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The map label for this gene is cysM [H]

Identifier: 50086082

GI number: 50086082

Start: 2997387

End: 2998310

Strand: Reverse

Name: cysM [H]

Synonym: ACIAD3071

Alternate gene names: 50086082

Gene position: 2998310-2997387 (Counterclockwise)

Preceding gene: 50086088

Following gene: 50086081

Centisome position: 83.32

GC content: 43.94

Gene sequence:

>924_bases
ATGAACACAGTAGAACCTAATTTTTTAGCTGATGAGTTTTTGTTAGATCATTATGTTGGAAAGACGCCATTGGTGCGATT
ACAGCGTTTGGCGTGTCATACACAATCGGTAGTATTGGCAAAATTAGAAGGCAACAATCCAGCAGGATCCGTTAAAGATC
GCCCTGCTTATAACATGATCATGCAAGCTGAAAAGCGTGGAAAGATTCGACCAGGCGATACATTGATTGAAGCAACCAGC
GGAAATACAGGAATTGCCTTGGCGATGGTTGCGGCCATGCGTGGTTATAAAATGAAGCTGATTATGCCCAATAACATGAG
CCAAGAGCGTAAAGATGCAATGTTGGCTTATGGTGCAGAGTTGATTGAAGTGACTCAGCAACAAGGCATGGAAGGCGCTC
GTGATTTAGCCTTGAAAATGCAATCAGAAGGTCAGGGGCTTGTTTTAAACCAGTTTGGTAATCCTGATAATGTTGAAGCA
CATTATCTCACCACTGGCCCTGAAATCTGGCAGCAGACTAATGGAAAAATCACGCATTTTGTGAGTTCGATGGGAACGAC
GGGCACCATTATGGGTGTATCAAAATATCTAAAAGAGCAAAATCCAGATATCCAGATTGTCGGTTTACAACCATCTGAAG
GATCAAGCATTGCGGGGATTCGACGTTGGCCACAAGAATATTTGCCAACCATTTTTGAACCGTCACGTGTCGATCGAATT
ATTGATATTCCGCAAATCGAAGCTGAAAAAACCATGCGCCGTCTTGCCAGAGAAGAAGGAATTAGTGCAGGAACTTCTTC
GGGGGGTGCAGTGTGGGCATCTCTCAAGATTGCGGAAGAGCAGCCCGATGCAGTCATTGTTTGTATTATTTGTGATCGCG
GTGATCGTTACTTGTCGACTGGACTATTTTCGGTTCAAGATTGA

Upstream 100 bases:

>100_bases
GATGGGGCTTTAAGCAAGCTTGAGAAAAACCTGAGGGAAAGGAGTGCAGGCGAGGTGTTTTTTTCATACAATAGCCGTCA
CCTTGATTCAGGTGTTGATC

Downstream 100 bases:

>100_bases
GCGATAAGTTATTTGCAAGCTGAGAGAGTTTGATGCGTTTTCCGACACTGGTTTTTGATATTGAAACACTCACCGATTTA
AAAGCGGGTGCGCATTTATA

Product: cysteine synthase B

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MNTVEPNFLADEFLLDHYVGKTPLVRLQRLACHTQSVVLAKLEGNNPAGSVKDRPAYNMIMQAEKRGKIRPGDTLIEATS
GNTGIALAMVAAMRGYKMKLIMPNNMSQERKDAMLAYGAELIEVTQQQGMEGARDLALKMQSEGQGLVLNQFGNPDNVEA
HYLTTGPEIWQQTNGKITHFVSSMGTTGTIMGVSKYLKEQNPDIQIVGLQPSEGSSIAGIRRWPQEYLPTIFEPSRVDRI
IDIPQIEAEKTMRRLAREEGISAGTSSGGAVWASLKIAEEQPDAVIVCIICDRGDRYLSTGLFSVQD

Sequences:

>Translated_307_residues
MNTVEPNFLADEFLLDHYVGKTPLVRLQRLACHTQSVVLAKLEGNNPAGSVKDRPAYNMIMQAEKRGKIRPGDTLIEATS
GNTGIALAMVAAMRGYKMKLIMPNNMSQERKDAMLAYGAELIEVTQQQGMEGARDLALKMQSEGQGLVLNQFGNPDNVEA
HYLTTGPEIWQQTNGKITHFVSSMGTTGTIMGVSKYLKEQNPDIQIVGLQPSEGSSIAGIRRWPQEYLPTIFEPSRVDRI
IDIPQIEAEKTMRRLAREEGISAGTSSGGAVWASLKIAEEQPDAVIVCIICDRGDRYLSTGLFSVQD
>Mature_307_residues
MNTVEPNFLADEFLLDHYVGKTPLVRLQRLACHTQSVVLAKLEGNNPAGSVKDRPAYNMIMQAEKRGKIRPGDTLIEATS
GNTGIALAMVAAMRGYKMKLIMPNNMSQERKDAMLAYGAELIEVTQQQGMEGARDLALKMQSEGQGLVLNQFGNPDNVEA
HYLTTGPEIWQQTNGKITHFVSSMGTTGTIMGVSKYLKEQNPDIQIVGLQPSEGSSIAGIRRWPQEYLPTIFEPSRVDRI
IDIPQIEAEKTMRRLAREEGISAGTSSGGAVWASLKIAEEQPDAVIVCIICDRGDRYLSTGLFSVQD

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=304, Percent_Identity=36.5131578947368, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI295821200, Length=304, Percent_Identity=36.5131578947368, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI4557415, Length=304, Percent_Identity=36.5131578947368, Blast_Score=176, Evalue=2e-44,
Organism=Escherichia coli, GI2367138, Length=289, Percent_Identity=68.8581314878893, Blast_Score=416, Evalue=1e-117,
Organism=Escherichia coli, GI1788754, Length=305, Percent_Identity=44.2622950819672, Blast_Score=209, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17535051, Length=297, Percent_Identity=41.7508417508418, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17562970, Length=297, Percent_Identity=41.4141414141414, Blast_Score=210, Evalue=8e-55,
Organism=Caenorhabditis elegans, GI32566674, Length=291, Percent_Identity=41.5807560137457, Blast_Score=204, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI115535073, Length=297, Percent_Identity=40.7407407407407, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17561720, Length=297, Percent_Identity=40.4040404040404, Blast_Score=182, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI25147552, Length=278, Percent_Identity=38.1294964028777, Blast_Score=141, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI32566672, Length=213, Percent_Identity=38.4976525821596, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17534315, Length=309, Percent_Identity=35.5987055016181, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6321594, Length=309, Percent_Identity=38.8349514563107, Blast_Score=171, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6321449, Length=326, Percent_Identity=32.5153374233129, Blast_Score=128, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24643623, Length=320, Percent_Identity=36.875, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI20129101, Length=320, Percent_Identity=36.875, Blast_Score=155, Evalue=5e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33714; Mature: 33714

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTVEPNFLADEFLLDHYVGKTPLVRLQRLACHTQSVVLAKLEGNNPAGSVKDRPAYNMI
CCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHH
MQAEKRGKIRPGDTLIEATSGNTGIALAMVAAMRGYKMKLIMPNNMSQERKDAMLAYGAE
HHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHH
LIEVTQQQGMEGARDLALKMQSEGQGLVLNQFGNPDNVEAHYLTTGPEIWQQTNGKITHF
HHHHHHHHCCCHHHHHHEEECCCCCEEEEECCCCCCCCEEEEEECCHHHHHHCCCCCEEH
VSSMGTTGTIMGVSKYLKEQNPDIQIVGLQPSEGSSIAGIRRWPQEYLPTIFEPSRVDRI
HHHCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHCCHHHCCCCCCCHHHHHE
IDIPQIEAEKTMRRLAREEGISAGTSSGGAVWASLKIAEEQPDAVIVCIICDRGDRYLST
ECCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCEEEEEEEECCCCCCHHC
GLFSVQD
CCEEECC
>Mature Secondary Structure
MNTVEPNFLADEFLLDHYVGKTPLVRLQRLACHTQSVVLAKLEGNNPAGSVKDRPAYNMI
CCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHH
MQAEKRGKIRPGDTLIEATSGNTGIALAMVAAMRGYKMKLIMPNNMSQERKDAMLAYGAE
HHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHH
LIEVTQQQGMEGARDLALKMQSEGQGLVLNQFGNPDNVEAHYLTTGPEIWQQTNGKITHF
HHHHHHHHCCCHHHHHHEEECCCCCEEEEECCCCCCCCEEEEEECCHHHHHHCCCCCEEH
VSSMGTTGTIMGVSKYLKEQNPDIQIVGLQPSEGSSIAGIRRWPQEYLPTIFEPSRVDRI
HHHCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHCCHHHCCCCCCCHHHHHE
IDIPQIEAEKTMRRLAREEGISAGTSSGGAVWASLKIAEEQPDAVIVCIICDRGDRYLST
ECCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCEEEEEEEECCCCCCHHC
GLFSVQD
CCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]