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The map label for this gene is serA [H]

Identifier: 50086287

GI number: 50086287

Start: 3209228

End: 3210460

Strand: Direct

Name: serA [H]

Synonym: ACIAD3302

Alternate gene names: 50086287

Gene position: 3209228-3210460 (Clockwise)

Preceding gene: 50086282

Following gene: 50086288

Centisome position: 89.18

GC content: 43.39

Gene sequence:

>1233_bases
ATGAGCCAACATCTATCACTACCTAAAGACAAAATTCGTTTCTTATTGTTAGAAGGCGTTCATCAAAACGCAGTCGACAC
TCTAAATGCAGCGGGTTATACCAATATCGATTATCGCAAGACAGCACTGGATGGCGATGCGCTGAAAGAAGCCGTCAAGG
ATGCTCACTTTATTGGTATTCGCTCCCGTACTCAGTTGACAGAAGATGTCTTTGCAGCTGCGAACAAGCTCATCGCAGTA
GGTTGTTTCTGTATCGGAACCAATCAGGTAGATCTAAAAGCAGCAATGGCACGTGGTATTCCTGTATTTAACGCGCCTTA
TTCAAACACCCGTTCAGTTGCTGAACTGGTGCTTGCTGAATTGATCCTTCTTCTGCGTCGTGTACCTGAAAAATCTGCAG
TCTGTCACCGTGGTGGCTGGGACAAATCTGCTGTAGGTTCTTATGAAACACGTGGCAAGACATTAGGTATTGTTGGTTAC
GGCTCAATTGGCTCACAACTTTCAGTCTTGGCTGAAAGCTTAGGCATGCACGTCATTTATTACGACACAGTCACTAAGCT
TCCAATGGGTAATGCTCGCCAAGTGGGTTCTTTGGATGAATTACTTGCAACTGCTGATGTTGTGACGTTGCATGTACCAG
ATGTTCCATCTACACGTAATTTCTTCAAGAAAGAACAATTTGCCAAAATGAAAGAAGGTGCGATCTTCTTGAACGCGGCA
CGCGGTACGTGTGTGATCATCGAAGACTTAGCAGATGCGTTGAAATCAGGTCACCTTGCAGGTGCTGCGGTAGACGTATT
CCCGAAAGAACCAAAAGCCAATGGTGAAGAATTTATTTCTCCATTACGTGGTCTGGACAATGTGATCCTGACACCTCACG
TGGGCGGTTCAACCATGGAGGCTCAAGCCAATATCGGACTTGAAGTTTCAGAAAAATTTGTGGCTTATTCTGATAAAGGT
ATGACCCTATCTGCGGTCAATTTCCCAGAAATTGCACTACCATTGACTGAAGGCAAGCACCGTTTATTGCATATTCATAA
AAATATTCCAGGTGTATTGTCTAAAATCAATAATCTATTTGCAGAACAAAATATCAATATCTCTGGTCAAAGTTTGATGA
CTAAAGGTGATATCGGTTACCTGATCATGGATGTAGATGCATCTGCTTCTCAAGAAGCACTTGATATGCTCAACCAGGTT
GAAGGTACTATTCGCGTTCGCGTTCTGTTCTAA

Upstream 100 bases:

>100_bases
CCATGATGTCAGTCATATCTCTTATTTATAATGGATAAACATGCAGCACGAGTTGTGATATGATATCGCGACTAAATTTG
GCCTTTGTAGCGGAGCCGTA

Downstream 100 bases:

>100_bases
TTGATGCATCTCGAGAAAGCCACAGACCGTCTGTGGCTTTTTTATATCAACATGAATTAAGATGAACCAAATATACCTAT
TGTTCAAAAAAAATGTCGTC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MSQHLSLPKDKIRFLLLEGVHQNAVDTLNAAGYTNIDYRKTALDGDALKEAVKDAHFIGIRSRTQLTEDVFAAANKLIAV
GCFCIGTNQVDLKAAMARGIPVFNAPYSNTRSVAELVLAELILLLRRVPEKSAVCHRGGWDKSAVGSYETRGKTLGIVGY
GSIGSQLSVLAESLGMHVIYYDTVTKLPMGNARQVGSLDELLATADVVTLHVPDVPSTRNFFKKEQFAKMKEGAIFLNAA
RGTCVIIEDLADALKSGHLAGAAVDVFPKEPKANGEEFISPLRGLDNVILTPHVGGSTMEAQANIGLEVSEKFVAYSDKG
MTLSAVNFPEIALPLTEGKHRLLHIHKNIPGVLSKINNLFAEQNINISGQSLMTKGDIGYLIMDVDASASQEALDMLNQV
EGTIRVRVLF

Sequences:

>Translated_410_residues
MSQHLSLPKDKIRFLLLEGVHQNAVDTLNAAGYTNIDYRKTALDGDALKEAVKDAHFIGIRSRTQLTEDVFAAANKLIAV
GCFCIGTNQVDLKAAMARGIPVFNAPYSNTRSVAELVLAELILLLRRVPEKSAVCHRGGWDKSAVGSYETRGKTLGIVGY
GSIGSQLSVLAESLGMHVIYYDTVTKLPMGNARQVGSLDELLATADVVTLHVPDVPSTRNFFKKEQFAKMKEGAIFLNAA
RGTCVIIEDLADALKSGHLAGAAVDVFPKEPKANGEEFISPLRGLDNVILTPHVGGSTMEAQANIGLEVSEKFVAYSDKG
MTLSAVNFPEIALPLTEGKHRLLHIHKNIPGVLSKINNLFAEQNINISGQSLMTKGDIGYLIMDVDASASQEALDMLNQV
EGTIRVRVLF
>Mature_409_residues
SQHLSLPKDKIRFLLLEGVHQNAVDTLNAAGYTNIDYRKTALDGDALKEAVKDAHFIGIRSRTQLTEDVFAAANKLIAVG
CFCIGTNQVDLKAAMARGIPVFNAPYSNTRSVAELVLAELILLLRRVPEKSAVCHRGGWDKSAVGSYETRGKTLGIVGYG
SIGSQLSVLAESLGMHVIYYDTVTKLPMGNARQVGSLDELLATADVVTLHVPDVPSTRNFFKKEQFAKMKEGAIFLNAAR
GTCVIIEDLADALKSGHLAGAAVDVFPKEPKANGEEFISPLRGLDNVILTPHVGGSTMEAQANIGLEVSEKFVAYSDKGM
TLSAVNFPEIALPLTEGKHRLLHIHKNIPGVLSKINNLFAEQNINISGQSLMTKGDIGYLIMDVDASASQEALDMLNQVE
GTIRVRVLF

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=290, Percent_Identity=37.2413793103448, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI145580578, Length=243, Percent_Identity=32.0987654320988, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI4557499, Length=243, Percent_Identity=32.0987654320988, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI61743967, Length=253, Percent_Identity=29.6442687747036, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI4557497, Length=253, Percent_Identity=29.6442687747036, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI6912396, Length=250, Percent_Identity=30, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI145580575, Length=243, Percent_Identity=32.0987654320988, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1789279, Length=408, Percent_Identity=61.0294117647059, Blast_Score=514, Evalue=1e-147,
Organism=Escherichia coli, GI87082289, Length=234, Percent_Identity=35.042735042735, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1787645, Length=235, Percent_Identity=26.8085106382979, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1788660, Length=377, Percent_Identity=28.6472148541114, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI87081824, Length=211, Percent_Identity=27.4881516587678, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=330, Percent_Identity=35.4545454545455, Blast_Score=181, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI25147481, Length=221, Percent_Identity=32.1266968325792, Blast_Score=104, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6320925, Length=414, Percent_Identity=48.792270531401, Blast_Score=398, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6322116, Length=414, Percent_Identity=47.5845410628019, Blast_Score=392, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6324964, Length=259, Percent_Identity=32.046332046332, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6324055, Length=281, Percent_Identity=28.4697508896797, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324980, Length=194, Percent_Identity=30.9278350515464, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6325144, Length=183, Percent_Identity=32.2404371584699, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19921140, Length=314, Percent_Identity=33.7579617834395, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI28574286, Length=264, Percent_Identity=30.6818181818182, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24646446, Length=235, Percent_Identity=33.1914893617021, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24646448, Length=235, Percent_Identity=33.1914893617021, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24646452, Length=235, Percent_Identity=33.1914893617021, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24646450, Length=235, Percent_Identity=33.1914893617021, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI62472511, Length=235, Percent_Identity=33.6170212765957, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28574284, Length=246, Percent_Identity=28.4552845528455, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI45551003, Length=246, Percent_Identity=28.4552845528455, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24585514, Length=246, Percent_Identity=28.4552845528455, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28574282, Length=246, Percent_Identity=28.4552845528455, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI45552429, Length=246, Percent_Identity=28.4552845528455, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28571528, Length=262, Percent_Identity=30.5343511450382, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24585516, Length=243, Percent_Identity=29.6296296296296, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR010771
- InterPro:   IPR016040
- ProDom:   PD147088 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44270; Mature: 44138

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQHLSLPKDKIRFLLLEGVHQNAVDTLNAAGYTNIDYRKTALDGDALKEAVKDAHFIGI
CCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHEEEE
RSRTQLTEDVFAAANKLIAVGCFCIGTNQVDLKAAMARGIPVFNAPYSNTRSVAELVLAE
CCHHHHHHHHHHHHHHEEEEEEEEECCCCHHHHHHHHCCCCEECCCCCCHHHHHHHHHHH
LILLLRRVPEKSAVCHRGGWDKSAVGSYETRGKTLGIVGYGSIGSQLSVLAESLGMHVIY
HHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCEEEE
YDTVTKLPMGNARQVGSLDELLATADVVTLHVPDVPSTRNFFKKEQFAKMKEGAIFLNAA
EECHHCCCCCCCCCCCCHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHCCEEEEEEC
RGTCVIIEDLADALKSGHLAGAAVDVFPKEPKANGEEFISPLRGLDNVILTPHVGGSTME
CCCEEEHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCEE
AQANIGLEVSEKFVAYSDKGMTLSAVNFPEIALPLTEGKHRLLHIHKNIPGVLSKINNLF
ECCCCCCEECCCEEEECCCCCEEEECCCCCEEEECCCCCEEEEEEECCCCHHHHHHHHHH
AEQNINISGQSLMTKGDIGYLIMDVDASASQEALDMLNQVEGTIRVRVLF
HHCCCCCCCCCEEECCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEEEEC
>Mature Secondary Structure 
SQHLSLPKDKIRFLLLEGVHQNAVDTLNAAGYTNIDYRKTALDGDALKEAVKDAHFIGI
CCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHEEEE
RSRTQLTEDVFAAANKLIAVGCFCIGTNQVDLKAAMARGIPVFNAPYSNTRSVAELVLAE
CCHHHHHHHHHHHHHHEEEEEEEEECCCCHHHHHHHHCCCCEECCCCCCHHHHHHHHHHH
LILLLRRVPEKSAVCHRGGWDKSAVGSYETRGKTLGIVGYGSIGSQLSVLAESLGMHVIY
HHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCEEEE
YDTVTKLPMGNARQVGSLDELLATADVVTLHVPDVPSTRNFFKKEQFAKMKEGAIFLNAA
EECHHCCCCCCCCCCCCHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHCCEEEEEEC
RGTCVIIEDLADALKSGHLAGAAVDVFPKEPKANGEEFISPLRGLDNVILTPHVGGSTME
CCCEEEHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCEE
AQANIGLEVSEKFVAYSDKGMTLSAVNFPEIALPLTEGKHRLLHIHKNIPGVLSKINNLF
ECCCCCCEECCCEEEECCCCCEEEECCCCCEEEECCCCCEEEEEEECCCCHHHHHHHHHH
AEQNINISGQSLMTKGDIGYLIMDVDASASQEALDMLNQVEGTIRVRVLF
HHCCCCCCCCCEEECCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]