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The map label for this gene is mmsB [H]

Identifier: 50084766

GI number: 50084766

Start: 1601344

End: 1602237

Strand: Direct

Name: mmsB [H]

Synonym: ACIAD1605

Alternate gene names: 50084766

Gene position: 1601344-1602237 (Clockwise)

Preceding gene: 50084765

Following gene: 50084767

Centisome position: 44.5

GC content: 42.17

Gene sequence:

>894_bases
ATGAATATTGCATTTATTGGTTTGGGAAATATGGGCGGAAAAATGGTCCAAAATTTACTCAAAACTGGCGCAACAGTGTA
TGGCTTTGATCTTAGTCAAACTGCGATTGCACATTTTGTTGAGGCAGGTGGCATTGCTTCAGATAGTCCACACGACGCTG
CAAAAAATGCGGATATTGTGATCACCATGCTACCTGCAGCCAAGCATGTCAAAGAGATTTATTTAGCTGAAGACGGCGTA
TTTACGGTACTCAAGCAAGGCAGTATATGTATCGATAGCAGTACCATTGACCCGCAAAGTATTAAAGATATTGCAAAAAT
TGGTGCAGAAAAAGGGATTAAAGTTTGTGATGCACCTGTATCGGGTGGAACCATTGGTGCACAAGCAGGCACATTAACAT
TTATGGTCGGAACGGATGCTGATCTATTTGAACAGGTGAAGTCTGTTTTAAGTTCAATGGGTAAAAACATTGTGTATTGT
GGTGAGGTCGGTTCGGGCCAGATTGCCAAGATTTGTAATAATTTAATTTTAGGCATTTCAATGACGGCAGTCGCAGAAGG
TATGGCGCTAGGTGCAAAACTAGGCATTGATCCGCAGATTTTGGCGGGCGTAATTAATAGCTCAAGTGGTCGTTGCTGGA
GTTCTGAAGTGTGCAATCCTTGGCCAGATGTTTCTGCCAATGCGCCTGCTGGTCGCGGTTATAGCGATGGATTTGCGACG
CAATTAATGTTGAAAGATCTTGGACTAGCGATAGAAGCGGCAGGACAAGTCAAACAGCCTGTACTTTTGGCTGGATTGGT
ACAACAACAATATCAACAGTTATGTATGCAAGGAAATGCACAACTGGATTTTTCAAGTATTATTCAGCAATATTTACCGC
AAAATTCGCAATAA

Upstream 100 bases:

>100_bases
ATACACAAACCAAAACCATTACCAGCCGTTGGTTTGAAGATACCCAGGAGAAAGGGGAAGTCAACACCACGATTAGTTTG
CGTTAAATAGGAGTTCAAGG

Downstream 100 bases:

>100_bases
AATCAGGCGAAGAAAAGCAATTAAACAGTAGAAATTTCGATTCAAAAATAACAATACATCTAGGATGGAGTATCTGATAT
GTTGGATTATCAAACGGTCG

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MNIAFIGLGNMGGKMVQNLLKTGATVYGFDLSQTAIAHFVEAGGIASDSPHDAAKNADIVITMLPAAKHVKEIYLAEDGV
FTVLKQGSICIDSSTIDPQSIKDIAKIGAEKGIKVCDAPVSGGTIGAQAGTLTFMVGTDADLFEQVKSVLSSMGKNIVYC
GEVGSGQIAKICNNLILGISMTAVAEGMALGAKLGIDPQILAGVINSSSGRCWSSEVCNPWPDVSANAPAGRGYSDGFAT
QLMLKDLGLAIEAAGQVKQPVLLAGLVQQQYQQLCMQGNAQLDFSSIIQQYLPQNSQ

Sequences:

>Translated_297_residues
MNIAFIGLGNMGGKMVQNLLKTGATVYGFDLSQTAIAHFVEAGGIASDSPHDAAKNADIVITMLPAAKHVKEIYLAEDGV
FTVLKQGSICIDSSTIDPQSIKDIAKIGAEKGIKVCDAPVSGGTIGAQAGTLTFMVGTDADLFEQVKSVLSSMGKNIVYC
GEVGSGQIAKICNNLILGISMTAVAEGMALGAKLGIDPQILAGVINSSSGRCWSSEVCNPWPDVSANAPAGRGYSDGFAT
QLMLKDLGLAIEAAGQVKQPVLLAGLVQQQYQQLCMQGNAQLDFSSIIQQYLPQNSQ
>Mature_297_residues
MNIAFIGLGNMGGKMVQNLLKTGATVYGFDLSQTAIAHFVEAGGIASDSPHDAAKNADIVITMLPAAKHVKEIYLAEDGV
FTVLKQGSICIDSSTIDPQSIKDIAKIGAEKGIKVCDAPVSGGTIGAQAGTLTFMVGTDADLFEQVKSVLSSMGKNIVYC
GEVGSGQIAKICNNLILGISMTAVAEGMALGAKLGIDPQILAGVINSSSGRCWSSEVCNPWPDVSANAPAGRGYSDGFAT
QLMLKDLGLAIEAAGQVKQPVLLAGLVQQQYQQLCMQGNAQLDFSSIIQQYLPQNSQ

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=287, Percent_Identity=48.0836236933798, Blast_Score=273, Evalue=1e-73,
Organism=Homo sapiens, GI40556376, Length=291, Percent_Identity=26.1168384879725, Blast_Score=113, Evalue=2e-25,
Organism=Escherichia coli, GI145693186, Length=291, Percent_Identity=34.020618556701, Blast_Score=164, Evalue=5e-42,
Organism=Escherichia coli, GI1786719, Length=289, Percent_Identity=31.8339100346021, Blast_Score=144, Evalue=8e-36,
Organism=Escherichia coli, GI1790315, Length=290, Percent_Identity=33.1034482758621, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1789092, Length=293, Percent_Identity=29.6928327645051, Blast_Score=100, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17557316, Length=294, Percent_Identity=45.9183673469388, Blast_Score=245, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24655230, Length=288, Percent_Identity=45.4861111111111, Blast_Score=243, Evalue=1e-64,
Organism=Drosophila melanogaster, GI19922568, Length=288, Percent_Identity=45.4861111111111, Blast_Score=243, Evalue=1e-64,
Organism=Drosophila melanogaster, GI28574115, Length=290, Percent_Identity=24.1379310344828, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 30873; Mature: 30873

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIAFIGLGNMGGKMVQNLLKTGATVYGFDLSQTAIAHFVEAGGIASDSPHDAAKNADIV
CEEEEEEECCCCHHHHHHHHHCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEE
ITMLPAAKHVKEIYLAEDGVFTVLKQGSICIDSSTIDPQSIKDIAKIGAEKGIKVCDAPV
EEECCCHHHHHHHHHCCCCCEEHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCEEECCCC
SGGTIGAQAGTLTFMVGTDADLFEQVKSVLSSMGKNIVYCGEVGSGQIAKICNNLILGIS
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHH
MTAVAEGMALGAKLGIDPQILAGVINSSSGRCWSSEVCNPWPDVSANAPAGRGYSDGFAT
HHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCHHHH
QLMLKDLGLAIEAAGQVKQPVLLAGLVQQQYQQLCMQGNAQLDFSSIIQQYLPQNSQ
HHHHHHHCHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MNIAFIGLGNMGGKMVQNLLKTGATVYGFDLSQTAIAHFVEAGGIASDSPHDAAKNADIV
CEEEEEEECCCCHHHHHHHHHCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEE
ITMLPAAKHVKEIYLAEDGVFTVLKQGSICIDSSTIDPQSIKDIAKIGAEKGIKVCDAPV
EEECCCHHHHHHHHHCCCCCEEHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCEEECCCC
SGGTIGAQAGTLTFMVGTDADLFEQVKSVLSSMGKNIVYCGEVGSGQIAKICNNLILGIS
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHH
MTAVAEGMALGAKLGIDPQILAGVINSSSGRCWSSEVCNPWPDVSANAPAGRGYSDGFAT
HHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCHHHH
QLMLKDLGLAIEAAGQVKQPVLLAGLVQQQYQQLCMQGNAQLDFSSIIQQYLPQNSQ
HHHHHHHCHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1339433; 10984043 [H]