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The map label for this gene is atoB [H]

Identifier: 50085595

GI number: 50085595

Start: 2471171

End: 2472355

Strand: Direct

Name: atoB [H]

Synonym: ACIAD2516

Alternate gene names: 50085595

Gene position: 2471171-2472355 (Clockwise)

Preceding gene: 50085594

Following gene: 50085602

Centisome position: 68.67

GC content: 48.19

Gene sequence:

>1185_bases
TTGGATATGTCAAAAATTATGATTGCAGCAGCAGCCCGAACCCCGATGGGAAGTTTTCAGGGAAGTCTTGCTGGCTTAAC
TGCACCTGATCTGGGTGCCGTCGTCATTCAGCGCGTATTAGAACAAACACAAATTCCAGCAGCAGATATTGATGAAGTCA
TTATGGGTTGTGTTTTGCCAGCAGGACTCAAACAGGCTCCAGCACGTCAGGCCATGCGTCAAGCAGGCTTGCCCGACCAT
GTGGGGGCGACAACCATCAATAAAGTCTGTGGCTCTGGTATGAAAGCGACTATGTTTGCAGCCGATGCAATTCTAGCAGG
CAGTATTCAGATTGCGGTGGTTGGCGGTATGGAATCCATGACCAATTCGCCTTATTTGTTGCCTAAAGCTCGATCTGGCT
ATCGTATGGGTCACGGACAAGTACTCGATCATATGTTTTTAGATGGTTTGGAAGATGCTTATACAGGCCGTGCCATGGGT
TCTTTTGCCCAAGACATGGCAAATCAAAAAGGTTACACCCGTGAACAGATGGATGCGTTTGCGATTCGCTCGCTGACTCG
CGCGCAACACGCCATTACAGCAGGCCATTTCCAATCTGAAATTGCACCAGTCACCGTAGCTACCCGTAAAGGCGACATAA
CCGTATCTGAGGATGAAAATCCAGGCAATGCAAAAATAGATAAAATTCCGAGCTTGCGTCCAGCGTTTGCTAAAGATGGA
ACGATTACTGCTGCCAATTCCAGCTCCATCAGTGATGGTGCATCTGCTTTGCTCATTACTTCAGAACAACAAGCAGAGCA
GCGTGGCCTCAAAGTATTAGCAGAAATTAAGGGTTACACCACTCATTCACAGCTTCCCGCCGAATTTACCATCGCACCTG
TCGGAGCGATTGAAAAATTACTTAAAAAAATTGGCTGGACAGCAGAAGAGGTCGATCTGTGGGAAATCAATGAAGCTTTT
GCCATGGTCACCATGGCCGCGATTGATGCTTTCAAGCTCGACGCAGAGAAGGTCAATATCAACGGTGGCGCATGTGCATT
AGGTCATCCGCTTGGCTCATCGGGCTCCAGAATCATTGTCACGCTTATTCATGCGCTAAAACGTCTGGGCAAACGTAAAG
GGATTGCAGCACTATGTATCGGCGGCGGTGAAGCCACTGCCCTTGCCATAGAACTTGTCGATTAA

Upstream 100 bases:

>100_bases
TATTATGGATTCTTGGAAAAACACTGAGCTATACCCCACCCGTATTTTAACGATGAGCATAAATGTGGTGTCTTAAAATC
ACATCCATTTAAGAAGGACT

Downstream 100 bases:

>100_bases
ACCCAAATATAAAGGACGGAACATGTCATGATCCGTCCTGATATGGATTTAATTCAATCGTTCAACTGATAAGTTTCTAC
AGGCTCACAAAGTCCTATCG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MDMSKIMIAAAARTPMGSFQGSLAGLTAPDLGAVVIQRVLEQTQIPAADIDEVIMGCVLPAGLKQAPARQAMRQAGLPDH
VGATTINKVCGSGMKATMFAADAILAGSIQIAVVGGMESMTNSPYLLPKARSGYRMGHGQVLDHMFLDGLEDAYTGRAMG
SFAQDMANQKGYTREQMDAFAIRSLTRAQHAITAGHFQSEIAPVTVATRKGDITVSEDENPGNAKIDKIPSLRPAFAKDG
TITAANSSSISDGASALLITSEQQAEQRGLKVLAEIKGYTTHSQLPAEFTIAPVGAIEKLLKKIGWTAEEVDLWEINEAF
AMVTMAAIDAFKLDAEKVNINGGACALGHPLGSSGSRIIVTLIHALKRLGKRKGIAALCIGGGEATALAIELVD

Sequences:

>Translated_394_residues
MDMSKIMIAAAARTPMGSFQGSLAGLTAPDLGAVVIQRVLEQTQIPAADIDEVIMGCVLPAGLKQAPARQAMRQAGLPDH
VGATTINKVCGSGMKATMFAADAILAGSIQIAVVGGMESMTNSPYLLPKARSGYRMGHGQVLDHMFLDGLEDAYTGRAMG
SFAQDMANQKGYTREQMDAFAIRSLTRAQHAITAGHFQSEIAPVTVATRKGDITVSEDENPGNAKIDKIPSLRPAFAKDG
TITAANSSSISDGASALLITSEQQAEQRGLKVLAEIKGYTTHSQLPAEFTIAPVGAIEKLLKKIGWTAEEVDLWEINEAF
AMVTMAAIDAFKLDAEKVNINGGACALGHPLGSSGSRIIVTLIHALKRLGKRKGIAALCIGGGEATALAIELVD
>Mature_394_residues
MDMSKIMIAAAARTPMGSFQGSLAGLTAPDLGAVVIQRVLEQTQIPAADIDEVIMGCVLPAGLKQAPARQAMRQAGLPDH
VGATTINKVCGSGMKATMFAADAILAGSIQIAVVGGMESMTNSPYLLPKARSGYRMGHGQVLDHMFLDGLEDAYTGRAMG
SFAQDMANQKGYTREQMDAFAIRSLTRAQHAITAGHFQSEIAPVTVATRKGDITVSEDENPGNAKIDKIPSLRPAFAKDG
TITAANSSSISDGASALLITSEQQAEQRGLKVLAEIKGYTTHSQLPAEFTIAPVGAIEKLLKKIGWTAEEVDLWEINEAF
AMVTMAAIDAFKLDAEKVNINGGACALGHPLGSSGSRIIVTLIHALKRLGKRKGIAALCIGGGEATALAIELVD

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=389, Percent_Identity=44.4730077120823, Blast_Score=325, Evalue=3e-89,
Organism=Homo sapiens, GI4557237, Length=391, Percent_Identity=43.2225063938619, Blast_Score=318, Evalue=7e-87,
Organism=Homo sapiens, GI167614485, Length=388, Percent_Identity=36.8556701030928, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI4501853, Length=374, Percent_Identity=36.096256684492, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI4504327, Length=425, Percent_Identity=29.4117647058824, Blast_Score=161, Evalue=9e-40,
Organism=Homo sapiens, GI194353979, Length=372, Percent_Identity=28.2258064516129, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1788554, Length=394, Percent_Identity=49.238578680203, Blast_Score=335, Evalue=2e-93,
Organism=Escherichia coli, GI87082165, Length=390, Percent_Identity=43.5897435897436, Blast_Score=335, Evalue=3e-93,
Organism=Escherichia coli, GI1787663, Length=402, Percent_Identity=36.318407960199, Blast_Score=228, Evalue=4e-61,
Organism=Escherichia coli, GI48994986, Length=405, Percent_Identity=36.7901234567901, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1788683, Length=404, Percent_Identity=29.2079207920792, Blast_Score=164, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI25147385, Length=385, Percent_Identity=41.2987012987013, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI17535921, Length=393, Percent_Identity=41.2213740458015, Blast_Score=288, Evalue=5e-78,
Organism=Caenorhabditis elegans, GI133906874, Length=389, Percent_Identity=38.3033419023136, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI17535917, Length=389, Percent_Identity=34.1902313624679, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=30.9859154929577, Blast_Score=179, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6325229, Length=397, Percent_Identity=45.8438287153652, Blast_Score=335, Evalue=8e-93,
Organism=Saccharomyces cerevisiae, GI6322031, Length=386, Percent_Identity=31.8652849740933, Blast_Score=167, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24655093, Length=390, Percent_Identity=47.9487179487179, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24640423, Length=391, Percent_Identity=44.2455242966752, Blast_Score=319, Evalue=2e-87,
Organism=Drosophila melanogaster, GI17648125, Length=394, Percent_Identity=37.3096446700508, Blast_Score=247, Evalue=9e-66,
Organism=Drosophila melanogaster, GI17137578, Length=422, Percent_Identity=29.3838862559242, Blast_Score=159, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41299; Mature: 41299

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMSKIMIAAAARTPMGSFQGSLAGLTAPDLGAVVIQRVLEQTQIPAADIDEVIMGCVLP
CCHHHEEHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
AGLKQAPARQAMRQAGLPDHVGATTINKVCGSGMKATMFAADAILAGSIQIAVVGGMESM
CCHHCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEHHHHHHHHEECCEEEEEEECHHHH
TNSPYLLPKARSGYRMGHGQVLDHMFLDGLEDAYTGRAMGSFAQDMANQKGYTREQMDAF
CCCCEEEECCCCCCCCCCHHHHHHHHHHCHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHH
AIRSLTRAQHAITAGHFQSEIAPVTVATRKGDITVSEDENPGNAKIDKIPSLRPAFAKDG
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCC
TITAANSSSISDGASALLITSEQQAEQRGLKVLAEIKGYTTHSQLPAEFTIAPVGAIEKL
EEEECCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECHHHHHHH
LKKIGWTAEEVDLWEINEAFAMVTMAAIDAFKLDAEKVNINGGACALGHPLGSSGSRIIV
HHHHCCCHHHEEEEEHHHHHHHHHHHHHHHHEECCEEEECCCCEEEECCCCCCCCCHHHH
TLIHALKRLGKRKGIAALCIGGGEATALAIELVD
HHHHHHHHHHHHCCEEEEEECCCCEEEEEEEECC
>Mature Secondary Structure
MDMSKIMIAAAARTPMGSFQGSLAGLTAPDLGAVVIQRVLEQTQIPAADIDEVIMGCVLP
CCHHHEEHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
AGLKQAPARQAMRQAGLPDHVGATTINKVCGSGMKATMFAADAILAGSIQIAVVGGMESM
CCHHCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEHHHHHHHHEECCEEEEEEECHHHH
TNSPYLLPKARSGYRMGHGQVLDHMFLDGLEDAYTGRAMGSFAQDMANQKGYTREQMDAF
CCCCEEEECCCCCCCCCCHHHHHHHHHHCHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHH
AIRSLTRAQHAITAGHFQSEIAPVTVATRKGDITVSEDENPGNAKIDKIPSLRPAFAKDG
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCC
TITAANSSSISDGASALLITSEQQAEQRGLKVLAEIKGYTTHSQLPAEFTIAPVGAIEKL
EEEECCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECHHHHHHH
LKKIGWTAEEVDLWEINEAFAMVTMAAIDAFKLDAEKVNINGGACALGHPLGSSGSRIIV
HHHHCCCHHHEEEEEHHHHHHHHHHHHHHHHEECCEEEECCCCEEEECCCCCCCCCHHHH
TLIHALKRLGKRKGIAALCIGGGEATALAIELVD
HHHHHHHHHHHHCCEEEEEECCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]