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The map label for this gene is thrS

Identifier: 50086067

GI number: 50086067

Start: 2981193

End: 2983115

Strand: Reverse

Name: thrS

Synonym: ACIAD3055

Alternate gene names: 50086067

Gene position: 2983115-2981193 (Counterclockwise)

Preceding gene: 50086069

Following gene: 50086066

Centisome position: 82.9

GC content: 43.06

Gene sequence:

>1923_bases
ATGCCAATTATCACATTGCCAAATGGCGATCAAAAATCATTTGATCAACCTGTCTCCGTTATGCAAGTCGCCCAAAGTAT
AGGGCCTGGTCTTGCTAAAAATACCGTCGCGGGTCGTGTTAATGATCGTCTAGTCGATGCATGTGACCTGATCACTGAAG
ATGCCACCTTGCAGATTATTACGCCTAAAGATCCTGAAGGTGTGGAAATCATTCGTCACTCTTGTGCACATCTGGTTGGA
CATGCGGTAAAACAATTGTTTCCAGACGTACAGATGGTCATTGGTCCAGTGATTGAAGAAGGGTTTTACTACGACATCTT
TAGTCCAAAGCCATTTACGCTAGACGACATGGCTGCAATCGAAGCGCGTATGAAGCAATTGATTGATCAGGACTATGATG
TTGTAAAAAAAATGACACCAAGAGAACAAGTCATTCAAGAATTTACAACACGTGGTGAAACCTACAAGCTACGCTTGATT
GATGACATGCCCGAAGAAACTCAAATGGGTTTGTACTATCATCAAGAATACGTTGACATGTGCCGTGGTCCGCATGTACC
AAACACTAAGTTTCTGAAAAATTTTAAATTAACAAAAATTTCTGGTGCATATTGGCGCGGTGATGCCAAAAATGAACAGC
TTCAGCGTATTTACGGTACTGCTTGGTCAGACAAGAAAGAACTCGCAGCCTATATTAAGCGTATTGAAGAAGCTGAAAAA
CGTGATCACCGTAAAATTGGTAAAGCACTTGATTTGTTTCATATGCAGGAAGAAGCACCAGGTATGGTGTTTTGGCACGC
CAATGGCTGGACCATTTATCAAGCGCTTGAACAATACATGCGTAAAGTTCAGCAAGACAACGGCTACCAAGAAGTCCGTA
CGCCACAAATTGTCGACTTTACACTTTGGGAAAAGTCGGGACATGCTGCCAATTATGCAGAAAACATGTTTACCACACAT
TCAGAAAGCCGTAACTATGCCGTCAAGCCAATGAACTGTCCATGTCACGTACAGGTTTTTAATCAAGGCTTGAAATCGTA
CCGTGACCTTCCTGTGCGTTTGGCTGAGTTTGGTTCGTGTCACCGTAACGAGCCGTCAGGTTCATTGCACGGTATTATGC
GTGTACGTGGCTTTACTCAAGACGATGGTCATATTTTCTGTACCAAAGAACAGATTGGTAAAGAAGTGGCAGACTTTATT
CAGTTGACGCTTGATGTCTACAAAGACTTTGGCTTTGAAGATGTTCAAATGAAACTGTCTACGCGTCCTGAAAAACGTGT
TGGCGATGATAGACTTTGGGATTTAGCAGAAAAATCATTGGCTGATGCCTTGGATGCTGCGGGTCTTGAATGGGAATTAC
AGCCGGGTGAAGGTGCATTCTACGGTCCAAAAATTGAATTCTCGTTGAAAGATTGCTTAGGCCGTGTCTGGCAATGCGGT
ACCATTCAATGTGACTTTAACTTACCAATACGTCTAGATGCTTCTTTTGTGACAGAAGACAATGAACGTGATCAGCCTGT
GATGTTGCACCGTGCAATACTTGGCAGTTTCGAGCGTTTTATTGGTATACTTATTGAACACTATGCGGGTTTTATGCCAC
CTTGGTTGGCGCCAGTGCAAGCTTGCGTGATGAATATTACCGATTCACAGGCTGAAGCATGTCAACAAGTGGTGGCAAAA
CTCAAAGAAAATGGTCTTAGAGCGATTTCTGACTTGAGAAATGAGAAAATCGGCTTTAAGATTCGTGAGCGTACACTTGA
GCGTATTCCGTACCTTTTAGTATTAGGTGACCGTGAGGTTGAGGAAGGTACTGTTAATGTTCGTACTCGCTCAGGAAAAA
ATTTAGGTACTATGTCAATCGATGCATTCGTTGACTTAGTGAAATCTGCCGTTGCCGAACGTGGCCGGTACATTGTGGAG
TAA

Upstream 100 bases:

>100_bases
TTTATTCATCCACCGTTTTTATCTTTTGAGGCTTACCTCGATCATAATCTCGCGGTGATATGCTCCATTGTGCGGGGCAT
CACTCCTTAAGGATTTTCTT

Downstream 100 bases:

>100_bases
GAGAGATTAAACAGCCTGACCGTAACCAACAACAAGGTGCAAAGAGTAACCGTCCTGCGATTAATGACGAGATTCGTTCT
AAAGAAGTGCGTCTCGTTGG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 640; Mature: 639

Protein sequence:

>640_residues
MPIITLPNGDQKSFDQPVSVMQVAQSIGPGLAKNTVAGRVNDRLVDACDLITEDATLQIITPKDPEGVEIIRHSCAHLVG
HAVKQLFPDVQMVIGPVIEEGFYYDIFSPKPFTLDDMAAIEARMKQLIDQDYDVVKKMTPREQVIQEFTTRGETYKLRLI
DDMPEETQMGLYYHQEYVDMCRGPHVPNTKFLKNFKLTKISGAYWRGDAKNEQLQRIYGTAWSDKKELAAYIKRIEEAEK
RDHRKIGKALDLFHMQEEAPGMVFWHANGWTIYQALEQYMRKVQQDNGYQEVRTPQIVDFTLWEKSGHAANYAENMFTTH
SESRNYAVKPMNCPCHVQVFNQGLKSYRDLPVRLAEFGSCHRNEPSGSLHGIMRVRGFTQDDGHIFCTKEQIGKEVADFI
QLTLDVYKDFGFEDVQMKLSTRPEKRVGDDRLWDLAEKSLADALDAAGLEWELQPGEGAFYGPKIEFSLKDCLGRVWQCG
TIQCDFNLPIRLDASFVTEDNERDQPVMLHRAILGSFERFIGILIEHYAGFMPPWLAPVQACVMNITDSQAEACQQVVAK
LKENGLRAISDLRNEKIGFKIRERTLERIPYLLVLGDREVEEGTVNVRTRSGKNLGTMSIDAFVDLVKSAVAERGRYIVE

Sequences:

>Translated_640_residues
MPIITLPNGDQKSFDQPVSVMQVAQSIGPGLAKNTVAGRVNDRLVDACDLITEDATLQIITPKDPEGVEIIRHSCAHLVG
HAVKQLFPDVQMVIGPVIEEGFYYDIFSPKPFTLDDMAAIEARMKQLIDQDYDVVKKMTPREQVIQEFTTRGETYKLRLI
DDMPEETQMGLYYHQEYVDMCRGPHVPNTKFLKNFKLTKISGAYWRGDAKNEQLQRIYGTAWSDKKELAAYIKRIEEAEK
RDHRKIGKALDLFHMQEEAPGMVFWHANGWTIYQALEQYMRKVQQDNGYQEVRTPQIVDFTLWEKSGHAANYAENMFTTH
SESRNYAVKPMNCPCHVQVFNQGLKSYRDLPVRLAEFGSCHRNEPSGSLHGIMRVRGFTQDDGHIFCTKEQIGKEVADFI
QLTLDVYKDFGFEDVQMKLSTRPEKRVGDDRLWDLAEKSLADALDAAGLEWELQPGEGAFYGPKIEFSLKDCLGRVWQCG
TIQCDFNLPIRLDASFVTEDNERDQPVMLHRAILGSFERFIGILIEHYAGFMPPWLAPVQACVMNITDSQAEACQQVVAK
LKENGLRAISDLRNEKIGFKIRERTLERIPYLLVLGDREVEEGTVNVRTRSGKNLGTMSIDAFVDLVKSAVAERGRYIVE
>Mature_639_residues
PIITLPNGDQKSFDQPVSVMQVAQSIGPGLAKNTVAGRVNDRLVDACDLITEDATLQIITPKDPEGVEIIRHSCAHLVGH
AVKQLFPDVQMVIGPVIEEGFYYDIFSPKPFTLDDMAAIEARMKQLIDQDYDVVKKMTPREQVIQEFTTRGETYKLRLID
DMPEETQMGLYYHQEYVDMCRGPHVPNTKFLKNFKLTKISGAYWRGDAKNEQLQRIYGTAWSDKKELAAYIKRIEEAEKR
DHRKIGKALDLFHMQEEAPGMVFWHANGWTIYQALEQYMRKVQQDNGYQEVRTPQIVDFTLWEKSGHAANYAENMFTTHS
ESRNYAVKPMNCPCHVQVFNQGLKSYRDLPVRLAEFGSCHRNEPSGSLHGIMRVRGFTQDDGHIFCTKEQIGKEVADFIQ
LTLDVYKDFGFEDVQMKLSTRPEKRVGDDRLWDLAEKSLADALDAAGLEWELQPGEGAFYGPKIEFSLKDCLGRVWQCGT
IQCDFNLPIRLDASFVTEDNERDQPVMLHRAILGSFERFIGILIEHYAGFMPPWLAPVQACVMNITDSQAEACQQVVAKL
KENGLRAISDLRNEKIGFKIRERTLERIPYLLVLGDREVEEGTVNVRTRSGKNLGTMSIDAFVDLVKSAVAERGRYIVE

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=632, Percent_Identity=40.3481012658228, Blast_Score=466, Evalue=1e-131,
Organism=Homo sapiens, GI38570111, Length=633, Percent_Identity=38.7045813586098, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI20070344, Length=636, Percent_Identity=36.4779874213836, Blast_Score=387, Evalue=1e-107,
Organism=Escherichia coli, GI1788013, Length=636, Percent_Identity=62.2641509433962, Blast_Score=860, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984184, Length=630, Percent_Identity=38.0952380952381, Blast_Score=444, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI71984192, Length=630, Percent_Identity=38.0952380952381, Blast_Score=444, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6322112, Length=638, Percent_Identity=38.0877742946708, Blast_Score=435, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6322654, Length=420, Percent_Identity=38.3333333333333, Blast_Score=295, Evalue=1e-80,
Organism=Drosophila melanogaster, GI24583842, Length=627, Percent_Identity=39.8724082934609, Blast_Score=480, Evalue=1e-135,
Organism=Drosophila melanogaster, GI28574141, Length=627, Percent_Identity=39.8724082934609, Blast_Score=480, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24583839, Length=627, Percent_Identity=39.8724082934609, Blast_Score=479, Evalue=1e-135,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_ACIAD (Q6F860)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_047577.1
- ProteinModelPortal:   Q6F860
- SMR:   Q6F860
- STRING:   Q6F860
- GeneID:   2880751
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD3055
- NMPDR:   fig|62977.3.peg.2770
- eggNOG:   COG0441
- HOGENOM:   HBG352811
- OMA:   GFEYEVE
- PhylomeDB:   Q6F860
- ProtClustDB:   PRK00413
- BioCyc:   ASP62977:ACIAD3055-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 72997; Mature: 72866

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIITLPNGDQKSFDQPVSVMQVAQSIGPGLAKNTVAGRVNDRLVDACDLITEDATLQII
CCEEECCCCCCCCCCCHHHHHHHHHHHCCCHHHCCHHCCHHHHHHHHHHHHCCCCEEEEE
TPKDPEGVEIIRHSCAHLVGHAVKQLFPDVQMVIGPVIEEGFYYDIFSPKPFTLDDMAAI
CCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHH
EARMKQLIDQDYDVVKKMTPREQVIQEFTTRGETYKLRLIDDMPEETQMGLYYHQEYVDM
HHHHHHHHCCCHHHHHHCCCHHHHHHHHHCCCCEEEEEEECCCCCCHHCCHHHHHHHHHH
CRGPHVPNTKFLKNFKLTKISGAYWRGDAKNEQLQRIYGTAWSDKKELAAYIKRIEEAEK
HCCCCCCCHHHHHCCCEEEECCCEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
RDHRKIGKALDLFHMQEEAPGMVFWHANGWTIYQALEQYMRKVQQDNGYQEVRTPQIVDF
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHCCCCEEEE
TLWEKSGHAANYAENMFTTHSESRNYAVKPMNCPCHVQVFNQGLKSYRDLPVRLAEFGSC
EEECCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCC
HRNEPSGSLHGIMRVRGFTQDDGHIFCTKEQIGKEVADFIQLTLDVYKDFGFEDVQMKLS
CCCCCCCHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
TRPEKRVGDDRLWDLAEKSLADALDAAGLEWELQPGEGAFYGPKIEFSLKDCLGRVWQCG
CCCHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEECCEEEEEHHHHHHHHHCCC
TIQCDFNLPIRLDASFVTEDNERDQPVMLHRAILGSFERFIGILIEHYAGFMPPWLAPVQ
EEEECCCCCEEECCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
ACVMNITDSQAEACQQVVAKLKENGLRAISDLRNEKIGFKIRERTLERIPYLLVLGDREV
HHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHCCEEEEECCCCC
EEGTVNVRTRSGKNLGTMSIDAFVDLVKSAVAERGRYIVE
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PIITLPNGDQKSFDQPVSVMQVAQSIGPGLAKNTVAGRVNDRLVDACDLITEDATLQII
CEEECCCCCCCCCCCHHHHHHHHHHHCCCHHHCCHHCCHHHHHHHHHHHHCCCCEEEEE
TPKDPEGVEIIRHSCAHLVGHAVKQLFPDVQMVIGPVIEEGFYYDIFSPKPFTLDDMAAI
CCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHH
EARMKQLIDQDYDVVKKMTPREQVIQEFTTRGETYKLRLIDDMPEETQMGLYYHQEYVDM
HHHHHHHHCCCHHHHHHCCCHHHHHHHHHCCCCEEEEEEECCCCCCHHCCHHHHHHHHHH
CRGPHVPNTKFLKNFKLTKISGAYWRGDAKNEQLQRIYGTAWSDKKELAAYIKRIEEAEK
HCCCCCCCHHHHHCCCEEEECCCEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
RDHRKIGKALDLFHMQEEAPGMVFWHANGWTIYQALEQYMRKVQQDNGYQEVRTPQIVDF
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHCCCCEEEE
TLWEKSGHAANYAENMFTTHSESRNYAVKPMNCPCHVQVFNQGLKSYRDLPVRLAEFGSC
EEECCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCC
HRNEPSGSLHGIMRVRGFTQDDGHIFCTKEQIGKEVADFIQLTLDVYKDFGFEDVQMKLS
CCCCCCCHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
TRPEKRVGDDRLWDLAEKSLADALDAAGLEWELQPGEGAFYGPKIEFSLKDCLGRVWQCG
CCCHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEECCEEEEEHHHHHHHHHCCC
TIQCDFNLPIRLDASFVTEDNERDQPVMLHRAILGSFERFIGILIEHYAGFMPPWLAPVQ
EEEECCCCCEEECCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
ACVMNITDSQAEACQQVVAKLKENGLRAISDLRNEKIGFKIRERTLERIPYLLVLGDREV
HHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHCCEEEEECCCCC
EEGTVNVRTRSGKNLGTMSIDAFVDLVKSAVAERGRYIVE
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA