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The map label for this gene is guaB [H]

Identifier: 50086461

GI number: 50086461

Start: 3427903

End: 3429369

Strand: Reverse

Name: guaB [H]

Synonym: ACIAD3503

Alternate gene names: 50086461

Gene position: 3429369-3427903 (Counterclockwise)

Preceding gene: 50086462

Following gene: 50086460

Centisome position: 95.3

GC content: 46.42

Gene sequence:

>1467_bases
ATGCTGACCATCGTTCAAGAAGCGTTAACCTTCGATGATGTCTTATTACTCCCTGCCTATTCTACAGTTCTCCCAAAAGA
TGTCTCCTTAAAGACACGTTTGACTCGCGGCATTCAATTAAATGTTCCACTTGTTTCAGCTGCAATGGATACAGTGACTG
AGTCACGTATGGCGATTGCGATGGCACAAAACGGTGGTATCGGTATTTTGCACAAAAACATGGACATTGCTGCACAAGCT
GCAGAAGTTCGTCGTGTGAAAAAATTTGAAGCAGGCATGGTCAAAGATCCGATTACGGTGAGCCCTGAAACCACAGTACG
TGAATTGATTGCAATCACACAAGCAAACAATATCAGCGGCGTACCTGTAGTGAAAGATGGTCAGGTTGTTGGAATTGTGA
CAGGACGCGATACACGCTTCGAAACGAATCTTGAGCAGCCTGTAAGCAATATCATGACACCACAAGATCGTTTGGTGACA
GTGAAAGAAGGCGCATCAAAAGAAAGCATTCAGGCATTACTACAAAAGCACCGCATTGAAAAAGTTTTAGTGGTGGATGA
CCTTCATGCGCTTAAAGGCTTGATTACTGTAACAGACTTTCGCAAAGCCGAACTTTATCCGAATGCATGTAAAGATGAAC
TTGGCCGTCTACGTGTGGGCGCAGCTGTCGGCACAGGTGCAGAAACGCCTGCACGTGTTGAAGCACTGGTTGAAGCAGGT
GCGGATGTGATTGTTGTGGATACAGCCCATGGTCATTCTGCAGGCGTCATTGAGCGTGTACGCTGGGTAAAACAGAACTA
CCCACAAGTACAGGTGATTGGTGGCAACATTGCAACAGGTGATGCAGCATTGGCTTTGCTTGATGCGGGTGCCGATGCAG
TTAAGGTCGGAATTGGTCCAGGTTCAATTTGTACCACACGTATTGTTGCGGGTATTGGTGTACCTCAAATTTCAGCCATT
GACAACGTTGCGCGTGCCTTGAAAGGTGAAATTCCATTAATTGCAGATGGTGGTATCCGCTTCTCTGGTGATATGGCTAA
GGCTATTGCTGCTGGTGCAAGTACGATTATGGTCGGTTCATTGATGGCAGGTACAGAAGAAGCACCTGGTGAAGTCGAGT
TCTTCCAGGGGCGTTATTACAAAGCTTATCGTGGTATGGGTTCTTTGGGTGCGATGTCTGGAGCAAGTGGCTCTTCAGAT
CGTTATTTCCAGGACGCGAAAGCGGGTGTCGAAAAGTTGGTCCCAGAAGGGATTGAAGGTCGTGTACCTTACAAAGGTCC
AATGAGTGCAATCGTGCATCAGATGATGGGTGGTTTACGTTCATCTATGGGCTATACAGGGTCTGCTGATATCGAAGCAA
TGCATCAAAATACCCAATTTGTGAAGATTACGGCTGCAGGTATGCAAGAGTCACATGTACATGATGTGACCATTACCAAA
GAAGCGCCAAACTACCGTATTGGTTAA

Upstream 100 bases:

>100_bases
CTGTGGAAAAGCAGGACAAATAAAAAATTAGCGCAAGAAAAATGAAATTTAGTGTTAAATTTGTTTATAATAGCTCACGG
AAATTACCAGTGAGATTGTT

Downstream 100 bases:

>100_bases
TTTTCAATACGGTTGAGCCTGAATAAAAAACGCCGTCAGTCCACTGACGGCGTTTTTGTTTTGGTGTAAAGTAAACAGAT
AGATGGTGGCTTCACCACAA

Product: IMP dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MLTIVQEALTFDDVLLLPAYSTVLPKDVSLKTRLTRGIQLNVPLVSAAMDTVTESRMAIAMAQNGGIGILHKNMDIAAQA
AEVRRVKKFEAGMVKDPITVSPETTVRELIAITQANNISGVPVVKDGQVVGIVTGRDTRFETNLEQPVSNIMTPQDRLVT
VKEGASKESIQALLQKHRIEKVLVVDDLHALKGLITVTDFRKAELYPNACKDELGRLRVGAAVGTGAETPARVEALVEAG
ADVIVVDTAHGHSAGVIERVRWVKQNYPQVQVIGGNIATGDAALALLDAGADAVKVGIGPGSICTTRIVAGIGVPQISAI
DNVARALKGEIPLIADGGIRFSGDMAKAIAAGASTIMVGSLMAGTEEAPGEVEFFQGRYYKAYRGMGSLGAMSGASGSSD
RYFQDAKAGVEKLVPEGIEGRVPYKGPMSAIVHQMMGGLRSSMGYTGSADIEAMHQNTQFVKITAAGMQESHVHDVTITK
EAPNYRIG

Sequences:

>Translated_488_residues
MLTIVQEALTFDDVLLLPAYSTVLPKDVSLKTRLTRGIQLNVPLVSAAMDTVTESRMAIAMAQNGGIGILHKNMDIAAQA
AEVRRVKKFEAGMVKDPITVSPETTVRELIAITQANNISGVPVVKDGQVVGIVTGRDTRFETNLEQPVSNIMTPQDRLVT
VKEGASKESIQALLQKHRIEKVLVVDDLHALKGLITVTDFRKAELYPNACKDELGRLRVGAAVGTGAETPARVEALVEAG
ADVIVVDTAHGHSAGVIERVRWVKQNYPQVQVIGGNIATGDAALALLDAGADAVKVGIGPGSICTTRIVAGIGVPQISAI
DNVARALKGEIPLIADGGIRFSGDMAKAIAAGASTIMVGSLMAGTEEAPGEVEFFQGRYYKAYRGMGSLGAMSGASGSSD
RYFQDAKAGVEKLVPEGIEGRVPYKGPMSAIVHQMMGGLRSSMGYTGSADIEAMHQNTQFVKITAAGMQESHVHDVTITK
EAPNYRIG
>Mature_488_residues
MLTIVQEALTFDDVLLLPAYSTVLPKDVSLKTRLTRGIQLNVPLVSAAMDTVTESRMAIAMAQNGGIGILHKNMDIAAQA
AEVRRVKKFEAGMVKDPITVSPETTVRELIAITQANNISGVPVVKDGQVVGIVTGRDTRFETNLEQPVSNIMTPQDRLVT
VKEGASKESIQALLQKHRIEKVLVVDDLHALKGLITVTDFRKAELYPNACKDELGRLRVGAAVGTGAETPARVEALVEAG
ADVIVVDTAHGHSAGVIERVRWVKQNYPQVQVIGGNIATGDAALALLDAGADAVKVGIGPGSICTTRIVAGIGVPQISAI
DNVARALKGEIPLIADGGIRFSGDMAKAIAAGASTIMVGSLMAGTEEAPGEVEFFQGRYYKAYRGMGSLGAMSGASGSSD
RYFQDAKAGVEKLVPEGIEGRVPYKGPMSAIVHQMMGGLRSSMGYTGSADIEAMHQNTQFVKITAAGMQESHVHDVTITK
EAPNYRIG

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=480, Percent_Identity=40.8333333333333, Blast_Score=341, Evalue=7e-94,
Organism=Homo sapiens, GI34328928, Length=480, Percent_Identity=40.8333333333333, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI34328930, Length=480, Percent_Identity=40.8333333333333, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI156616279, Length=480, Percent_Identity=40.8333333333333, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI217035152, Length=474, Percent_Identity=40.9282700421941, Blast_Score=334, Evalue=1e-91,
Organism=Homo sapiens, GI66933016, Length=483, Percent_Identity=39.9585921325052, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI217035148, Length=480, Percent_Identity=40, Blast_Score=327, Evalue=2e-89,
Organism=Homo sapiens, GI217035150, Length=480, Percent_Identity=38.125, Blast_Score=304, Evalue=1e-82,
Organism=Homo sapiens, GI50541956, Length=252, Percent_Identity=37.6984126984127, Blast_Score=165, Evalue=9e-41,
Organism=Homo sapiens, GI50541954, Length=252, Percent_Identity=37.6984126984127, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI50541952, Length=252, Percent_Identity=37.6984126984127, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI50541948, Length=252, Percent_Identity=37.6984126984127, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI156104880, Length=251, Percent_Identity=36.2549800796813, Blast_Score=158, Evalue=1e-38,
Organism=Escherichia coli, GI1788855, Length=490, Percent_Identity=63.8775510204082, Blast_Score=592, Evalue=1e-170,
Organism=Escherichia coli, GI1786293, Length=223, Percent_Identity=34.0807174887892, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71994385, Length=461, Percent_Identity=39.4793926247288, Blast_Score=294, Evalue=6e-80,
Organism=Caenorhabditis elegans, GI71994389, Length=421, Percent_Identity=42.0427553444181, Blast_Score=293, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI17560440, Length=224, Percent_Identity=37.0535714285714, Blast_Score=155, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6323585, Length=487, Percent_Identity=38.6036960985626, Blast_Score=321, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6322012, Length=491, Percent_Identity=38.2892057026477, Blast_Score=319, Evalue=8e-88,
Organism=Saccharomyces cerevisiae, GI6323464, Length=483, Percent_Identity=39.7515527950311, Blast_Score=314, Evalue=3e-86,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=38.3040935672515, Blast_Score=235, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6319353, Length=123, Percent_Identity=37.3983739837398, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24641071, Length=485, Percent_Identity=41.2371134020619, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI24641073, Length=485, Percent_Identity=41.2371134020619, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI28571163, Length=443, Percent_Identity=41.3092550790068, Blast_Score=300, Evalue=1e-81,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51535; Mature: 51535

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00487 IMP_DH_GMP_RED ; PS50175 ASP_PROT_RETROV

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTIVQEALTFDDVLLLPAYSTVLPKDVSLKTRLTRGIQLNVPLVSAAMDTVTESRMAIA
CCEEHHHHHCCCCEEEECCHHHHCCCCCCHHHHHCCCEEECCCHHHHHHHHHHHHHEEEE
MAQNGGIGILHKNMDIAAQAAEVRRVKKFEAGMVKDPITVSPETTVRELIAITQANNISG
EECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHCCCCCCC
VPVVKDGQVVGIVTGRDTRFETNLEQPVSNIMTPQDRLVTVKEGASKESIQALLQKHRIE
CEEEECCCEEEEEECCCCCCCCCHHHHHHHHCCCCHHEEEECCCCCHHHHHHHHHHHCCC
KVLVVDDLHALKGLITVTDFRKAELYPNACKDELGRLRVGAAVGTGAETPARVEALVEAG
EEEEEECHHHHHCEEEEECCHHHCCCCCHHHHHHCCEEEEEEECCCCCCHHHHHHHHHCC
ADVIVVDTAHGHSAGVIERVRWVKQNYPQVQVIGGNIATGDAALALLDAGADAVKVGIGP
CCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCEECCCCEEEEEECCCCEEEEECCC
GSICTTRIVAGIGVPQISAIDNVARALKGEIPLIADGGIRFSGDMAKAIAAGASTIMVGS
CHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEECCCEEECCHHHHHHHCCCHHHHHHH
LMAGTEEAPGEVEFFQGRYYKAYRGMGSLGAMSGASGSSDRYFQDAKAGVEKLVPEGIEG
HHCCCCCCCCCEEEECCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
RVPYKGPMSAIVHQMMGGLRSSMGYTGSADIEAMHQNTQFVKITAAGMQESHVHDVTITK
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEEEEECCCCCCCCEEEEEEC
EAPNYRIG
CCCCCCCC
>Mature Secondary Structure
MLTIVQEALTFDDVLLLPAYSTVLPKDVSLKTRLTRGIQLNVPLVSAAMDTVTESRMAIA
CCEEHHHHHCCCCEEEECCHHHHCCCCCCHHHHHCCCEEECCCHHHHHHHHHHHHHEEEE
MAQNGGIGILHKNMDIAAQAAEVRRVKKFEAGMVKDPITVSPETTVRELIAITQANNISG
EECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHCCCCCCC
VPVVKDGQVVGIVTGRDTRFETNLEQPVSNIMTPQDRLVTVKEGASKESIQALLQKHRIE
CEEEECCCEEEEEECCCCCCCCCHHHHHHHHCCCCHHEEEECCCCCHHHHHHHHHHHCCC
KVLVVDDLHALKGLITVTDFRKAELYPNACKDELGRLRVGAAVGTGAETPARVEALVEAG
EEEEEECHHHHHCEEEEECCHHHCCCCCHHHHHHCCEEEEEEECCCCCCHHHHHHHHHCC
ADVIVVDTAHGHSAGVIERVRWVKQNYPQVQVIGGNIATGDAALALLDAGADAVKVGIGP
CCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCEECCCCEEEEEECCCCEEEEECCC
GSICTTRIVAGIGVPQISAIDNVARALKGEIPLIADGGIRFSGDMAKAIAAGASTIMVGS
CHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEECCCEEECCHHHHHHHCCCHHHHHHH
LMAGTEEAPGEVEFFQGRYYKAYRGMGSLGAMSGASGSSDRYFQDAKAGVEKLVPEGIEG
HHCCCCCCCCCEEEECCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
RVPYKGPMSAIVHQMMGGLRSSMGYTGSADIEAMHQNTQFVKITAAGMQESHVHDVTITK
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEEEEECCCCCCCCEEEEEEC
EAPNYRIG
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA