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The map label for this gene is pdxH

Identifier: 50086459

GI number: 50086459

Start: 3425779

End: 3426435

Strand: Reverse

Name: pdxH

Synonym: ACIAD3501

Alternate gene names: 50086459

Gene position: 3426435-3425779 (Counterclockwise)

Preceding gene: 50086460

Following gene: 50086458

Centisome position: 95.22

GC content: 43.68

Gene sequence:

>657_bases
ATGAAAGATGTAATTAAAGATCTCAGCGAACTTCGCATGAGTTATGAAAAAGGTGAACTACACGAAGCGCAAGTGGACAC
CCATCCTCATGAGCAGTTCTTACAATGGTTTAATCATGCATTGCAATCGAATCTGCATGAACCTTACGCAATGTCATTGG
CGACCTGTAATCGTCAAGGACGTCCCCATGTAAGAACAGTTTTATTGCGCGGTGCAACAGCACAGGGTTATGACTTTTAT
ACCAATTATGACAGTCAGAAAGGCATCGATCTAGCCGAAAATCCATATGCAGAGTTGCTGTTTTACTGGCCGAGCCTAGA
GCGTCAAGTACGTATTGGTGGGATAGTCAATAAAATCTCGGAGCATGAATCGACAGATTACTACCATAAACGTCCTCGTG
ATAGTCAGATTGCTGCACATATTAGTACGCCGCAGAGTGGAATAATTGCAAATCGTGAAGAATTACAGCAACGTTTTAAT
CGGTTATATGAGCAAGTCGGTCAGCAGACGGTACTTTCTAAACCAGAGTTCTGGGGAGGATATCGTTTGCAGGCAGATTA
TTACGAGTTCTGGCAGGGGCGTCCGAATCGCTTACATGACCGTTTAAGTTATCAAAACACAGATGGCACATGGGTTGTGC
AACGACTGATGCCATAA

Upstream 100 bases:

>100_bases
TGTGATGGTTGAAGGTGACAATCAAAAAGAAGTCACTGACTTGGCTCATCGTTTGGCAGAATCTGTACGTACACATGCCG
CCTAAGGTAATCAATTCGCT

Downstream 100 bases:

>100_bases
ATGCGCACAATTCAAATCAAACAGCGACCGTTACTCACACATCCTGATCAATTTCAGGATGTGCCCGAATTTATTGCGCA
TATTTTAGCCCGTCGAGGTG

Product: pyridoxamine 5'-phosphate oxidase (acts also on pyridoxine phosphate and pyridoxine)

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MKDVIKDLSELRMSYEKGELHEAQVDTHPHEQFLQWFNHALQSNLHEPYAMSLATCNRQGRPHVRTVLLRGATAQGYDFY
TNYDSQKGIDLAENPYAELLFYWPSLERQVRIGGIVNKISEHESTDYYHKRPRDSQIAAHISTPQSGIIANREELQQRFN
RLYEQVGQQTVLSKPEFWGGYRLQADYYEFWQGRPNRLHDRLSYQNTDGTWVVQRLMP

Sequences:

>Translated_218_residues
MKDVIKDLSELRMSYEKGELHEAQVDTHPHEQFLQWFNHALQSNLHEPYAMSLATCNRQGRPHVRTVLLRGATAQGYDFY
TNYDSQKGIDLAENPYAELLFYWPSLERQVRIGGIVNKISEHESTDYYHKRPRDSQIAAHISTPQSGIIANREELQQRFN
RLYEQVGQQTVLSKPEFWGGYRLQADYYEFWQGRPNRLHDRLSYQNTDGTWVVQRLMP
>Mature_218_residues
MKDVIKDLSELRMSYEKGELHEAQVDTHPHEQFLQWFNHALQSNLHEPYAMSLATCNRQGRPHVRTVLLRGATAQGYDFY
TNYDSQKGIDLAENPYAELLFYWPSLERQVRIGGIVNKISEHESTDYYHKRPRDSQIAAHISTPQSGIIANREELQQRFN
RLYEQVGQQTVLSKPEFWGGYRLQADYYEFWQGRPNRLHDRLSYQNTDGTWVVQRLMP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=210, Percent_Identity=44.2857142857143, Blast_Score=172, Evalue=2e-43,
Organism=Escherichia coli, GI1787926, Length=216, Percent_Identity=40.2777777777778, Blast_Score=161, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17553712, Length=198, Percent_Identity=42.9292929292929, Blast_Score=160, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6319509, Length=209, Percent_Identity=36.8421052631579, Blast_Score=137, Evalue=2e-33,
Organism=Drosophila melanogaster, GI45551845, Length=230, Percent_Identity=38.695652173913, Blast_Score=151, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24644901, Length=230, Percent_Identity=39.1304347826087, Blast_Score=151, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24644903, Length=178, Percent_Identity=28.6516853932584, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_ACIAD (Q6F718)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_047969.1
- ProteinModelPortal:   Q6F718
- SMR:   Q6F718
- STRING:   Q6F718
- GeneID:   2878299
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD3501
- NMPDR:   fig|62977.3.peg.3162
- eggNOG:   COG0259
- HOGENOM:   HBG327559
- OMA:   FTFFTNY
- PhylomeDB:   Q6F718
- ProtClustDB:   CLSK2307561
- BioCyc:   ASP62977:ACIAD3501-MONOMER
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 25705; Mature: 25705

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 65-65 BINDING 68-68 BINDING 70-70 BINDING 87-87 BINDING 127-127 BINDING 131-131 BINDING 135-135

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDVIKDLSELRMSYEKGELHEAQVDTHPHEQFLQWFNHALQSNLHEPYAMSLATCNRQG
CHHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCC
RPHVRTVLLRGATAQGYDFYTNYDSQKGIDLAENPYAELLFYWPSLERQVRIGGIVNKIS
CCHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCHHHHEEECCCCCCHHHHHHHHHHHH
EHESTDYYHKRPRDSQIAAHISTPQSGIIANREELQQRFNRLYEQVGQQTVLSKPEFWGG
HHCCCCHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
YRLQADYYEFWQGRPNRLHDRLSYQNTDGTWVVQRLMP
EEEEHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHCC
>Mature Secondary Structure
MKDVIKDLSELRMSYEKGELHEAQVDTHPHEQFLQWFNHALQSNLHEPYAMSLATCNRQG
CHHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCC
RPHVRTVLLRGATAQGYDFYTNYDSQKGIDLAENPYAELLFYWPSLERQVRIGGIVNKIS
CCHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCHHHHEEECCCCCCHHHHHHHHHHHH
EHESTDYYHKRPRDSQIAAHISTPQSGIIANREELQQRFNRLYEQVGQQTVLSKPEFWGG
HHCCCCHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
YRLQADYYEFWQGRPNRLHDRLSYQNTDGTWVVQRLMP
EEEEHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA