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The map label for this gene is map [H]

Identifier: 50085373

GI number: 50085373

Start: 2240454

End: 2241218

Strand: Direct

Name: map [H]

Synonym: ACIAD2271

Alternate gene names: 50085373

Gene position: 2240454-2241218 (Clockwise)

Preceding gene: 50085369

Following gene: 50085374

Centisome position: 62.26

GC content: 42.75

Gene sequence:

>765_bases
ATGCGTATCGCGGGACGACTGGCAGCTGAAGTTCTTGACATGATTAAACCTCATATTCAGCTAGGGGTAAGTACACTTGA
GCTGGATCGAATCTGTCATGATCATATTGTCAATGCTCAACAAGCTATTCCTGCTTGCTTGGGGTATGGCGCAGCACCAG
GACGACCAGCGTTTCAACATACCATCTGTACTTCAGTCAATCATGTGGTGTGCCACGGCATCCCTTCTTCAGAGAAAATT
CTGAAAAAAGGTGATATTTTAAATATTGATGTGACTGTGATTAAAGATGGTTATCATGGCGATACCAACATGATGTATGT
AGTGGGCGGCGAAACTTCAATTCTCGCCAATCGTCTATGCAATGTGGCTCAAGAAGCCATGTATCGCGGTATGGAAACGG
TTCGTGCAGGTTCATTTATTGGTGACATCGGTTACGCCATTCAGAAATATGTAGAATCTGAACGCTTTAGTGTAGTGCGT
GAATATTGCGGACATGGGATTGGAACCGTGTTTCATGATGAACCACAAGTCCTTCACTATGGCCAAAAAGGCACAGGTAT
GCAGCTTGAAGCTGGCATGACATTTACTATTGAGCCAATGGTGAATGCTGGTGTTTGGCAAACCAAATTACTAGGCGATA
AATGGACTGTTGTCACTAAGGATCATAAATTATCTGCACAGTTTGAGCATACAATTTTAGTTACAGAAACTGGACTTGAG
GTTTTAACTGCCCGACCAGAAGAAGATTTATCTCGTTTTATGTAA

Upstream 100 bases:

>100_bases
ACCATAACTGCTTTCAAATTACCAAAAGTTTTTAAACATCATGAATAGTTCCTATACAGCCCCACGTCGACTGATCAAAA
CCCCTGAAGAAATTGAAAAA

Downstream 100 bases:

>100_bases
TTTTATATTTTCTAATGTGTATAAAAGGTCACTTTGTGGCCTTTTATTTGTTTAATTTATACATTTTTAGTTCACATTTT
TCATTTTTATTTCACTTTTA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MRIAGRLAAEVLDMIKPHIQLGVSTLELDRICHDHIVNAQQAIPACLGYGAAPGRPAFQHTICTSVNHVVCHGIPSSEKI
LKKGDILNIDVTVIKDGYHGDTNMMYVVGGETSILANRLCNVAQEAMYRGMETVRAGSFIGDIGYAIQKYVESERFSVVR
EYCGHGIGTVFHDEPQVLHYGQKGTGMQLEAGMTFTIEPMVNAGVWQTKLLGDKWTVVTKDHKLSAQFEHTILVTETGLE
VLTARPEEDLSRFM

Sequences:

>Translated_254_residues
MRIAGRLAAEVLDMIKPHIQLGVSTLELDRICHDHIVNAQQAIPACLGYGAAPGRPAFQHTICTSVNHVVCHGIPSSEKI
LKKGDILNIDVTVIKDGYHGDTNMMYVVGGETSILANRLCNVAQEAMYRGMETVRAGSFIGDIGYAIQKYVESERFSVVR
EYCGHGIGTVFHDEPQVLHYGQKGTGMQLEAGMTFTIEPMVNAGVWQTKLLGDKWTVVTKDHKLSAQFEHTILVTETGLE
VLTARPEEDLSRFM
>Mature_254_residues
MRIAGRLAAEVLDMIKPHIQLGVSTLELDRICHDHIVNAQQAIPACLGYGAAPGRPAFQHTICTSVNHVVCHGIPSSEKI
LKKGDILNIDVTVIKDGYHGDTNMMYVVGGETSILANRLCNVAQEAMYRGMETVRAGSFIGDIGYAIQKYVESERFSVVR
EYCGHGIGTVFHDEPQVLHYGQKGTGMQLEAGMTFTIEPMVNAGVWQTKLLGDKWTVVTKDHKLSAQFEHTILVTETGLE
VLTARPEEDLSRFM

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=254, Percent_Identity=42.9133858267717, Blast_Score=203, Evalue=1e-52,
Organism=Homo sapiens, GI40385867, Length=245, Percent_Identity=40, Blast_Score=179, Evalue=2e-45,
Organism=Escherichia coli, GI1786364, Length=250, Percent_Identity=58.8, Blast_Score=306, Evalue=8e-85,
Organism=Caenorhabditis elegans, GI71996291, Length=245, Percent_Identity=41.2244897959184, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6323273, Length=245, Percent_Identity=42.4489795918367, Blast_Score=206, Evalue=3e-54,
Organism=Drosophila melanogaster, GI21355531, Length=249, Percent_Identity=45.3815261044177, Blast_Score=207, Evalue=6e-54,
Organism=Drosophila melanogaster, GI24583427, Length=243, Percent_Identity=38.2716049382716, Blast_Score=171, Evalue=6e-43,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27969; Mature: 27969

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIAGRLAAEVLDMIKPHIQLGVSTLELDRICHDHIVNAQQAIPACLGYGAAPGRPAFQH
CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHH
TICTSVNHVVCHGIPSSEKILKKGDILNIDVTVIKDGYHGDTNMMYVVGGETSILANRLC
HHHHCCCEEEEECCCCHHHHHHCCCEEEEEEEEEECCCCCCCEEEEEECCCHHHHHHHHH
NVAQEAMYRGMETVRAGSFIGDIGYAIQKYVESERFSVVREYCGHGIGTVFHDEPQVLHY
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCEEEE
GQKGTGMQLEAGMTFTIEPMVNAGVWQTKLLGDKWTVVTKDHKLSAQFEHTILVTETGLE
CCCCCCEEEECCCEEEECCCCCCCCEEEEECCCEEEEEECCCCCCCEEEEEEEEEECCCE
VLTARPEEDLSRFM
EEECCCHHHHHHCC
>Mature Secondary Structure
MRIAGRLAAEVLDMIKPHIQLGVSTLELDRICHDHIVNAQQAIPACLGYGAAPGRPAFQH
CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHH
TICTSVNHVVCHGIPSSEKILKKGDILNIDVTVIKDGYHGDTNMMYVVGGETSILANRLC
HHHHCCCEEEEECCCCHHHHHHCCCEEEEEEEEEECCCCCCCEEEEEECCCHHHHHHHHH
NVAQEAMYRGMETVRAGSFIGDIGYAIQKYVESERFSVVREYCGHGIGTVFHDEPQVLHY
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCEEEE
GQKGTGMQLEAGMTFTIEPMVNAGVWQTKLLGDKWTVVTKDHKLSAQFEHTILVTETGLE
CCCCCCEEEECCCEEEECCCCCCCCEEEEECCCEEEEEECCCCCCCEEEEEEEEEECCCE
VLTARPEEDLSRFM
EEECCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]