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The map label for this gene is lpxB

Identifier: 50085418

GI number: 50085418

Start: 2286617

End: 2287807

Strand: Reverse

Name: lpxB

Synonym: ACIAD2324

Alternate gene names: 50085418

Gene position: 2287807-2286617 (Counterclockwise)

Preceding gene: 50085424

Following gene: 50085416

Centisome position: 63.57

GC content: 39.04

Gene sequence:

>1191_bases
TTGTATGGAACCTGCCACTTGTCTACACACAAACTTAAAATCGGAATCGTTGTGGGTGAAGTCTCAGGAGACACGCTTGG
TGTACAACTGATGCGTAGTTTTCGTGAGCAGGGGATCGACGCCGAATTTGAGGGAATAGGCGGGCCTCAAATGATTGCAG
AAGGATTTAATAGCTTTTATCCCATGGAAACATTGTCTGTGATGGGAATTGTTGAGGTATTAAAAGATATCAAAAAGCTA
TTTGCAGTCCGTGATGGTTTGGTGCAAAGATGGCGTGAACATCCTGTCGATGTTTTTGTTGGAATAGATGCACCTGATTT
TAATTTACGTTTATCTAAGTCATTAAAAGAAAAAAACTTACCGATTAGAACGGTACAATATGTGAGTCCATCTGTTTGGG
CATGGCGACAAGGGCGTGTCAAAGGCATTAAGGCAACGATTGATCTGGTCTTATGTCTATTTCCATTTGAAAAGAATTTT
TATGAACAGCATTCAGTGCGGGCTGCTTTTGTGGGGCACCCACTTGCTAAACTTTTGCCGCTGAATAATTCACTGGTTGA
AGCAAAGCAAGCGCTAGGCTTAAATCCAGAAAAAACGTATATTGCATTGTTACCGGGAAGCCGCAAAGGTGAGGTAGAGC
GTTTACTACCTATGTTATTGGGTAGTGCAGAAATACTATTGAAAAAATATCCTGATGTTGAATATTTGATTCCAGCGATT
AGTGACGTCAGAAAAAAACAAATTCAGGATGGAATTCAGTCAATTGCCCCCCAATATGCCCAGAAGTTACATGTTTTGGA
AAATCAGGATCAAGAATCAAAAATTGGACGGCAGGTGATGAATGCCAGTGATATTGTGGCTTTAGCATCGGGCACTGCAA
CACTCGAAGCGATGTTATTGCATCGTCCTATGGTGTCTTTTTATAAATTAAATACCTTAACTTATATCATTGCAAAATTA
TTGGTCAAAATTCAATATTATTCACTGCCGAATATTATTGCAGGCAAAAAGGTGATTGAAGAACTCATTCAGAAAGATGC
CAATCCAGAGCGTTTGGCGCATGAGATTGAAAAGCTTATGAATAATGAAACAGCAAAAATTCAGATGATGCAGCATTTTA
GTATGCATAAACAGCTTATTTCTGGAAATACTGAAGATCCTGTGCAAGCAATTATGACCTTAATTCAATAA

Upstream 100 bases:

>100_bases
TATTCGAATGTGATTTTAAATTTTGCTTGAAAATACAAGACATGAAATGAGAAGTTTTAAAGTGATGAAAGCACTATGCT
AATATCTTAGGTTTATTGAA

Downstream 100 bases:

>100_bases
AGAATGGAGCAATCATGCTCCATTTAGATTCTGATTAAGTGCGAAGAATAAGTTGATAACCAGAATATTTTCGAACGTTA
ATCACCCCAATATCAAAGAT

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MYGTCHLSTHKLKIGIVVGEVSGDTLGVQLMRSFREQGIDAEFEGIGGPQMIAEGFNSFYPMETLSVMGIVEVLKDIKKL
FAVRDGLVQRWREHPVDVFVGIDAPDFNLRLSKSLKEKNLPIRTVQYVSPSVWAWRQGRVKGIKATIDLVLCLFPFEKNF
YEQHSVRAAFVGHPLAKLLPLNNSLVEAKQALGLNPEKTYIALLPGSRKGEVERLLPMLLGSAEILLKKYPDVEYLIPAI
SDVRKKQIQDGIQSIAPQYAQKLHVLENQDQESKIGRQVMNASDIVALASGTATLEAMLLHRPMVSFYKLNTLTYIIAKL
LVKIQYYSLPNIIAGKKVIEELIQKDANPERLAHEIEKLMNNETAKIQMMQHFSMHKQLISGNTEDPVQAIMTLIQ

Sequences:

>Translated_396_residues
MYGTCHLSTHKLKIGIVVGEVSGDTLGVQLMRSFREQGIDAEFEGIGGPQMIAEGFNSFYPMETLSVMGIVEVLKDIKKL
FAVRDGLVQRWREHPVDVFVGIDAPDFNLRLSKSLKEKNLPIRTVQYVSPSVWAWRQGRVKGIKATIDLVLCLFPFEKNF
YEQHSVRAAFVGHPLAKLLPLNNSLVEAKQALGLNPEKTYIALLPGSRKGEVERLLPMLLGSAEILLKKYPDVEYLIPAI
SDVRKKQIQDGIQSIAPQYAQKLHVLENQDQESKIGRQVMNASDIVALASGTATLEAMLLHRPMVSFYKLNTLTYIIAKL
LVKIQYYSLPNIIAGKKVIEELIQKDANPERLAHEIEKLMNNETAKIQMMQHFSMHKQLISGNTEDPVQAIMTLIQ
>Mature_396_residues
MYGTCHLSTHKLKIGIVVGEVSGDTLGVQLMRSFREQGIDAEFEGIGGPQMIAEGFNSFYPMETLSVMGIVEVLKDIKKL
FAVRDGLVQRWREHPVDVFVGIDAPDFNLRLSKSLKEKNLPIRTVQYVSPSVWAWRQGRVKGIKATIDLVLCLFPFEKNF
YEQHSVRAAFVGHPLAKLLPLNNSLVEAKQALGLNPEKTYIALLPGSRKGEVERLLPMLLGSAEILLKKYPDVEYLIPAI
SDVRKKQIQDGIQSIAPQYAQKLHVLENQDQESKIGRQVMNASDIVALASGTATLEAMLLHRPMVSFYKLNTLTYIIAKL
LVKIQYYSLPNIIAGKKVIEELIQKDANPERLAHEIEKLMNNETAKIQMMQHFSMHKQLISGNTEDPVQAIMTLIQ

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=386, Percent_Identity=42.7461139896373, Blast_Score=306, Evalue=1e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_ACIAD (Q6FA07)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_046928.1
- ProteinModelPortal:   Q6FA07
- STRING:   Q6FA07
- GeneID:   2879759
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD2324
- NMPDR:   fig|62977.3.peg.2215
- eggNOG:   COG0763
- HOGENOM:   HBG584837
- OMA:   DFTHRVA
- PhylomeDB:   Q6FA07
- ProtClustDB:   CLSK707519
- BioCyc:   ASP62977:ACIAD2324-MONOMER
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 44514; Mature: 44514

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYGTCHLSTHKLKIGIVVGEVSGDTLGVQLMRSFREQGIDAEFEGIGGPQMIAEGFNSFY
CCCEEEEEEEEEEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCC
PMETLSVMGIVEVLKDIKKLFAVRDGLVQRWREHPVDVFVGIDAPDFNLRLSKSLKEKNL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCCC
PIRTVQYVSPSVWAWRQGRVKGIKATIDLVLCLFPFEKNFYEQHSVRAAFVGHPLAKLLP
CEEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHC
LNNSLVEAKQALGLNPEKTYIALLPGSRKGEVERLLPMLLGSAEILLKKYPDVEYLIPAI
CCCHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHCCHHHHHHHCCCHHHHHHHH
SDVRKKQIQDGIQSIAPQYAQKLHVLENQDQESKIGRQVMNASDIVALASGTATLEAMLL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHEEEECCHHHHHHHHH
HRPMVSFYKLNTLTYIIAKLLVKIQYYSLPNIIAGKKVIEELIQKDANPERLAHEIEKLM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
NNETAKIQMMQHFSMHKQLISGNTEDPVQAIMTLIQ
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHC
>Mature Secondary Structure
MYGTCHLSTHKLKIGIVVGEVSGDTLGVQLMRSFREQGIDAEFEGIGGPQMIAEGFNSFY
CCCEEEEEEEEEEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCC
PMETLSVMGIVEVLKDIKKLFAVRDGLVQRWREHPVDVFVGIDAPDFNLRLSKSLKEKNL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCCC
PIRTVQYVSPSVWAWRQGRVKGIKATIDLVLCLFPFEKNFYEQHSVRAAFVGHPLAKLLP
CEEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHC
LNNSLVEAKQALGLNPEKTYIALLPGSRKGEVERLLPMLLGSAEILLKKYPDVEYLIPAI
CCCHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHCCHHHHHHHCCCHHHHHHHH
SDVRKKQIQDGIQSIAPQYAQKLHVLENQDQESKIGRQVMNASDIVALASGTATLEAMLL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHEEEECCHHHHHHHHH
HRPMVSFYKLNTLTYIIAKLLVKIQYYSLPNIIAGKKVIEELIQKDANPERLAHEIEKLM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
NNETAKIQMMQHFSMHKQLISGNTEDPVQAIMTLIQ
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA