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The map label for this gene is acs [H]

Identifier: 50086436

GI number: 50086436

Start: 3400318

End: 3402279

Strand: Reverse

Name: acs [H]

Synonym: ACIAD3475

Alternate gene names: 50086436

Gene position: 3402279-3400318 (Counterclockwise)

Preceding gene: 50086439

Following gene: 50086435

Centisome position: 94.54

GC content: 45.67

Gene sequence:

>1962_bases
ATGAATGAAATCTATCCAGTACCTGAAGAGTTTAAAAAAACAGCCCGTACCGTAGAAGCGGATTATTTTACCCGCTATCA
AAAATCAATCGAAGATCCAGATGCTTTTTGGGCAGATGAAGCCCGCAATGTAGACTGGATAAAACCATTTACCCAAGTCA
AAAACAGCAACTATGATGCAGAGCAATTCAAAATTGAATGGTTTGCAGATGGTCAGCTCAATGTCTGCGCAAATTGTCTG
GATCGACATTTAAAAGAACATCCGCACAAACCCGCAATTATCTGGGAAGGTGATCATCCTTCACGACATAAAATTATTTC
CTTTAAAGAGCTATACGAAGAAGTTTGTCGGTTTGCCAATGTATTAAAAAAATATGGTATTTCCAAAGGCGACCGTGTTG
TACTTTATATGCCAATGGTGTCTGAAGCAGCGATTGCCATGTTGGCATGCGCGCGAATTGGTGCGGTGCACTGTGTGGTG
TTTGGTGGCTTTTCGCCAGACTCATTGGCAAGTCGGATTGAAGACTGTCAGGCCAAACTGGTGATTACCGCCGATGCAGG
TATGCGAGGAGGTAAATTACTTCCACTCAAGGACAGTGTAGATGAAGCACTTAAGCTTGAAGGAACTGAGTCGATTGAGC
ATGTGATTGTGGTGCATCGGACAGGTAATCCGATCCATTTTCAGGAAGGACGTGATCTCTGGTATCACGTGGTGATTACT
GAGGTGAATGAAATTTGCCCACCAGAACAAATGAATGCTGAAGATCCACTATTTATCCTGTATACCTCAGGCTCGACTGG
AAAGCCAAAAGGGGTGCTGCATACCACAGGCGGTTATCTGGTCTATGCCACCACAACATTCAGAGAAGTCTTTGACATTA
AACAAGATGATGTGTACTGGTGTACGGCTGATGTGGGCTGGATTACAGGTCATAGTTATCTGATTTATGGTCCACTTTCC
AATGGCACAACCACCCTGATGTTTGAAGGCATTCCGCAATATCCGACATGGGCACGAATTGGACATATTGTCGATAAACA
TAACGTCACGATTCTCTATACCGCACCGACTGCCATTCGTTCCATGATGCGTGAAGGAGATGCGTTTGTACGTGAAAGTG
ACCGTAGTAGCTTGCGCTTATTGGGTACAGTCGGTGAGCCAATCAATCCAGAAGCCTGGTCATGGTATTATAACGTGGTA
GGTGAAGGCCGTTGTCCTGTGGTCGATACATGGTGGCAAACAGAAACGGGCGGTATCCTGATTGCACCTTTACCTGGTGC
AACAGCATTAAAACCAGGATCGGCGACACGCCCATTTTTTGGTGTTCAACCAGGGCTTGTCGATGGCGATGGTCATGAGA
TTGAAGGTGCCGCAGAAGGAAACCTCGTGATTAAGGATTCTTGGCCAGGTCAGATGCGTGGTATTTGGGGAGATCCTAAA
CGCTTTATTGAAGCTTATTTTTCAACTTTCCCTGGTCGTTATTTTACTGGTGACGGTGCGCGCCGCGATGAAGATGGTTA
TTACTGGATTACAGGGCGTGTCGATGATGTTTTAAACATTTCAGGGCATCGTCTTGGAACAGCAGAAATTGAAAGTGCTT
TGGTGGCACATCCGCATGTGGCTGAGGCTGCCGTGGTAGGCATGCCACATGAAATCAAAGGTCAAGGCATTTGTACCTTT
GTGACCCTTCAGGCTGGTGTGGATGAATCGGAAGAGTTACGTAAAGAATTGGTACAGTGGGTTCGTAAGATTTTAGGGCC
GATTGCAACGCCTGATGCATTACATTGGGCACCCGCTTTGCCTAAAACCCGTTCTGGTAAAATCATGCGTCGTATATTAC
GTAAAATTGCGGCCAATGAGCTTGATAGTTTGGGGGACACCTCGACTCTGGCCGATCCAAGTGTGGTTGAGTATCTGATT
AACACGGTCTATCCAGAAAAAACGCAAAATTCCACATCATAG

Upstream 100 bases:

>100_bases
GAAAATATGTGGATACTGCTTGAGCTAGAACAAAAACATCAAACACAGTGTCGATATATAAGCTTCGTGACGAGGCGTAA
AAAATCAAGGAAGTGATACT

Downstream 100 bases:

>100_bases
TCATGCTCCCTGCAAGCCGAATAGACTTGCAGGGAAGTCTTTATATTTGTTGAAAAGTATTGCTGAAATTTGGATAAAGC
ACTGCACGGGTTTTTGTTAG

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 653; Mature: 653

Protein sequence:

>653_residues
MNEIYPVPEEFKKTARTVEADYFTRYQKSIEDPDAFWADEARNVDWIKPFTQVKNSNYDAEQFKIEWFADGQLNVCANCL
DRHLKEHPHKPAIIWEGDHPSRHKIISFKELYEEVCRFANVLKKYGISKGDRVVLYMPMVSEAAIAMLACARIGAVHCVV
FGGFSPDSLASRIEDCQAKLVITADAGMRGGKLLPLKDSVDEALKLEGTESIEHVIVVHRTGNPIHFQEGRDLWYHVVIT
EVNEICPPEQMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYATTTFREVFDIKQDDVYWCTADVGWITGHSYLIYGPLS
NGTTTLMFEGIPQYPTWARIGHIVDKHNVTILYTAPTAIRSMMREGDAFVRESDRSSLRLLGTVGEPINPEAWSWYYNVV
GEGRCPVVDTWWQTETGGILIAPLPGATALKPGSATRPFFGVQPGLVDGDGHEIEGAAEGNLVIKDSWPGQMRGIWGDPK
RFIEAYFSTFPGRYFTGDGARRDEDGYYWITGRVDDVLNISGHRLGTAEIESALVAHPHVAEAAVVGMPHEIKGQGICTF
VTLQAGVDESEELRKELVQWVRKILGPIATPDALHWAPALPKTRSGKIMRRILRKIAANELDSLGDTSTLADPSVVEYLI
NTVYPEKTQNSTS

Sequences:

>Translated_653_residues
MNEIYPVPEEFKKTARTVEADYFTRYQKSIEDPDAFWADEARNVDWIKPFTQVKNSNYDAEQFKIEWFADGQLNVCANCL
DRHLKEHPHKPAIIWEGDHPSRHKIISFKELYEEVCRFANVLKKYGISKGDRVVLYMPMVSEAAIAMLACARIGAVHCVV
FGGFSPDSLASRIEDCQAKLVITADAGMRGGKLLPLKDSVDEALKLEGTESIEHVIVVHRTGNPIHFQEGRDLWYHVVIT
EVNEICPPEQMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYATTTFREVFDIKQDDVYWCTADVGWITGHSYLIYGPLS
NGTTTLMFEGIPQYPTWARIGHIVDKHNVTILYTAPTAIRSMMREGDAFVRESDRSSLRLLGTVGEPINPEAWSWYYNVV
GEGRCPVVDTWWQTETGGILIAPLPGATALKPGSATRPFFGVQPGLVDGDGHEIEGAAEGNLVIKDSWPGQMRGIWGDPK
RFIEAYFSTFPGRYFTGDGARRDEDGYYWITGRVDDVLNISGHRLGTAEIESALVAHPHVAEAAVVGMPHEIKGQGICTF
VTLQAGVDESEELRKELVQWVRKILGPIATPDALHWAPALPKTRSGKIMRRILRKIAANELDSLGDTSTLADPSVVEYLI
NTVYPEKTQNSTS
>Mature_653_residues
MNEIYPVPEEFKKTARTVEADYFTRYQKSIEDPDAFWADEARNVDWIKPFTQVKNSNYDAEQFKIEWFADGQLNVCANCL
DRHLKEHPHKPAIIWEGDHPSRHKIISFKELYEEVCRFANVLKKYGISKGDRVVLYMPMVSEAAIAMLACARIGAVHCVV
FGGFSPDSLASRIEDCQAKLVITADAGMRGGKLLPLKDSVDEALKLEGTESIEHVIVVHRTGNPIHFQEGRDLWYHVVIT
EVNEICPPEQMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYATTTFREVFDIKQDDVYWCTADVGWITGHSYLIYGPLS
NGTTTLMFEGIPQYPTWARIGHIVDKHNVTILYTAPTAIRSMMREGDAFVRESDRSSLRLLGTVGEPINPEAWSWYYNVV
GEGRCPVVDTWWQTETGGILIAPLPGATALKPGSATRPFFGVQPGLVDGDGHEIEGAAEGNLVIKDSWPGQMRGIWGDPK
RFIEAYFSTFPGRYFTGDGARRDEDGYYWITGRVDDVLNISGHRLGTAEIESALVAHPHVAEAAVVGMPHEIKGQGICTF
VTLQAGVDESEELRKELVQWVRKILGPIATPDALHWAPALPKTRSGKIMRRILRKIAANELDSLGDTSTLADPSVVEYLI
NTVYPEKTQNSTS

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=665, Percent_Identity=53.2330827067669, Blast_Score=674, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=678, Percent_Identity=52.212389380531, Blast_Score=670, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=631, Percent_Identity=49.6038034865293, Blast_Score=635, Evalue=0.0,
Organism=Homo sapiens, GI13375727, Length=627, Percent_Identity=36.8421052631579, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI38505220, Length=538, Percent_Identity=29.7397769516729, Blast_Score=199, Evalue=7e-51,
Organism=Homo sapiens, GI42544132, Length=574, Percent_Identity=29.7909407665505, Blast_Score=198, Evalue=2e-50,
Organism=Homo sapiens, GI115511026, Length=523, Percent_Identity=29.0630975143403, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI122937307, Length=555, Percent_Identity=27.7477477477477, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI31982927, Length=619, Percent_Identity=25.0403877221325, Blast_Score=169, Evalue=1e-41,
Organism=Homo sapiens, GI58082049, Length=537, Percent_Identity=25.512104283054, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI157311624, Length=537, Percent_Identity=24.7672253258845, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI157311622, Length=537, Percent_Identity=24.7672253258845, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI187761345, Length=555, Percent_Identity=25.7657657657658, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI187761343, Length=555, Percent_Identity=25.7657657657658, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI42544134, Length=394, Percent_Identity=26.9035532994924, Blast_Score=102, Evalue=2e-21,
Organism=Homo sapiens, GI195947378, Length=444, Percent_Identity=23.4234234234234, Blast_Score=95, Evalue=3e-19,
Organism=Homo sapiens, GI156151445, Length=592, Percent_Identity=22.1283783783784, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1790505, Length=619, Percent_Identity=66.0743134087238, Blast_Score=871, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=626, Percent_Identity=38.6581469648562, Blast_Score=417, Evalue=1e-117,
Organism=Escherichia coli, GI221142682, Length=531, Percent_Identity=23.5404896421846, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1788107, Length=596, Percent_Identity=23.489932885906, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI145693145, Length=498, Percent_Identity=23.8955823293173, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786810, Length=529, Percent_Identity=22.6843100189036, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71982997, Length=635, Percent_Identity=49.6062992125984, Blast_Score=608, Evalue=1e-174,
Organism=Caenorhabditis elegans, GI71983001, Length=635, Percent_Identity=49.6062992125984, Blast_Score=608, Evalue=1e-174,
Organism=Caenorhabditis elegans, GI17569507, Length=647, Percent_Identity=23.1839258114374, Blast_Score=155, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17558820, Length=510, Percent_Identity=23.1372549019608, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI32563687, Length=542, Percent_Identity=22.140221402214, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17538037, Length=148, Percent_Identity=33.1081081081081, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17557194, Length=128, Percent_Identity=33.59375, Blast_Score=73, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6323182, Length=638, Percent_Identity=48.7460815047022, Blast_Score=620, Evalue=1e-178,
Organism=Saccharomyces cerevisiae, GI6319264, Length=639, Percent_Identity=48.8262910798122, Blast_Score=607, Evalue=1e-174,
Organism=Saccharomyces cerevisiae, GI6319699, Length=378, Percent_Identity=22.2222222222222, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24667955, Length=639, Percent_Identity=53.6776212832551, Blast_Score=674, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=559, Percent_Identity=57.0661896243292, Blast_Score=634, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=517, Percent_Identity=57.0599613152805, Blast_Score=585, Evalue=1e-167,
Organism=Drosophila melanogaster, GI21355225, Length=656, Percent_Identity=35.2134146341463, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI21355181, Length=520, Percent_Identity=23.4615384615385, Blast_Score=103, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24656500, Length=378, Percent_Identity=25.1322751322751, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24581924, Length=528, Percent_Identity=22.1590909090909, Blast_Score=80, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24648260, Length=376, Percent_Identity=23.936170212766, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI18859661, Length=131, Percent_Identity=35.1145038167939, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21356947, Length=363, Percent_Identity=24.5179063360882, Blast_Score=73, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 72807; Mature: 72807

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEIYPVPEEFKKTARTVEADYFTRYQKSIEDPDAFWADEARNVDWIKPFTQVKNSNYDA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCHHHHHCCCCCCH
EQFKIEWFADGQLNVCANCLDRHLKEHPHKPAIIWEGDHPSRHKIISFKELYEEVCRFAN
HHEEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEHHHHHHHHHHHHH
VLKKYGISKGDRVVLYMPMVSEAAIAMLACARIGAVHCVVFGGFSPDSLASRIEDCQAKL
HHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHCEEEEEEEECCCHHHHHHHHHCCCEEE
VITADAGMRGGKLLPLKDSVDEALKLEGTESIEHVIVVHRTGNPIHFQEGRDLWYHVVIT
EEEECCCCCCCEEECCCCCHHHHHCCCCCCCEEEEEEEEECCCEEEECCCCCEEEEEEEE
EVNEICPPEQMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYATTTFREVFDIKQDDVYW
HHHHCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEEEHHHHHHHCCCCCCEEE
CTADVGWITGHSYLIYGPLSNGTTTLMFEGIPQYPTWARIGHIVDKHNVTILYTAPTAIR
EECCCCEEECCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHEECCCEEEEEECHHHHH
SMMREGDAFVRESDRSSLRLLGTVGEPINPEAWSWYYNVVGEGRCPVVDTWWQTETGGIL
HHHHCCCHHHHCCCCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCEEECCCCCCCCCEE
IAPLPGATALKPGSATRPFFGVQPGLVDGDGHEIEGAAEGNLVIKDSWPGQMRGIWGDPK
EECCCCCCCCCCCCCCCCCCCCCCCEECCCCCEECCCCCCCEEEECCCCCCCCCCCCCHH
RFIEAYFSTFPGRYFTGDGARRDEDGYYWITGRVDDVLNISGHRLGTAEIESALVAHPHV
HHHHHHHHHCCCCEEECCCCCCCCCCEEEEECCCCCEEECCCCCCCHHHHHHHHHCCCCH
AEAAVVGMPHEIKGQGICTFVTLQAGVDESEELRKELVQWVRKILGPIATPDALHWAPAL
HHHHHCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
PKTRSGKIMRRILRKIAANELDSLGDTSTLADPSVVEYLINTVYPEKTQNSTS
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNEIYPVPEEFKKTARTVEADYFTRYQKSIEDPDAFWADEARNVDWIKPFTQVKNSNYDA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCHHHHHCCCCCCH
EQFKIEWFADGQLNVCANCLDRHLKEHPHKPAIIWEGDHPSRHKIISFKELYEEVCRFAN
HHEEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEHHHHHHHHHHHHH
VLKKYGISKGDRVVLYMPMVSEAAIAMLACARIGAVHCVVFGGFSPDSLASRIEDCQAKL
HHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHCEEEEEEEECCCHHHHHHHHHCCCEEE
VITADAGMRGGKLLPLKDSVDEALKLEGTESIEHVIVVHRTGNPIHFQEGRDLWYHVVIT
EEEECCCCCCCEEECCCCCHHHHHCCCCCCCEEEEEEEEECCCEEEECCCCCEEEEEEEE
EVNEICPPEQMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYATTTFREVFDIKQDDVYW
HHHHCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEEEHHHHHHHCCCCCCEEE
CTADVGWITGHSYLIYGPLSNGTTTLMFEGIPQYPTWARIGHIVDKHNVTILYTAPTAIR
EECCCCEEECCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHEECCCEEEEEECHHHHH
SMMREGDAFVRESDRSSLRLLGTVGEPINPEAWSWYYNVVGEGRCPVVDTWWQTETGGIL
HHHHCCCHHHHCCCCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCEEECCCCCCCCCEE
IAPLPGATALKPGSATRPFFGVQPGLVDGDGHEIEGAAEGNLVIKDSWPGQMRGIWGDPK
EECCCCCCCCCCCCCCCCCCCCCCCEECCCCCEECCCCCCCEEEECCCCCCCCCCCCCHH
RFIEAYFSTFPGRYFTGDGARRDEDGYYWITGRVDDVLNISGHRLGTAEIESALVAHPHV
HHHHHHHHHCCCCEEECCCCCCCCCCEEEEECCCCCEEECCCCCCCHHHHHHHHHCCCCH
AEAAVVGMPHEIKGQGICTFVTLQAGVDESEELRKELVQWVRKILGPIATPDALHWAPAL
HHHHHCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
PKTRSGKIMRRILRKIAANELDSLGDTSTLADPSVVEYLINTVYPEKTQNSTS
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA