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The map label for this gene is ethR [H]

Identifier: 50085844

GI number: 50085844

Start: 2741744

End: 2742349

Strand: Reverse

Name: ethR [H]

Synonym: ACIAD2793

Alternate gene names: 50085844

Gene position: 2742349-2741744 (Counterclockwise)

Preceding gene: 50085849

Following gene: 50085843

Centisome position: 76.21

GC content: 39.44

Gene sequence:

>606_bases
ATGACAACTCACCGTCGTAGACCAAAACATGATCCCAAAGAATCTGAGCAAGAAATTTTAAATGCAGCAAAGCAGTTTCT
TAATGAGCGACCTTTTCGAGAACTTACTGTAGATGAGGTTATGCGTCGAACTGGATTAAAAAGACCTGCTTTTTATGTAC
ATTTTCGTGATAAGCATGATCTTGCTTTGAGACTTGTACAGGCTATTGGTCAAGAATTATTTGGTATCGCTGATCGATGG
CTTGAGGGAGATAATCCTCAAGAAGATTTACGCAGAGCATTGGTTGGTTTAGTTGAAGTTTATATGAAACATAGCCATGT
ATTACGTGCTTTTGCAGAAGCTGCTAGTGGAGATGAGCGTGTTAATAGTATATATCGAGCTTTTGTACAGGAATTTATTT
CTGCCGCTGCTCAACATATTCGAGAAGAGCAAGCGACAGGTCAAATCCAAAAAGATATTGATATTGATGAGACTGCTCGG
GCTCTCATCTGGCTTGAAGAAAGATATCTTTCAGATGTCTTTGGAAGAATGCCCCCAGCCGATCCAGAAGTTGTGATTCG
TGTGCTTCAAAACATTTGGATATCTACACTTTATGGATCAAATTGA

Upstream 100 bases:

>100_bases
TTTTTAGAGATAGAGCCTGTACTGAATTGGTGCATTTATGCTTGTCTAAGTACTTTTTAGTGCCTACAATGACATTGTGT
CAATGAGAATATAGGAAGCC

Downstream 100 bases:

>100_bases
ACTATAAAAATTCATGTAAGGGAGTCATGAACACTCCCTTACTATCTAGAAATCAGTTTTTACTAATATATAAAAATAAT
ATTTTTTATCGATTTATCTC

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 201; Mature: 200

Protein sequence:

>201_residues
MTTHRRRPKHDPKESEQEILNAAKQFLNERPFRELTVDEVMRRTGLKRPAFYVHFRDKHDLALRLVQAIGQELFGIADRW
LEGDNPQEDLRRALVGLVEVYMKHSHVLRAFAEAASGDERVNSIYRAFVQEFISAAAQHIREEQATGQIQKDIDIDETAR
ALIWLEERYLSDVFGRMPPADPEVVIRVLQNIWISTLYGSN

Sequences:

>Translated_201_residues
MTTHRRRPKHDPKESEQEILNAAKQFLNERPFRELTVDEVMRRTGLKRPAFYVHFRDKHDLALRLVQAIGQELFGIADRW
LEGDNPQEDLRRALVGLVEVYMKHSHVLRAFAEAASGDERVNSIYRAFVQEFISAAAQHIREEQATGQIQKDIDIDETAR
ALIWLEERYLSDVFGRMPPADPEVVIRVLQNIWISTLYGSN
>Mature_200_residues
TTHRRRPKHDPKESEQEILNAAKQFLNERPFRELTVDEVMRRTGLKRPAFYVHFRDKHDLALRLVQAIGQELFGIADRWL
EGDNPQEDLRRALVGLVEVYMKHSHVLRAFAEAASGDERVNSIYRAFVQEFISAAAQHIREEQATGQIQKDIDIDETARA
LIWLEERYLSDVFGRMPPADPEVVIRVLQNIWISTLYGSN

Specific function: Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 23364; Mature: 23233

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTHRRRPKHDPKESEQEILNAAKQFLNERPFRELTVDEVMRRTGLKRPAFYVHFRDKHD
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCHHH
LALRLVQAIGQELFGIADRWLEGDNPQEDLRRALVGLVEVYMKHSHVLRAFAEAASGDER
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
VNSIYRAFVQEFISAAAQHIREEQATGQIQKDIDIDETARALIWLEERYLSDVFGRMPPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
DPEVVIRVLQNIWISTLYGSN
CHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TTHRRRPKHDPKESEQEILNAAKQFLNERPFRELTVDEVMRRTGLKRPAFYVHFRDKHD
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCHHH
LALRLVQAIGQELFGIADRWLEGDNPQEDLRRALVGLVEVYMKHSHVLRAFAEAASGDER
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
VNSIYRAFVQEFISAAAQHIREEQATGQIQKDIDIDETARALIWLEERYLSDVFGRMPPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
DPEVVIRVLQNIWISTLYGSN
CHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]