Click here to switch to the map view.

The map label for this gene is prlC [H]

Identifier: 50086179

GI number: 50086179

Start: 3110802

End: 3112856

Strand: Direct

Name: prlC [H]

Synonym: ACIAD3182

Alternate gene names: 50086179

Gene position: 3110802-3112856 (Clockwise)

Preceding gene: 50086178

Following gene: 50086180

Centisome position: 86.44

GC content: 42.34

Gene sequence:

>2055_bases
TTGATGACAAGCACAATGACCTTAGAAAAAGCAACCTTACCTGTTCCACAGTTTGATCAGATTCAGCTTGATCAACTTAA
ACAGGACATCGAGAAAAGTATTCATGCAGGTCAAGCATTTCTCAATCACTTAGAACAAGCTCCGCAAGATTTCGCTTCAC
AGCGCAAAACCATTGAACAGCTTGATACGCTTGAAAACCAGATGAGTGAATCTTGGGGGGTACTTTCACATTTAAATGCA
GTCATGAATAATCCCCAAACACGTGAAGTGTATCAGGAGTTATTACCTCACCTAAGCGCCTACTATACGCAACTTGGGCA
ACATACCCCGCTTTATCAAACTTATCAGCAAATTCATGATAGTACCGAATTTTCAAGCTTATCGGCTGCACAACAAAGTG
CCATTCGTTTAGCTTTGCGTGATTTTAAACTTTCGGGTGTGGCACTTGAAGGCGATGCAAAAAAACGTTATGCCGAAATT
TCAGCGCGTTTATCACAGTTGTCTTCAGACTTTTCTAATCACGTACTCGATGCCACACAAGCTTATTTCAAGCCATTAAG
TGAAGATCAACTCAAAGGCTTGCCACAGAGCAGTATCGAACTGTTAAAACAATATGGTCAACAACGTGAACTGGATCAGC
CCGTTGCAACACTAGATATTCCTGCTTATCTGGCAATTATGACCTACGCAGAAAATCGTGAGCTACGTGAGACACTCTAT
AAAGCATATACCACACGTGCTTCCGATGAGTCTGACCACAAAGAATATGACAACACGGCGATCATGGAAGAAATTCTAAG
CCTGCGCCAAGAAATGGCTCAGCTCCTTGGATTTGATAATTTTGCCGAATATTCTCTTGCCAGTAAAATGGCTCCAGATG
TTCAAACTGTACATGATTTTCTGGTCGATCTGGCAGAACACGCACGTACGCCAGCATTAAAGGAAATCAATGAACTGAAA
TTGATTGCCCAACAAGATGGTGTTGAGCAACTACAACCGTGGGATAGTGGTTATTATTCAGAAAAGCTCAAACAGCAACA
ATTTAATCTGTCACAGGAAGCATTAAAACCTTACTTCCCTGCACCTAAAATTATTCAGGGTCTATTCCAGATCGTTGATC
GCTTATATGGTGTTCAGATTGTAGAACGTGAAGCACCGCTCTGGCACCCTGATGTTCATTATTATGAACTTGAAGATCAA
GGAAAAGTCATTGCAGGATTCTACTTTGATTTGTATGCACGTAGTGGAAAACGTGGTGGAGCATGGATGAGCGGTTTCCG
TTCACGCATGCAAACGGCACAAGGCCTACAAAAACCAATTTGCTATATGGTATGTAACTTTACCCCGCCTGTCGGTCAAC
AACCTGCTTTGCTCACACATGATGAAGTCAATACTTTATTCCATGAATTTGGTCATGGCTTACATCATATGCTGACCGAA
GTGGATAATATTTCAGTTGCAGGAACACATGGCGTGGCATGGGATGCCGTCGAGTTGCCAAGTCAGTTTATGGAGTTCTG
GACATGGGATAAAGACAGTCTCGACCTCTTAAGCGAACATATCGAGACGCATGTACACCTACCAGAAGAGTTACTTAACG
CTTTACTTAATGCACGTTTTTTCCAGTCTGGTATGCAAACCTTACGTCAAATTGAATTTGCATTATTTGATCTCACTATT
CACGCCAAAAACCCAGCATTGAACAGTAGTGGCATTCAGAATGTTTTAAATGATATCCGCACACAGTTTGCAGTATTGCC
AACCGCAACATATAACCGTTTCCAACATAGTTTTAGCCATATTTTTGCAGGGGGCTATGCAGCAGGTTACTACTCTTACA
AGTGGGCAGAAGTATTGGCAAGTGATGCTTTTGATCGCTTTGAAGCAGAAGGTATTTTTAATACACAAACTGGTGCTGAG
TTCCGCAAGGCAATTTTAGCCGTAGGAGGTAAAGATACTGCACTGGATGCCTTCGTCAACTTCCGTGGTCGCGAACCCAA
AATTGATGCCTTGTTGCGTCATCAGGGTTGGACGAATGACCATCAAAACGCTTAG

Upstream 100 bases:

>100_bases
GCGTTGTTAAAAGCCACAATCTTATAAATTTTAAAAAAGAAAAACAGGATTGCTTGATTTCCACATCCAGAACCCTTACA
TCTAATGATAAGTTTAAAAT

Downstream 100 bases:

>100_bases
ACTAAATGGCATTAATGAATAAGGATGAAACAGCCATGAAACGCAGATTCATTGCAGGCGCGAAATGTCCAAAATGTGGT
GCAATGGATCGGGTAGTTAT

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 684; Mature: 684

Protein sequence:

>684_residues
MMTSTMTLEKATLPVPQFDQIQLDQLKQDIEKSIHAGQAFLNHLEQAPQDFASQRKTIEQLDTLENQMSESWGVLSHLNA
VMNNPQTREVYQELLPHLSAYYTQLGQHTPLYQTYQQIHDSTEFSSLSAAQQSAIRLALRDFKLSGVALEGDAKKRYAEI
SARLSQLSSDFSNHVLDATQAYFKPLSEDQLKGLPQSSIELLKQYGQQRELDQPVATLDIPAYLAIMTYAENRELRETLY
KAYTTRASDESDHKEYDNTAIMEEILSLRQEMAQLLGFDNFAEYSLASKMAPDVQTVHDFLVDLAEHARTPALKEINELK
LIAQQDGVEQLQPWDSGYYSEKLKQQQFNLSQEALKPYFPAPKIIQGLFQIVDRLYGVQIVEREAPLWHPDVHYYELEDQ
GKVIAGFYFDLYARSGKRGGAWMSGFRSRMQTAQGLQKPICYMVCNFTPPVGQQPALLTHDEVNTLFHEFGHGLHHMLTE
VDNISVAGTHGVAWDAVELPSQFMEFWTWDKDSLDLLSEHIETHVHLPEELLNALLNARFFQSGMQTLRQIEFALFDLTI
HAKNPALNSSGIQNVLNDIRTQFAVLPTATYNRFQHSFSHIFAGGYAAGYYSYKWAEVLASDAFDRFEAEGIFNTQTGAE
FRKAILAVGGKDTALDAFVNFRGREPKIDALLRHQGWTNDHQNA

Sequences:

>Translated_684_residues
MMTSTMTLEKATLPVPQFDQIQLDQLKQDIEKSIHAGQAFLNHLEQAPQDFASQRKTIEQLDTLENQMSESWGVLSHLNA
VMNNPQTREVYQELLPHLSAYYTQLGQHTPLYQTYQQIHDSTEFSSLSAAQQSAIRLALRDFKLSGVALEGDAKKRYAEI
SARLSQLSSDFSNHVLDATQAYFKPLSEDQLKGLPQSSIELLKQYGQQRELDQPVATLDIPAYLAIMTYAENRELRETLY
KAYTTRASDESDHKEYDNTAIMEEILSLRQEMAQLLGFDNFAEYSLASKMAPDVQTVHDFLVDLAEHARTPALKEINELK
LIAQQDGVEQLQPWDSGYYSEKLKQQQFNLSQEALKPYFPAPKIIQGLFQIVDRLYGVQIVEREAPLWHPDVHYYELEDQ
GKVIAGFYFDLYARSGKRGGAWMSGFRSRMQTAQGLQKPICYMVCNFTPPVGQQPALLTHDEVNTLFHEFGHGLHHMLTE
VDNISVAGTHGVAWDAVELPSQFMEFWTWDKDSLDLLSEHIETHVHLPEELLNALLNARFFQSGMQTLRQIEFALFDLTI
HAKNPALNSSGIQNVLNDIRTQFAVLPTATYNRFQHSFSHIFAGGYAAGYYSYKWAEVLASDAFDRFEAEGIFNTQTGAE
FRKAILAVGGKDTALDAFVNFRGREPKIDALLRHQGWTNDHQNA
>Mature_684_residues
MMTSTMTLEKATLPVPQFDQIQLDQLKQDIEKSIHAGQAFLNHLEQAPQDFASQRKTIEQLDTLENQMSESWGVLSHLNA
VMNNPQTREVYQELLPHLSAYYTQLGQHTPLYQTYQQIHDSTEFSSLSAAQQSAIRLALRDFKLSGVALEGDAKKRYAEI
SARLSQLSSDFSNHVLDATQAYFKPLSEDQLKGLPQSSIELLKQYGQQRELDQPVATLDIPAYLAIMTYAENRELRETLY
KAYTTRASDESDHKEYDNTAIMEEILSLRQEMAQLLGFDNFAEYSLASKMAPDVQTVHDFLVDLAEHARTPALKEINELK
LIAQQDGVEQLQPWDSGYYSEKLKQQQFNLSQEALKPYFPAPKIIQGLFQIVDRLYGVQIVEREAPLWHPDVHYYELEDQ
GKVIAGFYFDLYARSGKRGGAWMSGFRSRMQTAQGLQKPICYMVCNFTPPVGQQPALLTHDEVNTLFHEFGHGLHHMLTE
VDNISVAGTHGVAWDAVELPSQFMEFWTWDKDSLDLLSEHIETHVHLPEELLNALLNARFFQSGMQTLRQIEFALFDLTI
HAKNPALNSSGIQNVLNDIRTQFAVLPTATYNRFQHSFSHIFAGGYAAGYYSYKWAEVLASDAFDRFEAEGIFNTQTGAE
FRKAILAVGGKDTALDAFVNFRGREPKIDALLRHQGWTNDHQNA

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=637, Percent_Identity=31.0832025117739, Blast_Score=286, Evalue=6e-77,
Organism=Homo sapiens, GI14149738, Length=608, Percent_Identity=29.4407894736842, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI156105687, Length=635, Percent_Identity=24.7244094488189, Blast_Score=179, Evalue=6e-45,
Organism=Escherichia coli, GI1789913, Length=660, Percent_Identity=48.1818181818182, Blast_Score=637, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=694, Percent_Identity=29.3948126801153, Blast_Score=264, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI71999758, Length=563, Percent_Identity=24.866785079929, Blast_Score=128, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI32565901, Length=614, Percent_Identity=22.9641693811075, Blast_Score=124, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6319793, Length=650, Percent_Identity=30.3076923076923, Blast_Score=291, Evalue=3e-79,
Organism=Saccharomyces cerevisiae, GI6322715, Length=683, Percent_Identity=24.7437774524158, Blast_Score=152, Evalue=1e-37,
Organism=Drosophila melanogaster, GI21356111, Length=636, Percent_Identity=26.4150943396226, Blast_Score=218, Evalue=1e-56,
Organism=Drosophila melanogaster, GI20129717, Length=622, Percent_Identity=23.6334405144695, Blast_Score=176, Evalue=5e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 77795; Mature: 77795

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTSTMTLEKATLPVPQFDQIQLDQLKQDIEKSIHAGQAFLNHLEQAPQDFASQRKTIEQ
CCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDTLENQMSESWGVLSHLNAVMNNPQTREVYQELLPHLSAYYTQLGQHTPLYQTYQQIHD
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
STEFSSLSAAQQSAIRLALRDFKLSGVALEGDAKKRYAEISARLSQLSSDFSNHVLDATQ
CHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYFKPLSEDQLKGLPQSSIELLKQYGQQRELDQPVATLDIPAYLAIMTYAENRELRETLY
HHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHH
KAYTTRASDESDHKEYDNTAIMEEILSLRQEMAQLLGFDNFAEYSLASKMAPDVQTVHDF
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHH
LVDLAEHARTPALKEINELKLIAQQDGVEQLQPWDSGYYSEKLKQQQFNLSQEALKPYFP
HHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHCCCHHHHCCCCC
APKIIQGLFQIVDRLYGVQIVEREAPLWHPDVHYYELEDQGKVIAGFYFDLYARSGKRGG
CHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEECCCCCEEEHHHHHHHHHCCCCCC
AWMSGFRSRMQTAQGLQKPICYMVCNFTPPVGQQPALLTHDEVNTLFHEFGHGLHHMLTE
HHHHHHHHHHHHHHHHHCCHHHEEECCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHH
VDNISVAGTHGVAWDAVELPSQFMEFWTWDKDSLDLLSEHIETHVHLPEELLNALLNARF
HCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
FQSGMQTLRQIEFALFDLTIHAKNPALNSSGIQNVLNDIRTQFAVLPTATYNRFQHSFSH
HHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
IFAGGYAAGYYSYKWAEVLASDAFDRFEAEGIFNTQTGAEFRKAILAVGGKDTALDAFVN
HHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHH
FRGREPKIDALLRHQGWTNDHQNA
CCCCCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MMTSTMTLEKATLPVPQFDQIQLDQLKQDIEKSIHAGQAFLNHLEQAPQDFASQRKTIEQ
CCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDTLENQMSESWGVLSHLNAVMNNPQTREVYQELLPHLSAYYTQLGQHTPLYQTYQQIHD
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
STEFSSLSAAQQSAIRLALRDFKLSGVALEGDAKKRYAEISARLSQLSSDFSNHVLDATQ
CHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYFKPLSEDQLKGLPQSSIELLKQYGQQRELDQPVATLDIPAYLAIMTYAENRELRETLY
HHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHH
KAYTTRASDESDHKEYDNTAIMEEILSLRQEMAQLLGFDNFAEYSLASKMAPDVQTVHDF
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHH
LVDLAEHARTPALKEINELKLIAQQDGVEQLQPWDSGYYSEKLKQQQFNLSQEALKPYFP
HHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHCCCHHHHCCCCC
APKIIQGLFQIVDRLYGVQIVEREAPLWHPDVHYYELEDQGKVIAGFYFDLYARSGKRGG
CHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEECCCCCEEEHHHHHHHHHCCCCCC
AWMSGFRSRMQTAQGLQKPICYMVCNFTPPVGQQPALLTHDEVNTLFHEFGHGLHHMLTE
HHHHHHHHHHHHHHHHHCCHHHEEECCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHH
VDNISVAGTHGVAWDAVELPSQFMEFWTWDKDSLDLLSEHIETHVHLPEELLNALLNARF
HCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
FQSGMQTLRQIEFALFDLTIHAKNPALNSSGIQNVLNDIRTQFAVLPTATYNRFQHSFSH
HHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
IFAGGYAAGYYSYKWAEVLASDAFDRFEAEGIFNTQTGAEFRKAILAVGGKDTALDAFVN
HHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHH
FRGREPKIDALLRHQGWTNDHQNA
CCCCCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]