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The map label for this gene is ldc [H]

Identifier: 50085824

GI number: 50085824

Start: 2708185

End: 2709345

Strand: Reverse

Name: ldc [H]

Synonym: ACIAD2768

Alternate gene names: 50085824

Gene position: 2709345-2708185 (Counterclockwise)

Preceding gene: 50085825

Following gene: 50085823

Centisome position: 75.29

GC content: 35.23

Gene sequence:

>1161_bases
ATGAAGTTACCCCTGTATTTCCAAAGCAATATGAAAGATCATTTGGAAGATTTGGTAAGAACTAAAGATACACCATTTTT
AGTTTTAGATCTGAGTGTGATTGAAAAGCACTATTTAGAATTAAAACAAGGTTTTCCAAATACAGATATTTATTATGCAT
TGAAAGCTAATCCTGCAAATGAAGTGATTGATCGTTTAAACTCATTGGGCTCAAATTTTGATTTAGCTTCCGTTAATGAG
TTAAAAAAAGTTCAAGCATTTGGTGTTGATGCATCACGTTTAGCTTTTGGAAATACCATCAAAAAACGTATCGATATTCA
ATATTTTTATGATCAAGGCGTACGACTTTATGTCACAGATTCGGATATCGATTTAAATAACATTGCACACTATGCTCCAG
GTTCTAAGGTATTTTTTAGGTTATCAATTGATGGTTCAGAAACAGCAGATTGGCCACTTTCAGGTAAGTTTGGATGTAAT
GCTGAATGTGTTATCAGATTAGCAATAAAAGCCAAGGAATTGGGTCTCATTCCATATGGTATTTCTTTCCATGTCGGCTC
TCAACAACGAAAAATTGACTTGTGGGACAGTGCTTTACAGGAAACTAAAGCAATTTTTGATGTATTAGCCACTGAACATA
ATATTCGTCTAAAAATGCTAAATTTAGGTGGAGGATTACCTGCACAATATGTTCAGGAAACGGAAGCATTTGATAACTAT
TCTAAGCAAATTAATGCGGCACTTGAGATATTCAAGTCTTACCATCTAGAACAGATTATTTTAGAGCCAGGACGTTCATT
AGTAGGCAATGCAGGTATTTTGGTTTCTGAAATTGTTCTGATTTCACAGCGACCACAGTCGGGTACAAAGCGTTGGGTTT
ATACCGATGTTGGTGTGTTTAATGGTCTAATTGAAACATTAGGTGAATCAATCCAGTATCCAATTATGTGTAAAAAAACT
GGAAACAGTGATGACATCATATTGGCAGGTCCAACATGTGACAGTATGGATATCATGTATCAGAACAAAAAATATGAACT
CCCATTATCTCTCGAAATTGGCGATCATTTGTACTGGTTGTCGACGGGTGCATATACCACAAGTTATAGCTCGATTGAGT
TTAACGGTTTTCCACCACTGCAATATTATGCTTTGAATTAG

Upstream 100 bases:

>100_bases
TGCTTACCAAGAGTTTGCACCTTTGGAAGATGAAATTGTGACAACACTAAAAACAAAGCCTAAACCACAGCACACAAAAT
TATATTTTTAGGATATTAAA

Downstream 100 bases:

>100_bases
TTAGTTACTTGGGATGCTTTTCATTAAAAAGTATCCTTTTAATTCTTAAAATTTTGCTGTTATTTTCAAAGAGAATACTC
GTCATGAAGACAATATCAAA

Product: ornithine decarboxylase

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MKLPLYFQSNMKDHLEDLVRTKDTPFLVLDLSVIEKHYLELKQGFPNTDIYYALKANPANEVIDRLNSLGSNFDLASVNE
LKKVQAFGVDASRLAFGNTIKKRIDIQYFYDQGVRLYVTDSDIDLNNIAHYAPGSKVFFRLSIDGSETADWPLSGKFGCN
AECVIRLAIKAKELGLIPYGISFHVGSQQRKIDLWDSALQETKAIFDVLATEHNIRLKMLNLGGGLPAQYVQETEAFDNY
SKQINAALEIFKSYHLEQIILEPGRSLVGNAGILVSEIVLISQRPQSGTKRWVYTDVGVFNGLIETLGESIQYPIMCKKT
GNSDDIILAGPTCDSMDIMYQNKKYELPLSLEIGDHLYWLSTGAYTTSYSSIEFNGFPPLQYYALN

Sequences:

>Translated_386_residues
MKLPLYFQSNMKDHLEDLVRTKDTPFLVLDLSVIEKHYLELKQGFPNTDIYYALKANPANEVIDRLNSLGSNFDLASVNE
LKKVQAFGVDASRLAFGNTIKKRIDIQYFYDQGVRLYVTDSDIDLNNIAHYAPGSKVFFRLSIDGSETADWPLSGKFGCN
AECVIRLAIKAKELGLIPYGISFHVGSQQRKIDLWDSALQETKAIFDVLATEHNIRLKMLNLGGGLPAQYVQETEAFDNY
SKQINAALEIFKSYHLEQIILEPGRSLVGNAGILVSEIVLISQRPQSGTKRWVYTDVGVFNGLIETLGESIQYPIMCKKT
GNSDDIILAGPTCDSMDIMYQNKKYELPLSLEIGDHLYWLSTGAYTTSYSSIEFNGFPPLQYYALN
>Mature_386_residues
MKLPLYFQSNMKDHLEDLVRTKDTPFLVLDLSVIEKHYLELKQGFPNTDIYYALKANPANEVIDRLNSLGSNFDLASVNE
LKKVQAFGVDASRLAFGNTIKKRIDIQYFYDQGVRLYVTDSDIDLNNIAHYAPGSKVFFRLSIDGSETADWPLSGKFGCN
AECVIRLAIKAKELGLIPYGISFHVGSQQRKIDLWDSALQETKAIFDVLATEHNIRLKMLNLGGGLPAQYVQETEAFDNY
SKQINAALEIFKSYHLEQIILEPGRSLVGNAGILVSEIVLISQRPQSGTKRWVYTDVGVFNGLIETLGESIQYPIMCKKT
GNSDDIILAGPTCDSMDIMYQNKKYELPLSLEIGDHLYWLSTGAYTTSYSSIEFNGFPPLQYYALN

Specific function: Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=378, Percent_Identity=30.4232804232804, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI16506287, Length=363, Percent_Identity=28.9256198347107, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI22538418, Length=387, Percent_Identity=27.906976744186, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI21361583, Length=387, Percent_Identity=27.906976744186, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1789203, Length=385, Percent_Identity=24.9350649350649, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562780, Length=385, Percent_Identity=28.8311688311688, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6322664, Length=382, Percent_Identity=29.5811518324607, Blast_Score=149, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24586472, Length=370, Percent_Identity=29.7297297297297, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24586474, Length=372, Percent_Identity=27.4193548387097, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- InterPro:   IPR002433 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.17; =4.1.1.18 [H]

Molecular weight: Translated: 43408; Mature: 43408

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLPLYFQSNMKDHLEDLVRTKDTPFLVLDLSVIEKHYLELKQGFPNTDIYYALKANPAN
CCCCEEECCCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHCCCCCCEEEEEECCCHH
EVIDRLNSLGSNFDLASVNELKKVQAFGVDASRLAFGNTIKKRIDIQYFYDQGVRLYVTD
HHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHCCHHHHHEEEEEEECCCCEEEEEC
SDIDLNNIAHYAPGSKVFFRLSIDGSETADWPLSGKFGCNAECVIRLAIKAKELGLIPYG
CCCCHHHCEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEEHHHCCEEEEC
ISFHVGSQQRKIDLWDSALQETKAIFDVLATEHNIRLKMLNLGGGLPAQYVQETEAFDNY
EEEEECCCCCEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHH
SKQINAALEIFKSYHLEQIILEPGRSLVGNAGILVSEIVLISQRPQSGTKRWVYTDVGVF
HHHHHHHHHHHHHHCHHHHHHCCCCHHHCCCCHHHHHEEEEECCCCCCCCEEEEEHHHHH
NGLIETLGESIQYPIMCKKTGNSDDIILAGPTCDSMDIMYQNKKYELPLSLEIGDHLYWL
HHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCCEEEEECCCEEECEEEEEECCEEEEE
STGAYTTSYSSIEFNGFPPLQYYALN
ECCCEEEEECEEEECCCCCEEEEECC
>Mature Secondary Structure
MKLPLYFQSNMKDHLEDLVRTKDTPFLVLDLSVIEKHYLELKQGFPNTDIYYALKANPAN
CCCCEEECCCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHCCCCCCEEEEEECCCHH
EVIDRLNSLGSNFDLASVNELKKVQAFGVDASRLAFGNTIKKRIDIQYFYDQGVRLYVTD
HHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHCCHHHHHEEEEEEECCCCEEEEEC
SDIDLNNIAHYAPGSKVFFRLSIDGSETADWPLSGKFGCNAECVIRLAIKAKELGLIPYG
CCCCHHHCEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEEHHHCCEEEEC
ISFHVGSQQRKIDLWDSALQETKAIFDVLATEHNIRLKMLNLGGGLPAQYVQETEAFDNY
EEEEECCCCCEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHH
SKQINAALEIFKSYHLEQIILEPGRSLVGNAGILVSEIVLISQRPQSGTKRWVYTDVGVF
HHHHHHHHHHHHHHCHHHHHHCCCCHHHCCCCHHHHHEEEEECCCCCCCCEEEEEHHHHH
NGLIETLGESIQYPIMCKKTGNSDDIILAGPTCDSMDIMYQNKKYELPLSLEIGDHLYWL
HHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCCEEEEECCCEEECEEEEEECCEEEEE
STGAYTTSYSSIEFNGFPPLQYYALN
ECCCEEEEECEEEECCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11073919 [H]