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The map label for this gene is pth

Identifier: 50085940

GI number: 50085940

Start: 2845826

End: 2846407

Strand: Direct

Name: pth

Synonym: ACIAD2909

Alternate gene names: 50085940

Gene position: 2845826-2846407 (Clockwise)

Preceding gene: 50085939

Following gene: 50085941

Centisome position: 79.08

GC content: 42.61

Gene sequence:

>582_bases
GTGTCAAAAATTTCGCTAATTGTTGGTCTGGGTAATCCCGGTGCGGAATATGCCCAGACCCGTCACAATGCAGGTTTCTG
GTTTGTAGAACAACTTGCAGATCGATACAACATTACACTTAAAAAAGATCCAAAATTTCATGGATTCAGTGGCCGTGGGC
AAATTGAGGGACATGATGTTCGTCTTTTGATTCCAACAACCTTCATGAATCGTTCTGGACAAAGTGTTGTTCCCTTTTCA
AAATTTTATCAAATTTCTCCAGAAGCCATTCTAATTGCTCATGATGAGCTTGATATGGACCCAGGTGTAATTCGCTTGAA
AACAGGCGGAGGCCATGGCGGCCATAATGGTCTGCGTGATATCGTTCCCCATATTGGCGCAAACTTTCATCGTCTACGCA
TTGGTATTGGACATCCTGGCTCAAAAGATCGTGTTTCAGGTCATGTATTAGGTAAAGCTCCCCAAAATGAGCAGACACTC
ATGGAGGATGCCATTCATCATGCACTATCAAACACCAGACTTTTAGTCGATGGTCAGATTGCTCAAGCCATGAATCAAAT
CAACGCTTACAAACCAAAATAA

Upstream 100 bases:

>100_bases
TTGAAAACGTTAAAATTCAAGCGTTACAACGTCATCCTGCAAAAAACACACCTATGCACGCTGACTTCAAACGCGCGTAA
GTGAATAAAGGCGTAAATTA

Downstream 100 bases:

>100_bases
CATGAATTGTTGAACAATCATGCTTGCCATGTGTTTTGTTTCAGAGCAAAATGCGCATTTCCACCCACAATGATGTGGTC
GTGTACCGACTCAAGGACCA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MSKISLIVGLGNPGAEYAQTRHNAGFWFVEQLADRYNITLKKDPKFHGFSGRGQIEGHDVRLLIPTTFMNRSGQSVVPFS
KFYQISPEAILIAHDELDMDPGVIRLKTGGGHGGHNGLRDIVPHIGANFHRLRIGIGHPGSKDRVSGHVLGKAPQNEQTL
MEDAIHHALSNTRLLVDGQIAQAMNQINAYKPK

Sequences:

>Translated_193_residues
MSKISLIVGLGNPGAEYAQTRHNAGFWFVEQLADRYNITLKKDPKFHGFSGRGQIEGHDVRLLIPTTFMNRSGQSVVPFS
KFYQISPEAILIAHDELDMDPGVIRLKTGGGHGGHNGLRDIVPHIGANFHRLRIGIGHPGSKDRVSGHVLGKAPQNEQTL
MEDAIHHALSNTRLLVDGQIAQAMNQINAYKPK
>Mature_192_residues
SKISLIVGLGNPGAEYAQTRHNAGFWFVEQLADRYNITLKKDPKFHGFSGRGQIEGHDVRLLIPTTFMNRSGQSVVPFSK
FYQISPEAILIAHDELDMDPGVIRLKTGGGHGGHNGLRDIVPHIGANFHRLRIGIGHPGSKDRVSGHVLGKAPQNEQTLM
EDAIHHALSNTRLLVDGQIAQAMNQINAYKPK

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=178, Percent_Identity=33.7078651685393, Blast_Score=91, Evalue=8e-19,
Organism=Escherichia coli, GI1787455, Length=190, Percent_Identity=55.2631578947368, Blast_Score=201, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6321983, Length=180, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_ACIAD (Q6F8I7)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_047450.1
- ProteinModelPortal:   Q6F8I7
- SMR:   Q6F8I7
- STRING:   Q6F8I7
- GeneID:   2879340
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD2909
- NMPDR:   fig|62977.3.peg.2643
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- PhylomeDB:   Q6F8I7
- ProtClustDB:   PRK05426
- BioCyc:   ASP62977:ACIAD2909-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 21212; Mature: 21080

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKISLIVGLGNPGAEYAQTRHNAGFWFVEQLADRYNITLKKDPKFHGFSGRGQIEGHDV
CCCEEEEEECCCCCHHHHHHCCCCCCHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCEE
RLLIPTTFMNRSGQSVVPFSKFYQISPEAILIAHDELDMDPGVIRLKTGGGHGGHNGLRD
EEEEEEHCCCCCCCCCCCHHHHEEECCCEEEEEECCCCCCCCEEEEEECCCCCCCCCHHH
IVPHIGANFHRLRIGIGHPGSKDRVSGHVLGKAPQNEQTLMEDAIHHALSNTRLLVDGQI
HHHHCCCCEEEEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECHH
AQAMNQINAYKPK
HHHHHHHHCCCCC
>Mature Secondary Structure 
SKISLIVGLGNPGAEYAQTRHNAGFWFVEQLADRYNITLKKDPKFHGFSGRGQIEGHDV
CCEEEEEECCCCCHHHHHHCCCCCCHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCEE
RLLIPTTFMNRSGQSVVPFSKFYQISPEAILIAHDELDMDPGVIRLKTGGGHGGHNGLRD
EEEEEEHCCCCCCCCCCCHHHHEEECCCEEEEEECCCCCCCCEEEEEECCCCCCCCCHHH
IVPHIGANFHRLRIGIGHPGSKDRVSGHVLGKAPQNEQTLMEDAIHHALSNTRLLVDGQI
HHHHCCCCEEEEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECHH
AQAMNQINAYKPK
HHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA