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The map label for this gene is etfA [H]

Identifier: 50085723

GI number: 50085723

Start: 2609621

End: 2610556

Strand: Reverse

Name: etfA [H]

Synonym: ACIAD2654

Alternate gene names: 50085723

Gene position: 2610556-2609621 (Counterclockwise)

Preceding gene: 50085724

Following gene: 50085722

Centisome position: 72.54

GC content: 44.87

Gene sequence:

>936_bases
ATGAGTATTTTAGTTATCGCTGATCACAACAACCAAACACTTAACGGTGCAACGTTAAATGTTGTTGCGGCAGCACAAAA
AATCGGTGGTGATATTACTGTATTGGTTGCGGGTTCAGGCGCTCAGGCAGTTGCAGACGCTGCTGCAAAAGTGACTGGCG
TAAGCAAAGTATTACTTGCTGACAATGCAGTATATGCAAACCAACTGGCTGAAAATGTAGCCAAGCTGGTGGCTGATCTT
GCTAAAGGCGGTTACAAATATGTATTAGCAGCATCGACCACCACAGGTAAAAATATTCTTCCGCGTGCGGCTGCTTTACT
TGATGTCAGTATGATCACCGACATTATCGCGGTTGAATCTGCAAATACATTTAAGCGCCCAATCTATGCTGGTAATGCGA
TTGCAACTGTCCAATCTGACGAAGCAATTATTGTGGGTACAGTACGTGGTACAGCATTTGATCCTGTTGCTGCAGAAGGT
GGTTCTGCTGCGGTTGAAACTGTAGGTGAAGTCGCTGACGCGGGTGTTTCTTCATTCGTAAACGAAGAAATTGTTAAACT
TGATCGTCCAGAATTAACTGCTGCTCGTATTGTTGTTTCTGGTGGTCGTGGTGTGGGCTCTGGTGAAAACTATCACAAAG
TTCTTGATCCGTTAGCAGATAAACTAGGTGCTGCTCAAGGTGCGTCACGTGCTGCCGTCGATGCTGGTTTCGTTCCAAAC
GACTTTCAGGTGGGTCAAACGGGTAAAATCGTTGCCCCAGATCTTTATGTTGCGGTGGGTATCTCTGGTGCGATTCAGCA
TTTGGCTGGTATGAAAGACTCTAAAGTGATTGTTGCGATCAACAAAGATGAAGAAGCGCCAATCAACAGTGTAGCTGACT
ACTGGTTAGTGGGTGATTTGAACACTGTGATACCAGAATTGGTATCTAAACTTTAA

Upstream 100 bases:

>100_bases
CTGCTGATCGTAAAGCTGGCGTACAAGTGAAATCAGTCGATGAACTTGTTGAAAAATTAAAAAATGAAGCGAAAGTGATC
TAATACGGAAGGATAAAATC

Downstream 100 bases:

>100_bases
TTCTGTAAATTAAAGTTTAAAAGCGCTCTTGCGCGGGTAGCTAAGGTCATGCTTTGCTGCTCTGCTCAGGAGCGCTTTTT
TTATGTTAAAAAGCATGATC

Product: electron transfer flavoprotein alpha-subunit

Products: NA

Alternate protein names: Alpha-ETF; Electron transfer flavoprotein large subunit; ETFLS [H]

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MSILVIADHNNQTLNGATLNVVAAAQKIGGDITVLVAGSGAQAVADAAAKVTGVSKVLLADNAVYANQLAENVAKLVADL
AKGGYKYVLAASTTTGKNILPRAAALLDVSMITDIIAVESANTFKRPIYAGNAIATVQSDEAIIVGTVRGTAFDPVAAEG
GSAAVETVGEVADAGVSSFVNEEIVKLDRPELTAARIVVSGGRGVGSGENYHKVLDPLADKLGAAQGASRAAVDAGFVPN
DFQVGQTGKIVAPDLYVAVGISGAIQHLAGMKDSKVIVAINKDEEAPINSVADYWLVGDLNTVIPELVSKL

Sequences:

>Translated_311_residues
MSILVIADHNNQTLNGATLNVVAAAQKIGGDITVLVAGSGAQAVADAAAKVTGVSKVLLADNAVYANQLAENVAKLVADL
AKGGYKYVLAASTTTGKNILPRAAALLDVSMITDIIAVESANTFKRPIYAGNAIATVQSDEAIIVGTVRGTAFDPVAAEG
GSAAVETVGEVADAGVSSFVNEEIVKLDRPELTAARIVVSGGRGVGSGENYHKVLDPLADKLGAAQGASRAAVDAGFVPN
DFQVGQTGKIVAPDLYVAVGISGAIQHLAGMKDSKVIVAINKDEEAPINSVADYWLVGDLNTVIPELVSKL
>Mature_310_residues
SILVIADHNNQTLNGATLNVVAAAQKIGGDITVLVAGSGAQAVADAAAKVTGVSKVLLADNAVYANQLAENVAKLVADLA
KGGYKYVLAASTTTGKNILPRAAALLDVSMITDIIAVESANTFKRPIYAGNAIATVQSDEAIIVGTVRGTAFDPVAAEGG
SAAVETVGEVADAGVSSFVNEEIVKLDRPELTAARIVVSGGRGVGSGENYHKVLDPLADKLGAAQGASRAAVDAGFVPND
FQVGQTGKIVAPDLYVAVGISGAIQHLAGMKDSKVIVAINKDEEAPINSVADYWLVGDLNTVIPELVSKL

Specific function: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) [H]

COG id: COG2025

COG function: function code C; Electron transfer flavoprotein, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF alpha-subunit/fixB family [H]

Homologues:

Organism=Homo sapiens, GI4503607, Length=311, Percent_Identity=55.9485530546624, Blast_Score=336, Evalue=2e-92,
Organism=Homo sapiens, GI189181759, Length=275, Percent_Identity=57.0909090909091, Blast_Score=300, Evalue=2e-81,
Organism=Escherichia coli, GI1787990, Length=301, Percent_Identity=32.2259136212625, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786226, Length=293, Percent_Identity=31.3993174061433, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI87082157, Length=240, Percent_Identity=31.25, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17506929, Length=313, Percent_Identity=53.3546325878594, Blast_Score=303, Evalue=9e-83,
Organism=Saccharomyces cerevisiae, GI6325261, Length=293, Percent_Identity=43.6860068259386, Blast_Score=246, Evalue=3e-66,
Organism=Drosophila melanogaster, GI17136898, Length=313, Percent_Identity=59.1054313099042, Blast_Score=343, Evalue=1e-94,
Organism=Drosophila melanogaster, GI24652801, Length=313, Percent_Identity=59.1054313099042, Blast_Score=343, Evalue=1e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001308
- InterPro:   IPR014730
- InterPro:   IPR014731
- InterPro:   IPR018206
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01012 ETF; PF00766 ETF_alpha [H]

EC number: NA

Molecular weight: Translated: 31598; Mature: 31467

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00696 ETF_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILVIADHNNQTLNGATLNVVAAAQKIGGDITVLVAGSGAQAVADAAAKVTGVSKVLLA
CEEEEEECCCCCEECCCEEHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCEEEEEE
DNAVYANQLAENVAKLVADLAKGGYKYVLAASTTTGKNILPRAAALLDVSMITDIIAVES
CCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCC
ANTFKRPIYAGNAIATVQSDEAIIVGTVRGTAFDPVAAEGGSAAVETVGEVADAGVSSFV
CCHHCCCEECCCEEEEEECCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
NEEIVKLDRPELTAARIVVSGGRGVGSGENYHKVLDPLADKLGAAQGASRAAVDAGFVPN
HHHHHHCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHCCCCCCCC
DFQVGQTGKIVAPDLYVAVGISGAIQHLAGMKDSKVIVAINKDEEAPINSVADYWLVGDL
CCEECCCCCEECCCEEEEECHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHEEEECCH
NTVIPELVSKL
HHHHHHHHHCC
>Mature Secondary Structure 
SILVIADHNNQTLNGATLNVVAAAQKIGGDITVLVAGSGAQAVADAAAKVTGVSKVLLA
EEEEEECCCCCEECCCEEHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCEEEEEE
DNAVYANQLAENVAKLVADLAKGGYKYVLAASTTTGKNILPRAAALLDVSMITDIIAVES
CCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCC
ANTFKRPIYAGNAIATVQSDEAIIVGTVRGTAFDPVAAEGGSAAVETVGEVADAGVSSFV
CCHHCCCEECCCEEEEEECCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
NEEIVKLDRPELTAARIVVSGGRGVGSGENYHKVLDPLADKLGAAQGASRAAVDAGFVPN
HHHHHHCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHCCCCCCCC
DFQVGQTGKIVAPDLYVAVGISGAIQHLAGMKDSKVIVAINKDEEAPINSVADYWLVGDL
CCEECCCCCEECCCEEEEECHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHEEEECCH
NTVIPELVSKL
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]