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The map label for this gene is lpxC

Identifier: 50086468

GI number: 50086468

Start: 3437951

End: 3438853

Strand: Reverse

Name: lpxC

Synonym: ACIAD3510

Alternate gene names: 50086468

Gene position: 3438853-3437951 (Counterclockwise)

Preceding gene: 50086469

Following gene: 50086466

Centisome position: 95.56

GC content: 40.64

Gene sequence:

>903_bases
ATGTTGAAACAACGTACCCTCAAACGTGTGGTAAAGGCGAGTGGCATTGGTCTTCATAGTGGTCAGAAGGTCATGATCAA
TTTTTTGCCCCATACAGTTGATGGTGGAATCGTGTTTCGCAGAATTGATTTGGATCCACCTGTCGAAATTCAGGCAGATT
CGCTACTGATTCAAGAAGCTTTTATGTGTTCGAATCTGGTACTAGAAGACGTTAAGGTCGGAACGATTGAGCATGTCATG
AGTGCCATTGCAGGGCTTGGCATTGATAATCTGATTATCGAAGTATCTGCTTCTGAAGTACCAATTATGGATGGCAGTGC
AGGGCCGTTTATTTACTTGTTGATGCAAGGCGAGTTGCATGAACAAGATGCACCGAAAAAATTTATAAAAATATTAAAGC
CCGTTGAGGCGCTGATTGATGACAAACGTGCCATTTTTACGCCACACGAAGGTTTCCAGTTAAATTTTACAATTGATTTT
GATCATCCCGCATTTGCCAAAGAGTATCAGTCTGCCACGATTGACTTTTCGACAGAAGTATTTGTTTATGAAGTCAGTGG
CGCAAGAACATTCGGTTTTATGAAAGATCTTGATTATCTAAAAGCCAATAATCTGGCATTAGGAGCGAGTCTGGATAACG
CGATTGGCGTCGATGATACCGGTGTGGTGAATGAAGAAGGACTACGATTTTCGGACGAATTTGTTCGACATAAGATTCTG
GATGCTGTGGGTGATTTGTATCTCATGGGACATCAGATTATTGCCAAGTTTGATGGCTATAAATCTGGGCATGCACTGAA
TAATCAGTTATTACGCAATGTACAAAGTGATCCTTCTAACTACGAAATTGTAACATTTGATGACATTAAAAATTGTCCAA
TTCAGTATGTACACGTCGCCTAA

Upstream 100 bases:

>100_bases
AAGATAGCCAAAAGGTAGTGAGATTCACTACCTTTTTTATTTTTTATCAATAGCTAAATATGCTAACGTATATCGGTTTT
TAAGAGAAAGTTAGAGTAGC

Downstream 100 bases:

>100_bases
GTAATTGTGTTGTGGTTGAAATGTTATATTGTAATAAATTAAAAAGATAACTGCGTCACATATATTTTTAAAATAGACAT
TTTACTGAAATGGTTGTTAC

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MLKQRTLKRVVKASGIGLHSGQKVMINFLPHTVDGGIVFRRIDLDPPVEIQADSLLIQEAFMCSNLVLEDVKVGTIEHVM
SAIAGLGIDNLIIEVSASEVPIMDGSAGPFIYLLMQGELHEQDAPKKFIKILKPVEALIDDKRAIFTPHEGFQLNFTIDF
DHPAFAKEYQSATIDFSTEVFVYEVSGARTFGFMKDLDYLKANNLALGASLDNAIGVDDTGVVNEEGLRFSDEFVRHKIL
DAVGDLYLMGHQIIAKFDGYKSGHALNNQLLRNVQSDPSNYEIVTFDDIKNCPIQYVHVA

Sequences:

>Translated_300_residues
MLKQRTLKRVVKASGIGLHSGQKVMINFLPHTVDGGIVFRRIDLDPPVEIQADSLLIQEAFMCSNLVLEDVKVGTIEHVM
SAIAGLGIDNLIIEVSASEVPIMDGSAGPFIYLLMQGELHEQDAPKKFIKILKPVEALIDDKRAIFTPHEGFQLNFTIDF
DHPAFAKEYQSATIDFSTEVFVYEVSGARTFGFMKDLDYLKANNLALGASLDNAIGVDDTGVVNEEGLRFSDEFVRHKIL
DAVGDLYLMGHQIIAKFDGYKSGHALNNQLLRNVQSDPSNYEIVTFDDIKNCPIQYVHVA
>Mature_300_residues
MLKQRTLKRVVKASGIGLHSGQKVMINFLPHTVDGGIVFRRIDLDPPVEIQADSLLIQEAFMCSNLVLEDVKVGTIEHVM
SAIAGLGIDNLIIEVSASEVPIMDGSAGPFIYLLMQGELHEQDAPKKFIKILKPVEALIDDKRAIFTPHEGFQLNFTIDF
DHPAFAKEYQSATIDFSTEVFVYEVSGARTFGFMKDLDYLKANNLALGASLDNAIGVDDTGVVNEEGLRFSDEFVRHKIL
DAVGDLYLMGHQIIAKFDGYKSGHALNNQLLRNVQSDPSNYEIVTFDDIKNCPIQYVHVA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family

Homologues:

Organism=Escherichia coli, GI1786285, Length=297, Percent_Identity=51.1784511784512, Blast_Score=330, Evalue=7e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXC_ACIAD (Q6F709)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_047978.1
- ProteinModelPortal:   Q6F709
- SMR:   Q6F709
- STRING:   Q6F709
- GeneID:   2879760
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD3510
- NMPDR:   fig|62977.3.peg.3171
- eggNOG:   COG0774
- HOGENOM:   HBG482342
- OMA:   ATDPAKE
- PhylomeDB:   Q6F709
- ProtClustDB:   PRK13186
- BioCyc:   ASP62977:ACIAD3510-MONOMER
- HAMAP:   MF_00388
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.-

Molecular weight: Translated: 33272; Mature: 33272

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKQRTLKRVVKASGIGLHSGQKVMINFLPHTVDGGIVFRRIDLDPPVEIQADSLLIQEA
CCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCEEEHHHHHHHHH
FMCSNLVLEDVKVGTIEHVMSAIAGLGIDNLIIEVSASEVPIMDGSAGPFIYLLMQGELH
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCCCCEEEEEEECCCC
EQDAPKKFIKILKPVEALIDDKRAIFTPHEGFQLNFTIDFDHPAFAKEYQSATIDFSTEV
CCCCHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEEEEECCCCHHHHHHCCCEEEECCEE
FVYEVSGARTFGFMKDLDYLKANNLALGASLDNAIGVDDTGVVNEEGLRFSDEFVRHKIL
EEEEECCCEEHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
DAVGDLYLMGHQIIAKFDGYKSGHALNNQLLRNVQSDPSNYEIVTFDDIKNCPIQYVHVA
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEEC
>Mature Secondary Structure
MLKQRTLKRVVKASGIGLHSGQKVMINFLPHTVDGGIVFRRIDLDPPVEIQADSLLIQEA
CCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCEEEHHHHHHHHH
FMCSNLVLEDVKVGTIEHVMSAIAGLGIDNLIIEVSASEVPIMDGSAGPFIYLLMQGELH
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCCCCEEEEEEECCCC
EQDAPKKFIKILKPVEALIDDKRAIFTPHEGFQLNFTIDFDHPAFAKEYQSATIDFSTEV
CCCCHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEEEEECCCCHHHHHHCCCEEEECCEE
FVYEVSGARTFGFMKDLDYLKANNLALGASLDNAIGVDDTGVVNEEGLRFSDEFVRHKIL
EEEEECCCEEHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
DAVGDLYLMGHQIIAKFDGYKSGHALNNQLLRNVQSDPSNYEIVTFDDIKNCPIQYVHVA
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA