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The map label for this gene is mdcR [H]

Identifier: 50084913

GI number: 50084913

Start: 1766935

End: 1767855

Strand: Reverse

Name: mdcR [H]

Synonym: ACIAD1762

Alternate gene names: 50084913

Gene position: 1767855-1766935 (Counterclockwise)

Preceding gene: 50084914

Following gene: 50084903

Centisome position: 49.13

GC content: 37.46

Gene sequence:

>921_bases
ATGGAAATTGATGAAGAATTAACCTTAAAAAAACTCCAGATTTTTTTGGCCTTTATGCGTAATGGAAATCTTTCCAAAAC
TGCTTCCGAAATGGAAATTAGTAATGTCAGTGTTCATAAAGCACTACACTCATTGGAAAGTGCCCTACGCTGTCCACTAT
TTAAGCATGAAGGCCGCAACTTAATTCCGCTTAAAAGTGCTTATGTATTACAGGAACATTCGCATAAACTTGTTCAAGAT
ATTGTGGTGACTATCAATAAAACCAGAGAGGCAGCAGGTTTTGCTGCCAAAGTATTGCATTTAGGTTCATTATATTCACT
AACTGTCAATACGATTCCGAATGTGATCAGTCGCTTAAAGCTCAGACGCGGTGAACTAGATATTCAGTTATTGTTAAGTT
CAAATCTGGATCTGGTTAAAAAATTAAAATCGACAGAATTGGATGCGATTATTGTGGCACTCAATGAGACCACTCGGGAT
CCAGATTTTGAGAGTCTACCTATGTTTGAAGATAATATTTATCTTGCGGTTAACAAACATTCGCCCCTTGCTAGCTTAGA
TGAAATTGATTTAAGCACACTTAAGGATGAAACTTTTTTAACACTCTCTAAAGGTTTTGCGACTCGTAACGACAGTGACC
TAGTGTTTGAGAAAGCAGGAATAGACCCTAAAGTCTTTCTTCAGGTGAGTGATATTTTCACTTTAGTGAGTATGGTGAGT
ACTGGAGTTGGTTTGGCACTGTTGCCTGGACGTATCTCGACCATTTATGAAAGTTCGGTCAAACTAATTCCGTTACAAGG
GTCCTATCAAATCAAACAGGAAATCGGTCTGGTTTTTTTGAAAAGTAAGGAAAGAGATCCTAATTTACTGGCATTAGTCG
CAGAATGTCGAATGTTTGCCAAGCAATATATTGCAATATAA

Upstream 100 bases:

>100_bases
ACCGTGCCTGCTGGTAGTCAGATTTTACAATCTCCCTCTGAAACCTGTAAAAATATTGGCTAGTAATCTGGATAAATAAA
TAATCAGGGATGATTTTTAA

Downstream 100 bases:

>100_bases
ATTTGGGCAGCAGATTTAGCCCGCTGCCCATGAGTGAAAATTAAGCACCAATCAATGCTTTCACTGCAAAAAATAATACA
GTTGGCCCCATTAAGCAGCC

Product: malonate utilization transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MEIDEELTLKKLQIFLAFMRNGNLSKTASEMEISNVSVHKALHSLESALRCPLFKHEGRNLIPLKSAYVLQEHSHKLVQD
IVVTINKTREAAGFAAKVLHLGSLYSLTVNTIPNVISRLKLRRGELDIQLLLSSNLDLVKKLKSTELDAIIVALNETTRD
PDFESLPMFEDNIYLAVNKHSPLASLDEIDLSTLKDETFLTLSKGFATRNDSDLVFEKAGIDPKVFLQVSDIFTLVSMVS
TGVGLALLPGRISTIYESSVKLIPLQGSYQIKQEIGLVFLKSKERDPNLLALVAECRMFAKQYIAI

Sequences:

>Translated_306_residues
MEIDEELTLKKLQIFLAFMRNGNLSKTASEMEISNVSVHKALHSLESALRCPLFKHEGRNLIPLKSAYVLQEHSHKLVQD
IVVTINKTREAAGFAAKVLHLGSLYSLTVNTIPNVISRLKLRRGELDIQLLLSSNLDLVKKLKSTELDAIIVALNETTRD
PDFESLPMFEDNIYLAVNKHSPLASLDEIDLSTLKDETFLTLSKGFATRNDSDLVFEKAGIDPKVFLQVSDIFTLVSMVS
TGVGLALLPGRISTIYESSVKLIPLQGSYQIKQEIGLVFLKSKERDPNLLALVAECRMFAKQYIAI
>Mature_306_residues
MEIDEELTLKKLQIFLAFMRNGNLSKTASEMEISNVSVHKALHSLESALRCPLFKHEGRNLIPLKSAYVLQEHSHKLVQD
IVVTINKTREAAGFAAKVLHLGSLYSLTVNTIPNVISRLKLRRGELDIQLLLSSNLDLVKKLKSTELDAIIVALNETTRD
PDFESLPMFEDNIYLAVNKHSPLASLDEIDLSTLKDETFLTLSKGFATRNDSDLVFEKAGIDPKVFLQVSDIFTLVSMVS
TGVGLALLPGRISTIYESSVKLIPLQGSYQIKQEIGLVFLKSKERDPNLLALVAECRMFAKQYIAI

Specific function: Transcriptional regulator of the mau genes for malonate utilization [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=257, Percent_Identity=25.2918287937743, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790399, Length=282, Percent_Identity=21.9858156028369, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI2367136, Length=289, Percent_Identity=22.8373702422145, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788887, Length=271, Percent_Identity=21.0332103321033, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787530, Length=236, Percent_Identity=22.8813559322034, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34125; Mature: 34125

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIDEELTLKKLQIFLAFMRNGNLSKTASEMEISNVSVHKALHSLESALRCPLFKHEGRN
CCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCC
LIPLKSAYVLQEHSHKLVQDIVVTINKTREAAGFAAKVLHLGSLYSLTVNTIPNVISRLK
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHH
LRRGELDIQLLLSSNLDLVKKLKSTELDAIIVALNETTRDPDFESLPMFEDNIYLAVNKH
HHCCCCEEEEEECCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEECC
SPLASLDEIDLSTLKDETFLTLSKGFATRNDSDLVFEKAGIDPKVFLQVSDIFTLVSMVS
CCCCCHHHCHHHHHCCCEEEEEECCCCCCCCCCEEEEECCCCCEEEEEHHHHHHHHHHHH
TGVGLALLPGRISTIYESSVKLIPLQGSYQIKQEIGLVFLKSKERDPNLLALVAECRMFA
CCCCEEECCCHHHHHHHCCEEEEECCCCEEHHHHHCEEEEECCCCCCCHHHHHHHHHHHH
KQYIAI
HHHHCC
>Mature Secondary Structure
MEIDEELTLKKLQIFLAFMRNGNLSKTASEMEISNVSVHKALHSLESALRCPLFKHEGRN
CCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCC
LIPLKSAYVLQEHSHKLVQDIVVTINKTREAAGFAAKVLHLGSLYSLTVNTIPNVISRLK
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHH
LRRGELDIQLLLSSNLDLVKKLKSTELDAIIVALNETTRDPDFESLPMFEDNIYLAVNKH
HHCCCCEEEEEECCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEECC
SPLASLDEIDLSTLKDETFLTLSKGFATRNDSDLVFEKAGIDPKVFLQVSDIFTLVSMVS
CCCCCHHHCHHHHHCCCEEEEEECCCCCCCCCCEEEEECCCCCEEEEEHHHHHHHHHHHH
TGVGLALLPGRISTIYESSVKLIPLQGSYQIKQEIGLVFLKSKERDPNLLALVAECRMFA
CCCCEEECCCHHHHHHHCCEEEEECCCCEEHHHHHCEEEEECCCCCCCHHHHHHHHHHHH
KQYIAI
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA