Click here to switch to the map view.

The map label for this gene is crc [H]

Identifier: 50086482

GI number: 50086482

Start: 3453721

End: 3454578

Strand: Direct

Name: crc [H]

Synonym: ACIAD3526

Alternate gene names: 50086482

Gene position: 3453721-3454578 (Clockwise)

Preceding gene: 50086477

Following gene: 50086483

Centisome position: 95.97

GC content: 44.41

Gene sequence:

>858_bases
GTGCTCCAGATTCATCAATTGAGGTCAAACTTGCGCATGATACCAAAGGATAGCTATCCAAGTGATGTAAAAATTTTACG
TGTGGTTTCCATCAACGTAAATGGCTTACGTTCATCTGTGACCAAAGGGCTGCTCGAATGGCTCGAAAAATCCGAAGCAG
ATGTAATTTGCATGCAGGAAAGTCGTATTACTCATGCACAGTGGACAGACAAGTTTAAACCAGAAGGCTGGTACACGCAT
CTCTTTCCTGCCGAACGTGCAGGCTATGCAGGTACAGCCATTTATAGTCGGATTCCCTTTAAGTCGGTGCAGGATGGACT
GGGTTTTGAGCTAGCCGATTCGCAAGGCCGCTTTATTGCAGCAGAGTTTGATTTAGGTCTGAATCAGCCGGCTTACATCT
GTTCGTTATATTTGCCTTCGGGTTCATCTGGCGATGAAGCTCAAGCACGTAAAGATGTTTTTTTAGAAAAATATGCACAA
ATTTTAAAACAATGGCGTGATGAAAATAAATCGATCATTGTCTGTGGTGACTATAATATCGTCCATAAACGTATTGATAT
TAAAAACTGGTCGGGCAATCAAAAGTCGTCGGGCTGTTTACCGCACGAACGTGCATGGCTCGATCATATTTATGATGAAC
TCGGTTATGTCGATACTTTTCGTGAGGTTCGCCCTGAGGCAGAGCTGTACTCATGGTGGTCAAACCGCGGACAAGCGCGG
GCCAAAAATGTAGGGTGGCGTATCGACTACCATGCCTGCTCACCCGACTGGAAAACGCGTACTGTAAATGCCTGGGTTTA
TCGAGATGAATGGTATAGCGACCATGCGCCTGTCATTATTGATTATAAAATCAGTTAA

Upstream 100 bases:

>100_bases
CGCCCTGATTTTAAGGTAAACTCACCAAATTTAAGCACACCGCGTGATAACGCGAGTTCGATAAAGGCTTGCGGGTTAAA
AGACGATGGCGTTGTCATAG

Downstream 100 bases:

>100_bases
ATTGTGTACATTTGTACACTGAATAAACGCCAATTTCTTACACAAGATGTGGAAATTAAGTATTTTTATTACAGGTGTTT
AAGCGCATTATACACCCACG

Product: catabolite repression control protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MLQIHQLRSNLRMIPKDSYPSDVKILRVVSINVNGLRSSVTKGLLEWLEKSEADVICMQESRITHAQWTDKFKPEGWYTH
LFPAERAGYAGTAIYSRIPFKSVQDGLGFELADSQGRFIAAEFDLGLNQPAYICSLYLPSGSSGDEAQARKDVFLEKYAQ
ILKQWRDENKSIIVCGDYNIVHKRIDIKNWSGNQKSSGCLPHERAWLDHIYDELGYVDTFREVRPEAELYSWWSNRGQAR
AKNVGWRIDYHACSPDWKTRTVNAWVYRDEWYSDHAPVIIDYKIS

Sequences:

>Translated_285_residues
MLQIHQLRSNLRMIPKDSYPSDVKILRVVSINVNGLRSSVTKGLLEWLEKSEADVICMQESRITHAQWTDKFKPEGWYTH
LFPAERAGYAGTAIYSRIPFKSVQDGLGFELADSQGRFIAAEFDLGLNQPAYICSLYLPSGSSGDEAQARKDVFLEKYAQ
ILKQWRDENKSIIVCGDYNIVHKRIDIKNWSGNQKSSGCLPHERAWLDHIYDELGYVDTFREVRPEAELYSWWSNRGQAR
AKNVGWRIDYHACSPDWKTRTVNAWVYRDEWYSDHAPVIIDYKIS
>Mature_285_residues
MLQIHQLRSNLRMIPKDSYPSDVKILRVVSINVNGLRSSVTKGLLEWLEKSEADVICMQESRITHAQWTDKFKPEGWYTH
LFPAERAGYAGTAIYSRIPFKSVQDGLGFELADSQGRFIAAEFDLGLNQPAYICSLYLPSGSSGDEAQARKDVFLEKYAQ
ILKQWRDENKSIIVCGDYNIVHKRIDIKNWSGNQKSSGCLPHERAWLDHIYDELGYVDTFREVRPEAELYSWWSNRGQAR
AKNVGWRIDYHACSPDWKTRTVNAWVYRDEWYSDHAPVIIDYKIS

Specific function: Major Apurinic-Apyrimidinic Endonuclease Of E.Coli. It Removes The Damaged DNA At Cytosines And Guanines By Cleaving On The 3' Side Of The Ap Site By A Beta-Elimination Reaction. It Exhibits 3'-5'-Exonuclease, 3'-Phosphomonoesterase, 3'-Repair Diesterase

COG id: COG0708

COG function: function code L; Exonuclease III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA repair enzymes AP/ExoA family [H]

Homologues:

Organism=Homo sapiens, GI18375505, Length=260, Percent_Identity=29.2307692307692, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI18375503, Length=260, Percent_Identity=29.2307692307692, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI18375501, Length=260, Percent_Identity=29.2307692307692, Blast_Score=137, Evalue=2e-32,
Organism=Escherichia coli, GI1788046, Length=266, Percent_Identity=28.5714285714286, Blast_Score=85, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71989536, Length=261, Percent_Identity=31.0344827586207, Blast_Score=121, Evalue=4e-28,
Organism=Drosophila melanogaster, GI221330655, Length=282, Percent_Identity=33.6879432624113, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17136678, Length=282, Percent_Identity=33.6879432624113, Blast_Score=131, Evalue=4e-31,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000097
- InterPro:   IPR020847
- InterPro:   IPR020848
- InterPro:   IPR005135
- InterPro:   IPR004808 [H]

Pfam domain/function: PF03372 Exo_endo_phos [H]

EC number: =3.1.11.2 [H]

Molecular weight: Translated: 33017; Mature: 33017

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQIHQLRSNLRMIPKDSYPSDVKILRVVSINVNGLRSSVTKGLLEWLEKSEADVICMQE
CCCHHHHHHCCEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEC
SRITHAQWTDKFKPEGWYTHLFPAERAGYAGTAIYSRIPFKSVQDGLGFELADSQGRFIA
CCCCHHHCCCCCCCCCCEEEECCHHHCCCCCHHHHHCCCHHHHHCCCCEEEECCCCCEEE
AEFDLGLNQPAYICSLYLPSGSSGDEAQARKDVFLEKYAQILKQWRDENKSIIVCGDYNI
EEECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEE
VHKRIDIKNWSGNQKSSGCLPHERAWLDHIYDELGYVDTFREVRPEAELYSWWSNRGQAR
EEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHCCCCCC
AKNVGWRIDYHACSPDWKTRTVNAWVYRDEWYSDHAPVIIDYKIS
CCCCCEEEEEEECCCCCCCEEEEEEEEECCCCCCCCCEEEEEEEC
>Mature Secondary Structure
MLQIHQLRSNLRMIPKDSYPSDVKILRVVSINVNGLRSSVTKGLLEWLEKSEADVICMQE
CCCHHHHHHCCEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEC
SRITHAQWTDKFKPEGWYTHLFPAERAGYAGTAIYSRIPFKSVQDGLGFELADSQGRFIA
CCCCHHHCCCCCCCCCCEEEECCHHHCCCCCHHHHHCCCHHHHHCCCCEEEECCCCCEEE
AEFDLGLNQPAYICSLYLPSGSSGDEAQARKDVFLEKYAQILKQWRDENKSIIVCGDYNI
EEECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEE
VHKRIDIKNWSGNQKSSGCLPHERAWLDHIYDELGYVDTFREVRPEAELYSWWSNRGQAR
EEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHCCCCCC
AKNVGWRIDYHACSPDWKTRTVNAWVYRDEWYSDHAPVIIDYKIS
CCCCCEEEEEEECCCCCCCEEEEEEEEECCCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]