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The map label for this gene is cyoE [H]

Identifier: 50085514

GI number: 50085514

Start: 2395469

End: 2396356

Strand: Direct

Name: cyoE [H]

Synonym: ACIAD2429

Alternate gene names: 50085514

Gene position: 2395469-2396356 (Clockwise)

Preceding gene: 50085513

Following gene: 50085515

Centisome position: 66.57

GC content: 37.61

Gene sequence:

>888_bases
CTGGTTGTCATGCTAAAAAAGTATTTATTCCTGACAAAACCAGGAATTCTGTTTGGTAATTTCATTACCACTTTGGGCGG
CTTCTTCTTAGCCGCCCAAGGCCATGTAGATTTCCTCTTACTCATTCTTACCCTTCTAGGTACAACATTTGTTGTTGCTT
CAGGTTGTGTGGTCAATAATGTGATTGATCAAGACATTGACCAAAAAATGGAGCGCACACAAAACAGAGCCCTAGTTAAA
AAAACCGTCTCTCCGAGTACTGCTCTTATTTTTGCTTTTATTCTTGGCATCATTGGATTTGGTATTCTATGGTTTTGGGT
AAATCCTTATTCATTTTCATTTGCGATCATTGGCTTTGTCGTTTATGTAGGTTTTTATAGTCTTTGGACGAAACGTACCT
CTATTCATCAGACCATTATTGGTAGTATTTCTGGAGCTAGTCCACCTGTGATTGGCTACACAGCCGTAACTCATCAATTT
GATGTTGCTGCGCTACTTATTTTTTTAGCGTATGGTTTATGGCAAATGCCACATTCGTGGGCAATTGCAATTTATCGTTT
TGATGATTATAAGAATGCGGGTATTCCGATACTTCCTGTTGCCCGATCTGTGTACCGCACAAAAGTTGAGTGTCTGATTT
ACATTGTGTTGTTTGCAGCTGTACTCAATGGACTTTATTGCTTTGGATATACTAATGTTTTCTTTTTATTGACATTCAAT
GTGCTCACCGCATATTGGTTATATTTATCCATTATCGGATTTAAAGCAGAGAATGATCAACTCTGGGCAAAACGCTTATT
TCTTTTTTCAGTAATTCTAATTACGTTGTTAAGTCTAAGCTTTAGTTTTACCTACCAATCCCCTGCTCCAAATCTTCCTC
TCTTTTAA

Upstream 100 bases:

>100_bases
AACCTAATCGCGTTCATTTATACAGTTCTATGTATTGCTATCTTGCTTGTTGGTTCTGTATGGATTATGAATTATCTACA
TTTCAACATGATGATCTAAA

Downstream 100 bases:

>100_bases
TAAGAGAGGATATCTATTTGATTCATTCTTAAAAATCATAAAAACTATTTGTCTTAACCAATAATTTTCCTTATAATTCA
CGCTTCGCAATTTTGCGACA

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MVVMLKKYLFLTKPGILFGNFITTLGGFFLAAQGHVDFLLLILTLLGTTFVVASGCVVNNVIDQDIDQKMERTQNRALVK
KTVSPSTALIFAFILGIIGFGILWFWVNPYSFSFAIIGFVVYVGFYSLWTKRTSIHQTIIGSISGASPPVIGYTAVTHQF
DVAALLIFLAYGLWQMPHSWAIAIYRFDDYKNAGIPILPVARSVYRTKVECLIYIVLFAAVLNGLYCFGYTNVFFLLTFN
VLTAYWLYLSIIGFKAENDQLWAKRLFLFSVILITLLSLSFSFTYQSPAPNLPLF

Sequences:

>Translated_295_residues
MVVMLKKYLFLTKPGILFGNFITTLGGFFLAAQGHVDFLLLILTLLGTTFVVASGCVVNNVIDQDIDQKMERTQNRALVK
KTVSPSTALIFAFILGIIGFGILWFWVNPYSFSFAIIGFVVYVGFYSLWTKRTSIHQTIIGSISGASPPVIGYTAVTHQF
DVAALLIFLAYGLWQMPHSWAIAIYRFDDYKNAGIPILPVARSVYRTKVECLIYIVLFAAVLNGLYCFGYTNVFFLLTFN
VLTAYWLYLSIIGFKAENDQLWAKRLFLFSVILITLLSLSFSFTYQSPAPNLPLF
>Mature_295_residues
MVVMLKKYLFLTKPGILFGNFITTLGGFFLAAQGHVDFLLLILTLLGTTFVVASGCVVNNVIDQDIDQKMERTQNRALVK
KTVSPSTALIFAFILGIIGFGILWFWVNPYSFSFAIIGFVVYVGFYSLWTKRTSIHQTIIGSISGASPPVIGYTAVTHQF
DVAALLIFLAYGLWQMPHSWAIAIYRFDDYKNAGIPILPVARSVYRTKVECLIYIVLFAAVLNGLYCFGYTNVFFLLTFN
VLTAYWLYLSIIGFKAENDQLWAKRLFLFSVILITLLSLSFSFTYQSPAPNLPLF

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=252, Percent_Identity=30.1587301587302, Blast_Score=96, Evalue=6e-20,
Organism=Escherichia coli, GI1786631, Length=286, Percent_Identity=50, Blast_Score=299, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI71998235, Length=235, Percent_Identity=29.3617021276596, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6325085, Length=253, Percent_Identity=28.8537549407115, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI19921064, Length=262, Percent_Identity=30.9160305343511, Blast_Score=105, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 33176; Mature: 33176

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVMLKKYLFLTKPGILFGNFITTLGGFFLAAQGHVDFLLLILTLLGTTFVVASGCVVNN
CEEEHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHH
VIDQDIDQKMERTQNRALVKKTVSPSTALIFAFILGIIGFGILWFWVNPYSFSFAIIGFV
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
VYVGFYSLWTKRTSIHQTIIGSISGASPPVIGYTAVTHQFDVAALLIFLAYGLWQMPHSW
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCC
AIAIYRFDDYKNAGIPILPVARSVYRTKVECLIYIVLFAAVLNGLYCFGYTNVFFLLTFN
EEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VLTAYWLYLSIIGFKAENDQLWAKRLFLFSVILITLLSLSFSFTYQSPAPNLPLF
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCC
>Mature Secondary Structure
MVVMLKKYLFLTKPGILFGNFITTLGGFFLAAQGHVDFLLLILTLLGTTFVVASGCVVNN
CEEEHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHH
VIDQDIDQKMERTQNRALVKKTVSPSTALIFAFILGIIGFGILWFWVNPYSFSFAIIGFV
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
VYVGFYSLWTKRTSIHQTIIGSISGASPPVIGYTAVTHQFDVAALLIFLAYGLWQMPHSW
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCC
AIAIYRFDDYKNAGIPILPVARSVYRTKVECLIYIVLFAAVLNGLYCFGYTNVFFLLTFN
EEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VLTAYWLYLSIIGFKAENDQLWAKRLFLFSVILITLLSLSFSFTYQSPAPNLPLF
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA