BacMap

Definition	Acinetobacter sp. ADP1 chromosome, complete genome.
Accession	NC_005966
Length	3,598,621

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The map label for this gene is pcaK

Identifier: 50084863

GI number: 50084863

Start: 1713983

End: 1715356

Strand: Direct

Name: pcaK

Synonym: ACIAD1709

Alternate gene names: 50084863

Gene position: 1713983-1715356 (Clockwise)

Preceding gene: 50084862

Following gene: 50084864

Centisome position: 47.63

GC content: 42.58

Gene sequence:

>1374_bases
ATGCCTAAGGAGGCAAATATGGCGTCTCAGGATTACGCTACTCAAAGATCAAGTTTAGATGCACAGGCATTAATTAATGA
TGCTCCATTGAGTCGATATCAATGGCTCATTGCGATTGTTTGTTTTCTCATTGTTTTTGTTGATGGTATTGATACTGCTG
CAATGGGATTTATCGCGCCAGCATTGGCACAGGATTGGGGTGTAGATCGCTCTCAACTTGGTCCAGTGATGAGTGCAGCA
CTCGGCGGTATGATTATTGGTGCATTGGTTTCAGGGCCAACAGCAGACCGTTTCGGACGTAAAATCGTTTTATCTATGTC
CATGCTCGTTTTTGGTGGTTTTACACTGGCATGTGCTTATTCTACAAATTTAGATAGTTTGGTCATTTTCCGATTTCTAA
CAGGTATCGGATTGGGCGCAGCCATGCCAAATGCGACGACATTATTTTCTGAATATTGTCCAGCACGTATTCGTTCACTA
CTCGTGACGTGTATGTTTTGTGGTTATAACTTGGGTATGGCTATTGGTGGTTTTATCAGTAGCTGGCTTATTCCAGCTTT
TGGTTGGCACAGTCTGTTTCTTTTAGGCGGTTGGGCACCATTAATCTTGATGCTATTGGTCATTTTCTTCCTTCCAGAAT
CGTATCGTTTCTTGATCGTAAAAGGAAAAAATACCAAAAAAGTTCGTCAAATTTTATCGCGTATTGCACCACAAAAAGTT
CAAGGCGTGACCGAGTTTCATGTTCCAGAAGAAAAAGTTGAAGCAGGAACCAAGAAAGGTGTATTTGGCATGCTGTTTTC
AGCGAAATACGTCAAAGGTACGGTTTTGCTTTGGGTCACCTATTTTATGGGATTGGTCATGATTTATCTGTTGACCAGTT
GGTTGCCAACTTTGATGCGTGAAACAGGTGCATCTTTAGAGCGTGCAGCATTCTTGGGTGGTTTATTCCAGTTCGGTGGT
GTGCTTAGTGCGTTATTTATCGGTTGGGCAATGGATCGTTTCAATCCAAACCGAATTATTGCTGGCTTTTACTTGGCAGC
AGGTATCTTTGCGGTGATTGTGGGACAAAGCTTATCAAACCCAACGTTACTTGCTCTGTTTATTTTATGTGCAGGTATTG
CCGTCAATGGTGCTCAATCTTCAATGCCAGTATTGAGTGCGCGTTTCTATCCAACGCAATGTCGTGCAACAGGTGTGGCA
TGGATGTCTGGAATTGGCCGTTTTGGTGCCGTATTTGGTGCATGGATTGGTGCAGTTTTATTAGGAAATAACTGGTCATT
TACCATGATCCTGAGCATGTTGATTATTCCTGCTGCTGCCGCTGCAATTGCAATTTTTGTTAAATCCCTTGTTGCACATA
CAGATGCAACTTGA

Upstream 100 bases:

>100_bases
GCATCGCATCTTTCAAATATTGAACAACCTGAAAAATTTATTCAAATTTTCAGTGGATTTGTTAAATCTATTCAATAGCT
TAGAGATTTAAAAGGACTTT

Downstream 100 bases:

>100_bases
TGTGAGGTTTCTCTTATGAATGATGAACAACGTTATAAACAAGGGCTGGAAGTCCGTACAGAAGTTCTGGGTGAAAAGCA
TGTTAACCGTTCACTTGAGA

Product: 4-hydroxybenzoate transporter

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MPKEANMASQDYATQRSSLDAQALINDAPLSRYQWLIAIVCFLIVFVDGIDTAAMGFIAPALAQDWGVDRSQLGPVMSAA
LGGMIIGALVSGPTADRFGRKIVLSMSMLVFGGFTLACAYSTNLDSLVIFRFLTGIGLGAAMPNATTLFSEYCPARIRSL
LVTCMFCGYNLGMAIGGFISSWLIPAFGWHSLFLLGGWAPLILMLLVIFFLPESYRFLIVKGKNTKKVRQILSRIAPQKV
QGVTEFHVPEEKVEAGTKKGVFGMLFSAKYVKGTVLLWVTYFMGLVMIYLLTSWLPTLMRETGASLERAAFLGGLFQFGG
VLSALFIGWAMDRFNPNRIIAGFYLAAGIFAVIVGQSLSNPTLLALFILCAGIAVNGAQSSMPVLSARFYPTQCRATGVA
WMSGIGRFGAVFGAWIGAVLLGNNWSFTMILSMLIIPAAAAAIAIFVKSLVAHTDAT

Sequences:

>Translated_457_residues
MPKEANMASQDYATQRSSLDAQALINDAPLSRYQWLIAIVCFLIVFVDGIDTAAMGFIAPALAQDWGVDRSQLGPVMSAA
LGGMIIGALVSGPTADRFGRKIVLSMSMLVFGGFTLACAYSTNLDSLVIFRFLTGIGLGAAMPNATTLFSEYCPARIRSL
LVTCMFCGYNLGMAIGGFISSWLIPAFGWHSLFLLGGWAPLILMLLVIFFLPESYRFLIVKGKNTKKVRQILSRIAPQKV
QGVTEFHVPEEKVEAGTKKGVFGMLFSAKYVKGTVLLWVTYFMGLVMIYLLTSWLPTLMRETGASLERAAFLGGLFQFGG
VLSALFIGWAMDRFNPNRIIAGFYLAAGIFAVIVGQSLSNPTLLALFILCAGIAVNGAQSSMPVLSARFYPTQCRATGVA
WMSGIGRFGAVFGAWIGAVLLGNNWSFTMILSMLIIPAAAAAIAIFVKSLVAHTDAT
>Mature_456_residues
PKEANMASQDYATQRSSLDAQALINDAPLSRYQWLIAIVCFLIVFVDGIDTAAMGFIAPALAQDWGVDRSQLGPVMSAAL
GGMIIGALVSGPTADRFGRKIVLSMSMLVFGGFTLACAYSTNLDSLVIFRFLTGIGLGAAMPNATTLFSEYCPARIRSLL
VTCMFCGYNLGMAIGGFISSWLIPAFGWHSLFLLGGWAPLILMLLVIFFLPESYRFLIVKGKNTKKVRQILSRIAPQKVQ
GVTEFHVPEEKVEAGTKKGVFGMLFSAKYVKGTVLLWVTYFMGLVMIYLLTSWLPTLMRETGASLERAAFLGGLFQFGGV
LSALFIGWAMDRFNPNRIIAGFYLAAGIFAVIVGQSLSNPTLLALFILCAGIAVNGAQSSMPVLSARFYPTQCRATGVAW
MSGIGRFGAVFGAWIGAVLLGNNWSFTMILSMLIIPAAAAAIAIFVKSLVAHTDAT

Specific function: Could Be A Transporter For 3-Phenylpropionate (Hydrocinnamic Acid). [C]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family

Homologues:

Organism=Homo sapiens, GI24308167, Length=460, Percent_Identity=24.1304347826087, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI7662270, Length=336, Percent_Identity=25, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI216548223, Length=346, Percent_Identity=24.5664739884393, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI213021148, Length=404, Percent_Identity=22.7722772277228, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI73695465, Length=327, Percent_Identity=24.4648318042813, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI262399383, Length=260, Percent_Identity=26.9230769230769, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI296080721, Length=156, Percent_Identity=31.4102564102564, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI296080719, Length=156, Percent_Identity=31.4102564102564, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI24497499, Length=156, Percent_Identity=31.4102564102564, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI296080734, Length=156, Percent_Identity=31.4102564102564, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4507005, Length=353, Percent_Identity=25.4957507082153, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI166064021, Length=386, Percent_Identity=23.0569948186528, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI11415038, Length=342, Percent_Identity=26.3157894736842, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI87081723, Length=380, Percent_Identity=34.7368421052632, Blast_Score=167, Evalue=9e-43,
Organism=Escherichia coli, GI1788068, Length=432, Percent_Identity=23.6111111111111, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI87082159, Length=401, Percent_Identity=24.6882793017456, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI87082231, Length=419, Percent_Identity=22.9116945107399, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790463, Length=451, Percent_Identity=26.1640798226164, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786229, Length=388, Percent_Identity=20.6185567010309, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1788074, Length=363, Percent_Identity=22.5895316804408, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1789152, Length=327, Percent_Identity=23.8532110091743, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI32564663, Length=460, Percent_Identity=25.4347826086956, Blast_Score=117, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI17565978, Length=188, Percent_Identity=27.6595744680851, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320595, Length=154, Percent_Identity=31.1688311688312, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24640198, Length=475, Percent_Identity=25.2631578947368, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24640196, Length=475, Percent_Identity=25.2631578947368, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24640200, Length=475, Percent_Identity=25.2631578947368, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI19922874, Length=451, Percent_Identity=22.1729490022173, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI161077756, Length=444, Percent_Identity=23.1981981981982, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PCAK_ACIAD (Q43975)

Other databases:

- EMBL:   L05770
- EMBL:   CR543861
- RefSeq:   YP_046373.1
- ProteinModelPortal:   Q43975
- STRING:   Q43975
- GeneID:   2879440
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD1709
- NMPDR:   fig|62977.3.peg.1635
- eggNOG:   COG0477
- HOGENOM:   HBG715489
- OMA:   KEANMAS
- PhylomeDB:   Q43975
- ProtClustDB:   CLSK865703
- BioCyc:   ASP62977:ACIAD1709-MONOMER
- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- TIGRFAMs:   TIGR00895

Pfam domain/function: PF07690 MFS_1; SSF103473 MFS_gen_substrate_transporter

EC number: NA

Molecular weight: Translated: 49193; Mature: 49062

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: PS50850 MFS; PS00216 SUGAR_TRANSPORT_1; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x187f29e8)-; HASH(0x188ad220)-; HASH(0x1837abf4)-; HASH(0x164cccfc)-; HASH(0x18271030)-; HASH(0x1876b5e0)-; HASH(0x1801cf9c)-; HASH(0x18531e8c)-; HASH(0x188da1b8)-; HASH(0x188d1b74)-; HASH(0x186b09e0)-; HASH(0x180dfe68)-;

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKEANMASQDYATQRSSLDAQALINDAPLSRYQWLIAIVCFLIVFVDGIDTAAMGFIAP
CCCCCCCCHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
ALAQDWGVDRSQLGPVMSAALGGMIIGALVSGPTADRFGRKIVLSMSMLVFGGFTLACAY
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHEEEE
STNLDSLVIFRFLTGIGLGAAMPNATTLFSEYCPARIRSLLVTCMFCGYNLGMAIGGFIS
CCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SWLIPAFGWHSLFLLGGWAPLILMLLVIFFLPESYRFLIVKGKNTKKVRQILSRIAPQKV
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCHHHH
QGVTEFHVPEEKVEAGTKKGVFGMLFSAKYVKGTVLLWVTYFMGLVMIYLLTSWLPTLMR
CCCHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETGASLERAAFLGGLFQFGGVLSALFIGWAMDRFNPNRIIAGFYLAAGIFAVIVGQSLSN
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCC
PTLLALFILCAGIAVNGAQSSMPVLSARFYPTQCRATGVAWMSGIGRFGAVFGAWIGAVL
HHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGNNWSFTMILSMLIIPAAAAAIAIFVKSLVAHTDAT
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure 
PKEANMASQDYATQRSSLDAQALINDAPLSRYQWLIAIVCFLIVFVDGIDTAAMGFIAP
CCCCCCCHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
ALAQDWGVDRSQLGPVMSAALGGMIIGALVSGPTADRFGRKIVLSMSMLVFGGFTLACAY
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHEEEE
STNLDSLVIFRFLTGIGLGAAMPNATTLFSEYCPARIRSLLVTCMFCGYNLGMAIGGFIS
CCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SWLIPAFGWHSLFLLGGWAPLILMLLVIFFLPESYRFLIVKGKNTKKVRQILSRIAPQKV
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCHHHH
QGVTEFHVPEEKVEAGTKKGVFGMLFSAKYVKGTVLLWVTYFMGLVMIYLLTSWLPTLMR
CCCHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETGASLERAAFLGGLFQFGGVLSALFIGWAMDRFNPNRIIAGFYLAAGIFAVIVGQSLSN
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCC
PTLLALFILCAGIAVNGAQSSMPVLSARFYPTQCRATGVAWMSGIGRFGAVFGAWIGAVL
HHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGNNWSFTMILSMLIIPAAAAAIAIFVKSLVAHTDAT
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8063101