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The map label for this gene is dfp [H]

Identifier: 50086128

GI number: 50086128

Start: 3051780

End: 3053060

Strand: Reverse

Name: dfp [H]

Synonym: ACIAD3125

Alternate gene names: 50086128

Gene position: 3053060-3051780 (Counterclockwise)

Preceding gene: 50086131

Following gene: 50086127

Centisome position: 84.84

GC content: 45.51

Gene sequence:

>1281_bases
CTGCAACAGAAAGGTAAACTGTTCGTGAGCTTTGATTTAAGTGTCATTCCAAATAAAAATATTATTCTAGCTGTCACAGG
GGGAATTGCTGCCTATAAGAGCGCAATTTTAGTACGCCGTTTAAAAGATTATGGTTTTGATGTACGTGTGGTCATGACAC
ACGGCGCACAAGCCTTTATTACTCCGCTGACTTTTCAGGCACTGTCTGGGTATCCAGTACATACCGAATTGCTGGACCCT
GAAGCAGAAGCGGGAATGGGGCATATTGAACTGGCACGTTGGGCCGATCTGATACTGGTTGCCCCAGCAAGCTGTGATAC
GCTGGCAAAGTTTGCCCAAGGCTTAGCAGATGATTTGTTAAGTACACTTTATCTGGCAACCAAAGCGCCTGTCTGGGTTG
CACCTGCCATGAATCAGCAAATGTGGGCAGCTAAAGCCACTCAGCGTAACCTGCAAACACTGGTCGATGACGGTGTGCAT
GTCATTATGCCAGATGCGGGTGCACAGGCCTGTGGGGATGTTGGATTGGGCCGTATGCCTGAACCAGAGCAACTGGCTTA
TCAGGTTCGTGAATATTTTCATAAAGCTCAACGGGCTATTGCAGAGAAATTTGGTTTGCTTGCGGGGCAGCATGTGGTGA
TTACCGCAGGCCCAACGCGAGAGGCGATTGATCCAGTACGTTATATTTCCAATCATAGTACTGGAAAAATGGGATTCTCT
TTGGCTGCAGCCTGCTATGCAGCGGGTGCTAAAGTATCTTTAATTGCAGGGCCAGTGAGTTTGGATACCCCGAATGGTGT
CAAGCGGGTTAATGTGTCCTCAGCGGTACAGATGTTGGATGAAAGCCTGAAAACTTTAGAGCAGGGCTGTGATATTTTTA
TAGCGACTGCTGCCGTAGCGGATTATCGCGTTGCTCAAGTTTCAGATCAGAAAATTAAAAAATCAGGTGATGAACTTGAG
GTCAGTCTGATCAAAAATCCTGATATTGTGGCCACCATTGCCCAACAAGCTCAAAGACCCTTTATGGTAGGTTTTGCCGC
CGAAACACAAAATGTTGAAGAATATGCTGCTGGCAAGCTGGTTGCCAAGAATCTGGATATGATCGCTTGCAATGATGTAT
CACGTAAAGATATTGGATTTGCATCTGATGAAAATGCCATGGTGGTGTTTTTTGCAGAGCAATATCACTTGAAAAAACGT
GAATTAGAAAAAGCGTCTAAACAGGAAATTGCCCAGCAATTGGTTGAATCTATTTCGGATGCCTTACGACGAAAACTGTA
A

Upstream 100 bases:

>100_bases
ATAGATTGATTCATTATGATAAAAGTATGTACGTTGTAGTTTTGATTTGAAAATGACAATCACTTGGGTCAATTCATATT
TAATGCTATTGTGAGCGCCA

Downstream 100 bases:

>100_bases
ATCAAATAGTTATATTGTTTAGCTAAAGCTCCTGAAAAAGGAGCTTTATGTTTTTTGAGAAACCAGATATTTTGGTGAGG
CAGATAACCTGCACATCAAT

Product: bifunctional 4'-phosphopantothenoylcysteine decarboxylase/phosphopantothenoylcysteine synthetase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MQQKGKLFVSFDLSVIPNKNIILAVTGGIAAYKSAILVRRLKDYGFDVRVVMTHGAQAFITPLTFQALSGYPVHTELLDP
EAEAGMGHIELARWADLILVAPASCDTLAKFAQGLADDLLSTLYLATKAPVWVAPAMNQQMWAAKATQRNLQTLVDDGVH
VIMPDAGAQACGDVGLGRMPEPEQLAYQVREYFHKAQRAIAEKFGLLAGQHVVITAGPTREAIDPVRYISNHSTGKMGFS
LAAACYAAGAKVSLIAGPVSLDTPNGVKRVNVSSAVQMLDESLKTLEQGCDIFIATAAVADYRVAQVSDQKIKKSGDELE
VSLIKNPDIVATIAQQAQRPFMVGFAAETQNVEEYAAGKLVAKNLDMIACNDVSRKDIGFASDENAMVVFFAEQYHLKKR
ELEKASKQEIAQQLVESISDALRRKL

Sequences:

>Translated_426_residues
MQQKGKLFVSFDLSVIPNKNIILAVTGGIAAYKSAILVRRLKDYGFDVRVVMTHGAQAFITPLTFQALSGYPVHTELLDP
EAEAGMGHIELARWADLILVAPASCDTLAKFAQGLADDLLSTLYLATKAPVWVAPAMNQQMWAAKATQRNLQTLVDDGVH
VIMPDAGAQACGDVGLGRMPEPEQLAYQVREYFHKAQRAIAEKFGLLAGQHVVITAGPTREAIDPVRYISNHSTGKMGFS
LAAACYAAGAKVSLIAGPVSLDTPNGVKRVNVSSAVQMLDESLKTLEQGCDIFIATAAVADYRVAQVSDQKIKKSGDELE
VSLIKNPDIVATIAQQAQRPFMVGFAAETQNVEEYAAGKLVAKNLDMIACNDVSRKDIGFASDENAMVVFFAEQYHLKKR
ELEKASKQEIAQQLVESISDALRRKL
>Mature_426_residues
MQQKGKLFVSFDLSVIPNKNIILAVTGGIAAYKSAILVRRLKDYGFDVRVVMTHGAQAFITPLTFQALSGYPVHTELLDP
EAEAGMGHIELARWADLILVAPASCDTLAKFAQGLADDLLSTLYLATKAPVWVAPAMNQQMWAAKATQRNLQTLVDDGVH
VIMPDAGAQACGDVGLGRMPEPEQLAYQVREYFHKAQRAIAEKFGLLAGQHVVITAGPTREAIDPVRYISNHSTGKMGFS
LAAACYAAGAKVSLIAGPVSLDTPNGVKRVNVSSAVQMLDESLKTLEQGCDIFIATAAVADYRVAQVSDQKIKKSGDELE
VSLIKNPDIVATIAQQAQRPFMVGFAAETQNVEEYAAGKLVAKNLDMIACNDVSRKDIGFASDENAMVVFFAEQYHLKKR
ELEKASKQEIAQQLVESISDALRRKL

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=184, Percent_Identity=34.2391304347826, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI87082301, Length=410, Percent_Identity=52.1951219512195, Blast_Score=397, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17560194, Length=169, Percent_Identity=33.7278106508876, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322762, Length=208, Percent_Identity=28.8461538461538, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322925, Length=210, Percent_Identity=26.1904761904762, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24657262, Length=175, Percent_Identity=30.8571428571429, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 46136; Mature: 46136

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQKGKLFVSFDLSVIPNKNIILAVTGGIAAYKSAILVRRLKDYGFDVRVVMTHGAQAFI
CCCCCCEEEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEE
TPLTFQALSGYPVHTELLDPEAEAGMGHIELARWADLILVAPASCDTLAKFAQGLADDLL
CHHHHHHHCCCCCCHHCCCCCHHCCCCCEEHHHHCCEEEECCCCHHHHHHHHHHHHHHHH
STLYLATKAPVWVAPAMNQQMWAAKATQRNLQTLVDDGVHVIMPDAGAQACGDVGLGRMP
HHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHCCCCCCCCC
EPEQLAYQVREYFHKAQRAIAEKFGLLAGQHVVITAGPTREAIDPVRYISNHSTGKMGFS
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCCCCHHHH
LAAACYAAGAKVSLIAGPVSLDTPNGVKRVNVSSAVQMLDESLKTLEQGCDIFIATAAVA
HHHHHHHCCCEEEEEECCEECCCCCCCEEECHHHHHHHHHHHHHHHHCCCCEEEEEHHHH
DYRVAQVSDQKIKKSGDELEVSLIKNPDIVATIAQQAQRPFMVGFAAETQNVEEYAAGKL
HHHHHHCCHHHHHCCCCCEEEEEECCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHH
VAKNLDMIACNDVSRKDIGFASDENAMVVFFAEQYHLKKRELEKASKQEIAQQLVESISD
HHCCCCEEEECCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALRRKL
HHHHCC
>Mature Secondary Structure
MQQKGKLFVSFDLSVIPNKNIILAVTGGIAAYKSAILVRRLKDYGFDVRVVMTHGAQAFI
CCCCCCEEEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEE
TPLTFQALSGYPVHTELLDPEAEAGMGHIELARWADLILVAPASCDTLAKFAQGLADDLL
CHHHHHHHCCCCCCHHCCCCCHHCCCCCEEHHHHCCEEEECCCCHHHHHHHHHHHHHHHH
STLYLATKAPVWVAPAMNQQMWAAKATQRNLQTLVDDGVHVIMPDAGAQACGDVGLGRMP
HHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHCCCCCCCCC
EPEQLAYQVREYFHKAQRAIAEKFGLLAGQHVVITAGPTREAIDPVRYISNHSTGKMGFS
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCCCCHHHH
LAAACYAAGAKVSLIAGPVSLDTPNGVKRVNVSSAVQMLDESLKTLEQGCDIFIATAAVA
HHHHHHHCCCEEEEEECCEECCCCCCCEEECHHHHHHHHHHHHHHHHCCCCEEEEEHHHH
DYRVAQVSDQKIKKSGDELEVSLIKNPDIVATIAQQAQRPFMVGFAAETQNVEEYAAGKL
HHHHHHCCHHHHHCCCCCEEEEEECCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHH
VAKNLDMIACNDVSRKDIGFASDENAMVVFFAEQYHLKKRELEKASKQEIAQQLVESISD
HHCCCCEEEECCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALRRKL
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA