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The map label for this gene is bccA [H]

Identifier: 50085596

GI number: 50085596

Start: 2472480

End: 2474210

Strand: Reverse

Name: bccA [H]

Synonym: ACIAD2517

Alternate gene names: 50085596

Gene position: 2474210-2472480 (Counterclockwise)

Preceding gene: 50085597

Following gene: 50085590

Centisome position: 68.75

GC content: 45.47

Gene sequence:

>1731_bases
ATGAACAATCAAAAACATAAAATTTTAATTGCCAACCGTGGTGAAATTGCAGTGCGAATTATTCAGGCGTGTAAAGATCT
GGATATTGGATCTGTGGCAATTTATGCCGACGATGATATTCAGAGTTTACATGTCAAACTGGCCGATGAAGCATGGTCAT
TGTCAGGCATCACTGCCAAAGACACTTATTTGAATATTCCACGTATTATTGAGATTGCCCAAAAATCTCAGGCAACCATG
ATTCATCCAGGCTATGGTTTTTTGTCTGAACGGGCTGAATTTGCTCAGGCTGTCCTGGATGCTGGATTGATCTGGATTGG
ACCTTCACCACACAGTATTCAAAAACTCGGCGATAAAATTGAAGCGCGTAAAATTGCTGCTTCTGTAGGGGCACCCTTGG
TACAAGGAATCTCTGAACCGTTGCAAAACTCAAAACAAGCGCTGGATTTTGCCAAGGCAGTAGGTTTGCCTATTGCCATT
AAAGCAGCTTATGGCGGTGGTGGACGTGGTCTGAAAGTGGTTTGGACACTTGAAGAAGTCGAAACGTTATATGAGTCGGC
AGTGCGTGAAGCGGTCACTGCTTTTGGACGTGGTGAGTGTTTTGTCGAGCAATATCTGGATAAGCCACGGCATATTGAAG
CGCAAATTATTGCAGATCAACATGGCCATGTCGTGGTGGTTGGTACACGTGATTGTTCTCTGCAACGCCGTAATCAAAAG
TTGGTTGAGGAAGCGCCTGCACCGTTCATTGACGACACGATTTATCAGCAAATTTTAGAATCGTCTCGTAACATCTGCCG
TGCGGCTGATTATGTTGGTGCAGGAACCGTCGAATATCTGCTGAGTCGTGATGGCAAACTCTCGTTTTTAGAGGTGAATA
CGCGATTACAAGTTGAACATCCAGTAACAGAACAGACCTCAGGCATGGATCTGGTTGCAGAGCAGATTTCAATTGCTTTG
GGTAATCCGCTGAGCGTTCAAACAACACCTGTAGCACAAGGCCATGCCATTGAGTTTCGGATGAATGCCGAAGACCCAGC
AAGAGGATTTATCCCTGCGTTTGGGCAGATTAAAACCTTTACACCACCAACGGGTTTAGGTGTACGGGTGGATACAGGCG
TGTTTTCGGGTAGTCTGGTATCTCGGCACTTCGACTCACTCATGGCTAAACTGATTATTTCTGGCCCGACACGTGACATT
TGTTTGCAACGTGCCAAACGTGCTTTGGCCGCTTTTGAAATTGACGGGGTTGCTTCAGTTTTAGCATTTCATCGTGCGAT
AGTGAACGAAGCAGATTTTGTTGATGATTTTCAAGTACACACACGCTGGATCGAGGAGAATTTTCAGCAGCAATTTGAGC
CTCAGCCACGTAGCCAGTTTACTCAGGATGCCAATTTGCAGCGTTATCCGATTGAGATTGACGGCAAAATGCACGTTGTG
GGATTACCCGCAGGTTTATTCAATACCATTGCCACTCAACCCATTGAAACCAGTTCTGAAAAAACAGCCAGTTTGACTAC
GAATGATTTACGTGCGCCGATTAACGGGGTGATTAGTACATGGAAAATACAGGAAGGGGATCAGGTCGAGCAGGGGGCTG
TTGTGGCGATTATGGAAGCCATGAAAATGGAAATTCCAGTGGTTGCTCATCAGGCTGGAAAAATCCAGCATTTGGCAGTG
CCAGGCATGACCTGTCATGCTGATCAAAAAATTGCTGAAATTCTCCAATAA

Upstream 100 bases:

>100_bases
TTGCCATTGACCATCTAGACCGTGTTGCCCAGATTCCGCCAGGTTGTTTGATACAGTTTCGTCAAAAGTCAGAAATTTTA
GATTTGGATAAAGAGTCAAC

Downstream 100 bases:

>100_bases
AGCCAGAGGATGAGTAAACTGATTCGATAGGACTTTGTGAGCCTGTAGAAACTTATCAGTTGAACGATTGAATTAAATCC
ATATCAGGACGGATCATGAC

Product: bifunctional biotin carboxylase/biotin carboxyl carrier protein

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 576; Mature: 576

Protein sequence:

>576_residues
MNNQKHKILIANRGEIAVRIIQACKDLDIGSVAIYADDDIQSLHVKLADEAWSLSGITAKDTYLNIPRIIEIAQKSQATM
IHPGYGFLSERAEFAQAVLDAGLIWIGPSPHSIQKLGDKIEARKIAASVGAPLVQGISEPLQNSKQALDFAKAVGLPIAI
KAAYGGGGRGLKVVWTLEEVETLYESAVREAVTAFGRGECFVEQYLDKPRHIEAQIIADQHGHVVVVGTRDCSLQRRNQK
LVEEAPAPFIDDTIYQQILESSRNICRAADYVGAGTVEYLLSRDGKLSFLEVNTRLQVEHPVTEQTSGMDLVAEQISIAL
GNPLSVQTTPVAQGHAIEFRMNAEDPARGFIPAFGQIKTFTPPTGLGVRVDTGVFSGSLVSRHFDSLMAKLIISGPTRDI
CLQRAKRALAAFEIDGVASVLAFHRAIVNEADFVDDFQVHTRWIEENFQQQFEPQPRSQFTQDANLQRYPIEIDGKMHVV
GLPAGLFNTIATQPIETSSEKTASLTTNDLRAPINGVISTWKIQEGDQVEQGAVVAIMEAMKMEIPVVAHQAGKIQHLAV
PGMTCHADQKIAEILQ

Sequences:

>Translated_576_residues
MNNQKHKILIANRGEIAVRIIQACKDLDIGSVAIYADDDIQSLHVKLADEAWSLSGITAKDTYLNIPRIIEIAQKSQATM
IHPGYGFLSERAEFAQAVLDAGLIWIGPSPHSIQKLGDKIEARKIAASVGAPLVQGISEPLQNSKQALDFAKAVGLPIAI
KAAYGGGGRGLKVVWTLEEVETLYESAVREAVTAFGRGECFVEQYLDKPRHIEAQIIADQHGHVVVVGTRDCSLQRRNQK
LVEEAPAPFIDDTIYQQILESSRNICRAADYVGAGTVEYLLSRDGKLSFLEVNTRLQVEHPVTEQTSGMDLVAEQISIAL
GNPLSVQTTPVAQGHAIEFRMNAEDPARGFIPAFGQIKTFTPPTGLGVRVDTGVFSGSLVSRHFDSLMAKLIISGPTRDI
CLQRAKRALAAFEIDGVASVLAFHRAIVNEADFVDDFQVHTRWIEENFQQQFEPQPRSQFTQDANLQRYPIEIDGKMHVV
GLPAGLFNTIATQPIETSSEKTASLTTNDLRAPINGVISTWKIQEGDQVEQGAVVAIMEAMKMEIPVVAHQAGKIQHLAV
PGMTCHADQKIAEILQ
>Mature_576_residues
MNNQKHKILIANRGEIAVRIIQACKDLDIGSVAIYADDDIQSLHVKLADEAWSLSGITAKDTYLNIPRIIEIAQKSQATM
IHPGYGFLSERAEFAQAVLDAGLIWIGPSPHSIQKLGDKIEARKIAASVGAPLVQGISEPLQNSKQALDFAKAVGLPIAI
KAAYGGGGRGLKVVWTLEEVETLYESAVREAVTAFGRGECFVEQYLDKPRHIEAQIIADQHGHVVVVGTRDCSLQRRNQK
LVEEAPAPFIDDTIYQQILESSRNICRAADYVGAGTVEYLLSRDGKLSFLEVNTRLQVEHPVTEQTSGMDLVAEQISIAL
GNPLSVQTTPVAQGHAIEFRMNAEDPARGFIPAFGQIKTFTPPTGLGVRVDTGVFSGSLVSRHFDSLMAKLIISGPTRDI
CLQRAKRALAAFEIDGVASVLAFHRAIVNEADFVDDFQVHTRWIEENFQQQFEPQPRSQFTQDANLQRYPIEIDGKMHVV
GLPAGLFNTIATQPIETSSEKTASLTTNDLRAPINGVISTWKIQEGDQVEQGAVVAIMEAMKMEIPVVAHQAGKIQHLAV
PGMTCHADQKIAEILQ

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=447, Percent_Identity=45.1901565995526, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI106049295, Length=447, Percent_Identity=45.1901565995526, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI106049292, Length=447, Percent_Identity=45.1901565995526, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI116805327, Length=447, Percent_Identity=40.7158836689038, Blast_Score=355, Evalue=5e-98,
Organism=Homo sapiens, GI295821183, Length=617, Percent_Identity=34.3598055105348, Blast_Score=349, Evalue=4e-96,
Organism=Homo sapiens, GI189095269, Length=450, Percent_Identity=40.4444444444444, Blast_Score=348, Evalue=1e-95,
Organism=Homo sapiens, GI65506442, Length=450, Percent_Identity=40.4444444444444, Blast_Score=348, Evalue=1e-95,
Organism=Homo sapiens, GI38679974, Length=475, Percent_Identity=28.4210526315789, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI38679960, Length=475, Percent_Identity=28.4210526315789, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI38679977, Length=475, Percent_Identity=28.4210526315789, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI38679967, Length=475, Percent_Identity=28.4210526315789, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI38679971, Length=470, Percent_Identity=28.5106382978723, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI134142062, Length=500, Percent_Identity=28.2, Blast_Score=199, Evalue=5e-51,
Organism=Escherichia coli, GI1789654, Length=429, Percent_Identity=44.0559440559441, Blast_Score=336, Evalue=2e-93,
Organism=Caenorhabditis elegans, GI17562816, Length=466, Percent_Identity=44.6351931330472, Blast_Score=367, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17567343, Length=460, Percent_Identity=38.0434782608696, Blast_Score=330, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI71987519, Length=448, Percent_Identity=39.5089285714286, Blast_Score=325, Evalue=3e-89,
Organism=Caenorhabditis elegans, GI71997168, Length=509, Percent_Identity=28.6836935166994, Blast_Score=190, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI71997163, Length=509, Percent_Identity=28.6836935166994, Blast_Score=190, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI133931226, Length=456, Percent_Identity=28.9473684210526, Blast_Score=185, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6319695, Length=466, Percent_Identity=41.2017167381974, Blast_Score=343, Evalue=5e-95,
Organism=Saccharomyces cerevisiae, GI6321376, Length=466, Percent_Identity=42.7038626609442, Blast_Score=338, Evalue=1e-93,
Organism=Saccharomyces cerevisiae, GI6319685, Length=511, Percent_Identity=37.1819960861057, Blast_Score=308, Evalue=2e-84,
Organism=Saccharomyces cerevisiae, GI6324343, Length=509, Percent_Identity=28.2907662082515, Blast_Score=199, Evalue=8e-52,
Organism=Saccharomyces cerevisiae, GI6323863, Length=467, Percent_Identity=29.3361884368308, Blast_Score=199, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24652212, Length=454, Percent_Identity=42.9515418502203, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652210, Length=454, Percent_Identity=42.9515418502203, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652214, Length=454, Percent_Identity=42.9515418502203, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI19921944, Length=454, Percent_Identity=42.9515418502203, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652216, Length=454, Percent_Identity=42.9515418502203, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI281363050, Length=454, Percent_Identity=42.9515418502203, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652224, Length=454, Percent_Identity=42.9515418502203, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652222, Length=454, Percent_Identity=42.9515418502203, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652220, Length=454, Percent_Identity=42.9515418502203, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652218, Length=454, Percent_Identity=42.9515418502203, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24651757, Length=451, Percent_Identity=40.1330376940133, Blast_Score=347, Evalue=2e-95,
Organism=Drosophila melanogaster, GI24651759, Length=415, Percent_Identity=39.2771084337349, Blast_Score=309, Evalue=3e-84,
Organism=Drosophila melanogaster, GI161076409, Length=495, Percent_Identity=27.0707070707071, Blast_Score=195, Evalue=7e-50,
Organism=Drosophila melanogaster, GI161076407, Length=495, Percent_Identity=27.0707070707071, Blast_Score=195, Evalue=7e-50,
Organism=Drosophila melanogaster, GI24586460, Length=495, Percent_Identity=27.0707070707071, Blast_Score=195, Evalue=7e-50,
Organism=Drosophila melanogaster, GI24586458, Length=495, Percent_Identity=27.0707070707071, Blast_Score=195, Evalue=8e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 62943; Mature: 62943

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNQKHKILIANRGEIAVRIIQACKDLDIGSVAIYADDDIQSLHVKLADEAWSLSGITAK
CCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCCCCCCCCEEC
DTYLNIPRIIEIAQKSQATMIHPGYGFLSERAEFAQAVLDAGLIWIGPSPHSIQKLGDKI
CCCCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHH
EARKIAASVGAPLVQGISEPLQNSKQALDFAKAVGLPIAIKAAYGGGGRGLKVVWTLEEV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEEHHHH
ETLYESAVREAVTAFGRGECFVEQYLDKPRHIEAQIIADQHGHVVVVGTRDCSLQRRNQK
HHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEEEEECCCCCEEEEECCCCCHHHHHHH
LVEEAPAPFIDDTIYQQILESSRNICRAADYVGAGTVEYLLSRDGKLSFLEVNTRLQVEH
HHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHCCCCCEEEEEECCEEEECC
PVTEQTSGMDLVAEQISIALGNPLSVQTTPVAQGHAIEFRMNAEDPARGFIPAFGQIKTF
CCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCEEEC
TPPTGLGVRVDTGVFSGSLVSRHFDSLMAKLIISGPTRDICLQRAKRALAAFEIDGVASV
CCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
LAFHRAIVNEADFVDDFQVHTRWIEENFQQQFEPQPRSQFTQDANLQRYPIEIDGKMHVV
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCEECCEEECCEEEEE
GLPAGLFNTIATQPIETSSEKTASLTTNDLRAPINGVISTWKIQEGDQVEQGAVVAIMEA
ECCHHHHHHHHCCCCCCCCCCCCEECHHHHHCCHHHHEEEEEECCCCCCCCCHHHHHHHH
MKMEIPVVAHQAGKIQHLAVPGMTCHADQKIAEILQ
HHHCCCEEECCCCCEEEEECCCCEECCHHHHHHHHC
>Mature Secondary Structure
MNNQKHKILIANRGEIAVRIIQACKDLDIGSVAIYADDDIQSLHVKLADEAWSLSGITAK
CCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCCCCCCCCEEC
DTYLNIPRIIEIAQKSQATMIHPGYGFLSERAEFAQAVLDAGLIWIGPSPHSIQKLGDKI
CCCCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHH
EARKIAASVGAPLVQGISEPLQNSKQALDFAKAVGLPIAIKAAYGGGGRGLKVVWTLEEV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEEHHHH
ETLYESAVREAVTAFGRGECFVEQYLDKPRHIEAQIIADQHGHVVVVGTRDCSLQRRNQK
HHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEEEEECCCCCEEEEECCCCCHHHHHHH
LVEEAPAPFIDDTIYQQILESSRNICRAADYVGAGTVEYLLSRDGKLSFLEVNTRLQVEH
HHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHCCCCCEEEEEECCEEEECC
PVTEQTSGMDLVAEQISIALGNPLSVQTTPVAQGHAIEFRMNAEDPARGFIPAFGQIKTF
CCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCEEEC
TPPTGLGVRVDTGVFSGSLVSRHFDSLMAKLIISGPTRDICLQRAKRALAAFEIDGVASV
CCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
LAFHRAIVNEADFVDDFQVHTRWIEENFQQQFEPQPRSQFTQDANLQRYPIEIDGKMHVV
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCEECCEEECCEEEEE
GLPAGLFNTIATQPIETSSEKTASLTTNDLRAPINGVISTWKIQEGDQVEQGAVVAIMEA
ECCHHHHHHHHCCCCCCCCCCCCEECHHHHHCCHHHHEEEEEECCCCCCCCCHHHHHHHH
MKMEIPVVAHQAGKIQHLAVPGMTCHADQKIAEILQ
HHHCCCEEECCCCCEEEEECCCCEECCHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7909542; 11234002 [H]