Click here to switch to the map view.

The map label for this gene is ethA [H]

Identifier: 50086188

GI number: 50086188

Start: 3119865

End: 3121361

Strand: Reverse

Name: ethA [H]

Synonym: ACIAD3192

Alternate gene names: 50086188

Gene position: 3121361-3119865 (Counterclockwise)

Preceding gene: 50086189

Following gene: 50086186

Centisome position: 86.74

GC content: 39.41

Gene sequence:

>1497_bases
ATGGAAAAGCACATTGATATCTTAATTGTAGGTGCAGGGATTTCGGGTATTGGGATTGCTGCACATCTTTCTAAAGATGC
CCCTCAACGCCAGTTCGAGATTATTGAGCGTCGTGAAAATATTGGTGGGACTTGGGATTTGTTTCGTTATCCTGGGATTC
GTTCTGATTCTGATATGTCGACTTTTGGTTTTAATTTTAAACCGTGGCAAAGTCCAAATGTATTGGCCTCTGGCTCGTCA
ATTAAAGGCTATTTGAGTGAAGTTGTTGATGAATATGATTTAAAAAAGAAAATTCATTTTAAACATCGTGTACTGGCTGC
AAACTATGATACTGCATCTAAAAAATGGTATGTAGAAATCGAAGATGCCGCGCAGAAAAAACAGACGTGGATCGCCAATT
TTATTGTGGGTTGTACGGGCTATTACAATTACGATCAAGGTTTTGAGCCTGATTTTCCAAATAAAGATGCGTTTAAAGGA
CAATTTATTCATCCACAGCATTGGCCTGAAAACTTGGATTATGTTGGTAAGAAAGTTGTGATTATTGGCAGTGGAGCTAC
TGCAATTACTCTAGTTCCAGCAATGTCGAAAGGTGGGGCAGAACATGTCACGATGTTGCAGCGTTCTCCAACGTATATCG
CATCGATTCCATCGATTGATTTTGTCTATGACAAAATGCGCAAAGTTTTACCTGAGGATCTTGCATATAAACTCACACGT
GCCCGCAATATCGGTGTACAGCGTGGTATCTATACTTTATCACAAAAGCAGCCTAAACTGGTACGCAAATTCTTATTGAA
ATCGATTGAGATGCAATTGAAAGGTAAAGTGGATATGAAACACTTTACACCAAGCTATAACCCATGGGATCAGCGTTTGT
GCGTTGTGCCAGATGGTGATTTATTTAAGATTTTGCGCTCTGGACAAGCAAGCGTTGAAACCGATCAGATCGAGAAATTT
ACTGAGACAGGTATTCAGTTGAAATCTGGTAAACATCTTGATGCTGATATTGTGGTTTCCGCGACTGGTTTAGAGATCCA
GATTTTAGGGGGAATTAAAGGCACAATTGATGGTCAGCCTTTAGATACATCTAAATCGATGCTTTATCAAGGGGTGATGG
TCAGTGATGTACCAAATATGGCGATGATCATTGGTTATATCAATGCTTCTTGGACATTAAAGGTCGATGTAGCGGCAGAT
TATATTTGTCGTTTATTAAACTATATGGATAAACAGGGTTATGACGAGGTAATTCCTGAAGGTGATCAAACTGAATTGAT
GGAAGATACGGTTATGGGGAGTTTAACCTCAGGTTATATTGCTCGTGCTGCCAATGTGATGCCAAAACAGGGTAAGCATG
CACCTTGGAAAGTGACCAATAATTATCTAGCTGATCGTAAAGCACTTAAAAATGCTCGTTTTGATGATGGTGTACTACAC
TTTGACAAGAAAACAGACACGGTTGAGCGTAAAACAAAACCCAAATTAGTATCCTAA

Upstream 100 bases:

>100_bases
ACTGACATAAAAAACCGATAAATGGATTAAACTTGACATTGTGTATTGTCAAATTTGTGTTTTAATAAAATAGAATTGTT
CTCAAGGTTATAAAAACAAT

Downstream 100 bases:

>100_bases
CTTGAGCTAAACAAAAAAAGGAGCTTAAACAAAGCTCCTTTTTTTGTTTATGAAAACTTAACTTTTAAAGGGTTCGAGAA
ATTAATTCTTTCATAATTTC

Product: flavin-binding family monooxygenase

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MEKHIDILIVGAGISGIGIAAHLSKDAPQRQFEIIERRENIGGTWDLFRYPGIRSDSDMSTFGFNFKPWQSPNVLASGSS
IKGYLSEVVDEYDLKKKIHFKHRVLAANYDTASKKWYVEIEDAAQKKQTWIANFIVGCTGYYNYDQGFEPDFPNKDAFKG
QFIHPQHWPENLDYVGKKVVIIGSGATAITLVPAMSKGGAEHVTMLQRSPTYIASIPSIDFVYDKMRKVLPEDLAYKLTR
ARNIGVQRGIYTLSQKQPKLVRKFLLKSIEMQLKGKVDMKHFTPSYNPWDQRLCVVPDGDLFKILRSGQASVETDQIEKF
TETGIQLKSGKHLDADIVVSATGLEIQILGGIKGTIDGQPLDTSKSMLYQGVMVSDVPNMAMIIGYINASWTLKVDVAAD
YICRLLNYMDKQGYDEVIPEGDQTELMEDTVMGSLTSGYIARAANVMPKQGKHAPWKVTNNYLADRKALKNARFDDGVLH
FDKKTDTVERKTKPKLVS

Sequences:

>Translated_498_residues
MEKHIDILIVGAGISGIGIAAHLSKDAPQRQFEIIERRENIGGTWDLFRYPGIRSDSDMSTFGFNFKPWQSPNVLASGSS
IKGYLSEVVDEYDLKKKIHFKHRVLAANYDTASKKWYVEIEDAAQKKQTWIANFIVGCTGYYNYDQGFEPDFPNKDAFKG
QFIHPQHWPENLDYVGKKVVIIGSGATAITLVPAMSKGGAEHVTMLQRSPTYIASIPSIDFVYDKMRKVLPEDLAYKLTR
ARNIGVQRGIYTLSQKQPKLVRKFLLKSIEMQLKGKVDMKHFTPSYNPWDQRLCVVPDGDLFKILRSGQASVETDQIEKF
TETGIQLKSGKHLDADIVVSATGLEIQILGGIKGTIDGQPLDTSKSMLYQGVMVSDVPNMAMIIGYINASWTLKVDVAAD
YICRLLNYMDKQGYDEVIPEGDQTELMEDTVMGSLTSGYIARAANVMPKQGKHAPWKVTNNYLADRKALKNARFDDGVLH
FDKKTDTVERKTKPKLVS
>Mature_498_residues
MEKHIDILIVGAGISGIGIAAHLSKDAPQRQFEIIERRENIGGTWDLFRYPGIRSDSDMSTFGFNFKPWQSPNVLASGSS
IKGYLSEVVDEYDLKKKIHFKHRVLAANYDTASKKWYVEIEDAAQKKQTWIANFIVGCTGYYNYDQGFEPDFPNKDAFKG
QFIHPQHWPENLDYVGKKVVIIGSGATAITLVPAMSKGGAEHVTMLQRSPTYIASIPSIDFVYDKMRKVLPEDLAYKLTR
ARNIGVQRGIYTLSQKQPKLVRKFLLKSIEMQLKGKVDMKHFTPSYNPWDQRLCVVPDGDLFKILRSGQASVETDQIEKF
TETGIQLKSGKHLDADIVVSATGLEIQILGGIKGTIDGQPLDTSKSMLYQGVMVSDVPNMAMIIGYINASWTLKVDVAAD
YICRLLNYMDKQGYDEVIPEGDQTELMEDTVMGSLTSGYIARAANVMPKQGKHAPWKVTNNYLADRKALKNARFDDGVLH
FDKKTDTVERKTKPKLVS

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Homo sapiens, GI4503757, Length=228, Percent_Identity=25.4385964912281, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17561948, Length=411, Percent_Identity=22.8710462287105, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17506045, Length=213, Percent_Identity=26.2910798122066, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17555726, Length=401, Percent_Identity=22.9426433915212, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193202226, Length=256, Percent_Identity=26.171875, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 55897; Mature: 55897

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKHIDILIVGAGISGIGIAAHLSKDAPQRQFEIIERRENIGGTWDLFRYPGIRSDSDMS
CCCCEEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCEEHHCCCCCCCCCCCH
TFGFNFKPWQSPNVLASGSSIKGYLSEVVDEYDLKKKIHFKHRVLAANYDTASKKWYVEI
HCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCEEEEEE
EDAAQKKQTWIANFIVGCTGYYNYDQGFEPDFPNKDAFKGQFIHPQHWPENLDYVGKKVV
HHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEE
IIGSGATAITLVPAMSKGGAEHVTMLQRSPTYIASIPSIDFVYDKMRKVLPEDLAYKLTR
EEECCCCEEEEEECCCCCCCHHHHHHHCCCCEEEECCCHHHHHHHHHHHCHHHHHHHHHH
ARNIGVQRGIYTLSQKQPKLVRKFLLKSIEMQLKGKVDMKHFTPSYNPWDQRLCVVPDGD
HHCCCHHHCEEECCCCCHHHHHHHHHHHHHHHHCCCEEHHHCCCCCCCCCCEEEECCCCH
LFKILRSGQASVETDQIEKFTETGIQLKSGKHLDADIVVSATGLEIQILGGIKGTIDGQP
HHHHHHCCCCCCCHHHHHHHHHCCEEEECCCCCCCEEEEEECCEEEEEECCCCCCCCCCC
LDTSKSMLYQGVMVSDVPNMAMIIGYINASWTLKVDVAADYICRLLNYMDKQGYDEVIPE
CCCHHHHHHCCCCCCCCCCEEEEEEEECCEEEEEEEHHHHHHHHHHHHHHHCCCHHHCCC
GDQTELMEDTVMGSLTSGYIARAANVMPKQGKHAPWKVTNNYLADRKALKNARFDDGVLH
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHHCCCCCCCEEE
FDKKTDTVERKTKPKLVS
ECCCCCHHHHCCCCCCCC
>Mature Secondary Structure
MEKHIDILIVGAGISGIGIAAHLSKDAPQRQFEIIERRENIGGTWDLFRYPGIRSDSDMS
CCCCEEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCEEHHCCCCCCCCCCCH
TFGFNFKPWQSPNVLASGSSIKGYLSEVVDEYDLKKKIHFKHRVLAANYDTASKKWYVEI
HCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCEEEEEE
EDAAQKKQTWIANFIVGCTGYYNYDQGFEPDFPNKDAFKGQFIHPQHWPENLDYVGKKVV
HHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEE
IIGSGATAITLVPAMSKGGAEHVTMLQRSPTYIASIPSIDFVYDKMRKVLPEDLAYKLTR
EEECCCCEEEEEECCCCCCCHHHHHHHCCCCEEEECCCHHHHHHHHHHHCHHHHHHHHHH
ARNIGVQRGIYTLSQKQPKLVRKFLLKSIEMQLKGKVDMKHFTPSYNPWDQRLCVVPDGD
HHCCCHHHCEEECCCCCHHHHHHHHHHHHHHHHCCCEEHHHCCCCCCCCCCEEEECCCCH
LFKILRSGQASVETDQIEKFTETGIQLKSGKHLDADIVVSATGLEIQILGGIKGTIDGQP
HHHHHHCCCCCCCHHHHHHHHHCCEEEECCCCCCCEEEEEECCEEEEEECCCCCCCCCCC
LDTSKSMLYQGVMVSDVPNMAMIIGYINASWTLKVDVAADYICRLLNYMDKQGYDEVIPE
CCCHHHHHHCCCCCCCCCCEEEEEEEECCEEEEEEEHHHHHHHHHHHHHHHCCCHHHCCC
GDQTELMEDTVMGSLTSGYIARAANVMPKQGKHAPWKVTNNYLADRKALKNARFDDGVLH
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHHCCCCCCCEEE
FDKKTDTVERKTKPKLVS
ECCCCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA