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The map label for this gene is cyoB [H]

Identifier: 50085511

GI number: 50085511

Start: 2392528

End: 2394516

Strand: Direct

Name: cyoB [H]

Synonym: ACIAD2426

Alternate gene names: 50085511

Gene position: 2392528-2394516 (Clockwise)

Preceding gene: 50085510

Following gene: 50085512

Centisome position: 66.48

GC content: 41.93

Gene sequence:

>1989_bases
ATGTTGTTATTAGGTAAACTCGGATGGGACTCAATCCCTAAAGAGCCAATTGTACTAGTGACAATGGTCTTAATGGCTAT
TGGTGCAATTGCAGTTCTAGGCGGTATCACCTACTTCAAAAAATGGGGTTACCTCTGGAAAGAATGGTTTATTACAGTAG
ACCATAAAAAAATTGGTATTATGTACATCCTTGTATCTGTCGTCATGCTTTTGCGTGGTTTCGCCGATGCAATTATGATG
CGTCTTCAACTGTTCCTTGCTAAAGGTGGCGGTGAAGGTTATTTACATCCAGACCATTACGACCAGATCTTCACCGCGCA
TGGCGTGATCATGATCTTCTTCGTAGCAATGGGTCTTGTTGTGGGTATGATGAATATCTCTGTACCACTTCAAATTGGTG
CACGTGACGTTGCATTCCCGCTACTTAACTCTTTAAGCTTCTGGTTGTTTGCTGGTGCAGCTGGCTTGATGATGGCATCT
CTCGTACTCGGTGAGTTTGCTGCTACAGGCTGGATGGCATACCCTCCTCTTTCTGGTATTCAATACTCTCCTGGTGTTGG
TGTCGATTACTATATCTGGGCACTGCAAGTCTCAGGTCTTGGTACGCTTTTATCTGGTGTAAACTTTTTTGTGACCATCA
TTAAAATGCGTGCGCCAGGCATGAAGTTGATGGACATGCCAATTTTTACATGGACATCATTATGTACAGCGGTTTTGATC
ATTGCATCATTCCCTGTCTTAACAGCCACCCTTGCCATGTTAACGCTAGACCGTTACTTTGGTTTCCATTTCTTCACAAA
TGAGCTTGGTGGTAGTCCAATGCTGTATGTGAACTTGATCTGGACATGGGGTCACCCAGAAGTATATATCTTGGTATTAC
CTGCATTTGGTTTGTATTCAGAGATTGTTGCAACCTTCTCTCGCAAAGCATTGTTTGGTTATAAATCAATGGTATATGCA
ACGATTGCAATTACTGTATTGGCATTCGTTGTGTGGTTACACCACTTCTTTACCATGGGTGCAGGTGCAAACGTTAACGC
GTTCTTCGGTATCATGACCATGATTATTGCAATCCCTACAGGGGTGAAAATTTTCTCTTGGTTATTTACCATGTACAAAG
GACGTATCTCGTTCGAAACACCAATGCTCTGGACACTTGGTTTCCTTGTGACGTTTGGTATTGGCGGTTTAACCGGCGTA
CTAATGGCTGTACCACCAGCAGACTTTTTGGTTCATAACTCATTATTCCTCATTGCTCACTTCCATAACGTAATTATTGG
TGGTGTTGTATTTGGTATGTTTGCGGGCATCATTTTCTACTGGCCAAAAATGTTTGGTTGGAAGCTCAATGAAGCTTGGG
GTAAAGCAGCATTCTGGTTCTGGTTCTTTGGTTTCTATTTTGCATTCATGCCATTGTATATCCTCGGTTTCATGGGTATG
ACACGTCGTTTGAATACATATGACAACCCTGAATGGGATCCGTATTTGGCTATTGCACTTTTTGGTGCGGTGTTAGTTGC
AATTGGTATTGCATGTTTCTTAATGCAAATCATTGTTGGCTTCTTACAACGTCATCAAAATATGGACCATACTGGCGACC
CATGGGATAGCCGTACTTTAGAATGGTCTACTTCTTCTCCTGCTCCATTTTATAACTTTGCACATGTTCCAAATGGTAAC
GGTGTAGATGCATTCTGGGTAGACAAAGAGAATGGTATAGCCTACGCACGTAATACCAAATATGAAGATATTCATATGCC
AACTGACCGTGCTGCTGGTTTTGTAATTGCGATGTTCATTACAACAATGGGCTTTGCTTTAATCTGGCATATCTGGTGGC
TCGTTGCAGTTTGTTTCATTGCTTCAATTGTAAGCTTGATCCGTAGTTCATTCACAAAAGAAGTGGATTACTATGTACCA
GCAGCAGAAGTTGAGCGCATTGAAAATGAACGCTATGCGTTACTTGAAAAACACTTGAAGAAGGACTAA

Upstream 100 bases:

>100_bases
GAGCAACTATCACGGAGCTGATCATTCAGCTACTGCTGAACATGGTTCACAAGCTCATGCTGCTAATGCACATGCAACTG
CTTCTGTAGAGGAATAAGCC

Downstream 100 bases:

>100_bases
GGATATGGCTGAAGTACTTCATCACGACAACCACGGACACGATGGTCATCATGAACATGATGATACCGATTTAACAGTCT
TTGGTTTCTGGACTTACTTG

Product: cytochrome o ubiquinol oxidase subunit I

Products: NA

Alternate protein names: Cytochrome o subunit 1; Cytochrome o ubiquinol oxidase subunit 1; Oxidase BO(3) subunit 1; Ubiquinol oxidase polypeptide I [H]

Number of amino acids: Translated: 662; Mature: 662

Protein sequence:

>662_residues
MLLLGKLGWDSIPKEPIVLVTMVLMAIGAIAVLGGITYFKKWGYLWKEWFITVDHKKIGIMYILVSVVMLLRGFADAIMM
RLQLFLAKGGGEGYLHPDHYDQIFTAHGVIMIFFVAMGLVVGMMNISVPLQIGARDVAFPLLNSLSFWLFAGAAGLMMAS
LVLGEFAATGWMAYPPLSGIQYSPGVGVDYYIWALQVSGLGTLLSGVNFFVTIIKMRAPGMKLMDMPIFTWTSLCTAVLI
IASFPVLTATLAMLTLDRYFGFHFFTNELGGSPMLYVNLIWTWGHPEVYILVLPAFGLYSEIVATFSRKALFGYKSMVYA
TIAITVLAFVVWLHHFFTMGAGANVNAFFGIMTMIIAIPTGVKIFSWLFTMYKGRISFETPMLWTLGFLVTFGIGGLTGV
LMAVPPADFLVHNSLFLIAHFHNVIIGGVVFGMFAGIIFYWPKMFGWKLNEAWGKAAFWFWFFGFYFAFMPLYILGFMGM
TRRLNTYDNPEWDPYLAIALFGAVLVAIGIACFLMQIIVGFLQRHQNMDHTGDPWDSRTLEWSTSSPAPFYNFAHVPNGN
GVDAFWVDKENGIAYARNTKYEDIHMPTDRAAGFVIAMFITTMGFALIWHIWWLVAVCFIASIVSLIRSSFTKEVDYYVP
AAEVERIENERYALLEKHLKKD

Sequences:

>Translated_662_residues
MLLLGKLGWDSIPKEPIVLVTMVLMAIGAIAVLGGITYFKKWGYLWKEWFITVDHKKIGIMYILVSVVMLLRGFADAIMM
RLQLFLAKGGGEGYLHPDHYDQIFTAHGVIMIFFVAMGLVVGMMNISVPLQIGARDVAFPLLNSLSFWLFAGAAGLMMAS
LVLGEFAATGWMAYPPLSGIQYSPGVGVDYYIWALQVSGLGTLLSGVNFFVTIIKMRAPGMKLMDMPIFTWTSLCTAVLI
IASFPVLTATLAMLTLDRYFGFHFFTNELGGSPMLYVNLIWTWGHPEVYILVLPAFGLYSEIVATFSRKALFGYKSMVYA
TIAITVLAFVVWLHHFFTMGAGANVNAFFGIMTMIIAIPTGVKIFSWLFTMYKGRISFETPMLWTLGFLVTFGIGGLTGV
LMAVPPADFLVHNSLFLIAHFHNVIIGGVVFGMFAGIIFYWPKMFGWKLNEAWGKAAFWFWFFGFYFAFMPLYILGFMGM
TRRLNTYDNPEWDPYLAIALFGAVLVAIGIACFLMQIIVGFLQRHQNMDHTGDPWDSRTLEWSTSSPAPFYNFAHVPNGN
GVDAFWVDKENGIAYARNTKYEDIHMPTDRAAGFVIAMFITTMGFALIWHIWWLVAVCFIASIVSLIRSSFTKEVDYYVP
AAEVERIENERYALLEKHLKKD
>Mature_662_residues
MLLLGKLGWDSIPKEPIVLVTMVLMAIGAIAVLGGITYFKKWGYLWKEWFITVDHKKIGIMYILVSVVMLLRGFADAIMM
RLQLFLAKGGGEGYLHPDHYDQIFTAHGVIMIFFVAMGLVVGMMNISVPLQIGARDVAFPLLNSLSFWLFAGAAGLMMAS
LVLGEFAATGWMAYPPLSGIQYSPGVGVDYYIWALQVSGLGTLLSGVNFFVTIIKMRAPGMKLMDMPIFTWTSLCTAVLI
IASFPVLTATLAMLTLDRYFGFHFFTNELGGSPMLYVNLIWTWGHPEVYILVLPAFGLYSEIVATFSRKALFGYKSMVYA
TIAITVLAFVVWLHHFFTMGAGANVNAFFGIMTMIIAIPTGVKIFSWLFTMYKGRISFETPMLWTLGFLVTFGIGGLTGV
LMAVPPADFLVHNSLFLIAHFHNVIIGGVVFGMFAGIIFYWPKMFGWKLNEAWGKAAFWFWFFGFYFAFMPLYILGFMGM
TRRLNTYDNPEWDPYLAIALFGAVLVAIGIACFLMQIIVGFLQRHQNMDHTGDPWDSRTLEWSTSSPAPFYNFAHVPNGN
GVDAFWVDKENGIAYARNTKYEDIHMPTDRAAGFVIAMFITTMGFALIWHIWWLVAVCFIASIVSLIRSSFTKEVDYYVP
AAEVERIENERYALLEKHLKKD

Specific function: Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain that predominates when cells are grown at high aeration. This ubiquinol oxidase shows proton pump activity across the membrane in addition to the electron transfer [H]

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=510, Percent_Identity=38.8235294117647, Blast_Score=321, Evalue=1e-87,
Organism=Escherichia coli, GI1786634, Length=661, Percent_Identity=66.4145234493192, Blast_Score=906, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6226519, Length=464, Percent_Identity=40.5172413793103, Blast_Score=337, Evalue=3e-93,
Organism=Saccharomyces cerevisiae, GI6226524, Length=325, Percent_Identity=42.4615384615385, Blast_Score=251, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6226523, Length=247, Percent_Identity=35.6275303643725, Blast_Score=141, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014207 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: 1.10.3.-

Molecular weight: Translated: 74376; Mature: 74376

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLLGKLGWDSIPKEPIVLVTMVLMAIGAIAVLGGITYFKKWGYLWKEWFITVDHKKIGI
CEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHH
MYILVSVVMLLRGFADAIMMRLQLFLAKGGGEGYLHPDHYDQIFTAHGVIMIFFVAMGLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VGMMNISVPLQIGARDVAFPLLNSLSFWLFAGAAGLMMASLVLGEFAATGWMAYPPLSGI
HHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCC
QYSPGVGVDYYIWALQVSGLGTLLSGVNFFVTIIKMRAPGMKLMDMPIFTWTSLCTAVLI
CCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
IASFPVLTATLAMLTLDRYFGFHFFTNELGGSPMLYVNLIWTWGHPEVYILVLPAFGLYS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCEEEEEEECCHHHHH
EIVATFSRKALFGYKSMVYATIAITVLAFVVWLHHFFTMGAGANVNAFFGIMTMIIAIPT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC
GVKIFSWLFTMYKGRISFETPMLWTLGFLVTFGIGGLTGVLMAVPPADFLVHNSLFLIAH
CHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHCHHHHHHH
FHNVIIGGVVFGMFAGIIFYWPKMFGWKLNEAWGKAAFWFWFFGFYFAFMPLYILGFMGM
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRRLNTYDNPEWDPYLAIALFGAVLVAIGIACFLMQIIVGFLQRHQNMDHTGDPWDSRTL
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
EWSTSSPAPFYNFAHVPNGNGVDAFWVDKENGIAYARNTKYEDIHMPTDRAAGFVIAMFI
EECCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHH
TTMGFALIWHIWWLVAVCFIASIVSLIRSSFTKEVDYYVPAAEVERIENERYALLEKHLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHC
KD
CC
>Mature Secondary Structure
MLLLGKLGWDSIPKEPIVLVTMVLMAIGAIAVLGGITYFKKWGYLWKEWFITVDHKKIGI
CEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHH
MYILVSVVMLLRGFADAIMMRLQLFLAKGGGEGYLHPDHYDQIFTAHGVIMIFFVAMGLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VGMMNISVPLQIGARDVAFPLLNSLSFWLFAGAAGLMMASLVLGEFAATGWMAYPPLSGI
HHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCC
QYSPGVGVDYYIWALQVSGLGTLLSGVNFFVTIIKMRAPGMKLMDMPIFTWTSLCTAVLI
CCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
IASFPVLTATLAMLTLDRYFGFHFFTNELGGSPMLYVNLIWTWGHPEVYILVLPAFGLYS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCEEEEEEECCHHHHH
EIVATFSRKALFGYKSMVYATIAITVLAFVVWLHHFFTMGAGANVNAFFGIMTMIIAIPT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC
GVKIFSWLFTMYKGRISFETPMLWTLGFLVTFGIGGLTGVLMAVPPADFLVHNSLFLIAH
CHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHCHHHHHHH
FHNVIIGGVVFGMFAGIIFYWPKMFGWKLNEAWGKAAFWFWFFGFYFAFMPLYILGFMGM
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRRLNTYDNPEWDPYLAIALFGAVLVAIGIACFLMQIIVGFLQRHQNMDHTGDPWDSRTL
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
EWSTSSPAPFYNFAHVPNGNGVDAFWVDKENGIAYARNTKYEDIHMPTDRAAGFVIAMFI
EECCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHH
TTMGFALIWHIWWLVAVCFIASIVSLIRSSFTKEVDYYVPAAEVERIENERYALLEKHLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHC
KD
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Protoheme IX (Heme B55 and B562); Copper B. [C]

Metal ions: Fe; Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9868765 [H]