Click here to switch to the map view.

The map label for this gene is maeB [H]

Identifier: 50085386

GI number: 50085386

Start: 2257214

End: 2259484

Strand: Direct

Name: maeB [H]

Synonym: ACIAD2287

Alternate gene names: 50085386

Gene position: 2257214-2259484 (Clockwise)

Preceding gene: 50085385

Following gene: 50085387

Centisome position: 62.72

GC content: 42.45

Gene sequence:

>2271_bases
ATGGACGATCAATCATTAAAACAAGCTGCTTTGTATTATCACGAAAACCCGACTCCAGGGAAAATTAGCGTTACACCGAG
TAAGCAGCTTGTCAATCAGCATGACCTGGCACTTGCCTATTCTCCAGGAGTTGCTGCTCCATGTTTAGAGATTGAACGTG
ATCCTTCTACTGCTGCCAAATATACAGCACGCGGAAATTTAGTGGCTGTTGTAACGAACGGTACTGCTGTTTTAGGCCTA
GGTAACATTGGACCTTTGGCCTCTAAACCTGTCATGGAAGGTAAAGGCGTTTTATTTAAGAAATTTGCTGGTGTCGATGT
TTTTGATATTGAGATTGCAGAAAATGATCCAGACAAAATCGTAGATATCGTTGCTGCACTTGAGCCTACTTTTGGCGGTA
TCAACCTAGAAGATATTAAAGCGCCAGAATGTTTTTATATTGAGAAAAAACTTCGTGAACGCATGAATATCCCTGTGTTC
CATGATGACCAGCACGGTACCAGTATTATTGTTGGTTCGGCTTTACTCAATGCCCTGCAACTTGTAAACAAAAAGATTGA
AGATATCAAGATTGTTGCCTCTGGCGCGGGTGCTGCAGCACTGTCTTGTCTTGATCTACTATGTGCACTGGGTGCACGTA
AAGAAAACATCATCGTCGCCGATTCACGTGGTTTGTTAACCACATCTCGTGATGGTCTTGATGAATCTAAAAAACGTTAT
GTTCAGGATATTACGGCAACCCAGTTACATGAAGTCATTACTGGTGCCGACATGTTCCTTGGCCTTTCAGCAGCAGGCAT
TCTCACCAAAGAAATGGTGAAAGGCATGGCTGAAAATCCAATTATTTTTGCACTTGCAAACCCAGATCCAGAAATTTTAC
CAGAGCACGCACATGAAGTACGTCCAGACGTCATCATGGCGACAGGCCGTTCTGACTATCCAAACCAAGTCAATAATGCA
CTGTGCTTCCCTTATATCTTCCGTGGTGCACTTGATGTCGGTGCAACCACAATTAATGAAGATATGAAAATTGCTTGTGT
ACATGCGATTGCACGCATGGCGCATGTAGAAGCCGATGCAGCAACTTATGGTGAAAAATCAGCCTCCTTTGGTCGTGATT
ATTTAATTCCACGTCCACTTGACCAACGTTTGATTCTTGAAATTGCGCCTGCTGTGGCTCAGGCAGCGATGGATTCTGGT
GTTGCAACACGCCCAATCGAAGATTTTTCTGCATATCGTCAAAAACTGTCTGAGTTTGTTTATAACTCGGCATTTATTAT
GAAGCCAATTTTCTCTCAGGCAAAAGCTGATCCAAAACGCATCGCTTATGCTGAAGGTGAAGATTATCGTGTATTGCGTA
CAGCTCAAATTGTCGTTGATGACGGTATTGCCTTCCCTGTGTTGGTTGGTCGTACTGCCGTGATTGAAGCCAATATCAAA
AAGCTAGGACTTCGCCTTGAAAATGGCGTAAATATTGAGATTGTTGATCAAGAAAATAATCCACTTTATGAAGAGTTCTG
GAAAGATTATTACCAAATCATGCAACGTAAGGGCGTAACCGTTGAATATGCACAACGCGAAGCTCGTCGTCGTTCAACCC
TGATTGCAGCGATGCTTGTAAAATTTGGTAAAGCTGACGGTATGCTATGTGGTACCTATAGTAGCTACGATATTCACTTG
GATTTTGTAAGCAAAGTGATCGGTTTAAAAGAAGGAATGAATAATTTCTTTACCTTAAATGCATTAATGCTTGAAGACCG
TAATCTATTTATTGCAGATACCTACGTAAATACCAATCCTACTGCTGAACAGCTTGCAGACATGACAATCTTGGCAGCAG
AAGAAGTACGCCGTTTTGGTATTACACCTCGCGTAGCACTTCTTTCTCATTCAAGCTTTGGTAGTAACCAAGAAGACCCA
AGTGCACAAAAGATGCGTGAAGTGTATCGCCTTCTGAATGAACGTGCGCCTGAACTTGAAGTTGAAGGTGAAATGCATGG
TGATGCAGCACTTGACGAAAGTATCCGTCATTCTGCATTCCCTGGATCAAACTTCAAAGGTTCTGCAAACCTGTTAATCA
TGCCGAATCTTGATGCCGCGAATATCTCCTTTAATCTTTTAAAGGCGACTTCTGGTAACAATGTCACAATTGGCCCAATT
TTACTGGGTGCAGCAAAACCTGTTCATATCCTTACACCAACAGCGACGACACGCCGTGTATTAAATATGACAGCCTTAAC
TGTTGCAGAAATTCAGCAAAGCGAAGGTTAA

Upstream 100 bases:

>100_bases
TGACTGTGAGAAGTTACAAAGTAATGGTATATTCGATGCAATTTAGCCCATTACACCCTGTATTTGACTAGTTAAACCCT
TGTAACAACCCGAGACTCAG

Downstream 100 bases:

>100_bases
TCCTTTGCTTTATTGAAAAGCACAACTTTGTGACTTGTGAAAACCTCTGTTCTGTTGCATGATTGCTTTGAGAACAGAGG
TTTTTTCATGCAAGTGTATT

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 756; Mature: 756

Protein sequence:

>756_residues
MDDQSLKQAALYYHENPTPGKISVTPSKQLVNQHDLALAYSPGVAAPCLEIERDPSTAAKYTARGNLVAVVTNGTAVLGL
GNIGPLASKPVMEGKGVLFKKFAGVDVFDIEIAENDPDKIVDIVAALEPTFGGINLEDIKAPECFYIEKKLRERMNIPVF
HDDQHGTSIIVGSALLNALQLVNKKIEDIKIVASGAGAAALSCLDLLCALGARKENIIVADSRGLLTTSRDGLDESKKRY
VQDITATQLHEVITGADMFLGLSAAGILTKEMVKGMAENPIIFALANPDPEILPEHAHEVRPDVIMATGRSDYPNQVNNA
LCFPYIFRGALDVGATTINEDMKIACVHAIARMAHVEADAATYGEKSASFGRDYLIPRPLDQRLILEIAPAVAQAAMDSG
VATRPIEDFSAYRQKLSEFVYNSAFIMKPIFSQAKADPKRIAYAEGEDYRVLRTAQIVVDDGIAFPVLVGRTAVIEANIK
KLGLRLENGVNIEIVDQENNPLYEEFWKDYYQIMQRKGVTVEYAQREARRRSTLIAAMLVKFGKADGMLCGTYSSYDIHL
DFVSKVIGLKEGMNNFFTLNALMLEDRNLFIADTYVNTNPTAEQLADMTILAAEEVRRFGITPRVALLSHSSFGSNQEDP
SAQKMREVYRLLNERAPELEVEGEMHGDAALDESIRHSAFPGSNFKGSANLLIMPNLDAANISFNLLKATSGNNVTIGPI
LLGAAKPVHILTPTATTRRVLNMTALTVAEIQQSEG

Sequences:

>Translated_756_residues
MDDQSLKQAALYYHENPTPGKISVTPSKQLVNQHDLALAYSPGVAAPCLEIERDPSTAAKYTARGNLVAVVTNGTAVLGL
GNIGPLASKPVMEGKGVLFKKFAGVDVFDIEIAENDPDKIVDIVAALEPTFGGINLEDIKAPECFYIEKKLRERMNIPVF
HDDQHGTSIIVGSALLNALQLVNKKIEDIKIVASGAGAAALSCLDLLCALGARKENIIVADSRGLLTTSRDGLDESKKRY
VQDITATQLHEVITGADMFLGLSAAGILTKEMVKGMAENPIIFALANPDPEILPEHAHEVRPDVIMATGRSDYPNQVNNA
LCFPYIFRGALDVGATTINEDMKIACVHAIARMAHVEADAATYGEKSASFGRDYLIPRPLDQRLILEIAPAVAQAAMDSG
VATRPIEDFSAYRQKLSEFVYNSAFIMKPIFSQAKADPKRIAYAEGEDYRVLRTAQIVVDDGIAFPVLVGRTAVIEANIK
KLGLRLENGVNIEIVDQENNPLYEEFWKDYYQIMQRKGVTVEYAQREARRRSTLIAAMLVKFGKADGMLCGTYSSYDIHL
DFVSKVIGLKEGMNNFFTLNALMLEDRNLFIADTYVNTNPTAEQLADMTILAAEEVRRFGITPRVALLSHSSFGSNQEDP
SAQKMREVYRLLNERAPELEVEGEMHGDAALDESIRHSAFPGSNFKGSANLLIMPNLDAANISFNLLKATSGNNVTIGPI
LLGAAKPVHILTPTATTRRVLNMTALTVAEIQQSEG
>Mature_756_residues
MDDQSLKQAALYYHENPTPGKISVTPSKQLVNQHDLALAYSPGVAAPCLEIERDPSTAAKYTARGNLVAVVTNGTAVLGL
GNIGPLASKPVMEGKGVLFKKFAGVDVFDIEIAENDPDKIVDIVAALEPTFGGINLEDIKAPECFYIEKKLRERMNIPVF
HDDQHGTSIIVGSALLNALQLVNKKIEDIKIVASGAGAAALSCLDLLCALGARKENIIVADSRGLLTTSRDGLDESKKRY
VQDITATQLHEVITGADMFLGLSAAGILTKEMVKGMAENPIIFALANPDPEILPEHAHEVRPDVIMATGRSDYPNQVNNA
LCFPYIFRGALDVGATTINEDMKIACVHAIARMAHVEADAATYGEKSASFGRDYLIPRPLDQRLILEIAPAVAQAAMDSG
VATRPIEDFSAYRQKLSEFVYNSAFIMKPIFSQAKADPKRIAYAEGEDYRVLRTAQIVVDDGIAFPVLVGRTAVIEANIK
KLGLRLENGVNIEIVDQENNPLYEEFWKDYYQIMQRKGVTVEYAQREARRRSTLIAAMLVKFGKADGMLCGTYSSYDIHL
DFVSKVIGLKEGMNNFFTLNALMLEDRNLFIADTYVNTNPTAEQLADMTILAAEEVRRFGITPRVALLSHSSFGSNQEDP
SAQKMREVYRLLNERAPELEVEGEMHGDAALDESIRHSAFPGSNFKGSANLLIMPNLDAANISFNLLKATSGNNVTIGPI
LLGAAKPVHILTPTATTRRVLNMTALTVAEIQQSEG

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=350, Percent_Identity=26.5714285714286, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI62420882, Length=344, Percent_Identity=27.6162790697674, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI62420880, Length=344, Percent_Identity=27.6162790697674, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI239049447, Length=344, Percent_Identity=27.6162790697674, Blast_Score=84, Evalue=5e-16,
Organism=Escherichia coli, GI1788806, Length=757, Percent_Identity=61.9550858652576, Blast_Score=967, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=345, Percent_Identity=29.2753623188406, Blast_Score=139, Evalue=9e-34,
Organism=Escherichia coli, GI1788800, Length=327, Percent_Identity=32.1100917431193, Blast_Score=135, Evalue=8e-33,
Organism=Escherichia coli, GI87081919, Length=464, Percent_Identity=23.2758620689655, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17537199, Length=396, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322823, Length=239, Percent_Identity=29.2887029288703, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI281362674, Length=472, Percent_Identity=25.8474576271186, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI281362672, Length=472, Percent_Identity=25.8474576271186, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21356279, Length=472, Percent_Identity=25.8474576271186, Blast_Score=91, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24646388, Length=352, Percent_Identity=27.8409090909091, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24646386, Length=352, Percent_Identity=27.8409090909091, Blast_Score=82, Evalue=2e-15,
Organism=Drosophila melanogaster, GI78707242, Length=430, Percent_Identity=24.6511627906977, Blast_Score=80, Evalue=7e-15,
Organism=Drosophila melanogaster, GI78707238, Length=430, Percent_Identity=24.6511627906977, Blast_Score=80, Evalue=7e-15,
Organism=Drosophila melanogaster, GI78707240, Length=340, Percent_Identity=25.5882352941176, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI281363505, Length=342, Percent_Identity=25.7309941520468, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI78707236, Length=342, Percent_Identity=25.7309941520468, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281363503, Length=342, Percent_Identity=25.7309941520468, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI78707232, Length=347, Percent_Identity=26.2247838616715, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 82441; Mature: 82441

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDQSLKQAALYYHENPTPGKISVTPSKQLVNQHDLALAYSPGVAAPCLEIERDPSTAAK
CCCHHHHHHHHEECCCCCCCEEEECCHHHHHCCCCEEEEECCCCCCCCEEECCCCCHHHE
YTARGNLVAVVTNGTAVLGLGNIGPLASKPVMEGKGVLFKKFAGVDVFDIEIAENDPDKI
EEECCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCEEEEHCCCCEEEEEEECCCCHHHH
VDIVAALEPTFGGINLEDIKAPECFYIEKKLRERMNIPVFHDDQHGTSIIVGSALLNALQ
HHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEHHHHHHHHH
LVNKKIEDIKIVASGAGAAALSCLDLLCALGARKENIIVADSRGLLTTSRDGLDESKKRY
HHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEECCCCCCCHHHHHH
VQDITATQLHEVITGADMFLGLSAAGILTKEMVKGMAENPIIFALANPDPEILPEHAHEV
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHC
RPDVIMATGRSDYPNQVNNALCFPYIFRGALDVGATTINEDMKIACVHAIARMAHVEADA
CCCEEEECCCCCCCHHHCCCEEHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHCCHH
ATYGEKSASFGRDYLIPRPLDQRLILEIAPAVAQAAMDSGVATRPIEDFSAYRQKLSEFV
HHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
YNSAFIMKPIFSQAKADPKRIAYAEGEDYRVLRTAQIVVDDGIAFPVLVGRTAVIEANIK
HCCHHHHHHHHHHCCCCCHHEEECCCCCEEEEEEEEEEEECCCEEHHHHCCEEEEECCHH
KLGLRLENGVNIEIVDQENNPLYEEFWKDYYQIMQRKGVTVEYAQREARRRSTLIAAMLV
HHCEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHH
KFGKADGMLCGTYSSYDIHLDFVSKVIGLKEGMNNFFTLNALMLEDRNLFIADTYVNTNP
HHCCCCCEEEECCCCCEEEHHHHHHHHHHHHCCCCEEEEEEEEEECCCEEEEEEEECCCC
TAEQLADMTILAAEEVRRFGITPRVALLSHSSFGSNQEDPSAQKMREVYRLLNERAPELE
CHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEE
VEGEMHGDAALDESIRHSAFPGSNFKGSANLLIMPNLDAANISFNLLKATSGNNVTIGPI
ECCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCEEEEEE
LLGAAKPVHILTPTATTRRVLNMTALTVAEIQQSEG
EECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDDQSLKQAALYYHENPTPGKISVTPSKQLVNQHDLALAYSPGVAAPCLEIERDPSTAAK
CCCHHHHHHHHEECCCCCCCEEEECCHHHHHCCCCEEEEECCCCCCCCEEECCCCCHHHE
YTARGNLVAVVTNGTAVLGLGNIGPLASKPVMEGKGVLFKKFAGVDVFDIEIAENDPDKI
EEECCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCEEEEHCCCCEEEEEEECCCCHHHH
VDIVAALEPTFGGINLEDIKAPECFYIEKKLRERMNIPVFHDDQHGTSIIVGSALLNALQ
HHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEHHHHHHHHH
LVNKKIEDIKIVASGAGAAALSCLDLLCALGARKENIIVADSRGLLTTSRDGLDESKKRY
HHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEECCCCCCCHHHHHH
VQDITATQLHEVITGADMFLGLSAAGILTKEMVKGMAENPIIFALANPDPEILPEHAHEV
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHC
RPDVIMATGRSDYPNQVNNALCFPYIFRGALDVGATTINEDMKIACVHAIARMAHVEADA
CCCEEEECCCCCCCHHHCCCEEHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHCCHH
ATYGEKSASFGRDYLIPRPLDQRLILEIAPAVAQAAMDSGVATRPIEDFSAYRQKLSEFV
HHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
YNSAFIMKPIFSQAKADPKRIAYAEGEDYRVLRTAQIVVDDGIAFPVLVGRTAVIEANIK
HCCHHHHHHHHHHCCCCCHHEEECCCCCEEEEEEEEEEEECCCEEHHHHCCEEEEECCHH
KLGLRLENGVNIEIVDQENNPLYEEFWKDYYQIMQRKGVTVEYAQREARRRSTLIAAMLV
HHCEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHH
KFGKADGMLCGTYSSYDIHLDFVSKVIGLKEGMNNFFTLNALMLEDRNLFIADTYVNTNP
HHCCCCCEEEECCCCCEEEHHHHHHHHHHHHCCCCEEEEEEEEEECCCEEEEEEEECCCC
TAEQLADMTILAAEEVRRFGITPRVALLSHSSFGSNQEDPSAQKMREVYRLLNERAPELE
CHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEE
VEGEMHGDAALDESIRHSAFPGSNFKGSANLLIMPNLDAANISFNLLKATSGNNVTIGPI
ECCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCEEEEEE
LLGAAKPVHILTPTATTRRVLNMTALTVAEIQQSEG
EECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]