVPAQQPVIIDVYADWCVACQPIEHRVLKDHDVQQALKSYYLIKLDLSHYDVSHQHLLN
EWEILGPPTYLFLDQHHQEIRNLRLTGAFSKNELLQQLAAFKNIQR

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=561, Percent_Identity=32.0855614973262, Blast_Score=285, Evalue=7e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 68373; Mature: 68373

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKSVQVQKIVAWFFGTIVLMLSLLVLPTYAAESLLSPEQAFSFSVESTDSNQAVLSWKI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEEEEECCCCCCEEEEEEE
QPNYYLYQHKFEVRQSDQSIRLNLPPATDQYDENFGHSKVYYSHVQLSIKTAPAQHYQVT
CCCEEEEEEHHHHHCCCCCEEEECCCCCCCHHCCCCCCCEEEEEEEEEEEECCCCCEEEE
WQGCAKDRICYPPQTISFQTDQEGLVSQQNTSFTGKKRLTDLASLSAQATSEQADTPDHR
ECCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
SVSMSSSAVAQDQVWSSKLEQHSLGYGILLFLGLGILLAFTPCSLPMLPILTSLIVREHR
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHC
GLKAWAVALTFVVSMATVYAVLGLIASSAGLNFQRWLQQPATLIGFSLLFIVFALNLFGL
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHH
FELKLPQKLINQLDQIQSVQQGGTLIGAAVMGVISALLVGPCMTAPLAGTLLFIAQTQDQ
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEEECCCHH
WRGALLLFCLGFGMGIPLLIATFLGTKILPKAGQWMHQIKVIFAFIMLALAIYFIRPLLS
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DGWIQIVSLILGIAFIVYALYRLIKYPDQLKWLYLLLLLVVTPLVAFDQYQHSQRWFVQD
CCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
TQKTVQWHTARTAVEFKQLLERVPAQQPVIIDVYADWCVACQPIEHRVLKDHDVQQALKS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHCCHHHHHHHCCCHHHHHHHC
YYLIKLDLSHYDVSHQHLLNEWEILGPPTYLFLDQHHQEIRNLRLTGAFSKNELLQQLAA
EEEEEEECCCCCCHHHHHHHCCCCCCCCEEEEEHHHHHHHHCEEEECCCCHHHHHHHHHH
FKNIQR
HHCCCC
>Mature Secondary Structure
MLKSVQVQKIVAWFFGTIVLMLSLLVLPTYAAESLLSPEQAFSFSVESTDSNQAVLSWKI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEEEEECCCCCCEEEEEEE
QPNYYLYQHKFEVRQSDQSIRLNLPPATDQYDENFGHSKVYYSHVQLSIKTAPAQHYQVT
CCCEEEEEEHHHHHCCCCCEEEECCCCCCCHHCCCCCCCEEEEEEEEEEEECCCCCEEEE
WQGCAKDRICYPPQTISFQTDQEGLVSQQNTSFTGKKRLTDLASLSAQATSEQADTPDHR
ECCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
SVSMSSSAVAQDQVWSSKLEQHSLGYGILLFLGLGILLAFTPCSLPMLPILTSLIVREHR
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHC
GLKAWAVALTFVVSMATVYAVLGLIASSAGLNFQRWLQQPATLIGFSLLFIVFALNLFGL
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHH
FELKLPQKLINQLDQIQSVQQGGTLIGAAVMGVISALLVGPCMTAPLAGTLLFIAQTQDQ
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEEECCCHH
WRGALLLFCLGFGMGIPLLIATFLGTKILPKAGQWMHQIKVIFAFIMLALAIYFIRPLLS
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DGWIQIVSLILGIAFIVYALYRLIKYPDQLKWLYLLLLLVVTPLVAFDQYQHSQRWFVQD
CCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
TQKTVQWHTARTAVEFKQLLERVPAQQPVIIDVYADWCVACQPIEHRVLKDHDVQQALKS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHCCHHHHHHHCCCHHHHHHHC
YYLIKLDLSHYDVSHQHLLNEWEILGPPTYLFLDQHHQEIRNLRLTGAFSKNELLQQLAA
EEEEEEECCCCCCHHHHHHHCCCCCCCCEEEEEHHHHHHHHCEEEECCCCHHHHHHHHHH
FKNIQR
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA