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The map label for this gene is lysA [H]

Identifier: 50085728

GI number: 50085728

Start: 2614272

End: 2615522

Strand: Reverse

Name: lysA [H]

Synonym: ACIAD2660

Alternate gene names: 50085728

Gene position: 2615522-2614272 (Counterclockwise)

Preceding gene: 50085729

Following gene: 50085727

Centisome position: 72.68

GC content: 42.69

Gene sequence:

>1251_bases
ATGAGTTTCTCCCGCATTAATGGGGTATTGCATGCCGAGCAATGTTCACTCGATCAGCTCGCGCAGCAATTTGGCACACC
GCTTTATGTCTATTCAAAAGCTGCTTTTGAAAAGCATTATAAAGACATGGATCGTGCTTTTGATTTTATCGATCATCAGA
TCTGTTTTGCAGTGAAATCAAACTCTAATTTGGCGGTACTCAATGTTTTGGCAAAACTGGGTTCTGGATTTGATATTGTG
ACAGGTGGCGAACTTGCACGTGTATTGGCGGCTGGCGGTGATCCAAGCAAAATTGTATTTTCAGGTTTAGGTAAATCCGA
AGCTGATATTCAAAAAGCGCTTGAAGTTGGAATTGCCTGTTTTAATGTTGAATCTTATGCAGAGCTAGATCGAATTCAAA
AAGTAGCGGTGCGACTTGATCAAAAGGCGCCTGTTTCTTTACGAGTGAATCCTGATGTCGATGCCAAAACGCATCCTTAT
ATCTCAACAGGTTTGAAAGAAAACAAGTTTGGTATTCCAAGTGATACCGTATTTGAAACTTATCAATACGCAGCATCCCT
GTCTCATCTGGATGTTGTTGGAATTGACTGTCACATTGGTTCCCAATTGACCGAAACTAAACCTTTTGTCGATGCGCTTG
ATCGCGTGATGGTGATGATCGAGCAACTGAACAAGCTAGGAATTAACCTTAAACATATCGATATTGGCGGTGGTCTGGGG
GTTTGCTACAAAGATGAAACACCTCCAAGTGTTGCAGAGTATGCCAATGCGCTCAAACCAGCTTTAGAAAAGTTGGGTTT
AAAAGTTTACATGGAACCAGGACGTAGTATTAGTGCCAATGCTGGTGTGTTATTGACACGTGTGGATCTGCTCAAACCGA
CCAATCATCGTAACTTTGCTATTATTGATGCAGCAATGAATGATTTGATTCGTCCTTCACTTTATGAAGCATGGATGGAT
ATTCAGTCTGTGAATGAAAGCACATCAGCAGAAGCGAAAGAGTGGGATGTAGTGGGGGCTATTTGTGAAACGGGTGATTT
TTTAGGCAAAGCGCGTACGCTTGCGATTCAGGAAAATGATATTTTGGCAGTACTGGGTGCTGGCGCATATGGTTTTGTCA
TGAGCTCAAATTACAACACTCGTGGCCGTGCTGCTGAGGTCATGGTCGATGATGAAAAACCTCATCTGATTCGTGAGCGT
GAAAGCATTGAATCGTTGTGGGAAAGAGAGCGTTTGTTGCCTGAGGAGTAA

Upstream 100 bases:

>100_bases
TCCTGAAGCTGAACATACTCAAAAGGATTCTGCTAAAGAATCTGCTGCTTCTCAACCTGTATCATCTTCTTCACCTTAAG
CTAAAAATAAGGATGCATTC

Downstream 100 bases:

>100_bases
GACATGTTACTTGAGTTTACCAAAATGCATGGGTTGGGTAACGACTTCGTTGTCCTTGATCTCATCAGTCAGCGTGCCTA
TTTAGATACCACCACCATCC

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MSFSRINGVLHAEQCSLDQLAQQFGTPLYVYSKAAFEKHYKDMDRAFDFIDHQICFAVKSNSNLAVLNVLAKLGSGFDIV
TGGELARVLAAGGDPSKIVFSGLGKSEADIQKALEVGIACFNVESYAELDRIQKVAVRLDQKAPVSLRVNPDVDAKTHPY
ISTGLKENKFGIPSDTVFETYQYAASLSHLDVVGIDCHIGSQLTETKPFVDALDRVMVMIEQLNKLGINLKHIDIGGGLG
VCYKDETPPSVAEYANALKPALEKLGLKVYMEPGRSISANAGVLLTRVDLLKPTNHRNFAIIDAAMNDLIRPSLYEAWMD
IQSVNESTSAEAKEWDVVGAICETGDFLGKARTLAIQENDILAVLGAGAYGFVMSSNYNTRGRAAEVMVDDEKPHLIRER
ESIESLWERERLLPEE

Sequences:

>Translated_416_residues
MSFSRINGVLHAEQCSLDQLAQQFGTPLYVYSKAAFEKHYKDMDRAFDFIDHQICFAVKSNSNLAVLNVLAKLGSGFDIV
TGGELARVLAAGGDPSKIVFSGLGKSEADIQKALEVGIACFNVESYAELDRIQKVAVRLDQKAPVSLRVNPDVDAKTHPY
ISTGLKENKFGIPSDTVFETYQYAASLSHLDVVGIDCHIGSQLTETKPFVDALDRVMVMIEQLNKLGINLKHIDIGGGLG
VCYKDETPPSVAEYANALKPALEKLGLKVYMEPGRSISANAGVLLTRVDLLKPTNHRNFAIIDAAMNDLIRPSLYEAWMD
IQSVNESTSAEAKEWDVVGAICETGDFLGKARTLAIQENDILAVLGAGAYGFVMSSNYNTRGRAAEVMVDDEKPHLIRER
ESIESLWERERLLPEE
>Mature_415_residues
SFSRINGVLHAEQCSLDQLAQQFGTPLYVYSKAAFEKHYKDMDRAFDFIDHQICFAVKSNSNLAVLNVLAKLGSGFDIVT
GGELARVLAAGGDPSKIVFSGLGKSEADIQKALEVGIACFNVESYAELDRIQKVAVRLDQKAPVSLRVNPDVDAKTHPYI
STGLKENKFGIPSDTVFETYQYAASLSHLDVVGIDCHIGSQLTETKPFVDALDRVMVMIEQLNKLGINLKHIDIGGGLGV
CYKDETPPSVAEYANALKPALEKLGLKVYMEPGRSISANAGVLLTRVDLLKPTNHRNFAIIDAAMNDLIRPSLYEAWMDI
QSVNESTSAEAKEWDVVGAICETGDFLGKARTLAIQENDILAVLGAGAYGFVMSSNYNTRGRAAEVMVDDEKPHLIRERE
SIESLWERERLLPEE

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=238, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI22538418, Length=238, Percent_Identity=26.4705882352941, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI21361583, Length=238, Percent_Identity=26.4705882352941, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI16506287, Length=274, Percent_Identity=27.3722627737226, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1789203, Length=412, Percent_Identity=31.7961165048544, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1789307, Length=312, Percent_Identity=25.6410256410256, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562780, Length=236, Percent_Identity=27.1186440677966, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322664, Length=370, Percent_Identity=24.0540540540541, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24586474, Length=345, Percent_Identity=23.768115942029, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45646; Mature: 45515

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFSRINGVLHAEQCSLDQLAQQFGTPLYVYSKAAFEKHYKDMDRAFDFIDHQICFAVKS
CCHHHHCCCEEHHHCCHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHCCEEEEEEEC
NSNLAVLNVLAKLGSGFDIVTGGELARVLAAGGDPSKIVFSGLGKSEADIQKALEVGIAC
CCCCHHHHHHHHHCCCCEEEECHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCEEE
FNVESYAELDRIQKVAVRLDQKAPVSLRVNPDVDAKTHPYISTGLKENKFGIPSDTVFET
ECCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHCCCCCCCCCCCCHHHHHH
YQYAASLSHLDVVGIDCHIGSQLTETKPFVDALDRVMVMIEQLNKLGINLKHIDIGGGLG
HHHHHHHCCCEEEEEEEECCCCHHHCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCEE
VCYKDETPPSVAEYANALKPALEKLGLKVYMEPGRSISANAGVLLTRVDLLKPTNHRNFA
EEECCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEEHHHCCCCCCCEE
IIDAAMNDLIRPSLYEAWMDIQSVNESTSAEAKEWDVVGAICETGDFLGKARTLAIQEND
EEHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCC
ILAVLGAGAYGFVMSSNYNTRGRAAEVMVDDEKPHLIRERESIESLWERERLLPEE
EEEEEECCCEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SFSRINGVLHAEQCSLDQLAQQFGTPLYVYSKAAFEKHYKDMDRAFDFIDHQICFAVKS
CHHHHCCCEEHHHCCHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHCCEEEEEEEC
NSNLAVLNVLAKLGSGFDIVTGGELARVLAAGGDPSKIVFSGLGKSEADIQKALEVGIAC
CCCCHHHHHHHHHCCCCEEEECHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCEEE
FNVESYAELDRIQKVAVRLDQKAPVSLRVNPDVDAKTHPYISTGLKENKFGIPSDTVFET
ECCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHCCCCCCCCCCCCHHHHHH
YQYAASLSHLDVVGIDCHIGSQLTETKPFVDALDRVMVMIEQLNKLGINLKHIDIGGGLG
HHHHHHHCCCEEEEEEEECCCCHHHCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCEE
VCYKDETPPSVAEYANALKPALEKLGLKVYMEPGRSISANAGVLLTRVDLLKPTNHRNFA
EEECCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEEHHHCCCCCCCEE
IIDAAMNDLIRPSLYEAWMDIQSVNESTSAEAKEWDVVGAICETGDFLGKARTLAIQEND
EEHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCC
ILAVLGAGAYGFVMSSNYNTRGRAAEVMVDDEKPHLIRERESIESLWERERLLPEE
EEEEEECCCEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3143046; 10984043 [H]