Click here to switch to the map view.

The map label for this gene is dcaH [H]

Identifier: 50084845

GI number: 50084845

Start: 1694564

End: 1696081

Strand: Reverse

Name: dcaH [H]

Synonym: ACIAD1690

Alternate gene names: 50084845

Gene position: 1696081-1694564 (Counterclockwise)

Preceding gene: 50084846

Following gene: 50084844

Centisome position: 47.13

GC content: 41.37

Gene sequence:

>1518_bases
ATGACACATCCAATTAAGAAAATTGCCATTATTGGCGTTGGTGTAATGGGTAGTGGTATCGCCCAAATTGCCGCACAATC
AGGACATATAACTTATTTATATGACGCTAAAGCAGGTGCAGCACAACAGGCCAAACAACAATTAGCAATTACGTTTCAAA
AACTGCTTGATAAAAACAAAATAACGACTGAATACGCAGATGCAGCCAATGCCAATCTTCTGATTGCCAACGAACTGCAT
GATTTAAAAGACTGTGACTTAATCGTTGAAGCAATTGTTGAACGTCTGGACATTAAACAGTCATTGATGAGTCAGCTTGA
GGCAATTGTACCCGAAACCACAATTTTGGCTTCAAACACTTCCTCACTTTCAATTACAGCGATTGCCTCCAACTGCAAGC
ATCCTGAGCGTGTCGCTGGCTATCATTTCTTTAATCCTGTACCACTCATGAAGGTGGTAGAAGTGATTCAGGGTTTAAAG
ACTGATCCCAAACACATTGAAACCTTGAATCAATTATCGCGGGTATTGGGTCATCGCCCAGTTGTCGCAAAAGATACCCC
AGGATTTATTATTAACCATGCGGGTCGTGCTTATGGCACAGAAGCCTTAAAAATCCTGAATGAAAATGTCACAGATATTA
GTGAAATTGACCGTATTTTACGTGATGGCGTCGGCTTTAGAATGGGACCATTCGAGCTTATGGATCTCACTGGACTTGAT
GTTTCACATCCAGTGATGGAATCAATTTATCATCAATATTATGAAGAAGCACGTTATCGTCCAAATTCATTGACCAAACA
AATGCTCGAAGCGAAACAATTAGGTCGTAAAGTGGGTCAAGGTTTTTATGATTATCGTACAGGGAGCAAAACTGGTGAGA
CTTCTGCCAAAGTGGCTGAACGCTTAACACTGTACCCAAAAGTATGGATTGCTGCTGATTTTGAAGATGATAAACAATTA
CTTATAAATTATCTCACCACACACAATATTCAACTTGATGTAGGTGCCAAGCCGCAGGCGGACAGTTTATGTTTGTTGGC
TTGTTATGGGGAAGATACAACGCATGCAGCGCTACGTCTCAATGTTAATCCAGCACATAGTGTTGCAATTGATATGCTCT
ACGGCATTGAAAAACACCGTACTTTAATGCCATCACTCATAACCGAAGTGACGTATAGTCATGCAGCTCATTCGATCTTC
AATTTAGATGGTGCAATGGTTAGCACTATTGGTGAAAGTATCGGCTTTGTGGCACAGCGCATATTGGCTATGGTCATCAA
CTTAGGCTGTGATATAGCTCAACAAGCAATTGCCTCTGTGGATGATATTAATGCAGCCGTAAGGTTGGGCTTGGGCTATC
CATTTGGGCCAATTGAATGGGGTGATGAAATTGGTTCGAATAAGATCTTACTTATTCTAAACCGCATTACTGCATTGACC
TCTGACCCACGTTACCGCCCTAGTCCATGGTTACAACGCCGTGTTGCGCTTAATCTTCCACTTACATTTACTACTTAA

Upstream 100 bases:

>100_bases
AATTTCAGGACAAATTTTACCAATTGATGGTGATAAGCAGCGACTGACCTAATTCTTCATCATCAATATCAACGGAATCA
AATCTCTAAGGACAGTCAGC

Downstream 100 bases:

>100_bases
TTTAAAAGGGAATTTAATTCATGTTAAATGCATATATTTATGATGGTTTACGTACGCCATTTGGTCGCCATGCAGGTGAA
CTTGCTTCAATCCGTCCCGA

Product: 3-hydroxy-acyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MTHPIKKIAIIGVGVMGSGIAQIAAQSGHITYLYDAKAGAAQQAKQQLAITFQKLLDKNKITTEYADAANANLLIANELH
DLKDCDLIVEAIVERLDIKQSLMSQLEAIVPETTILASNTSSLSITAIASNCKHPERVAGYHFFNPVPLMKVVEVIQGLK
TDPKHIETLNQLSRVLGHRPVVAKDTPGFIINHAGRAYGTEALKILNENVTDISEIDRILRDGVGFRMGPFELMDLTGLD
VSHPVMESIYHQYYEEARYRPNSLTKQMLEAKQLGRKVGQGFYDYRTGSKTGETSAKVAERLTLYPKVWIAADFEDDKQL
LINYLTTHNIQLDVGAKPQADSLCLLACYGEDTTHAALRLNVNPAHSVAIDMLYGIEKHRTLMPSLITEVTYSHAAHSIF
NLDGAMVSTIGESIGFVAQRILAMVINLGCDIAQQAIASVDDINAAVRLGLGYPFGPIEWGDEIGSNKILLILNRITALT
SDPRYRPSPWLQRRVALNLPLTFTT

Sequences:

>Translated_505_residues
MTHPIKKIAIIGVGVMGSGIAQIAAQSGHITYLYDAKAGAAQQAKQQLAITFQKLLDKNKITTEYADAANANLLIANELH
DLKDCDLIVEAIVERLDIKQSLMSQLEAIVPETTILASNTSSLSITAIASNCKHPERVAGYHFFNPVPLMKVVEVIQGLK
TDPKHIETLNQLSRVLGHRPVVAKDTPGFIINHAGRAYGTEALKILNENVTDISEIDRILRDGVGFRMGPFELMDLTGLD
VSHPVMESIYHQYYEEARYRPNSLTKQMLEAKQLGRKVGQGFYDYRTGSKTGETSAKVAERLTLYPKVWIAADFEDDKQL
LINYLTTHNIQLDVGAKPQADSLCLLACYGEDTTHAALRLNVNPAHSVAIDMLYGIEKHRTLMPSLITEVTYSHAAHSIF
NLDGAMVSTIGESIGFVAQRILAMVINLGCDIAQQAIASVDDINAAVRLGLGYPFGPIEWGDEIGSNKILLILNRITALT
SDPRYRPSPWLQRRVALNLPLTFTT
>Mature_504_residues
THPIKKIAIIGVGVMGSGIAQIAAQSGHITYLYDAKAGAAQQAKQQLAITFQKLLDKNKITTEYADAANANLLIANELHD
LKDCDLIVEAIVERLDIKQSLMSQLEAIVPETTILASNTSSLSITAIASNCKHPERVAGYHFFNPVPLMKVVEVIQGLKT
DPKHIETLNQLSRVLGHRPVVAKDTPGFIINHAGRAYGTEALKILNENVTDISEIDRILRDGVGFRMGPFELMDLTGLDV
SHPVMESIYHQYYEEARYRPNSLTKQMLEAKQLGRKVGQGFYDYRTGSKTGETSAKVAERLTLYPKVWIAADFEDDKQLL
INYLTTHNIQLDVGAKPQADSLCLLACYGEDTTHAALRLNVNPAHSVAIDMLYGIEKHRTLMPSLITEVTYSHAAHSIFN
LDGAMVSTIGESIGFVAQRILAMVINLGCDIAQQAIASVDDINAAVRLGLGYPFGPIEWGDEIGSNKILLILNRITALTS
DPRYRPSPWLQRRVALNLPLTFTT

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=288, Percent_Identity=36.8055555555556, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI296179427, Length=305, Percent_Identity=35.4098360655738, Blast_Score=192, Evalue=8e-49,
Organism=Homo sapiens, GI20127408, Length=379, Percent_Identity=30.3430079155673, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI261878539, Length=393, Percent_Identity=25.1908396946565, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI68989263, Length=393, Percent_Identity=25.1908396946565, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI115430219, Length=245, Percent_Identity=26.1224489795918, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1787661, Length=494, Percent_Identity=35.6275303643725, Blast_Score=307, Evalue=8e-85,
Organism=Escherichia coli, GI1790281, Length=209, Percent_Identity=33.4928229665072, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1788682, Length=224, Percent_Identity=35.7142857142857, Blast_Score=128, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17549919, Length=293, Percent_Identity=36.1774744027304, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17553560, Length=287, Percent_Identity=34.4947735191638, Blast_Score=179, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI71985923, Length=297, Percent_Identity=32.996632996633, Blast_Score=174, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI17563036, Length=294, Percent_Identity=32.9931972789116, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI71985930, Length=298, Percent_Identity=31.2080536912752, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17508951, Length=321, Percent_Identity=30.2180685358255, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17508953, Length=321, Percent_Identity=30.2180685358255, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI25144276, Length=311, Percent_Identity=30.5466237942122, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17558304, Length=321, Percent_Identity=30.2180685358255, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24583077, Length=290, Percent_Identity=28.9655172413793, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24583079, Length=290, Percent_Identity=28.9655172413793, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI19921000, Length=290, Percent_Identity=28.9655172413793, Blast_Score=139, Evalue=7e-33,
Organism=Drosophila melanogaster, GI45549573, Length=244, Percent_Identity=27.4590163934426, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI20129993, Length=225, Percent_Identity=27.1111111111111, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR011967
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 55568; Mature: 55436

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHPIKKIAIIGVGVMGSGIAQIAAQSGHITYLYDAKAGAAQQAKQQLAITFQKLLDKNK
CCCCHHEEEEEEECHHCCHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCC
ITTEYADAANANLLIANELHDLKDCDLIVEAIVERLDIKQSLMSQLEAIVPETTILASNT
CCHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
SSLSITAIASNCKHPERVAGYHFFNPVPLMKVVEVIQGLKTDPKHIETLNQLSRVLGHRP
CCEEEEEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
VVAKDTPGFIINHAGRAYGTEALKILNENVTDISEIDRILRDGVGFRMGPFELMDLTGLD
EEECCCCCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCHHHEEECCCC
VSHPVMESIYHQYYEEARYRPNSLTKQMLEAKQLGRKVGQGFYDYRTGSKTGETSAKVAE
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHH
RLTLYPKVWIAADFEDDKQLLINYLTTHNIQLDVGAKPQADSLCLLACYGEDTTHAALRL
HHHCCCEEEEEECCCCCHHHHHHHHHHCCEEEEECCCCCCCCEEEEEEECCCCCCEEEEE
NVNPAHSVAIDMLYGIEKHRTLMPSLITEVTYSHAAHSIFNLDGAMVSTIGESIGFVAQR
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
ILAMVINLGCDIAQQAIASVDDINAAVRLGLGYPFGPIEWGDEIGSNKILLILNRITALT
HHHHHHHCCCHHHHHHHHHHHHCCHHHEECCCCCCCCCCCCHHCCCCCEEEEEEHHHHHC
SDPRYRPSPWLQRRVALNLPLTFTT
CCCCCCCCHHHHHHEEEECCEEECC
>Mature Secondary Structure 
THPIKKIAIIGVGVMGSGIAQIAAQSGHITYLYDAKAGAAQQAKQQLAITFQKLLDKNK
CCCHHEEEEEEECHHCCHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCC
ITTEYADAANANLLIANELHDLKDCDLIVEAIVERLDIKQSLMSQLEAIVPETTILASNT
CCHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
SSLSITAIASNCKHPERVAGYHFFNPVPLMKVVEVIQGLKTDPKHIETLNQLSRVLGHRP
CCEEEEEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
VVAKDTPGFIINHAGRAYGTEALKILNENVTDISEIDRILRDGVGFRMGPFELMDLTGLD
EEECCCCCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCHHHEEECCCC
VSHPVMESIYHQYYEEARYRPNSLTKQMLEAKQLGRKVGQGFYDYRTGSKTGETSAKVAE
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHH
RLTLYPKVWIAADFEDDKQLLINYLTTHNIQLDVGAKPQADSLCLLACYGEDTTHAALRL
HHHCCCEEEEEECCCCCHHHHHHHHHHCCEEEEECCCCCCCCEEEEEEECCCCCCEEEEE
NVNPAHSVAIDMLYGIEKHRTLMPSLITEVTYSHAAHSIFNLDGAMVSTIGESIGFVAQR
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
ILAMVINLGCDIAQQAIASVDDINAAVRLGLGYPFGPIEWGDEIGSNKILLILNRITALT
HHHHHHHCCCHHHHHHHHHHHHCCHHHEECCCCCCCCCCCCHHCCCCCEEEEEEHHHHHC
SDPRYRPSPWLQRRVALNLPLTFTT
CCCCCCCCHHHHHHEEEECCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]