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The map label for this gene is ftsJ

Identifier: 50085896

GI number: 50085896

Start: 2791860

End: 2792510

Strand: Reverse

Name: ftsJ

Synonym: ACIAD2854

Alternate gene names: 50085896

Gene position: 2792510-2791860 (Counterclockwise)

Preceding gene: 50085899

Following gene: 50085895

Centisome position: 77.6

GC content: 41.63

Gene sequence:

>651_bases
ATGGCGACACGCATCACCAACCAGAAGTTATCTAAAAGTAGTCGTGCGTGGATGAGAGAGCATCTGGATGATCCCTTTGT
TAAAAAGGCTCAAAAAGAGGGCTATCGAGCACGTGCTGCGTATAAACTTCTTGAAATTCAAGAAAAATATCGGCTGATCA
AACCTGGTATGACCGTAGTAGATTTGGGAGCAGCTCCAGGAAGCTGGTCTCAAATTGCTGGTAAACTTGTCGGTAGTAAG
GGATTGGTCATCGCGTCTGATATTTTGGCAATGGATACTCTGCCTGATGTGACATTCCTGCAAGGTGACTTTCGGGAAGA
AGAAGTATTCGAAAAATTGTTAAATATTTTAAATGGGCGTACTGTAGACATTGTAATTTCAGATATGGCCCCCAATACAT
CAGGTAATAGGGCAGTAGATCAGCCACGTCAGATTTATTTATGTGAATTGGCTTTAGATTTTGCTCAAAAAGTACTTGGT
CCAGATGGTCAGTTTGTCGTTAAAGTTTTCCAGGGATCAGGTTTTGATGAATTTCGTAAGCAGGTTGTCGATAGTTTTGA
TGTCCTAAAAACTGTAAAACCTGCTGCCTCTCGTGCACGATCAAAAGAAGTTTTCTTGATCGGTCAGGGCCGTAAAAAAG
CCTTGCAATAA

Upstream 100 bases:

>100_bases
ATCACATAAAAGCATATTGATTAGATACATATCCATACTGCAAGCATATTGATTTTCACGTACAATATAAGATCGGAAGT
TTTTTAATATTTAGTAAGTT

Downstream 100 bases:

>100_bases
AGTTTACTTGCCAATCTGCTAAAAATTGTGCATTTTGTACTTTTTGAAATTGCAAGCACGAGACTTGCTGTGTACTACGG
TCAACCCATGTATGTGGGCA

Product: cell division protein

Products: NA

Alternate protein names: 23S rRNA Um2552 methyltransferase; rRNA (uridine-2'-O-)-methyltransferase

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MATRITNQKLSKSSRAWMREHLDDPFVKKAQKEGYRARAAYKLLEIQEKYRLIKPGMTVVDLGAAPGSWSQIAGKLVGSK
GLVIASDILAMDTLPDVTFLQGDFREEEVFEKLLNILNGRTVDIVISDMAPNTSGNRAVDQPRQIYLCELALDFAQKVLG
PDGQFVVKVFQGSGFDEFRKQVVDSFDVLKTVKPAASRARSKEVFLIGQGRKKALQ

Sequences:

>Translated_216_residues
MATRITNQKLSKSSRAWMREHLDDPFVKKAQKEGYRARAAYKLLEIQEKYRLIKPGMTVVDLGAAPGSWSQIAGKLVGSK
GLVIASDILAMDTLPDVTFLQGDFREEEVFEKLLNILNGRTVDIVISDMAPNTSGNRAVDQPRQIYLCELALDFAQKVLG
PDGQFVVKVFQGSGFDEFRKQVVDSFDVLKTVKPAASRARSKEVFLIGQGRKKALQ
>Mature_215_residues
ATRITNQKLSKSSRAWMREHLDDPFVKKAQKEGYRARAAYKLLEIQEKYRLIKPGMTVVDLGAAPGSWSQIAGKLVGSKG
LVIASDILAMDTLPDVTFLQGDFREEEVFEKLLNILNGRTVDIVISDMAPNTSGNRAVDQPRQIYLCELALDFAQKVLGP
DGQFVVKVFQGSGFDEFRKQVVDSFDVLKTVKPAASRARSKEVFLIGQGRKKALQ

Specific function: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit

COG id: COG0293

COG function: function code J; 23S rRNA methylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RlmE family

Homologues:

Organism=Homo sapiens, GI7019377, Length=224, Percent_Identity=36.6071428571429, Blast_Score=161, Evalue=4e-40,
Organism=Homo sapiens, GI29029591, Length=189, Percent_Identity=36.5079365079365, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI29029589, Length=189, Percent_Identity=36.5079365079365, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI7110661, Length=189, Percent_Identity=36.5079365079365, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI194097365, Length=187, Percent_Identity=32.620320855615, Blast_Score=115, Evalue=2e-26,
Organism=Escherichia coli, GI1789569, Length=208, Percent_Identity=53.8461538461538, Blast_Score=227, Evalue=5e-61,
Organism=Caenorhabditis elegans, GI17553474, Length=205, Percent_Identity=36.5853658536585, Blast_Score=127, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI71987550, Length=186, Percent_Identity=31.7204301075269, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71987561, Length=186, Percent_Identity=31.7204301075269, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17553860, Length=186, Percent_Identity=31.7204301075269, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17554650, Length=187, Percent_Identity=31.5508021390374, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319535, Length=197, Percent_Identity=32.994923857868, Blast_Score=113, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6319796, Length=188, Percent_Identity=34.5744680851064, Blast_Score=113, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6321302, Length=125, Percent_Identity=34.4, Blast_Score=79, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21356387, Length=213, Percent_Identity=38.4976525821596, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24647580, Length=194, Percent_Identity=32.9896907216495, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI18859957, Length=187, Percent_Identity=31.5508021390374, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24648639, Length=194, Percent_Identity=32.4742268041237, Blast_Score=99, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RLME_ACIAD (Q6F8N1)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_047406.1
- ProteinModelPortal:   Q6F8N1
- SMR:   Q6F8N1
- STRING:   Q6F8N1
- GeneID:   2878830
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD2854
- NMPDR:   fig|62977.3.peg.2599
- eggNOG:   COG0293
- HOGENOM:   HBG398270
- OMA:   SDMAANT
- PhylomeDB:   Q6F8N1
- ProtClustDB:   CLSK830698
- BioCyc:   ASP62977:ACIAD2854-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01547
- InterPro:   IPR015507
- InterPro:   IPR002877
- PANTHER:   PTHR10920
- PIRSF:   PIRSF005461

Pfam domain/function: PF01728 FtsJ

EC number: =2.1.1.166

Molecular weight: Translated: 24049; Mature: 23918

Theoretical pI: Translated: 10.08; Mature: 10.08

Prosite motif: NA

Important sites: ACT_SITE 168-168 BINDING 67-67 BINDING 69-69 BINDING 87-87 BINDING 103-103 BINDING 128-128

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATRITNQKLSKSSRAWMREHLDDPFVKKAQKEGYRARAAYKLLEIQEKYRLIKPGMTVV
CCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEE
DLGAAPGSWSQIAGKLVGSKGLVIASDILAMDTLPDVTFLQGDFREEEVFEKLLNILNGR
ECCCCCCCHHHHHHHHHCCCCCEEHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHCCC
TVDIVISDMAPNTSGNRAVDQPRQIYLCELALDFAQKVLGPDGQFVVKVFQGSGFDEFRK
EEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHH
QVVDSFDVLKTVKPAASRARSKEVFLIGQGRKKALQ
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHCCC
>Mature Secondary Structure 
ATRITNQKLSKSSRAWMREHLDDPFVKKAQKEGYRARAAYKLLEIQEKYRLIKPGMTVV
CCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEE
DLGAAPGSWSQIAGKLVGSKGLVIASDILAMDTLPDVTFLQGDFREEEVFEKLLNILNGR
ECCCCCCCHHHHHHHHHCCCCCEEHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHCCC
TVDIVISDMAPNTSGNRAVDQPRQIYLCELALDFAQKVLGPDGQFVVKVFQGSGFDEFRK
EEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHH
QVVDSFDVLKTVKPAASRARSKEVFLIGQGRKKALQ
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA