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The map label for this gene is dapL [H]

Identifier: 50085201

GI number: 50085201

Start: 2062476

End: 2063645

Strand: Direct

Name: dapL [H]

Synonym: ACIAD2080

Alternate gene names: 50085201

Gene position: 2062476-2063645 (Clockwise)

Preceding gene: 50085200

Following gene: 50085208

Centisome position: 57.31

GC content: 39.74

Gene sequence:

>1170_bases
ATGAACTCAAGCTTGTCTCTTTTACATCCCTATCCTTTTGAAAAATTGAATGTACTTTTCAAAGATGTCACGCCAGCAGA
TTTGCCATTAATTCCCCTTTCTATTGGCGAACCTAAGCACCCTGCGCCAGAATTTGTAAAACAGGCCATCATTGATAATT
TTAATCACTTATCGACTTATCCAAATAGTAAGGGCTTACCTGAACTCCGTGAAAGTATTGCAAGATGGTTAACTCAGCGT
TTTCAGCTTAATCATATTAGTTCCGAAGATCACATCTTGCCAGTTACAGGCACACGTGAAGGAATTTTCTCTTTTGTACA
GGCACTGATTAATCGTGACGAAGCACCTTATGTCGTCATGCCAAATCCCTTTTACCAGATTTATGAAGGTGCAACTTTAC
TTGCGGGTGCAAAACCTTATTTTATCAATTGCACCGCAGAGAATGACTATTTAGGTGACTTTGATGCAGTGCCTTCGGAA
GTATGGGAAAAGACTGCATTACTTTTTGTGTGTACTCCAGGCAACCCAACGGGTGCTGTACTTTCGAAAGAAAAGCTTAA
AAAATTAATTCAATTGTCTGATCAATATAATTTTGTGATCGCATCAGATGAGTGCTATTCGGAATTATGGTTTGATCAAG
CACCTGTTGGTTTATTAGAAGTGTGTGCTGAAATCGGACGCGATAATTATAAAAACTGTATCGTTTTTCATTCATTATCC
AAGCGCTCTAACTTACCAGGTATGCGTTCTGGCTTTGTTGCAGGTGATGCTGAACTTTTAAAACCTTATTTAAAGTTCCG
TACTTATCATGGTGCTGCAATGCCTGTACAACATCAACTTGCTTCGATTGCTGCATGGAATGATGAAGCACATGTTGAAG
AAAATCGTCAGCAATACCGTGCTAAATTTAATTTGTTCCAGTCCGAACTGGGTCAGTTGATTCCTCTAAAAAAACCAGAT
GCTGGATTTTATTACTGGTTACACGTGGATAATGACGAAGCCTTTGCAAAAATGCTCATGGAAAAAGCACATATTAAGGT
GCTACCAGGTCGCTACTTATCACGTGAAACAGAACAAGGCAATCCAGGTGAAAATCACGTGCGCATGGCATTGGTCGCAG
ATCTGGCGCAATGTGAACAGGTAGTTCAACGCTTGAAGAAAGTTCTTTAA

Upstream 100 bases:

>100_bases
AAGCACATATTTTTTCTGCTCAATTAAAGCTAGCTTTAGATGAAGCATCTAATCAAATTGTTAGTCAACATTAATACTTT
TCGTTACTGGTAACTGTTTA

Downstream 100 bases:

>100_bases
CAGCCCATATAAATTGGTTTTGTAGAAAATAAAGGCTCAGTTTCAACTGAGCCTCTATTTAAGTGGATTATCGAGAATTC
GCTACAACAATTGAACCAAT

Product: succinyldiaminopimelate transaminase

Products: NA

Alternate protein names: DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MNSSLSLLHPYPFEKLNVLFKDVTPADLPLIPLSIGEPKHPAPEFVKQAIIDNFNHLSTYPNSKGLPELRESIARWLTQR
FQLNHISSEDHILPVTGTREGIFSFVQALINRDEAPYVVMPNPFYQIYEGATLLAGAKPYFINCTAENDYLGDFDAVPSE
VWEKTALLFVCTPGNPTGAVLSKEKLKKLIQLSDQYNFVIASDECYSELWFDQAPVGLLEVCAEIGRDNYKNCIVFHSLS
KRSNLPGMRSGFVAGDAELLKPYLKFRTYHGAAMPVQHQLASIAAWNDEAHVEENRQQYRAKFNLFQSELGQLIPLKKPD
AGFYYWLHVDNDEAFAKMLMEKAHIKVLPGRYLSRETEQGNPGENHVRMALVADLAQCEQVVQRLKKVL

Sequences:

>Translated_389_residues
MNSSLSLLHPYPFEKLNVLFKDVTPADLPLIPLSIGEPKHPAPEFVKQAIIDNFNHLSTYPNSKGLPELRESIARWLTQR
FQLNHISSEDHILPVTGTREGIFSFVQALINRDEAPYVVMPNPFYQIYEGATLLAGAKPYFINCTAENDYLGDFDAVPSE
VWEKTALLFVCTPGNPTGAVLSKEKLKKLIQLSDQYNFVIASDECYSELWFDQAPVGLLEVCAEIGRDNYKNCIVFHSLS
KRSNLPGMRSGFVAGDAELLKPYLKFRTYHGAAMPVQHQLASIAAWNDEAHVEENRQQYRAKFNLFQSELGQLIPLKKPD
AGFYYWLHVDNDEAFAKMLMEKAHIKVLPGRYLSRETEQGNPGENHVRMALVADLAQCEQVVQRLKKVL
>Mature_389_residues
MNSSLSLLHPYPFEKLNVLFKDVTPADLPLIPLSIGEPKHPAPEFVKQAIIDNFNHLSTYPNSKGLPELRESIARWLTQR
FQLNHISSEDHILPVTGTREGIFSFVQALINRDEAPYVVMPNPFYQIYEGATLLAGAKPYFINCTAENDYLGDFDAVPSE
VWEKTALLFVCTPGNPTGAVLSKEKLKKLIQLSDQYNFVIASDECYSELWFDQAPVGLLEVCAEIGRDNYKNCIVFHSLS
KRSNLPGMRSGFVAGDAELLKPYLKFRTYHGAAMPVQHQLASIAAWNDEAHVEENRQQYRAKFNLFQSELGQLIPLKKPD
AGFYYWLHVDNDEAFAKMLMEKAHIKVLPGRYLSRETEQGNPGENHVRMALVADLAQCEQVVQRLKKVL

Specific function: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713254, Length=282, Percent_Identity=27.6595744680851, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI56713256, Length=282, Percent_Identity=27.6595744680851, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI95147551, Length=290, Percent_Identity=25.5172413793103, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI169881279, Length=290, Percent_Identity=25.5172413793103, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1788722, Length=374, Percent_Identity=25.9358288770053, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1788627, Length=228, Percent_Identity=28.9473684210526, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1787710, Length=340, Percent_Identity=24.7058823529412, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71994476, Length=405, Percent_Identity=21.7283950617284, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71994472, Length=405, Percent_Identity=21.7283950617284, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17567663, Length=387, Percent_Identity=23.7726098191214, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17567369, Length=284, Percent_Identity=23.2394366197183, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6322401, Length=394, Percent_Identity=25.3807106598985, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6320317, Length=377, Percent_Identity=22.8116710875332, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323118, Length=375, Percent_Identity=24.2666666666667, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI28573069, Length=246, Percent_Identity=26.0162601626016, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24646114, Length=246, Percent_Identity=26.0162601626016, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28573067, Length=246, Percent_Identity=26.0162601626016, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28573065, Length=246, Percent_Identity=26.0162601626016, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR019881
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.83 [H]

Molecular weight: Translated: 44044; Mature: 44044

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSSLSLLHPYPFEKLNVLFKDVTPADLPLIPLSIGEPKHPAPEFVKQAIIDNFNHLSTY
CCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCHHHCCC
PNSKGLPELRESIARWLTQRFQLNHISSEDHILPVTGTREGIFSFVQALINRDEAPYVVM
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCCEEEE
PNPFYQIYEGATLLAGAKPYFINCTAENDYLGDFDAVPSEVWEKTALLFVCTPGNPTGAV
CCCHHHHHCCCEEEECCCCEEEEEECCCCCCCCCCCCCHHHHCCEEEEEEECCCCCCCHH
LSKEKLKKLIQLSDQYNFVIASDECYSELWFDQAPVGLLEVCAEIGRDNYKNCIVFHSLS
CCHHHHHHHHHHCCCCCEEEECHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEEECH
KRSNLPGMRSGFVAGDAELLKPYLKFRTYHGAAMPVQHQLASIAAWNDEAHVEENRQQYR
HHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
AKFNLFQSELGQLIPLKKPDAGFYYWLHVDNDEAFAKMLMEKAHIKVLPGRYLSRETEQG
HHHHHHHHHHHCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCEEECCCHHHCCCCCCC
NPGENHVRMALVADLAQCEQVVQRLKKVL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MNSSLSLLHPYPFEKLNVLFKDVTPADLPLIPLSIGEPKHPAPEFVKQAIIDNFNHLSTY
CCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCHHHCCC
PNSKGLPELRESIARWLTQRFQLNHISSEDHILPVTGTREGIFSFVQALINRDEAPYVVM
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCCEEEE
PNPFYQIYEGATLLAGAKPYFINCTAENDYLGDFDAVPSEVWEKTALLFVCTPGNPTGAV
CCCHHHHHCCCEEEECCCCEEEEEECCCCCCCCCCCCCHHHHCCEEEEEEECCCCCCCHH
LSKEKLKKLIQLSDQYNFVIASDECYSELWFDQAPVGLLEVCAEIGRDNYKNCIVFHSLS
CCHHHHHHHHHHCCCCCEEEECHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEEECH
KRSNLPGMRSGFVAGDAELLKPYLKFRTYHGAAMPVQHQLASIAAWNDEAHVEENRQQYR
HHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
AKFNLFQSELGQLIPLKKPDAGFYYWLHVDNDEAFAKMLMEKAHIKVLPGRYLSRETEQG
HHHHHHHHHHHCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCEEECCCHHHCCCCCCC
NPGENHVRMALVADLAQCEQVVQRLKKVL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA