Click here to switch to the map view.

The map label for this gene is mmgC [H]

Identifier: 50084768

GI number: 50084768

Start: 1604041

End: 1605168

Strand: Direct

Name: mmgC [H]

Synonym: ACIAD1607

Alternate gene names: 50084768

Gene position: 1604041-1605168 (Clockwise)

Preceding gene: 50084767

Following gene: 50084769

Centisome position: 44.57

GC content: 42.29

Gene sequence:

>1128_bases
ATGCAATTTAATGAAGAACAGCTATTAATTCAGGATATGGCGAAAAGTTTTGCCAATGAACAGATTAAATCTAATGCAGC
AGAATGGGATAAGCATAGCATTTTTCCAAAAGACGTTTTGTCCCAAATGGGGCAATTGGGTTTTATGGGAATGCTGGTGA
GTGAGAAATGGGGCGGATCAAATACAGGAAATTTAGCTTATGTGCTGGCACTTGAAGAAATCGCTGCCGCAGATGGTGCG
ACTTCAACCATTATGAGTGTACATAATTCTGTTGGCTGTGTACCCATTGCTAAATTTGGTACAGAGGAGCAAAAGCAGAA
ATATCTAGTGCCTTTAGCACAAGGTGAAATGATCGGTGCATTTGCTTTAACGGAACCACATACAGGTTCCGATGCCGCAG
CCATTAAAACCCGAGCAATTAAACAAGGTGATGAATGGATTATTAATGGCGCTAAACAATTTATAACATCAGGTCATAAT
GCGGGCGTGATTATTGTATTTGCTGTGACAGATCCGAATGCAGGGAAAAAAGGGCTGAGTGCATTTATTGTGCCGCGTGA
AACCTTGGGTTATGAGGTGATTCGCACCGAAGAAAAATTGGGTTTACATGCGTCAGATACGTGCCAAATTGCTTTAACGG
ATGTTCGAGTACATCACAGCTTAATGCTTGGTCAGGAAGGTGAGGGACTAAAAATAGCATTGTCTAATCTGGAAGGTGGC
CGTATTGGGATTGCAGCGCAAGCCGTTGGTTTGGCACGTGCTGCACTAGAAGAAGCGACAAAATATGCCAAAGAGCGTGT
GACCTTTGGAAAGCCTATTTTTGAGCATCAGGCGTTAGCCTTTCGTTTAGCCAGTATGGCCACAGAAATTGAAGCAGCAC
GACAATTGGTTCATTACGCAGCGCGGCTTAAAGAAGCTGGAAAACCTTGTTTAAATGAAGCATCAATGGCGAAATTATTT
TCATCTGAAATGGTCGAACGCGTATGTTCTGCTGCTTTGCAAATCTTTGGTGGCTATGGCTATTTAAAAGACTTTCCCAT
CGAGCGAATTTATCGTGATGCACGTATTTGCCAGATTTATGAAGGTACAAGTGATATTCAGCGTTTAGTGATAGCAAGAA
GCCTATAA

Upstream 100 bases:

>100_bases
GATTGCCAAGCAATCCTAATCAATTCAACCTAAAAAATGATTGCTTAAAATAAGCAGTTTTGCTTAATGCATTGTATAAA
AATGAGCCAAGGAATGTGAA

Downstream 100 bases:

>100_bases
CTGACCTTTGCTGCTGTATTTTTATCATAAAATTAAGATAAGGATTCTAAAAATGACATTCGCAACAATTTTATTGGAAA
AACGTAAGGGTGTGGGCTTG

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MQFNEEQLLIQDMAKSFANEQIKSNAAEWDKHSIFPKDVLSQMGQLGFMGMLVSEKWGGSNTGNLAYVLALEEIAAADGA
TSTIMSVHNSVGCVPIAKFGTEEQKQKYLVPLAQGEMIGAFALTEPHTGSDAAAIKTRAIKQGDEWIINGAKQFITSGHN
AGVIIVFAVTDPNAGKKGLSAFIVPRETLGYEVIRTEEKLGLHASDTCQIALTDVRVHHSLMLGQEGEGLKIALSNLEGG
RIGIAAQAVGLARAALEEATKYAKERVTFGKPIFEHQALAFRLASMATEIEAARQLVHYAARLKEAGKPCLNEASMAKLF
SSEMVERVCSAALQIFGGYGYLKDFPIERIYRDARICQIYEGTSDIQRLVIARSL

Sequences:

>Translated_375_residues
MQFNEEQLLIQDMAKSFANEQIKSNAAEWDKHSIFPKDVLSQMGQLGFMGMLVSEKWGGSNTGNLAYVLALEEIAAADGA
TSTIMSVHNSVGCVPIAKFGTEEQKQKYLVPLAQGEMIGAFALTEPHTGSDAAAIKTRAIKQGDEWIINGAKQFITSGHN
AGVIIVFAVTDPNAGKKGLSAFIVPRETLGYEVIRTEEKLGLHASDTCQIALTDVRVHHSLMLGQEGEGLKIALSNLEGG
RIGIAAQAVGLARAALEEATKYAKERVTFGKPIFEHQALAFRLASMATEIEAARQLVHYAARLKEAGKPCLNEASMAKLF
SSEMVERVCSAALQIFGGYGYLKDFPIERIYRDARICQIYEGTSDIQRLVIARSL
>Mature_375_residues
MQFNEEQLLIQDMAKSFANEQIKSNAAEWDKHSIFPKDVLSQMGQLGFMGMLVSEKWGGSNTGNLAYVLALEEIAAADGA
TSTIMSVHNSVGCVPIAKFGTEEQKQKYLVPLAQGEMIGAFALTEPHTGSDAAAIKTRAIKQGDEWIINGAKQFITSGHN
AGVIIVFAVTDPNAGKKGLSAFIVPRETLGYEVIRTEEKLGLHASDTCQIALTDVRVHHSLMLGQEGEGLKIALSNLEGG
RIGIAAQAVGLARAALEEATKYAKERVTFGKPIFEHQALAFRLASMATEIEAARQLVHYAARLKEAGKPCLNEASMAKLF
SSEMVERVCSAALQIFGGYGYLKDFPIERIYRDARICQIYEGTSDIQRLVIARSL

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=369, Percent_Identity=46.3414634146341, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI4501859, Length=373, Percent_Identity=43.1635388739946, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI4557231, Length=377, Percent_Identity=41.1140583554377, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI187960098, Length=377, Percent_Identity=41.1140583554377, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI7656849, Length=376, Percent_Identity=38.8297872340425, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=36, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI226958414, Length=359, Percent_Identity=35.3760445682451, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI21361497, Length=379, Percent_Identity=37.2031662269129, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI4501857, Length=375, Percent_Identity=33.3333333333333, Blast_Score=211, Evalue=9e-55,
Organism=Homo sapiens, GI4557235, Length=385, Percent_Identity=34.2857142857143, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI76496475, Length=385, Percent_Identity=34.2857142857143, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI4503943, Length=376, Percent_Identity=28.9893617021277, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI7669494, Length=362, Percent_Identity=28.4530386740331, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI48976061, Length=286, Percent_Identity=30.7692307692308, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI211971008, Length=286, Percent_Identity=30.7692307692308, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI38505218, Length=287, Percent_Identity=29.9651567944251, Blast_Score=118, Evalue=1e-26,
Organism=Escherichia coli, GI1786223, Length=378, Percent_Identity=27.5132275132275, Blast_Score=164, Evalue=9e-42,
Organism=Escherichia coli, GI87081958, Length=348, Percent_Identity=31.3218390804598, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI87082384, Length=288, Percent_Identity=28.4722222222222, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87081702, Length=360, Percent_Identity=26.9444444444444, Blast_Score=89, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17508101, Length=372, Percent_Identity=41.6666666666667, Blast_Score=288, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI17506239, Length=371, Percent_Identity=40.7008086253369, Blast_Score=288, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI17534899, Length=379, Percent_Identity=40.6332453825858, Blast_Score=270, Evalue=9e-73,
Organism=Caenorhabditis elegans, GI17569725, Length=379, Percent_Identity=39.5778364116095, Blast_Score=258, Evalue=5e-69,
Organism=Caenorhabditis elegans, GI17538396, Length=375, Percent_Identity=32.5333333333333, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17570075, Length=379, Percent_Identity=35.3562005277045, Blast_Score=238, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI71990804, Length=293, Percent_Identity=41.6382252559727, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17533517, Length=364, Percent_Identity=34.6153846153846, Blast_Score=227, Evalue=8e-60,
Organism=Caenorhabditis elegans, GI71985184, Length=356, Percent_Identity=35.3932584269663, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17551932, Length=378, Percent_Identity=31.2169312169312, Blast_Score=191, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=39.8268398268398, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17505929, Length=378, Percent_Identity=29.8941798941799, Blast_Score=181, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI17534353, Length=376, Percent_Identity=30.5851063829787, Blast_Score=177, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI71982178, Length=269, Percent_Identity=36.4312267657993, Blast_Score=171, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI71985192, Length=281, Percent_Identity=34.8754448398576, Blast_Score=160, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI17531909, Length=239, Percent_Identity=35.9832635983264, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17562446, Length=287, Percent_Identity=31.3588850174216, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17531913, Length=177, Percent_Identity=36.1581920903955, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI86563383, Length=273, Percent_Identity=29.3040293040293, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI86563381, Length=273, Percent_Identity=29.3040293040293, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17540912, Length=287, Percent_Identity=25.0871080139373, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21356377, Length=373, Percent_Identity=44.5040214477212, Blast_Score=327, Evalue=9e-90,
Organism=Drosophila melanogaster, GI24646207, Length=374, Percent_Identity=43.8502673796791, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24666513, Length=372, Percent_Identity=41.1290322580645, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24660351, Length=377, Percent_Identity=40.8488063660477, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI21355753, Length=377, Percent_Identity=34.4827586206897, Blast_Score=228, Evalue=7e-60,
Organism=Drosophila melanogaster, GI281363737, Length=357, Percent_Identity=35.8543417366947, Blast_Score=215, Evalue=4e-56,
Organism=Drosophila melanogaster, GI19920834, Length=381, Percent_Identity=31.758530183727, Blast_Score=172, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 40711; Mature: 40711

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFNEEQLLIQDMAKSFANEQIKSNAAEWDKHSIFPKDVLSQMGQLGFMGMLVSEKWGGS
CCCCHHHHHHHHHHHHHHHHHHHCCHHCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCC
NTGNLAYVLALEEIAAADGATSTIMSVHNSVGCVPIAKFGTEEQKQKYLVPLAQGEMIGA
CCCCEEEEEEEHHHHHCCCCHHHHHHHHHCCCCEEEHHCCCHHHHHHEEEEECCCCEEEE
FALTEPHTGSDAAAIKTRAIKQGDEWIINGAKQFITSGHNAGVIIVFAVTDPNAGKKGLS
EEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCE
AFIVPRETLGYEVIRTEEKLGLHASDTCQIALTDVRVHHSLMLGQEGEGLKIALSNLEGG
EEEEEHHHHCCHHEECHHHHCCCCCCCEEEEEEEHHHHHHHHCCCCCCCEEEEEECCCCC
RIGIAAQAVGLARAALEEATKYAKERVTFGKPIFEHQALAFRLASMATEIEAARQLVHYA
EEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARLKEAGKPCLNEASMAKLFSSEMVERVCSAALQIFGGYGYLKDFPIERIYRDARICQIY
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHHEEEE
EGTSDIQRLVIARSL
CCHHHHHHHHHHHCC
>Mature Secondary Structure
MQFNEEQLLIQDMAKSFANEQIKSNAAEWDKHSIFPKDVLSQMGQLGFMGMLVSEKWGGS
CCCCHHHHHHHHHHHHHHHHHHHCCHHCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCC
NTGNLAYVLALEEIAAADGATSTIMSVHNSVGCVPIAKFGTEEQKQKYLVPLAQGEMIGA
CCCCEEEEEEEHHHHHCCCCHHHHHHHHHCCCCEEEHHCCCHHHHHHEEEEECCCCEEEE
FALTEPHTGSDAAAIKTRAIKQGDEWIINGAKQFITSGHNAGVIIVFAVTDPNAGKKGLS
EEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCE
AFIVPRETLGYEVIRTEEKLGLHASDTCQIALTDVRVHHSLMLGQEGEGLKIALSNLEGG
EEEEEHHHHCCHHEECHHHHCCCCCCCEEEEEEEHHHHHHHHCCCCCCCEEEEEECCCCC
RIGIAAQAVGLARAALEEATKYAKERVTFGKPIFEHQALAFRLASMATEIEAARQLVHYA
EEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARLKEAGKPCLNEASMAKLFSSEMVERVCSAALQIFGGYGYLKDFPIERIYRDARICQIY
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHHEEEE
EGTSDIQRLVIARSL
CCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]