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The map label for this gene is ispA [H]

Identifier: 50085991

GI number: 50085991

Start: 2896765

End: 2897673

Strand: Reverse

Name: ispA [H]

Synonym: ACIAD2968

Alternate gene names: 50085991

Gene position: 2897673-2896765 (Counterclockwise)

Preceding gene: 50085994

Following gene: 50085986

Centisome position: 80.52

GC content: 44.55

Gene sequence:

>909_bases
GTGACATCGATTTCACATGTAAATGCAAATGTCTTGCAAGCAGCTCAGGAACGTATCCAGCAAGATTTAACTACAGCGCT
AGATGCTTTTGATTTACCAGAGCCTTTAAAATCGGCTGTCTATCATACCGTGATGCTGGGTGGAAAACGTGTTCGACCTG
CCTTATGTTATGCAGTTGCATCAATGGAGAAAAATCCAAATTATGCTGCTGCTCGTCGTGCAGCAGTTGCCGTTGAATTG
ATCCACTGCTATTCACTTGCGCATGATGACTTGCCTTGTATGGACAACGATTTGCTGCGTCGCGGACAACCGACCTGCCA
TGTGGCTTTTGGCGAAGATACTGCATTGTTGGCAGGTGATATTTTGCAGTCGATGGCATTTGAGGTGCTGGGCAGTCGAT
TATTTGATCAGCAAAATTCCGTCGATGCCTCGATTGTACTCAGACAGATGCAGATTTTGGCAACAGCAAGCTCTAAGATG
GTTTGTGGTCAAGTTCTTGATTTGCAGGCAGAAGGAAAGGAAATTGATCAGGAGCAACTGGAAAACATTCATCGTAATAA
AACAGGTGCGCTCATACAGGCCGCACTCATGATGGGTGCAGTGACCCTATTTAGTGGGATGGATCAGGCTATTCCTCATT
TACGTCAGTTTGGGCAACGGATTGGTCTGGCATTTCAGGTACAGGATGATATTCTGGATATTATTTCGAGTACCGAAACA
TTAGGTAAAACGGCTGGTAAAGATCAGCAGGTTCAAAAATCAACTTATCCAGCATTGATGGGCCTGGACGCTGCGCAGAA
TTATGCCAAAAACTTGCATGATCAGGCTTTGGCTTCTCTGGATTATTTTGGTGATGCTGCTATCGAGTTACAGCAGATCG
TGCAGTTTTTATTATCGCGAAAAAGTTAA

Upstream 100 bases:

>100_bases
TTCAATTCTTCTTCAATATTTACGCAGCAAGCTTTGACTCAACACTAGAATTTCATCGACAATAGCCCCATGTCGACATC
CCATCTATTTCGAGGCCATT

Downstream 100 bases:

>100_bases
TTCTTCCAAAATTGTTGTATTAAAAAAGCGGTTTCATAAAAGATGAAACCGCTTTTTTATTGAATGCGTCTGGCTTTAGT
TTTGTGAACGGCCCATCACA

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MTSISHVNANVLQAAQERIQQDLTTALDAFDLPEPLKSAVYHTVMLGGKRVRPALCYAVASMEKNPNYAAARRAAVAVEL
IHCYSLAHDDLPCMDNDLLRRGQPTCHVAFGEDTALLAGDILQSMAFEVLGSRLFDQQNSVDASIVLRQMQILATASSKM
VCGQVLDLQAEGKEIDQEQLENIHRNKTGALIQAALMMGAVTLFSGMDQAIPHLRQFGQRIGLAFQVQDDILDIISSTET
LGKTAGKDQQVQKSTYPALMGLDAAQNYAKNLHDQALASLDYFGDAAIELQQIVQFLLSRKS

Sequences:

>Translated_302_residues
MTSISHVNANVLQAAQERIQQDLTTALDAFDLPEPLKSAVYHTVMLGGKRVRPALCYAVASMEKNPNYAAARRAAVAVEL
IHCYSLAHDDLPCMDNDLLRRGQPTCHVAFGEDTALLAGDILQSMAFEVLGSRLFDQQNSVDASIVLRQMQILATASSKM
VCGQVLDLQAEGKEIDQEQLENIHRNKTGALIQAALMMGAVTLFSGMDQAIPHLRQFGQRIGLAFQVQDDILDIISSTET
LGKTAGKDQQVQKSTYPALMGLDAAQNYAKNLHDQALASLDYFGDAAIELQQIVQFLLSRKS
>Mature_301_residues
TSISHVNANVLQAAQERIQQDLTTALDAFDLPEPLKSAVYHTVMLGGKRVRPALCYAVASMEKNPNYAAARRAAVAVELI
HCYSLAHDDLPCMDNDLLRRGQPTCHVAFGEDTALLAGDILQSMAFEVLGSRLFDQQNSVDASIVLRQMQILATASSKMV
CGQVLDLQAEGKEIDQEQLENIHRNKTGALIQAALMMGAVTLFSGMDQAIPHLRQFGQRIGLAFQVQDDILDIISSTETL
GKTAGKDQQVQKSTYPALMGLDAAQNYAKNLHDQALASLDYFGDAAIELQQIVQFLLSRKS

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=222, Percent_Identity=30.1801801801802, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1786623, Length=272, Percent_Identity=46.3235294117647, Blast_Score=201, Evalue=7e-53,
Organism=Escherichia coli, GI1789578, Length=223, Percent_Identity=30.9417040358744, Blast_Score=91, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17505681, Length=271, Percent_Identity=26.1992619926199, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319475, Length=226, Percent_Identity=31.4159292035398, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24651612, Length=194, Percent_Identity=32.9896907216495, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32974; Mature: 32843

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSISHVNANVLQAAQERIQQDLTTALDAFDLPEPLKSAVYHTVMLGGKRVRPALCYAVA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHH
SMEKNPNYAAARRAAVAVELIHCYSLAHDDLPCMDNDLLRRGQPTCHVAFGEDTALLAGD
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCEEEEECCCHHHHHHH
ILQSMAFEVLGSRLFDQQNSVDASIVLRQMQILATASSKMVCGQVLDLQAEGKEIDQEQL
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHH
ENIHRNKTGALIQAALMMGAVTLFSGMDQAIPHLRQFGQRIGLAFQVQDDILDIISSTET
HHHHCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCEEEEEHHHHHHHHHHHHH
LGKTAGKDQQVQKSTYPALMGLDAAQNYAKNLHDQALASLDYFGDAAIELQQIVQFLLSR
HHHCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHC
KS
CC
>Mature Secondary Structure 
TSISHVNANVLQAAQERIQQDLTTALDAFDLPEPLKSAVYHTVMLGGKRVRPALCYAVA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHH
SMEKNPNYAAARRAAVAVELIHCYSLAHDDLPCMDNDLLRRGQPTCHVAFGEDTALLAGD
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCEEEEECCCHHHHHHH
ILQSMAFEVLGSRLFDQQNSVDASIVLRQMQILATASSKMVCGQVLDLQAEGKEIDQEQL
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHH
ENIHRNKTGALIQAALMMGAVTLFSGMDQAIPHLRQFGQRIGLAFQVQDDILDIISSTET
HHHHCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCEEEEEHHHHHHHHHHHHH
LGKTAGKDQQVQKSTYPALMGLDAAQNYAKNLHDQALASLDYFGDAAIELQQIVQFLLSR
HHHCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHC
KS
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2089044; 9278503 [H]